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822篇 您的检索式：作者名="Connes"

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	题名	作者	年代	出处	被引量
1	Persistent risk for new, subsequent new and recurrent hepatocellular carcinoma despite successful anti-hepatitis B virus therapy and tumor ablation: The need for hepatitis B virus cure显示文摘Hepatitis B virus(HBV) is one of the most significant hepatocarcinogens. The ultimate goal of anti-HBV treatment is to prevent the development of hepatocellular carcinoma(HCC). During the last two decades, with the use of currently available anti-HBV therapies(lamivudine, entecavir and tenofovir disoproxil fumatate), there has been a decrease in the incidence of HBVassociated HCC(HBV-HCC). Furthermore, several studies have demonstrated a reduction in recurrent or new HCC development after initial HCC tumor ablation. However, during an observation period spanning 10 to 20 years, several case reports have demonstrated the development of new, subsequent new and recurrent HCC even in patients with undetectable serum HBV DNA. The persistent risk for HCC is attributed to the presence of covalently closed circular DNA(cccDNA) in the hepatocyte nucleus which continues to work as a template for HBV replication. While a functional cure(loss of hepatitis B surface antigen and undetectable viral DNA) can be attained with nucleos(t)ide analogues, these therapies do not eliminate cccDNA. Of utmost importance is successful eradication of the transcriptionally active HBV cccDNA from hepatocyte nuclei which would be considered a complete cure. The unpredictable nature of HCC development in patients with chronic HBV infection shows the need for a complete cure. Continued support and encouragement for research efforts aimed at developing curative therapies is imperative. The aims of this minireview are to highlight these observations and emphasize the need for a cure for HBV.	Brianna J Shinn Aaron Martin Robert M Coben Mitchell I Conn Jorge Prieto Howard Kroop Anthony J DiMarino Hie-Won Hann	2019	World Journal of Hepatology2019，11，1：	3
2	Adrenocorticosteroid therapy in alcoholic hepatitis显示文摘	Bennett L. Blitzer MD Milton G. Mutchnick MD Prakash H. Joshi MD Michael M. Phillips MD J. Michael Fessel MD Harold O. Conn MD	1977	The American Journal of Digestive Diseases1977，，6：	2
3	Soil seed bank changes after forest clearing and agricultural use in Alaska显示文摘	CONN J S COCHRANE C L DELAPP J A	1984	Weed Science1984，32，3：	1
4	Revascularization in treat- ment of mesenteric infarction 显示文摘	Bergan J J Dean RH Conn JJr	1975	Ann Surg1975，182，4：	1
5	The impact of childhood asthma on parental quality of life显示文摘	Halterman JS Yoos HL Conn KM	2004	J Asthma2004，41，6：	1
6	CUTE: constrained and unconstrained testing environment显示文摘	Bongartz J Conn A R Gould N I M	1995	ACM Tran Math Software1995，，：	1
7	Clinical characteristics of pri mary aldosteronism from an analysis of 145 cases显示文摘	Conn JW Knopf RF Nesbit RM	1964	Am J Surg1964，107，1：	1
8	Soil factors influencing the efficacy ofliquid swine manure added to soil to kill Verticillium dahliae显示文摘	Conn K L Lazarovits G	2000	Can J Plant Pathol2000，22，：	1
9	Gonadotropin-releasing hormone and its analogues 显示文摘	CONN PM CROWLEY WF Jr	1991	N Engl J Med1991，324，2：	1
10	Transjugular intrahepatic portorosystemic shunt: The state of art显示文摘	Conn HD	1993	Hepamlogy1993，17，1：	1
11	Basement membranes in urothelial carcinoma显示文摘	Conn IG Croker J Wallace DM	1987	Br J Urol1987，60，：	1
12	Metabotropic glutamate receptors in brain function and pathology显示文摘	Schoepp DD Conn PJ	1993	TiPS1993，14，：	1
13	Total hip revision using a cup design with a peg to treat severe pelvic bone defects显示文摘	Desbonnet P Connes H Escare P	2012	Orthop Traunatol Surg Res2012，98，3：	1
14	Trends in infections disease mortality in the United States during the 20th century显示文摘	Conn LA Pinnet RW	1999	JAMA1999，281，：	1
15	A peek at the Child-Turcotte classification显示文摘		1981	Hepatology1981，1，6：	1
16	Direct peritoneal resuscitation as adjunct to conventional resuscitation from hemorrhagic shock:a better outcome显示文摘	Garrison RN Conn AC Harris PD	2004	Surgery2004，13，4：	1
17	Root decomposition across a barrier island chronosequence:Litter quality and environmental controls显示文摘	Christine E Conn Frank P Day Jr	1997	Plant and Soil1997，195，2：	1
18	Reversible water- solubilization of single-walled carbon nanotubes by polymer wrapping显示文摘	O'ConnelI M J BouI P Ericson L M	2001	Chem Phys Lett2001，342，34：	1
19	Meta-analysis of quality-of-life outcomes from physical activity interventions显示文摘	CONN V S HAFDAHL A R BROWN L M	2009	Nurs Res2009，58，3：	1
20	Coexistence of ankylosing spondylitis and rheumatoid arthritis显示文摘	luthra H S Ferguson R H Conn D L	2004	Arthritis Rheum2004，19，：	1

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