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| 1 | Incidence of hepatocellular carcinoma in outpatients with cirrhosis in Brazil: A 10-year retrospective cohort study显示文摘AIM To determine the incidence of hepatocellular carcinoma(HCC) and the impact of HCC surveillance on early diagnosis and survival of cirrhotic outpatients. METHODS In this retrospective cohort study, cirrhotic outpatients undergoing HCC surveillance between March 2005 and March 2014 were analyzed. Exclusion criteria were HIV coinfection; previous organ transplantation; diagnosis of HCC at first consultation; missing data in the medical chart; and less than 1 year of follow-up. Surveillance was carried out every six months using ultrasound and serum alpha-fetoprotein determination. Ten-year cumulative incidence and survival were estimated through Kaplan-Meier analysis. RESULTS Four hundred and fifty-three patients were enrolled, of which 57.6% were male. Mean age was 55 years. Hepatitis C virus and heavy use of alcohol were the main etiologic agents of cirrhosis. HCC was diagnosed in 75 patients(16.6%), with an estimated cumulative incidence of 2.6% in the 1st year, 15.4% in the 5th year, and 28.8% in the 10 th year. Median survival was estimated at 17.6 mo in HCC patients compared to 234 mo in non-HCC patients(P < 0.001). Early-stage HCC was more often detected in patients who underwent surveillance every 6 mo or less(P = 0.05). However, survival was not different between patients with early stage vs non-early stage tumors [HR = 0.54(0.15-1.89), P = 0.33].CONCLUSION HCC is a frequent complication in patients with cirrhosis and adherence to surveillance programs favors early diagnosis. | Marcelo Campos Appel-da-Silva Suelen Aparecida da Silva Miozzo Isabella de Azevedo Dossin Cristiane Valle Tovo Fernanda Branco Angelo Alves de Mattos | 2016 | World Journal of Gastroenterology2016，22，46： | 7 |
| 2 | Influence of proton pump inhibitors in the development of spontaneous bacterial peritonitis显示文摘AIM To investigate whether the use of proton pump inhibitors(PPIs) increases the incidence of spontaneous bacterial peritonitis(SBP) in patients with cirrhosis and ascites.METHODS An historical cohort study was carried out in cirrhotic outpatients with ascites followed in a specialized clinic at a tertiary hospital in Southern Brazil. Patient charts were reviewed to collect information on the variables of interest as the use of PPIs. Primary outcome was defined as development of SBP during the study period. SBP was diagnosed based on ascitic fluid polymorphonuclear cell count ≥ 250 cells/mm3 without evidence of an intraabdominal, surgically treatable source of infection.RESULTS Of 738 cirrhotic patients, 582(58.2% male) were enrolled, with mean age of 53.6 ± 12 years. Hepatitis C virus infection(36.2%) and alcohol abuse(25.6%) were the main etiologies of cirrhosis. The presence of ascites was detected in 299(51.4%) patients during the development of the study. Nineteen patients with previous diagnosis of SBP undergoing secondary prophylaxis and 22 patients with insufficient PPI data were further excluded. Of 258 patients with ascites, 151 used PPIs, and 34 developed SBP(22.5%). Among 107 non-users of PPIs, 23 developed SBP(21.5%)(HR = 1.44, 95%CI: 0.85-2.47, P = 0.176). The median follow-up time of patients using PPI was 27 mo vs 32 mo for non-users. Univariate analysis of the risk factors associated with the development of SBP revealed a significant association of SPB with the severity of liver disease according to the Child-Turcotte-Pugh(CTP) score. Multivariate analysis confirmed that CTP score was the only independent variable influencing the occurrence of SBP. Survival at 60 mo(Kaplan-Meier analysis) was similar in users and non-users of PPI, independently of the presence of SBP(58.4% vs 62.7% respectively, P = 0.66). For patients with SBP, survival at 60 mo was 55.1%, vs 61.7% in patients without SBP(P = 0.34). CONCLUSION In conclusion, the rate of SBP was not significantly different in users or non-users of PPIs in this cohort of cirrhotic with ascites. | Suelen A S Miozzo Jorge A John Marcelo C Appel-da-Silva Isabella A Dossin Cristiane V Tovo Angelo A Mattos | 2017 | World Journal of Hepatology2017，9，35： | 5 |
| 3 | Y chromosome loss in male patients with primary biliary cirrhosis显示文摘 | Ana Lleo Sabine Oertelt-Prigione Ilaria Bianchi Lisa Caliari Palma Finelli Monica Miozzo Roberta Lazzari Annarosa Floreani Francesca Donato Massimo Colombo M. Eric Gershwin Mauro Podda Pietro Invernizzi | 2013 | Journal of Autoimmunity2013，，： | 2 |
| 4 | Routing schemes in heterogeneous wireless networks based on access advertisement and backward utilities for QoS support 显示文摘 | BADIA L MIOZZO M ROSSI M | 2007 | IEEE Communications Magazine2007，45，2： | 1 |
| 5 | Networks and innovation in European construction: Benefits from inter-organisational cooperation in a fragmented industry 显示文摘 | MIOZZO Marcela DEWICK Paul | 2004 | International Journal of Technology Management2004，27，1： | 1 |
| 6 | Institutional effects on the IT outaourcing markets analysing clients,suppliers and staff transfer in Germany and the UK显示文摘 | Grimshaw D Miozzo M | 2006 | Organization Studies2006，27，9： | 1 |
| 7 | The frequency of monosomy X in women with primary biliary cirrhosis 显示文摘 | Invernizzi P Miozzo M Battezatti PM | 2004 | Lancet2004，363，： | 1 |
| 8 | Innovation and networks:Benefits from inter-firm cooperation in a fragmented industry显示文摘 | MIOZZO M DEWICK P | 2004 | International Journal of Technology Management2004，27，1： | 1 |
| 9 | Epigenetic modulation of the IGF2/H19 imprinted domain in human embryonic and extra-embryonic compartments and its possible role in fetal growth restriction显示文摘 | Silvia Tabano Patrizia Colapietro Irene Cetin Francesca R. Grati Susanna Zanutto Chiara Mandò Patrizio Antonazzo Paola Pileri Franca Rossella Lidia Larizza Silvia M. Sirchia Monica Miozzo | 2010 | Epigenetics2010，，4： | 1 |
| 10 | Networks and innovation: sustainable technologies in Scottish social housing显示文摘 | Paul Dewick Marcela Miozzo | 2004 | R&D Management2004，34，4： | 1 |
| 11 | Networks and innovation in European construction: Benefits from inter-organisational cooperation in a fragmented industry 显示文摘 | MIOZZO Marcela DEWICK Paul | 2004 | International Journal of Technology Management2004，27，1： | 1 |
| 12 | The specific- word frequency effect: Implications for the representation of homophones in speech production显示文摘 | Caramazza A Costa A Miozzo M | 2001 | Journal of Experimental Psychology: Learning Memory and Cognition2001，27，： | 1 |
| 13 | Genetic evidence for an independent origin of multiple preneoplastic and neoplastic lung lesions 显示文摘 | SOZZI G0 MIOZZO M PASTORINO U | 1995 | Cancer Res1995，55，1： | 1 |
| 14 | Modularity and Innovation in Knowledge-intensive Business Services:IT Outsourcing in Germany and the UK显示文摘 | Miozzo Marcela Grimshaw Damian | 2005 | Research Policy2005，34，9： | 1 |
| 15 | Innovation and the transformation of work:the case of UK telecommunications显示文摘 | Marcela Miozzo Matias Ramirez | 2003 | New Technology Work and Employment2003，18，3： | 1 |
| 16 | Fetal growth restriction: a workshop report显示文摘 | Cetin I Foidart JM Miozzo M | 2004 | Placenta2004，25，89： | 1 |
| 17 | Routing schemes in heterogeneous wireless networks based on access advertisement and backward utilities for QoS support显示文摘 | Leonardo Badia Marco Miozzo Michele Rossi | 2007 | IEEE Communications Magazine2007，45，： | 1 |
| 18 | Internationalization of Services : a Technological Perspective显示文摘 | Miozzo M Soete L | 2001 | Technological Forecasting and Social Change2001，，67： | 1 |
| 19 | Deletions of 17p and p53 mutatio ns in preneoplastic lesions of the oung显示文摘 | Sozzi G Miozzo M Donghi R | 1992 | Cancer Res1992，52，： | 1 |
| 20 | Building Competitive Advantage: Inno- vation and Corporate Governance in European Construction 显示文摘 | Miozzo M Dewicki P | 2002 | Research Policy2002，31，6： | 1 |
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