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| 1 | Photoactivated CRY1 and phyB Interact Directly with AUX/IAA Proteins to Inhibit Auxin Signaling in Arabidopsis显示文摘光是在 Arabidopsis 通过蓝色和调停 cryptochrome 的 red/far-red 光光敏电阻器和调停 phytochrome 的小径禁止胚轴房间延伸的关键环境暗示。相反,作为枢轴的内长的植物激素,植物生长素通过 AUX/IAA 蛋白质(AUX/IAAs ) 的植物生长素受体 TIR1/AFBs-mediated 降级支持胚轴延伸。然而,位于发信号的光和植物生长素的对抗相互作用下面的分子的机制仍然保持不清楚。这里,我们报导光禁止由 cryptochrome 的蓝、红的轻依赖者的相互作用通过 AUX/IAAs 的稳定发信号的植物生长素 1 (CRY1 ) 并且有 AUX/IAAs 的 phytochrome B 分别地。有 AUX/IAAs 的 CRY1 的蓝被触发光的相互作用与 AUX/IAAs 禁止 TIR1 的协会,导致这些蛋白质的导致植物生长素的降级的压抑。我们的结果显示光敏电阻器下游地直接作为一样与植物生长素受体分享 AUX/IAAs 表明部件。我们建议由光敏电阻器和植物生长素受体的 AUX/IAA 蛋白质稳定性的那条对抗规定允许植物平衡光和植物生长素信号优化他们的生长。 | Feng Xu Shengbo He Jingyi Zhang Zhilei Mao Wenxiu Wang Ting Li Jie Hua Shasha Du Pengbo Xu Ling Li Hongli Lian Hong-Quan Yang | 2018 | Molecular Plant2018，11，4： | 24 |
| 2 | Photoexcited CRYPTOCHROME 1 Interacts Directly with G-Protein 13 Subunit AGB1 to Regulate the DNA-Binding Activity of HY5 and Photomorphogenesis in Arabidopsis显示文摘 | Hongli Lian Pengbo Xu Shengbo He Jun Wu Jian Pan Wenxiu Wang Feng Xu Sheng Wang Junsong Pan Jirong Huang Hong-Quan Yang | 2018 | Molecular Plant2018，11，10： | 10 |
| 3 | Phytochrome B and AGB1 Coordinately Regulate Photomorphogenesis by Antagonistically Modulating PIF3 Stability in Arabidopsis显示文摘Phytochrome B (phyB), the primary red light photoreceptor, promotes photomorphogenesis in Arabidopsis by interacting with the basic helix-loop-helix transcriptional factor PIF3 and inducing its phosphorylation and degradation. Heterotrimeric G proteins are known to regulate various developmental processes in plants and animals. In Arabidopsis, the G-protein β subunit AGB1 is known to repress photomorphogenesis. However, whether and how phyB and AGB1 coordinately regulate photomorphogenesis are largely unknown. Here we show that phyB physically interacts with AGB1 in a red light-dependent manner and that AGB1 interacts directly with PIF3. Moreover, we demonstrate that the AGB1-PIF3 interaction inhibits the association of PIF3 with phyB, leading to reduced phosphorylation and degradation of PIF3, whereas the phyB-AGB1 interaction represses the association of PIF3 with AGB1, resulting in enhaneed phosphorylation and degradation of PIF3. Our results suggest that phyB and AGB1 antagonistically regulate PIF3 stability by dynamically interacting with each other and PIF3. This dynamic mechanism may allow plants to balanee phyB and G-protein signaling to optimize photomorphogenesis. | Pengbo Xu Hongli Lian Feng Xu Ting Zhang Sheng Wang Wenxiu Wang Shasha Du Jirong Huang Hong-Quan Yang | 2019 | Molecular Plant2019，12，2： | 5 |
| 4 | Dynamical decoupling of electron spins in phosphorus-doped silicon显示文摘Quantum coherence is an important enabling feature underpinning quantum computation. However, because of couplings with its noisy surrounding environment, qubits suffer from the decoherence effects. The dynamical decoupling (DD) technique uses pulse-induced qubit flips to effectively mitigate couplings between qubits and environment. Optimal DD eliminates dephasing up to a given order with the minimum number of pulses. In this paper, we first introduce our recent work on prolonging electron spin coherence in γ-irradiated malonic acid crystals and analyze different decoherence mechanisms in this solid system. Then we focus on electron spin relaxation properties in another system, phosphorous-doped silicon (Si:P) crystals. These properties have been investigated by pulse electron paramagnetic resonance (EPR). We also investigate the performance of the dynamical decoupling technique on this system. Using 8-pulse periodic DD, the coherence time can be extended to 296 μs compared with 112 μs with one-pulse control. | RONG Xing WANG Ya YANG JiaHui ZHU JinXian XU WanJie FENG PengBo WEN XuJie SU JiHu DU JiangFeng | 2011 | Chinese Science Bulletin2011，56，7： | 4 |
| 5 | Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach cancers.Accumulating evidence suggests inherited genetic susceptibility to lung cancer.The present study aimed to survey the prevalence of pathogenic germline BRCA mutations(gBRCAm) and explore the potential association between gBRCAm and disease onset in Chinese advanced non-small cell lung cancer(NSCLC) patients.Methods: A total of 6,220 NSCLC patients were screened using capture-based ultra-deep targeted sequencing to identify patients harboring germline BRCA1/2 mutations.Results: Out of the 6,220 patients screened, 1.03%(64/6,220) of the patients harbored the pathogenic gB RCAm, with BRCA2 mutations being the most predominant mutations(49/64, 76.5%).Patients who developed NSCLC before 50 years of age were more likely to carry gBRCAm(P = 0.036).Among the patients harboring classic lung cancer driver mutations, those with concurrent gBRCAm were significantly younger than those harboring the wild-type gBRCA(P = 0.029).By contrast, the age of patients with or without concurrent gBRCAm was comparable to those of patients without the driver mutations(P = 0.972).In addition, we identified EGFR-mutant patients with concurrent gBRCAm who showed comparable progression-free survival but significantly longer overall survival(P = 0.002) compared to EGFR-mutant patients with wild-type germline BRCA.Conclusions: Overall, our study is the largest survey of the prevalence of pathogenic gBRCAm in advanced Chinese NSCLC patients.Results suggested a lack of association between germline BRCA status and treatment outcome of EGFR-TKI.In addition,results showed a positive correlation between pathogenic gB RCAm and an early onset of NSCLC. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 6 | Mild Breakthrough Infection in a Healthcare Professional Working in the Isolation Area of a Hospital Designated for Treating COVID-19 Patients—Shaanxi Province,China,March,2021显示文摘Summary What is already known about this topic?Healthcare workers are at high risk of acquiring COVID-19 from occupational exposure to COVID-19 virus during their daily medical service work.Excellent infection prevention and control measures and adequate personal protective equipment(PPE)are essential to reduce the risk of hospital-acquired COVID-19. | Chaofeng Ma Songtao Xu Yecheng Yao Pengbo Yu You Xu Rui Wu Hailong Chen Xiaoping Dong | 2021 | China CDC weekly2021，3，19： | 4 |
| 7 | Unexpected intercalation-dominated potassium storage in WS2 as a I potassium-ion battery anode显示文摘Unexpected intercalation-dominated process is observed duri ng K^+insertion in WS2 in a voltage range of 0.01-3.0 V.This is different fromthe previously reported two-dimensional(2D)transition metal dichalcogenides that undergo a conversion reaction in a low voltage rangewhen used as anodes in potassium-ion batteries.Charge/discharge processes in the K and Na cells are studied in parallel to demonstrate thedifferention storage mechanisms.The Na^+storage proceeds through intercalation and conversion reactions while the K^+storage is governedby an intercalation reaction.Owing to the reversible K^+intercalation in the van der Waals gaps,the WS2 anode exhibits a low decay rate of 0.07%per cycle,delivering a capacity of 103 mAh·g^-1 after 100 cycles at 100 mA·g^-1.It maintains 57%capacity at 800 mA·g^-1 and shows stablecyclability up to 400 cycles at 500 mA·g^-1.Kinetics study proves the facilitation of K^+transport is derived from the intercalation-dominatedmecha nism.Furthermore,the mechanismis verified by the density functional theory(DFT)calculations,showing that the progressive expansion of the interlayer space can account for the observed results. | Vuhan Wu Yang Xu Yueliang Li Pengbo Lyu Jin Wen Chenglin Zhang Min Zhou Yaoguo Fang Huaping Zhao Ute Kaiser Yong Lei | 2019 | Nano Research2019，12，12： | 3 |
| 8 | Molecular Characterisation of the Faecal Microbiota in Patients with Type II Diabetes显示文摘 | Xiaokang Wu Chaofeng Ma Lei Han Muhammad Nawaz Fei Gao Xuyan Zhang Pengbo Yu Chang’an Zhao Lianchuan Li Aiping Zhou Juan Wang John E. Moore B. Cherie Millar Jiru Xu | 2010 | Current Microbiology2010，，1： | 2 |
| 9 | Erratum to Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘In the published article1,the affiliation for the first author,Xingshcng Hu,is'Department of Medical Oncology,Cancer Hospital,Chinese Academy of Medical Sciences',we would like to update it to'Department of Medical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China'.We apologize for the errors and for any confusion it may have caused. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2020 | Cancer Biology & Medicine2020，17，2： | 1 |
| 10 | Nested PCR-denaturing gradient gel electrophoresis analysis of human skin microbial diversity with age显示文摘 | Wei Li Lei Han Pengbo Yu Chaofeng Ma Xiaokang Wu Jiru Xu | 2014 | Microbiological Research2014，，： | 1 |
| 11 | Effect of interfacial interaction on the mechanical properties of electron beam irradiated HDPE/STC blend显示文摘 | Wen Xu Pengbo Liu | 2002 | J Appl Polym Sci2002，84，： | 1 |
| 12 | Guiding and routing of a weak signal via a reconfigurable gravity-like potential显示文摘We demonstrate both experimentally and theoretically the trapping and guiding of a weak signal pulse via a selfaccelerating Airy pulse. This is achieved by launching the Airy pulse in the anomalous dispersion regime of an optical fiber, thereby inducing a gravity-like potential that can compel the signal pulse in the normal dispersion regime to undergo co-acceleration. Such guiding pulse by pulse can be controlled at ease simply by altering the acceleration conditions of the Airy pulse. Furthermore, the guided signal can be featured with either single or double peaks, which is explained by using the theory of fundamental and second-order quasi-modes associated with the gravity-like potential. Our work represents, to our knowledge, the first demonstration of pulse guiding in the anomalous dispersion regime of any self-accelerating pulse. | ZHILI LI PING ZHANG XUE MU PENGBO JIA YI HU ZHIGANG CHEN JINGJUN XU | 2019 | Photonics Research2019，7，9： | 1 |
| 13 | Pilot survey of raw whole milk in China for Listeria monocytogenes using PCR显示文摘 | Pengbo Ning Kangkang Guo Liang Cheng Lei Xu Chengcheng Zhang Hongjie Cui Yuanyuan Cheng Rui Xu Wei Liu Qizhuang Lv Weiwei Cao Yanming Zhang | 2013 | Food Control2013，，1： | 1 |
| 14 | Arabidopsis cryptochrome 1 promotes stomatal development through repression of AGB1 inhibition of SPEECHLESS DNA-binding activity显示文摘Cryptochromes are blue light photoreceptors that mediate various light responses in plants and mammals. The heterotrimeric G-protein is known to regulate various physiological processes in plants and mammals. In Arabidopsis, cryptochrome 1(CRY1) and the G-protein β subunit AGB1 act antagonistically to regulate stomatal development.The molecular mechanism by which CRY1 and AGB1 regulate this process remains unknown.Here, we show that Arabidopsis CRY1 acts partially through AGB1, and AGB1 acts through SPEECHLESS(SPCH), a master transcription factor that drives stomatal initiation and proliferation, to regulate stomatal development. We demonstrate that AGB1 physically interacts with SPCH to block the b HLH DNA-binding domain of SPCH and inhibit its DNA-binding activity. Moreover, we demonstrate that photoexcited CRY1 represses the interaction of AGB1 with SPCH to release AGB1 inhibition of SPCH DNA-binding activity, leading to the expression of SPCH-target genes promoting stomatal development. Taken together, our results suggest that the mechanism by which CRY1 promotes stomatal development involves positive regulation of the DNA-binding activity of SPCH mediated by CRY1 inhibition of the AGB1-SPCH interaction. We propose that the antagonistic regulation of SPCH DNA-binding activity by CRY1 and AGB1 may allow plants to balance light and G-protein signaling and optimize stomatal density and pattern. | Xiaoli Cao Pengbo Xu Yao Liu Guangqiong Yang Minqing Liu Li Chen Yingyu Cheng Peng Xu Langxi Miao Zhilei Mao Wenxiu Wang Shuang Kou Tongtong Guo Hong‐Quan Yang | 2021 | Journal of Integrative Plant Biology2021，63，11： | 1 |
| 15 | Outbreak of acute respiratory disease caused by human adenovirus type 7 in a military training camp in Shaanxi, China显示文摘 | Pengbo Yu Chaofeng Ma Muhammad Nawaz Lei Han Jianfang Zhang Quanli Du Lixia Zhang Qunling Feng Jingjun Wang Jiru Xu | 2013 | Microbiol Immunol2013，，8： | 1 |
| 16 | Carbon nanodots enhanced performance of Cs_(0.15)FA_(0.85)PbI_(3) perovskite solar cells显示文摘A high-quality hybrid Cs_(0.15)FA_(0.85)PbI_(3) thin film is deposited through doping of carbon nanodots(CNDs)into perovskite precursor solution.The corresponding inverted planar perovskite solar cells(PSCs)of ITO/PTAA/Cs_(0.15)FA_(0.85)PbI_(3)/PC_(61)BM/BCP/Ag exhibit an improvement in efficiency from 17.36%to 20.06%,which could be attributed to the passivation of the defects at the crystallized perovskite thin film and enhanced perovskite phase uniformity.The results of electron trap density indicate that the addition of CNDs significantly reduces the defects density at the perovskite thin film and the recombination of charge carriers in transport process is minimized.These results demonstrate that low-cost CNDs are effective additives for passivating defects,further reducing charge carrier recombination and improving device efficiency. | Yu Gao Wenzhan Xu Fang He Pengbo Nie Qingdan Yang Zhichun Si Hong Meng Guodan Wei | 2021 | Nano Research2021，14，7： | 0 |
| 17 | Highly Emissive Luminogens in Both Solution and Aggregate States显示文摘Organic light-emitting materials have attracted considerable attention because of their promising applications in diverse areas.Most fluorophores emit brightly in either dilute solutions or aggregate states;the former generally suffer from aggregation-caused quenching problem,and the latter encounter intensity loss at low concentrations.Herein,we propose a new strategy to overcome these dilemmas by balancing the planar and distorted structures of terphenyl-based luminogens and obtain three luminogens,2PB-AC,2Me2PB-AC,and 2T2PB-AC,with bright emission in both solution and aggregate states.Among them,2PB-AC shows absolute photoluminescence quantum yields(ФPL)higher than 90%in both tetrahydrofuran solution(90.2%)and aggregate states(92.7%for powder and 95.3%for crystal).Thus,2PB-AC could be an efficient probe to realize dual-channel explosive detection in both solution and aggregate states.Moreover,it could be used to image live-cell lipid droplets at a wide range of concentrations.In addition,benefiting from its thermodynamically favorable intersystem crossing process,2Me2PB-AC could be doped in polymethyl methacrylate matrix to provide efficient room-temperature phosphorescence.Thus,this work provides a feasible strategy for the design of luminogens with highly efficient emission in both solution and aggregate states,greatly facilitating and broadening their practical applications. | Pengbo Han Guiquan Zhang Jia Wang Yejun Yao Yanping Qiu He Xu Anjun Qin Ben Zhong Tang | 2023 | CCS Chemistry2023，5，7： | 0 |
| 18 | Drainage pattern recognition method considering local basin shape based on graph neural network显示文摘Drainage pattern recognition is crucial for geospatial understanding and hydrologic modelling.Currently,drainage pattern recognition methods employ geometric measures of overall and local features of river networks but lack measures of river basin unit shape features,so that potential correlations between river segments are usually ignored,resulting in poor drainage pattern recognition results.In order to overcome this problem,this paper proposes a supervised graph neural network method that considers the local basin unit shape of river networks.First,based on the overall hierarchy of the river networks,the confluence angle of river segments and the shape of river basin units,multiple drainage pattern classification features are extracted.Then,typical drainage pattern samples from the multi-scale NSDI and USGS databases are used to complete the training,validation and testing steps.Experimental results show that the drainage pattern indexes proposed can describe the characteristics of different drainage patterns.The method can effectively sample the adjacent river segments,flexibly transfer the associated pattern features among river segment neighbours,and aggregate the deeper characteristics of the river networks,thus improving the drainage pattern recognition accuracy relative to other methods and reliably distinguishing different drainage patterns. | Wenning Wang Haowen Yan Xiaomin Lu Yi He Tao Liu Wende Li Pengbo Li Fang Xu | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
| 19 | Spatio-temporal distribution of Konosirus punctatus spawning and nursing ground in the South Yellow Sea显示文摘In recent years,Konosirus punctatus has accounted for a large portion in catch composition and become important economic species in the South Yellow Sea.However,the distribution of K.punctatus early life stages is still poorly understood.In this study,generalized additive models with Tweedie distribution were used to analyze the relationships between K.punctatus ichthyoplankton and environmental factors(longitude and latitude,sea surface temperature(SST),sea surface salinity(SSS)and depth),and predict distribution K.punctatus spawning ground and nursing ground,based on samplings collected in 6 months during 2014–2017.The results showed that K.punctatus’spawning ground were mainly distributed in central and north study area(from 33.0°N to 37.0°N).By comparison,the nursing ground shifted southward,which were approximately located along central and south coast of study area(from 31.7°N to 35.5°N).The optimal models identified that suitable SST,SSS and depth for eggs were 19–26℃,25–30 and 9–23 m,respectively.The suitable SSS for larvae were 29–31.The K.punctatus spawning habit might have changed in the past decades,which was a response to increasing SST and fishing pressure.That needs to be proved in further study.The study provides references of conservation and exploitation for K.punctatus. | Xiangyu Long Rong Wan Zengguang Li Yiping Ren Pengbo Song Yongjun Tian Binduo Xu Ying Xue | 2021 | Acta Oceanologica Sinica2021，40，8： | 0 |
| 20 | α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure显示文摘The sarcomeric interaction ofα-myosin heavy chain(α-MHC)with Titin is vital for cardiac structure and contraction.However,the mechanism regulating this interaction in normal and failing hearts remains unknown.Lactate is a crucial energy substrate of the heart.Here,we identify thatα-MHC undergoes lactylation on lysine 1897 to regulate the interaction ofα-MHC with Titin.We observed a reduction ofα-MHC K1897 lactylation in mice and patients with heart failure.Loss of K1897 lactylation inα-MHC K1897R knock-in mice reducesα-MHC–Titin interaction and leads to impaired cardiac structure and function.Furthermore,we identified that p300 and Sirtuin 1 act as the acyltransferase and delactylase ofα-MHC,respectively.Decreasing lactate production by chemical or genetic manipulation reducesα-MHC lactylation,impairsα-MHC–Titin interaction and worsens heart failure.By contrast,upregulation of the lactate concentration by administering sodium lactate or inhibiting the pivotal lactate transporter in cardiomyocytes can promoteα-MHC K1897 lactylation andα-MHC–Titin interaction,thereby alleviating heart failure.In conclusion,α-MHC lactylation is dynamically regulated and an important determinant of overall cardiac structure and function.Excessive lactate efflux and consumption by cardiomyocytes may decrease the intracellular lactate level,which is the main cause of reducedα-MHC K1897 lactylation during myocardial injury.Our study reveals that cardiac metabolism directly modulates the sarcomeric structure and function through lactate-dependent modification ofα-MHC. | Naijin Zhang Ying Zhang Jiaqi Xu Pengbo Wang Boquan Wu Saien Lu Xinxin Lu Shilong You Xinyue Huang Mohan Li Yuanming Zou Mengke Liu Yuanhui Zhao Guozhe Sun Wenbin Wang Danxi Geng Jingwei Liu Liu Cao Yingxian Sun | 2023 | Cell Research2023，33，9： | 0 |
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