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2篇 您的检索式：作者名="Alexander Scheer"

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		题名	作者	年代	出处	被引量
	1	Systemic inflammatory response syndrome predicts increased mortality in patients after transcatheter aortic valve implantation显示文摘	Jan-Malte Sinning Anne-Cathérine Scheer Viktoria Adenauer Alexander Ghanem Christoph Hammerstingl Robert Schueler Cornelius Müller Mariuca Vasa-Nicotera Eberhard Grube Georg Nickenig Nikos Werner	2012	European Heart Journal2012，，：	1
	2	Multiparametric characterization of red blood cell physiology after hypotonic dialysis based drug encapsulation process显示文摘Red blood cells(RBCs)can act as carriers for therapeutic agents and can substantially improve the safety,pharmacokinetics,and pharmacodynamics of many drugs.Maintaining RBCs integrity and lifespan is important for the efficacy of RBCs as drug carrier.We investigated the impact of drug encapsulation by hypotonic dialysis on RBCs physiology and integrity.Several parameters were compared between processed RBCs loaded with l-asparaginase(“eryaspase”),processed RBCs without drug and non-processed RBCs.Processed RBCs were less hydrated and displayed a reduction of intracellular content.We observed a change in the metabolomic but not in the proteomic profile of processed RBCs.Encapsulation process caused moderate morphological changes and was accompanied by an increase of RBCs-derived Extracellular Vesicles release.Despite a decrease in deformability,processed RBCs were not mechanically retained in a spleen-mimicking device and had increased surface-to-volume ratio and osmotic resistance.Processed RBCs half-life was not significantly affected in a mouse model and our previous phase 1 clinical study showed that encapsulation of asparaginase in RBCs prolonged its in vivo half-life compared to free forms.Our study demonstrated that encapsulation by hypotonic dialysis may affect certain characteristics of RBCs but does not significantly affect the in vivo longevity of RBCs or their drug carrier function.	Mélanie Robert Bastien Laperrousaz Diana Piedrahita Emilie-Fleur Gautier Travis Nemkov Florian Dupuy Elie Nader Virginie Salnot Patrick Mayeux Angelo D’Alessandro Catherine Lavazec Philippe Joly Alexander Scheer Philippe Connes Agnès Cibiel	2022	Acta Pharmaceutica Sinica B2022，12，4：	0

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