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| 1 | Metabolic profiling analysis of a D-galactosamine/lipopolysaccharide- induced mouse model of fulminant hepatic failure显示文摘 | Feng, B Wu, SM Lv, S Liu, F Chen, HS Yan, XZ Li, Y Dong, FT Wei, L | 2007 | 中国生物学文摘2007，21，11： | 23 |
| 2 | A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein显示文摘最新新兴的中东呼吸症候群 coronavirus (MERS-CoV ) 能在人引起严重、致命的急性呼吸疾病。尽管有全球努力,潜力为一联系在未来流行不能被排除。有效相对的措施的发展是迫切的。MERS-CoV-specific 抗病毒的药或疫苗是还没可得到的。使用 MERS-CoV (MERS-RBD ) 的尖铁受体绑定领域使老鼠免疫,我们识别了二抵销 monoclonal 抗体(mAbs ) 4C2 和 2E6。两 mAbs potently 与高功效在 vitro 绑在 MERS-RBD 和块病毒入口。我们进一步由使在 Fab 碎片和 RBD 之间的建筑群结晶调查了他们中立化的机制,并且解决了 4C2 Fab/MERS-RBD 建筑群的结构。结构证明 4C2 认出部分重叠的 epitope 在 MERS-RBD 的受体绑定脚印,从而由位的阻碍者和接口残余竞争防碍病毒 / 受体相互作用。2E6 也堵住受体绑定,并且为绑定与 4C2 竞争到 MERS-RBD。基于结构,我们进一步由保存仅仅 paratope 残余并且从人的免疫球蛋白与对应物代替留下的氨基酸使 4C2 人性化。人性化的 4C2 (4C2h ) 抗体支撑了类似的抵销的活动和生物化学的特征到父母老鼠抗体。最后,我们证明 4C2h 能显著地在感染 MERS-CoV 的 Ad5-hCD26-transduced 鼠标的肺消除病毒 titers,因此在临床的设置为预防和治疗代表一个有希望的代理人。 | Yan Li YuhuaWan Peipei Liu Jincun Zhao Guangwen Lu Jianxun Qi Qihui Wang Xuancheng LU Ying Wu Weniun Liu Buchang Zhang Kwok-Yung Yuen Stanley Perlman George F Gao Jinghua Yan | 2015 | Cell Research2015，25，11： | 14 |
| 3 | Osteoclast fusion and regulation by RANKL-dependent and independent factors显示文摘Osteoclasts are the bone resorbing cells essential for bone remodeling.Osteoclasts are formed from hematopoietic progenitors in the monocyte/macrophage lineage.Osteoclastogenesis is composed of several steps including progenitor survival,differentiation to mononuclear pre-osteoclasts,fusion to multi-nuclear mature osteoclasts,and activation to bone resorbing osteoclasts.The regulation of osteoclastogenesis has been extensively studied,in which the receptor activator of NF-κB ligand(RANKL)-mediated signaling pathway and downstream transcription factors play essential roles.However,less is known about osteoclast fusion,which is a property of mature osteoclasts and is required for osteoclasts to resorb bone.Several proteins that affect cell fusion have been identified.Among them,dritic cell-specific transmembrane protein(DC-STAMP)is directly associated to osteoclast fusion in vivo.Cytokines and factors influence osteoclast fusion through regula-tion of DC-STAMP.Here we review the recently discovered new factors that regulate osteoclast fusion with specific focus on DC-STAMP.A better understanding of the mechanistic basis of osteoclast fusion will lead to the development of a new therapeutic strategy for bone disorders due to elevated osteoclast bone resorption.Cell-cell fusion is essential for a variety of cellular biological processes.In mammals,there is a limited number of cell types that fuse to form multinucleated cells,such as the fusion of myoblasts for the formation of skeletal muscle and the fusion of cells of the monocyte/macrophage lineage for the formation of multinucleated osteoclasts and giant cells.In most cases,cellcell fusion is beneficial for cells by enhancing function.Myoblast fusion increases myofiber size and diameter and thereby increases contractile strength.Multinucleated osteoclasts have far more bone resorbing activity than their mono-nuclear counterparts.Multinucleated giant cells are much more efficient in the removal of implanted materials and bacteria due to chronic infection than macrophages.Therefore,they are also called foreign-body giant cells.Cell fusion is a complicated process involving cell migration,chemotaxis,cell-cell recognition and attachment,as well as changes into a fusion-competent status.All of these steps are regulated by multiple factors.In this review,we will discuss osteoclast fusion and regulation. | Lianping Xing Yan Xiu Brendan F Boyce | 2012 | World Journal of Orthopedics2012，3，12： | 14 |
| 4 | Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy显示文摘 | Kefang Liu ShuguangTan Yan Chai Danqing Chen Hao Song Catherine Wei-Hong Zhang yi Shi Jun Liu Wenjie Tan Jianxin Lyu Shah Gao Jinghua Yan Jianxun Qi George F Gao | 2017 | Cell Research2017，27，1： | 11 |
| 5 | Optimal controlled teleportation via several kinds of three-qubit states显示文摘The probability of successful controlled teleportation of an unknown qubit using a general three-particle state is investigated. The analytic expressions of maximal probabilities via several kinds of tripartite states are given, including a tripartite Greenberger-Horne-Zeilinger state and a tripartite W-state. | GAO Ting1,2, YAN FengLi2,3 & LI YouCheng3 1 College of Mathematics and Information Science, Hebei Normal University, Shijiazhuang 050016, China 2 Max-Planck-Institut für Quantenoptik, Hans-Kopfermann-Str. 1, D-85748 Garching, Germany 3 College of Physics and Information Engineering, Hebei Normal University, Shijiazhuang 050016, China | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，10： | 9 |
| 6 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 7 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 8 | Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver显示文摘 | Yang F Yan S He Y | | 0，，： | 2 |
| 9 | H^+,N^+和Ar^+离子束辐射诱导碳纳米结构的变化(英文)显示文摘在室温和高温下,以不同辐射剂量的H+、N+和Ar+离子辐照多壁碳纳米管和无定形碳纳米线。利用透射电镜和拉曼光谱研究多壁碳纳米管和无定形碳纳米线的结构变化及损伤。以70keV N+离子束辐射多壁碳纳米管在室温下可形成无定形碳纳米线。1000K下70keV的H+离子束照射导致无定形碳纳米线向金刚石结构转变。离子辐照多壁碳纳米管的有序程度足够高,70keV的N+和Ar+离子能够引起碳从多壁碳纳米管的剥落。离子辐射能够为缺陷的转化提供必需的动力学驱动力。 | A Ishaq Shahid Iqbal Naveed Ali A A Khurram A U Akrajas C F Dee Shahzad Naseem H M Rafique Yan Long | 2013 | 新型炭材料2013，28，2： | 2 |
| 10 | Hypoxia-associated induction of early growth response-1 gene expression 显示文摘 | Yan S F Lu J Zou Y S | 1999 | J Biol Chem1999，274，15： | 2 |
| 11 | Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses显示文摘 | Di Liu Weifeng Shi Yi Shi Dayan Wang Haixia Xiao Wei Li Yuhai Bi Ying Wu Xianbin Li Jinghua Yan Wenjun Liu Guoping Zhao Weizhong Yang Yu Wang Juncai Ma Yuelong Shu Fumin Lei George F Gao | 2013 | The Lancet2013，，9881： | 2 |
| 12 | Ventricular repolarization components on the electrocardiogram显示文摘 | Gan-Xin Yan Ramarao S Lankipalli James F Burke Simone Musco Peter R Kowey | 2003 | Journal of the American College of Cardiology2003，，： | 2 |
| 13 | Increasing anthropogenic nitrogen inputs and riverine DIN exports from the Changjiang River basin under changing human pressures显示文摘 | Yan Weijin Mayorga Emilio Li Xinyan Seitzinger Sybil P. Bouwman A. F | 2010 | Global Biogeochemical Cycles2010，，： | 2 |
| 14 | 卫星专用传感器微波成像仪/探测仪(SSMIS)观测资料在天气和气候研究中的应用(英文)显示文摘2003年10月18日,美国国防气象卫星计划成功发射搭载了专用传感器微波成像仪/探测仪的F-16卫星。然而由于天线自身热辐射和校准暖黑体的不稳定,第一个专用传感器微波成像仪/探测仪出现了一些重要的异常观测。美国海军实验室与美国国家海洋和大气管理局(NOAA)分别开发了两种算法来订正这些异常值。剔除了定标异常值后,专用传感器微波成像仪/探测仪资料目前在探空数据产品反演和资料同化中发挥了更加显著的作用。NOAA利用专用传感器微波成像仪已有算法生成了专用传感器微波成像仪/探测仪成像仪产品。此外,一些新开发的算法可以从专用传感器微波成像仪/探测仪资料中提取出云和降水的信息。在云冰云水的反演算法中,亮温是与云冰云水路径和粒子的平均直径相关的。利用一维变分反演系统,同时反演出了多数大气和地表条件下的大气温度、湿度以及水凝物的垂直廓线。在各种天气形势下,由专用传感器微波成像仪/探测仪资料反演得到的温度和湿度廓线的均方根误差通常分别小于2K和15%。为了同化专用传感器微波成像仪/探测仪资料,还发展了新的质量控制和偏差订正方法。在NOAA的全球预报系统中同化了专用传感器微波成像仪/探测仪资料后,对提高全球中期数值预报水平产生了中性和较小的正效果。 | Weng F Zou X Yan B Han Y Liu Q | 2011 | 气象科技进展2011，1，1： | 2 |
| 15 | Adaptive radiation therapy显示文摘 | Yan D Vicini F Wong J | 1997 | Phys Med Biol1997，42，1： | 1 |
| 16 | Phylogenetic analysis reveals that a dwarfing disease on different cereal crops in China is due to rice black streaked dwarf virus (RBSDV) 显示文摘 | BAI F W YAN J QU Z C | 2002 | Virus Genes2002，25，2： | 1 |
| 17 | Transient analysis of reactant gas transport and performance of PEM fuel cells 显示文摘 | YAN W M SOONG C Y CHEN F | 2005 | Journal of Power Sources2005，143，12： | 1 |
| 18 | Soil nutrient factors related to salidroside production of rhodiola sachalinensis distributed in chang bai mountain显示文摘 | YAN X F WU S X WANG Y SHANG X H DAI S J | 2004 | Environmental and Experimental Botsny2004，52，： | 1 |
| 19 | Analysis on the weld defects of AZ91D magnesium alloy joints显示文摘 | YE H YAN Z L SHEN B XUE Z F | 2009 | Materials Science Forum2009，610，： | 1 |
| 20 | Origin and technic significance of a Mesozoic multi-layer over-thrust system within the Yangtze Block (South china)显示文摘 | Yan D P Zhou M F Song H L | 2003 | Tectonophysics2003，361，： | 1 |
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