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| 1 | 肠易激综合征发病机制研究新进展显示文摘肠易激综合征(irritable bowel syndrome,IBS)是功能性胃肠疾病的一种,严重影响着人们的生活质量,有效控制IBS是一个全世界面临的医疗卫生保健问题,但其发病原因和机制尚未完全明确,其发病涉及多种复杂因素的相互作用,本文就IBS发病机制方面的研究新进展作一概述。 | 古巧燕 张军 | 2017 | 胃肠病学和肝病学杂志2017，26，12： | 26 |
| 2 | 肠易激综合征发病机制研究及治疗进展显示文摘肠易激综合征(Irritable bowel syndrome,IBS)是最常见的消化系统疾病之一,是一组包括持续或间歇发作的腹痛,腹胀,排便习惯和大便性状异常而又缺乏生化学和形态学可解释的症候群。IBS是一种全球性疾病,人群患病率较高,且有逐年增高的趋势。对患者生活质量影响较大且需花费高额医疗费用。 | 卢璐 袁建业 费晓燕 卞慧 | 2015 | 中国中西医结合消化杂志2015，23，9： | 22 |
| 3 | 肠易激综合征发病机制的研究进展显示文摘肠易激综合征(IBS)是临床常见的慢性胃肠功能紊乱性疾病,以不定部位的腹痛、腹胀,或伴排便习惯和大便性状异常为特征。该病症状处于持续或间歇发作状态,且经相关检查无器质性病变。研究表明[1-2],1997年北京地区IBS流行率在7%左右,而在西方国家,成年人中IBS发病率约为8%~23%。该病病程较长,且反复发作, | 金世禄 张学娜 | 2012 | 实用临床医药杂志2012，16，13： | 14 |
| 4 | Complementary and alternative medicines in irritable bowel syndrome: An integrative view显示文摘Irritable bowel syndrome(IBS)is a common gastrointestinal disorder with a high incidence in the general population.The diagnosis of IBS is mainly based on exclusion of other intestinal conditions through the absence of inflammatory markers and specific antigens.The current pharmacological treatment approaches available focus on reducing symptom severity while often limiting quality of life because of significant side effects.This has led to an effectiveness gap for IBS patients that seek further relief to increase their quality of life.Complementary and alternative medicines(CAM)have been associated with a higher degree of symptom management and quality of life in IBS patients.Over the past decade,a number of important clinical trials have shown that specific herbal therapies(peppermint oil and Iberogast?),hypnotherapy,cognitive behavior therapy,acupuncture,and yoga present with improved treatment outcomes in IBS patients.We propose an integrative approach to treating the diverse symptoms of IBS by combining the benefits of and need for pharmacotherapy with known CAM therapies to provide IBS patients with the best treatment outcome achievable.Initial steps in this direction are already being considered with an increasing number of practitioners recommending CAM therapies to their patients if pharmacotherapy alone does not alleviate symptoms sufficiently. | Oliver Grundmann Saunjoo L Yoon | 2014 | World Journal of Gastroenterology2014，20，2： | 13 |
| 5 | Role of negative affects in pathophysiology and clinical expression of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is regarded as a multifactorial disease in which alterations in the brain-gut axis signaling play a major role.The biopsychosocial model applied to the understanding of IBS pathophysiology assumes that psychosocial factors,interacting with peripheral/central neuroendocrine and immune changes,may induce symptoms of IBS,modulate symptom severity,influence illness experience and quality of life,and affect outcome.The present review focuses on the role of negative affects,including depression,anxiety,and anger,on pathogenesis and clinical expression of IBS.The potential role of the autonomic nervous system,stress-hormone system,and immune system in the pathophysiology of both negative affects and IBS are taken into account.Psychiatric comorbidity and subclinical variations in levels of depression,anxiety,and anger are further discussed in relation to the main pathophysiological and symptomatic correlates of IBS,such as sensorimotor functions,gut microbiota,inflammation/immunity,and symptom reporting. | Maria Rosaria A Muscatello Antonio Bruno Giuseppe Scimeca Gianluca Polfo Rocco A Zoccali | 2014 | World Journal of Gastroenterology2014，20，24： | 9 |
| 6 | 肠易激综合征脑-肠轴机制的研究进展显示文摘肠易激综合征(IBS)是一种以腹痛或腹部不适伴排便习惯改变和(或)大便性状异常的功能性肠病,该病缺乏可解释症状的形态学改变和生化异常.属中医学“泄泻”、“便秘”、“腹痛”范畴,患者症状可间歇或持续发作。据2006年公布的“IBS罗马III诊断标准”该病可分为腹泻型、便秘型和混合型。 | 朱莉 孙建华 | 2014 | 中国中医急症2014，23，4： | 9 |
| 7 | Recent advances in pharmacological treatment of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS) is a highly prevalent functional disorder that reduces patients' quality of life. It is a chronic disorder characterized by abdominal pain or discomfort associated with disordered defecation in the absence of identifiable structural or biochemical abnormalities. IBS imposes a significant economic burden to the healthcare system. Alteration in neurohumoral mechanisms and psychological factors, bacterial overgrowth, genetic factors, gut motility, visceral hypersensitivity, and immune system factors are currently believed to influence the pathogenesis of IBS. It is possible that there is an interaction of one or more of these etiologic factors leading to heterogeneous symptoms of IBS. IBS treatment is predicated upon the patient's most bothersome symptoms. Despite the wide range of medications and the high prevalence of the disease, to date no completely effective remedy is available. This article reviews the literature from January 2008 to July 2013 on the subject of IBS peripherally acting pharmacological treatment. Drugs are categorized according to their administration for IBS-C, IBS-D or abdominal pain predominant IBS. | Georgia Lazaraki Grigoris Chatzimavroudis Panagiotis Katsinelos | 2014 | World Journal of Gastroenterology2014，20，27： | 5 |
| 8 | 儿童轮状病毒感染性腹泻早期血清CD4^+T细胞相关细胞因子水平检测显示文摘目的:分析儿童轮状病毒感染性腹泻疾病中CD4+T细胞相关细胞因子所起的作用。方法:采用ELISA法定量检测40例轮状病毒感染性腹泻儿童及同期40例正常对照儿童的血清CD4+T细胞相关细胞因子IL-17、IL-6、IFN-γ、IL-4、TGF-β水平。结果:观察组患儿血清IL-17、IL-6、IFN-γ、IL-4的水平与正常对照组相近(P>0.05);而血清中TGF-β水平则观察组高于对照组(P<0.05)。结论:轮状病毒感染性腹泻儿童引起腹泻的重要原因是早期病毒活化具有免疫抑制作用的调节性T细胞,导致免疫功能失调。 | 张艳平 | 2012 | 中国妇幼保健2012，27，32： | 1 |
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