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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | 先进的陆地和海底管道涂覆技术显示文摘油气工业的快速发展给诸如在寒冷的气候和深水环境中、具有独特应用地位的管道涂覆技术的革新带来了巨大的挑战和机遇。突出强调了几种独特的、先进的并已经过证实的管道涂覆技术,这些技术适用于陆地和海底管道的保护,包括高效复合涂层系统(HPCC)、高强度钢粉末涂层低温涂覆技术和Thermotite稳流保证技术。给出了一些案例和收集的技术数据。 | Shiwei William Guan Nick Gritis Adam Jackson Peter Singh | 2005 | 油气储运2005，24，B12： | 11 |
| 3 | 腐植酸对高岭土吸附四价铀的影响显示文摘在土壤中,对放射性废物处理的安全性评估,要求评价放射性核素的迁移。pH值从4到8,腐植酸浓度从15mg/kg到200mg/kg条件下,腐植酸对高岭土吸附四价铀的影响试验表明,没有腐植酸的情况下,20%~40%的四价铀存在于溶液中;pH值越高,吸附作用越强。在腐植酸的存在下,随着腐植酸浓度和pH值的升高,四价铀的溶解度随之增大,四价铀在腐植酸中的可溶性最高可达90%。腐植酸吸附和四价铀的吸附是对立的,通过测量腐植酸的吸附,可以比较腐植酸吸附四价铀的能力高低。但是,随着pH值的上升,这种吸附作用的影响减弱。敏感性分析表明,在这些系统中,腐植酸表面吸附是线性可加模型模拟这些体系的控制。 | Nick Evans Peter Warwick Tara Lewis Nick Bryan 王曰鑫 戚新革 | 2011 | 腐植酸2011，，1： | 3 |
| 4 | 香港九龙大坑东地下蓄水方案数值研究显示文摘香港九龙大坑东地下蓄水方案(Tai Hang Tung Storage Scheme-THTSS)是香港西九龙渠道改善二期计划的一个重要组成部分,其目标是解决香港九龙繁华拥挤、人口稠密的商业中心旺角一带的洪水淹没问题。THTSS即是在经常洪水淹没区域(大坑东和界限街水渠交接处)上游足球场下面建立一个100 000 m3的地下蓄水池。本文建立了一个能处理明渠缓流和急流、封闭管道有压流、侧流堰和渠道汇合处过渡流于一体的一维水力数学模型,用1∶22正态物理模型恒定流下的结果进行验证。数值模型计算了在50年一遇暴雨下,非恒定洪水在不同的侧流堰方案下的流动过程。结合物理模型试验结果,选择最佳的地下蓄水方案。计算结果表明,大坑东地下蓄水方案确实能加强旺角地区地洪水控制能力,并能通过50年一遇暴雨的洪水。 | 匡翠萍 李行伟 陈孝章 Peter Clark Nick Townsend Raymond Siu | 2006 | 水科学进展2006，17，3： | 3 |
| 5 | Lgr5 +ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro显示文摘 | Nick Barker Meritxell Huch Pekka Kujala Marc van de Wetering Hugo J. Snippert Johan H. van Es Toshiro Sato Daniel E. Stange Harry Begthel Maaike van den Born Esther Danenberg Stieneke van den Brink Jeroen Korving Arie Abo Peter J. Peters Nick Wright Richa | 2010 | Cell Stem Cell2010，，1： | 2 |
| 6 | 端粒酶逆转录酶在结肠癌组织中表达的临床意义显示文摘背景与目的:尽管能够在70%~90%的恶性肿瘤细胞中可检测到端粒酶活性,但其活性与恶性肿瘤患者预后的关系仍存在争议。本研究旨在探讨端粒酶逆转录酶(humantelomerasereversetranscriptase,hTERT)在结肠癌组织中表达的临床意义。方法:用定量实时RT-PCR检测59例大肠癌标本的癌组织和癌旁非癌组织hTERT表达。结果:癌组织和癌旁非癌组织hTERT表达与临床病理学特征无相关性。32例DukesA和B期患者中,18例(56%)癌组织hTERT表达低于0.6,14例(44%)表达高于0.6,前者的预后较后者好。20例(62%)癌组织/癌旁非癌组织hTERT表达差异低于0.5,12例(38%)表达差异高于0.5,前者的预后较后者好。27例DukesC和D期患者中,癌组织hTERT表达和癌组织/癌旁非癌组织hTERT表达差异对预测患者的预后无意义。结论:结肠癌组织hTERT表达和癌组织/癌旁非癌组织hTERT表达差异可作为DukesA和B期结肠癌患者预后的指标之一。 | 李力人 万德森 潘志忠 Jenny Hardingham Nick Rieger Peter Hewett 周志伟 陈功 | 2004 | 癌症2004，23，z1： | 2 |
| 7 | Generation and preservation of continental crust in the Grenville Orogeny显示文摘Detrital zircons from modern sediments display an episodic temporal distribution of U-Pb crystallization ages forming a series of 'peaks' and 'troughs'.The peaks are interpreted to represent either periods of enhanced generation of granitic magma perhaps associated with mantle overturn and superplume events,or preferential preservation of continental crust during global collisional orogenesis.The close association of those peaks with the assembly of supercontinents implies a causal relationship between collisional orogenesis and the presence of zircon age peaks.Here these two end-member models(episodic periodicity of increased magmatism versus selective preservation during collisional orogenesis) are assessed using U-Pb,Hf,and O analysis of detrital zircons from sedimentary successions deposited during the ~ 1.3-1.1Ca accretionary.~1.1-0.9 Ga collisional,and < 0.9 Ga extensional collapse phases of the Grenville orogenic cycle in Labrador and Scotland.The pre-collisional,accretionary stage provides a baseline of continental crust present prior to orogenesis and is dominated by Archean and Paleoproterozoic age peaks associated with pre-1300 Ma Laurentian geology.Strata deposited during the Grenville Orogeny display similar Archean and Paleoproterozoic detrital populations along with a series of broad muted peaks from~ 1500 to 1100 Ma.However,post-collisional sedimentary successions display a dominant age peak between 1085 and 985 Ma,similar to that observed in modern North American river sediments.Zircons within the post-orogenic sedimentary successions have progressively lower εHf and higherδ^(18)O values from ~ 1800 to ~ 1200 Ma whereupon they have higher εHf and δ^(18) within the dominant1085-985 Ma age peak.Furthermore,the Lu-Hf isotopic profile of the Grenville-related age peak is consistent with significant assimilation and contamination by older crustal material.The timing of this dominant age peak coincides with the peak of metamorphism and magmatism associated with the Crenville Orogeny,which is a typical collisional orogenic belt.The change from broad muted age peaks in the syn-orogenic strata to a single peak in the post-orogenic sedimentary successions and in the modern river sediments implies a significant shift in provenance following continental collision.This temporal change in provenance highlights that the source(s),from which detrital zircons within syn-orogenic strata were derived,was no longer available during the later stages of the accretionary and collisional stages of the orogenic cycle.This may reflect some combination of tectonic burial,erosion,or possibly recycling into the mantle by tectonic erosion of the source(s).During continental collision,the incorporated continental crust is isolated from crustal recycling processes operative at subduction margins.This tectonic isolation combined with sedimentaiy recycling likely controls the presence of the isotopic signature associated with the Grenville Orogeny in the modern Mississippi and Appalachian river sediments.These results imply that zircon age peaks,which developed in conjunction with supercontinents,are the product of selective crustal preservation resulting from collisional orogenesis. | Christopher J.Spencer Peter A.Cawood Chris J.Hawkesworth Anthony R.Prave Nick M.W.Roberts Matthew S.A.Horstwood Martin J.Whitehouse EIMF | 2015 | Geoscience Frontiers2015，6，3： | 1 |
| 8 | The impact of a stimulus to energy efficiency on the economy and the environment:A regional computable general equilibrium analysis显示文摘 | Nick D.Hanley Peter G.McGregor J.Kim Swales Karen Turner | | 0，，31： | 1 |
| 9 | Failure of Fluid Dilled Structures Due To High Velocity Fragment Impact显示文摘 | David Townsend Nick Park Peter M. Devall | 2004 | International Journal of Impact Engineering2004，，1： | 1 |
| 10 | Buenfeld, Influence of aggregate size and volume fraction on shrinkage indueed micro-cracking of concrete and mortar显示文摘 | GRASSL Peter WONG Hong S NICK R | 2010 | Cement and Concrete Research2010，，1： | 1 |
| 11 | The potential impact of the next influenza pandemic on a national primary care medical workforce显示文摘 | Nick Wilson Michael Baker Peter Crampton | 2005 | Human Resources for Health2005，，3： | 1 |
| 12 | The impact of a stimulus to energy efficiency on the economy and the environment: A regional computable general equilibrium analysis 显示文摘 | NICK D HANLEY PETER G MCGREGOR J KIM SWALES KABEN TURNER | 2006 | Renewable Energy2006，，： | 1 |
| 13 | Trends in age-specific coronary heart disease mortality in the European Union over three decades: 1980–2009显示文摘 | Melanie Nichols Nick Townsend Peter Scarborough Mike Rayner | 2013 | European Heart Journal2013，，39： | 1 |
| 14 | Management of acute organophosphorus pesticide poisoning显示文摘 | Michael E Nick AB Peter E | 2008 | Lancet2008，371，9612： | 1 |
| 15 | Management of upper gastrointestinal haemorrhage complicating dual anti-platelet therapy显示文摘 | Peter AH Kekvin P Nick AB | 2008 | Q J Med2008，101，： | 1 |
| 16 | Implicit knowledge and motor skill: What people who know how to catch don’t know显示文摘 | Nick Reed Peter McLeod Zoltan Dienes | 2009 | Consciousness and Cognition2009，，1： | 1 |
| 17 | Management of acute or-ganophos-phorus pesticide poisoning显示文摘 | Michael E Nick AB Peter E | 2008 | Lancet2008，371，9612： | 1 |
| 18 | The Impact of a Stimulus to Energy Efficiency on the Economy and the Environment: A Regional Computable General Equilibrium Analysis显示文摘 | NICK D H PETER G M | 2006 | Renewable Energy2006，31，2： | 1 |
| 19 | Long-term retrograde amnesia… the crucial role of the hippocampus显示文摘 | Lisa Cipolotti Tim Shallice Dennis Chan Nick Fox Rachel Scahill Gail Harrison John Stevens Peter Rudge | 2001 | Neuropsychologia2001，，2： | 1 |
| 20 | Medical management of acute organophosphorus pesticide self-poisoning显示文摘 | Michael E Nick AB Peter E | 2008 | Lancet2008，371，9612： | 1 |
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