Does endurance training improve red blood cell aging and hemorheology in moderate-trained healthy individuals?

查看全文 作　　者：Daniel [1]A.Bizjak;Fabian [1]Tomschi;Gunnar [1]Bales;Elie [2,3]Nader;Marc [3,4]Romana;Philippe [2,3,5]Connes;Wilhelm [1,6]Bloch;Marijke [1]Grau

机构地区：[1]Department of Molecular and Cellular Sports Medicine,German Sport University Cologne,Cologne 50933,Germany;[2]Laboratoire LIBM EA7424-Equipe“Biologie Vasculaire et du Globule Rouge”,UniversitéClaude Bernard Lyon 1,Villeurbanne 69100,France;[3]Laboratoire d’Excellence du Globule Rouge GR-Ex,Paris 75015,France;[4]Universitédes Antilles,Inserm,UnitéBiologie Intégrée du Globule Rouge,CHU de PointeàPitre,Pointe_a Pitre,Guadeloupe 97157,France;[5]Institut Universitaire de France,Paris 75231,France;[6]The German Research Centre of Elite Sport,German Sport University Cologne,Cologne 50933,Germany

出　　处：《Journal of Sport and Health Science》索引2020年第9卷第6期,共9页

基　　金：supported by the Hochschulinterne Forschungsforderung(HIF)of the German Sport University Cologne. 摘　　要：Objective:To examine the impact of a 6-week endurance training on red blood cell(RBC)aging and deformability of healthy participants to detect possible improved hemorheological and performance-related adaptations.Methods:A total of 31 participants(17 females and 14 males)performed a 6-week moderate training protocol(three 1-h running sessions per week at 70%of maximal heart rate).Blood was sampled before and after the training.RBCs from each participant were fractioned according to density and age into 4 RBC subfractions.Subfractions were examined for changes of RBC properties,including aging distribution,RBC deformability,RBC microparticles,and phosphatidylserine concentrations.RBC and plasma nitrite levels were measured as indicators of nitric oxide metabolism.Results:Aerobic performance,peak oxygen consumption,ventilatory thresholds,velocity at the aerobic-anaerobic threshold,and lactate at exhaustion improved after training.The relative amount of both young RBCs and old RBCs increased,and the amount of the main RBC fraction decreased.Phosphatidylserine externalization and RBC-derived microparticles decreased.Overall deformability expressed as shear stress required to achieve half-maximum deformation to theoretical maximal elongation index at infinite shear stress improved in unfractioned RBCs(p<0.001).Nitrite decreased in total(p=0.001),young(p<0.001),main(p<0.001),and old(p=0.020)aged RBCs and in plasma(p=0.002),but not in very old RBCs.Conclusion:These results indicate that non-endurance-trained healthy participants benefit from a regular moderate running training program because performance-related parameters improve and a younger RBC population with improved RBC properties is induced,which might support oxygen supply in the microcirculation. 关键词：Cellular adaptation HEMORHEOLOGY Nitric oxide Performance RBC physiology and aging

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Does endurance training improve red blood cell aging and hemorheology in moderate-trained healthy individuals?

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