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| 1 | Ghrelin and gastrin in advanced gastric cancer before and after gastrectomy显示文摘AIM: To investigate plasma ghrelin, gastrin and growth hormone secretagogue receptor (GHS-R) expression in advanced gastric cancer (GC) before and after resection. METHODS: Seventy subjects in whom endoscopy of the upper gastrointestinal tract was performed in the Department of General Surgery at Cracow University during the past decade: (1) 25 patients with GC associated with Helicobacter pylori (H. pylori) infection; (2) 10 patients with GC 4-5 years after (total or subtotal) gastrectomy; (3) 25 healthy H. pylori-negative controls, matched by age and BMI to the above two groups; and (4) 10 GC patients 4-5 years after total gastrectomy. Ghrelin and gastrin plasma concentrations were measured by specific radioimmunoassay under fasting conditions and postprandially at 60 and 90 min after ingestion of a mixed meal. GHS-R expression was examined in biopsy samples from intact healthy mucosa and GC tissue using semi-quantitative reverse transcription-polymerase chain reaction. RESULTS: In healthy controls, fasting plasma ghrelin levels were significantly elevated and declined markedly at 60 and 90 min after a mixed meal. The concomitant enhanced ghrelin, GHS-R and gastrin expression in GC tissue over that recorded in intact mucosa, and the marked rise in plasma gastrin in these subjects under fasting conditions indicate the role of these hormonal factors in GC formation. Fasting plasma levels and postprandial response of ghrelin and gastrin appear to be inversely correlated in healthy subjects. Feeding in the controls resulted in a significant fall in plasma ghrelin with a subsequent rise in plasma gastrin, but in H. pylori-positive GC patients submitted to total or distal gastrectomy, feeding failed to affect significantly the fall in plasma ghrelin that was recorded in these patients before surgery. Fasting ghrelin concentrations were significantly lower in patients 4-5 years after total gastrectomy compared to those in healthy controls and to these in GC patients before surgery. CONCLUSION: Elevated plasma gastrin and suppression of fasting ghrelin in patients with GC suggest the existence of a close relationship between these two hormones in gastric carcinogenesis. | Anna Zub-Pokrowiecka Kazimierz Rembiasz Peter C Konturek Andrzej Budzyński Stanisaw J Konturek Marek Winiarski Wadysaw Bielański | 2011 | World Journal of Gastroenterology2011，17，4： | 7 |
| 2 | Anesthetic concentrations of propofol protect against oxidative stress in primary astrocyte cultures: comparison with hypothermia 显示文摘 | PETERS CE KORCOK J GELB AW | 2001 | Anesthesiology2001，94，2： | 1 |
| 3 | Polymer concepts in tissue engineering 显示文摘 | Peter S J Miller M J Yasko AW | 1998 | J Biomed Mater Res1998，43，4： | 1 |
| 4 | Regulation of experimental lung inflammation 显示文摘 | Alex B Peter AW | 2001 | Respiration Physiology2001，128，： | 1 |
| 5 | The accuracy of frozen section diagnosis of ovarian tumors显示文摘 | Twaalfoven F C M Peters A AW Trimbos J B | 1991 | GynecolOncol1991，41，1： | 1 |
| 6 | Acute hypoxia causes anhedonia and weight loss in mice, which is absent after a second hypoxic exposure 显示文摘 | York JM McDaniel AW Peters VA | 2009 | Brain Behavior and Immunity2009，23，7： | 1 |
| 7 | Visualising scanning patterns of pathologists in the grading of cervical intraepithelial neoplasia显示文摘 | Tiersma ESM Peters AW Mooij HA | 2003 | J Clin Pathol2003，56，： | 1 |
| 8 | Combined matched filter and arbitrary in- terpolator for symbol timing synchronization in SDR receivers 显示文摘 | Aw~ M Peter K | 2010 | Design and Diagnostics of Electronic Circuits and Sys- tems2010，19，12： | 1 |
| 9 | ATM and RPA in meioticchromosome synapsis and recombination 显示文摘 | Plug AW Peters AH Xu Y | 1997 | Nat Genet1997，17，4： | 1 |
| 10 | High--dose intravenous levetiracetam for acute seizure exacerbation in children with intractable epilepsy显示文摘 | Depositario--Cabacar DT Peters JM Pong AW | 2010 | Ep- ilepsia2010，51，13： | 1 |
| 11 | Anesthetic concentrations of propofol protect against oxidative stress in primary astrocyte cultures 显示文摘 | Peters CE Korcok J Gelb AW | 2001 | Anesthesiology2001，94，： | 1 |
| 12 | Nephrogenic systemic fibrosis and gadolinium-based contrast media: updated ESUR Contrast Medium Safety Committee guidelines显示文摘 | Henrik S. Thomsen Sameh K. Morcos Torsten Almén Marie-France Bellin Michele Bertolotto Georg Bongartz Olivier Clement Peter Leander Gertraud Heinz-Peer Peter Reimer Fulvio Stacul Aart Molen Judith AW Webb | 2013 | European Radiology2013，，2： | 1 |
| 13 | Relation of microscopic aematuria in ankylosing spondylitis显示文摘 | Peters AJ Van den Wall Back AW van Dalsen AD | 1988 | Clin Nephrol1988，47，64： | 1 |
| 14 | Polymer concepts in tissue engineering显示文摘 | Peter SJ Miller MJ Yasko AW | 1998 | J Biomed Mater Res1998，43，4： | 1 |
| 15 | Relation of microscopic haematuria In ankylosing spondylitis to ciculating IgA containing immune complexes 显示文摘 | Peters AJ Van den Wall Bake AW vall DaIsen AD | 1988 | Ann Rheum Dis1988，47，： | 1 |
| 16 | Systematic survey on the prevalence of genes coding for staphylococcal enterotoxins SEIM, SEIO, and SEIN 显示文摘 | Becker K Friedrich AW Peters G | 2004 | Mol Nutr Food Res2004，48，： | 1 |
| 17 | Killing multiple myeloma cells with the small molecule 3-bromopyruvate: implications for therapy显示文摘 | Gra?yna Majkowska-Skrobek Daria Augustyniak Pawe? Lis Anna Bartkowiak Mykhailo Gonchar Young H. Ko Peter L. Pedersen Andre Goffeau Stanis?aw U?aszewski | 2014 | Anti-Cancer Drugs2014，，6： | 1 |
| 18 | Progenitor cell therapies for traumatic brain injury:Barriers and opportunities in translation 显示文摘 | Peter AW Shinil KS Matthew T | 2009 | Disease Models Mechanisms2009，2，12： | 1 |
| 19 | High-dose intravenous levetiracetam for acute seizure exacerbation in children with intractable epilepsy显示文摘 | DEPOSITARIO-CABACAR DT PETERS JM PONG AW | 2010 | Epilepsia2010，51，7： | 1 |
| 20 | mdrl expression is an independent prognostic factor for response and survival in denovo acute myeloid leukemia 显示文摘 | Marry M Bronno H Peter AW | 1997 | Br J Haemol1997，99，： | 1 |
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