5篇
您的检索式：作者名="Francesca Meda"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Experimental evidence on the immunopathogenesis of primary biliary cirrhosis显示文摘Primary biliary cirrhosis(PBC)is a chronic cholestatic liver disease for which an autoimmune pathogenesis is supported by clinical and experimental data,including the presence of autoantibodies and autoreactive T cells.The etiology remains to be determined,yet data suggest that both a susceptible genetic background and unknown environmental factors determine disease onset.Multiple infectious and chemical candidates have been proposed to trigger the disease in a genetically susceptible host,mostly by molecular mimicry.Most recently,several murine models have been reported,including genetically determined models as well as models induced by immunization with xenobiotics and bacteria. | Carlo Selmi Francesca Meda Anaid Kasangian Pietro Invernizzi Zhigang Tian Zhexiong Lian Mauro Podda M Eric Gershwin | 2010 | Cellular & Molecular Immunology2010，7，1： | 14 |
| 2 | The epigenetics of autoimmunity显示文摘The etiology of autoimmune diseases remains largely unknown.Concordance rates in monozygotic twins are lower than 50% while genome-wide association studies propose numerous significant associations representing only a minority of patients.These lines of evidence strongly support other complementary mechanisms involved in the regulation of genes expression ultimately causing overt autoimmunity.Alterations in the post-translational modification of histones and DNA methylation are the two major epigenetic mechanisms that may potentially cause a breakdown of immune tolerance and the perpetuation of autoimmune diseases.In recent years,several studies both in clinical settings and experimental models proposed that the epigenome may hold the key to a better understanding of autoimmunity initiation and perpetuation.More specifically,data support the impact of epigenetic changes in systemic lupus erythematosus,rheumatoid arthritis,multiple sclerosis and other autoimmune diseases,in some cases based on mechanistical observations.We herein discuss what we currently know and what we expect will come in the next future.Ultimately,epigenetic treatments already being used in oncology may soon prove beneficial also in autoimmune diseases. | Francesca Meda Marco Folci Andrea Baccarelli Carlo Selmi | 2011 | Cellular & Molecular Immunology2011，8，3： | 8 |
| 3 | Knowledge, attitude and practice in primary and secondary cervical cancer prevention among young adult Italian women显示文摘 | Serena Donati Cristina Giambi Silvia Declich Stefania Salmaso Antonietta Filia Marta Luisa Ciofi degli Atti Maria Pia Alibrandi Silvia Brezzi Francesca Carozzi Natalina Collina Daniela Franchi Amedeo Lattanzi Margherita Meda Maria Carmela Minna Roberto Na | 2012 | Vaccine2012，，： | 1 |
| 4 | Serum autoantibodies: A road map for the clinical hepatologist显示文摘 | Francesca Meda Massimo Zuin Pietro Invernizzi Diego Vergani Carlo Selmi | 2008 | Autoimmunity2008，，1： | 1 |
| 5 | Nerves and hydrogen peroxide: how old enemies become new friends显示文摘ROS and nerves play together during the regeneration process:For many years,the role of reactive oxygen species(ROS)in neurobiology has mainly focused on its pathological implications in neurodegenerative diseases.Contrasting with this view,ROS were recently put forward as key positive signals for axon growth and repair,highlighting beneficial functions of ROS signalling in the vertebrate adult brain(Borquez et al.,2016). | francesca meda alain joliot sophie vriz | 2017 | Neural Regeneration Research2017，12，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员