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您的检索式：作者名="Philippe Connes"
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| 1 | New guidelines for hemorheological laboratory techniques显示文摘 | Oguz K. Baskurt Michel Boynard Giles C. Cokelet Philippe Connes Brian M. Cooke Sandro Forconi Fulong Liao Max R. Hardeman Friedrich Jung Herbert J. Meiselman Gerard Nash Norbert Nemeth Bj?rn Neu Bo Sandhagen Sehyun Shin George Thurston Jean Luc Wautier | 2009 | Clinical Hemorheology and Microcirculation2009，，： | 1 |
| 2 | Hemorheology and heart rate variability: Is there a relationship?显示文摘 | Philippe Connes Olivier Hue Marie-Dominique Hardy-Dessources John H. Boucher Vincent Pichot Jean-Claude Barthélémy | 2008 | Clinical Hemorheology and Microcirculation2008，，4： | 1 |
| 3 | Does endurance training improve red blood cell aging and hemorheology in moderate-trained healthy individuals?显示文摘Objective:To examine the impact of a 6-week endurance training on red blood cell(RBC)aging and deformability of healthy participants to detect possible improved hemorheological and performance-related adaptations.Methods:A total of 31 participants(17 females and 14 males)performed a 6-week moderate training protocol(three 1-h running sessions per week at 70%of maximal heart rate).Blood was sampled before and after the training.RBCs from each participant were fractioned according to density and age into 4 RBC subfractions.Subfractions were examined for changes of RBC properties,including aging distribution,RBC deformability,RBC microparticles,and phosphatidylserine concentrations.RBC and plasma nitrite levels were measured as indicators of nitric oxide metabolism.Results:Aerobic performance,peak oxygen consumption,ventilatory thresholds,velocity at the aerobic-anaerobic threshold,and lactate at exhaustion improved after training.The relative amount of both young RBCs and old RBCs increased,and the amount of the main RBC fraction decreased.Phosphatidylserine externalization and RBC-derived microparticles decreased.Overall deformability expressed as shear stress required to achieve half-maximum deformation to theoretical maximal elongation index at infinite shear stress improved in unfractioned RBCs(p<0.001).Nitrite decreased in total(p=0.001),young(p<0.001),main(p<0.001),and old(p=0.020)aged RBCs and in plasma(p=0.002),but not in very old RBCs.Conclusion:These results indicate that non-endurance-trained healthy participants benefit from a regular moderate running training program because performance-related parameters improve and a younger RBC population with improved RBC properties is induced,which might support oxygen supply in the microcirculation. | Daniel A.Bizjak Fabian Tomschi Gunnar Bales Elie Nader Marc Romana Philippe Connes Wilhelm Bloch Marijke Grau | 2020 | Journal of Sport and Health Science2020，9，6： | 0 |
| 4 | Multiparametric characterization of red blood cell physiology after hypotonic dialysis based drug encapsulation process显示文摘Red blood cells(RBCs)can act as carriers for therapeutic agents and can substantially improve the safety,pharmacokinetics,and pharmacodynamics of many drugs.Maintaining RBCs integrity and lifespan is important for the efficacy of RBCs as drug carrier.We investigated the impact of drug encapsulation by hypotonic dialysis on RBCs physiology and integrity.Several parameters were compared between processed RBCs loaded with l-asparaginase(“eryaspase”),processed RBCs without drug and non-processed RBCs.Processed RBCs were less hydrated and displayed a reduction of intracellular content.We observed a change in the metabolomic but not in the proteomic profile of processed RBCs.Encapsulation process caused moderate morphological changes and was accompanied by an increase of RBCs-derived Extracellular Vesicles release.Despite a decrease in deformability,processed RBCs were not mechanically retained in a spleen-mimicking device and had increased surface-to-volume ratio and osmotic resistance.Processed RBCs half-life was not significantly affected in a mouse model and our previous phase 1 clinical study showed that encapsulation of asparaginase in RBCs prolonged its in vivo half-life compared to free forms.Our study demonstrated that encapsulation by hypotonic dialysis may affect certain characteristics of RBCs but does not significantly affect the in vivo longevity of RBCs or their drug carrier function. | Mélanie Robert Bastien Laperrousaz Diana Piedrahita Emilie-Fleur Gautier Travis Nemkov Florian Dupuy Elie Nader Virginie Salnot Patrick Mayeux Angelo D’Alessandro Catherine Lavazec Philippe Joly Alexander Scheer Philippe Connes Agnès Cibiel | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
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