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| 1 | Evidence of endometrial amino acid metabolism and transport modulation by peri-ovulatory endocrine profiles driving uterine receptivity显示文摘Background: In beef cattle, changes in the periovulatory endocrine milieu are associated with fertility and conceptus growth. A large preovulatory follicle(POF) and the resulting elevated concentrations of progesterone(P4) during diestrus positively affect pregnancy rates. Amino acids(AA) are important components of maternally derived secretions that are crucial for embryonic survival before implantation. The hypothesis is that the size of the POF and the concentration of P4 in early diestrus modulate the endometrial abundance of SLC transcripts related to AA transport and metabolism and subsequently impact luminal concentrations of AA. The follicle growth of Nelore cows was manipulated to produce two experimental groups: large POF and CL(LF-LCL group) and small POF and CL(SF-SCL group). On Day 4(D4; Experiment 1) and Day 7(D7; Experiment 2) after Gn RH-induced ovulation(Gn RH treatment = D0), the animals were slaughtered and uterine tissues and uterine washings were collected. q RT-PCR was used to evaluate the expression levels of AA transporters in D4 and D7 endometrial tissues.The concentrations of AA were quantified in D4 and D7 uterine washings by HPLC.Results: Transcript results show that, on D4, SLC6 A6, SLC7 A4, SLC17 A5, SLC38 A1, SLC38 A7 and SCLY and on D7 SLC1 A4, SLC6 A1, SLC6 A14, SLC7 A4, SLC7 A7, SLC7 A8, SLC17 A5, SLC38 A1, SLC38 A7, SLC43 A2 and DDO were more abundant in the endometria of cows from the LF-LCL group(P < 0.05). In addition, concentrations of AA in the uterine lumen were influenced by the endocrine profiles of the mother. In this context, D4 uterine washings revealed that greater concentrations of taurine, alanine and α-aminobutyric acid were present in SF-SCL(P < 0.05).In contrast, lower concentrations of valine and cystathionine were quantified on D7 uterine washings from SF-SCL cows(P < 0.05).Conclusion: The present study revealed an association between the abundance of transcripts related to AA transport and metabolism in the endometrium and specific periovulatory endocrine profiles related to the receptive status of the mother. Such insights suggest that AAs are involved in uterine function to support embryo development. | Moana Rodrigues Franca Maressa Izabel Santos da Silva Guilherme Pugliesi Veerle Van Hoeck Mario Binelli | 2017 | Journal of Animal Science and Biotechnology2017，8，4： | 4 |
| 2 | Calcium potentiates the effect of estradiol on PGF2α production in the bovine endometrium显示文摘Background: Estradiol(E2) is required for luteolysis in cows and its injection stimulates prostaglandin F2α(PGF2α)release. The main goal of our study was to investigate the ability of endometrial explants and cells treated with E2 and the calcium ionophore(CI) A23187 to synthesize PGF2α.Results: Treatment with E2 in vivo resulted in a 48.4% increase of PGF2α production by endometrial explants treated in vitro with A23187. Production of PGF2α was better stimulated with A23187 at concentrations of 10-6and10-5mol/L compared with other concentrations used. The concentration of PGF2α for untreated bovine endometrial cell cultures was 33.1 pg/m L, while for cultures treated with E2, A23187, or a combination of E2 and A23187, the PGF2α concentration was 32.5, 92.4 and 145.6 pg/m L, respectively.Conclusions: Treatment with A23187 tended to stimulate PGF2α production. In the presence of E2, A23187 significantly stimulated PGF2α synthesis. It appears that A23187 potentiates the effects of E2 with respect to synthesis of endometrial PGF2α in cattle. | Claudia Maria Bertan Membrive Pauline Martins da Cunha Flávio Vieira Meirelles Mario Binelli | 2015 | Journal of Animal Science and Biotechnology2015，6，2： | 2 |
| 3 | POPs in edible clams from different Italian and European markets and possible human health risk显示文摘 | Binelli A Provini A | 2003 | Marine Pollution Bulletin2003，46，： | 1 |
| 4 | Effects of triclosan in the freshwater mussel Dreissena polymorpha:A proteomic investigation显示文摘 | RIVA C CRISTONI S BINELLI A | 2012 | Aquatic Toxicology2012，，： | 1 |
| 5 | Influence of surgery and antiepileptic drugs on seizures symptomatic of cerebral tumors 显示文摘 | FRANCESCHETTI S BINELLI S CASAZZA M | 1990 | Acta Neurochir (Wien)1990，103，12： | 1 |
| 6 | Outcome of an outbreak of acute hepatitis C among healthy volunteers participating in pharmacokinetics studies显示文摘 | Alberto Larghi Massimo Zuin Andrea Crosignani Maria Lisa Ribero Cristina Pipia Pier Maria Battezzati Giorgio Binelli Francesco Donato Alessandro Remo Zanetti Mauro Podda Alessandro Tagger | 2002 | Hepatology2002，，4： | 1 |
| 7 | Chronic effects induced by ibu-profen on the freshwater bivalve Dreissena polymorpha 显示文摘 | Parolini M Binelli A Provini A | 2011 | Eco-toxicology and Environmental Safety2011，74，6： | 1 |
| 8 | DDT is still a problem in developed countries: the heavy pollution of Lake Maggiore 显示文摘 | Binelli A Provini A | 2003 | Chemosphere2003，52，： | 1 |
| 9 | POPs in edible clams from different Italian and European markets and possible human health risk 显示文摘 | Binelli A Provini A | 2003 | Marine Pollution Bulletin2003，46，7： | 1 |
| 10 | Different real time PCR approaches for the fine quantification of SNP' s alleles in DNA pools: assays development, characterization and pre- validation 显示文摘 | Mattarucchi E Marsoni M Binelli G | 2005 | J Biochem Mol Biol2005，38，5： | 1 |
| 11 | Contamination by polyhrominated diphenyl ethers of sediments from the Lake Maggiore basin ( Italy and Switzerland) 显示文摘 | GUZZELLA L ROSCIOLI C BINELLI A | 2008 | Chemosphere2008，73，10： | 1 |
| 12 | In vivo experiments for the evaluation of genotoxic and cytotoxic effects of triclosan in zebra mussel hemocytes显示文摘 | BINELLI A COGNI D PAROLINI M | 2009 | Aquatic Toxicology2009，91，3： | 1 |
| 13 | Photosensitive epilepsy: spectral and coherence analyses of EEG us- ing 14 Hz intermittent photic stimulation显示文摘 | Visani E Varotto G Binelli S | 2010 | Clinical Neurophysiology2010，121，3： | 1 |
| 14 | POPs in edible clams from different I- talian and European markets and possible human health risk 显示文摘 | BINELLI A PROVINI A | 2003 | Mar Pollut Bull2003，46，7： | 1 |
| 15 | A Micro-econometric Analysis of Public Support to Private R&D in Argentina显示文摘 | Chiara Binelli Alessandro Maffioli | 2007 | International Review of Applied Economics2007，，3： | 1 |
| 16 | cDNA encoding sequences for myostatin and FGF6 in sea bass and the effect of fasting and refeeding on their abundance levels 显示文摘 | Terova G Bernardini G Binelli G | 2006 | Domestic Animal Endocrinology2006，30，4： | 1 |
| 17 | POPs in edible clams from different Italian and European markets and possible human health risk 显示文摘 | Binelli A Provini A | 2003 | Mar Pollut Bull2003，46，7： | 1 |
| 18 | Evaluation of DNA damage induced by decabromodiphenyl_ ether (BDE-209) in hemocytes of Dreissena polymorpha using the comet and micronucleus assays 显示文摘 | Riva C Binelli A Cogni D | 2007 | Environ Mol Mutagen2007，203，： | 1 |
| 19 | Contamination bypolybrominated diphenyl ethers of sediments from the LakeMaggiore basin(Italy and Switzerland ) 显示文摘 | Guzzella L Roscioli C Binelli A | 2008 | Chemosphere2008，73，10： | 1 |
| 20 | Evaluation of several priority pollutants in zebra mussels (Dreissena polymorpha ) in the largest Italian Subalpine lakes 显示文摘 | RIVA C BINELLI A PROVINI A | 2008 | Environ Pollut2008，151，3： | 1 |
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