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| 1 | pORF5 plasmid protein of Chlamydia trachomatis induces MAPK-mediated pro-inflammatory cytokines via TLR2 activation in THP-1 cells显示文摘Infection with Chlamydia trachomatis induces inflammatory pathologies in the urogenital tract that can lead to infertility and ectopic pregnancy.Pathogenesis of infection has been mostly attributed to excessive cytokine production.However,precise mechanisms on how C.trachomatis triggers this production,and which protein(s) stimulate inflammatory cytokines remains unknown.In the present study,the C.trachomatis pORF5 protein induced tumor necrosis factor alpha(TNF-α),interleukin-1 beta(IL-1β) and interleukin-8(IL-8) in dose-and time-dependent manners in the THP-1 human monocyte cell line.We found that intracellular p38/mitogen-activated protein kinase(MAPK) and extracellular signal-regulated kinase(ERK)/MAPK signaling pathways were required for the induction of TNF-α,IL-1β and IL-8.Blockade of toll-like receptor 2(TLR2) signaling reduced induction levels of TNF-α,IL-8 and IL-1β.We concluded that the C.trachomatis pORF5 protein might contribute to the inflammatory processes associated with chlamydial infections. | ZHOU Hui HUANG QiuLin LI ZhongYu WU YiMou XIE XiaoBing MA KangKang CAO WenJuan ZHOU Zhou LU ChunXue ZHONG GuangMing | 2013 | Science China(Life Sciences)2013，56，5： | 26 |
| 2 | Fast cross validation for regularized extreme learning machine显示文摘A method for fast l-fold cross validation is proposed for the regularized extreme learning machine(RELM). The computational time of fast l-fold cross validation increases as the fold number decreases, which is opposite to that of naive l-fold cross validation. As opposed to naive l-fold cross validation, fast l-fold cross validation takes the advantage in terms of computational time, especially for the large fold number such as l > 20. To corroborate the efficacy and feasibility of fast l-fold cross validation,experiments on five benchmark regression data sets are evaluated. | Yongping Zhao Kangkang Wang | 2014 | Journal of Systems Engineering and Electronics2014，25，5： | 8 |
| 3 | Flexible conductive polymer composites for smart wearable strain sensors显示文摘Wearable strain sensors based on flexible conductive polymer composites(FCPCs)have attracted great attention due to their applications in the fields of human–machine interaction,disease diagnostics,human motion detection,and soft robotic skin.In recent decades,FCPC‐based strain sensors with high stretchability and sensitivity,short response time,and excellent stability have been developed,which are expected to be more versatile and intelligent.Smart strain sensors are required to provide wearable comfort,such as breathability,selfcooling ability,and so forth.To adapt to the harsh environment,wearable strain sensors should also be highly adaptive to protect the skin and the sensor itself.In addition,portable power supply system,multisite sensing capability,and multifunctionality are crucial for the next generation of FCPC‐based strain sensor. | Kangkang Zhou Kun Dai Chuntai Liu Changyu Shen | 2020 | SmartMat2020，1，1： | 7 |
| 4 | Pitting corrosion of 2Cr13 stainless steel in deep-sea environment显示文摘Pitting corrosion of 2Cr13 stainless steel was investigated by deep-sea exposure test at various depths of 500 m,800 m and 1200 m in the South China Sea for 4 months.With the aid of electrochemical measurements in simulated deep-sea environments and grey relational analysis,the influence of deepsea environments on passive film and the mechanism of pitting corrosion were discussed.The results indicated that with the increase of sea depth,pitting depth of 2Cr13 stainless steel increased,which can be attributed to the change of chemical composition and the degradation of pitting resistance of passive film.Film growth was greatly retarded in the condition of low seawater temperature and low dissolved oxygen content of deep sea,resulting in an unstable and vulnerable film.Pitting depth was most influenced by hydrostatic pressure,which can increase the adsorption and penetration of Cl-ion,and promote the proliferation of point defects in passive film,leading to rapid deconstruction of protective oxides of the film.Pitting sensitivity of 2Cr13 stainless steel increased eventually with the combination of accelerated dissolution and suppressed self-healing of passive film in deep sea. | Xinhua Wang Lin Fan Kangkang Ding Likun Xu Weimin Guo Jian Hou Tigang Duan | 2021 | Journal of Materials Science & Technology2021，，5： | 6 |
| 5 | Up‐regulated long non‐coding RNA H19 contributes to proliferation of gastric cancer cells显示文摘 | Feng Yang Jianwei Bi Xuchao Xue Luming Zheng Kangkang Zhi Jide Hua Guoen Fang | 2012 | FEBS Journal2012，，17： | 5 |
| 6 | A Soft Robotic Fish with Variable-stiffness Decoupled Mechanisms显示文摘 | Kangkang Li Hongzhou Jiang Siyu Wang Jianmin Yu | 2018 | Journal of Bionic Engineering2018，15，4： | 5 |
| 7 | A Fiber Tractography Study of Social-Emotional Related Fiber Tracts in Children and Adolescents with Autism Spectrum Disorder显示文摘The symptoms of autism spectrum disorder(ASD) have been hypothesized to be caused by changes in brain connectivity. From the clinical perspective, the‘‘disconnectivity'' hypothesis has been used to explain characteristic impairments in ‘‘socio-emotional'' function.Therefore, in this study we compared the facial emotional recognition(FER) feature and the integrity of socialemotional-related white-matter tracts between children and adolescents with high-functioning ASD(HFA) and their typically developing(TD) counterparts. The correlation between the two factors was explored to find out if impairment of the white-matter tracts is the neural basis of social-emotional disorders. Compared with the TD group,FER was significantly impaired and the fractional anisotropy value of the right cingulate fasciculus was increased in the HFA group(P \ 0.01). In conclusion, the FER function of children and adolescents with HFA was impaired and the microstructure of the cingulate fasciculus had abnormalities. | Yun Li Hui Fang Wenming Zheng Lu Qian Yunhua Xiao Qiaorong Wu Chen Chang Chaoyong Xiao Kangkang Chu Xiaoyan Ke | 2017 | Neuroscience Bulletin2017，33，6： | 5 |
| 8 | Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma显示文摘 | Feng Yang Xuchao Xue Jianwei Bi Luming Zheng Kangkang Zhi Yan Gu Guoen Fang | 2013 | Journal of Cancer Research and Clinical Oncology2013，，3： | 5 |
| 9 | Single small molecule-assembled nanoparticles mediate efficient oral drug delivery显示文摘Oral drug delivery,which requires surviving the harsh environment in the gastrointestinal(Gl)tract and penetrating the intestinal epithelium,has not bee n achieved using simple formulatio n nan oparticles(NPs).Medici nal natural products(MNPs)have bee n widely used in traditi onal medicine for disease management through oral consumption.However,most pharmacologically active compounds within MNPs do not have the properties suitable for oral applicatio ns.We hypothesize that some MNPs contain n atural nano materials that can convert those compounds into oral formulations by forming NPs.After screening 66 MNPs,we identified five classes of small molecules that form NPs,many of which are capable of efficient drug encapsulation and Gl penetration.We show that one of them,dehydrotrametenolic acid(DTA),is capable of mediating oral delivery for effective disease treatment.We determined that DTA NPs assemble through hydrogen bonding and penetra怕the Gl tract via apical sodium-depe ndent bile acid tran sporter.Our study reveals a no vel class of single comp orient,small molecule-assembled NPs for oral drug delivery,and suggests a n ovel approach to modernizi ng MNPs through nano material discovery. | Xin Yang Chao Ma Zeming Chen Jun Liu Fuyao Liu Rongbin Xie Haitian Zhao Gang Deng Ann TChen Ningbo Gong Lei Yao Pengjian Zuo Kangkang Zhi Jiacheng Wang Xiaobin Gao Jing Wang Louzhen Fan Jiangbing Zhou | 2019 | Nano Research2019，12，10： | 4 |
| 10 | Variable stiffness design of redundantly actuated planar rotational parallel mechanisms显示文摘Redundantly actuated planar rotational parallel mechanisms(RAPRPMs) adapt to the requirements of robots under different working conditions by changing the antagonistic internal force to tune their stiffness.The geometrical parameters of the mechanism impact the performances of modulating stiffness.Analytical expressions relating stiffness and geometrical parameters of the mechanism were formulated to obtain the necessary conditions of variable stiffness.A novel method of variable stiffness design was presented to optimize the geometrical parameters of the mechanism.The stiffness variation with the internal force was maximized.The dynamic change of stiffness with the dynamic location of the mechanism was minimized,and the robustness of stiffness during the motion of the mechanism was ensured.This new approach to variable stiffness design can enable off-line planning of the internal force to avoid the difficulties of on-line control of the internal force. | Li Kangkang Jiang Hongzhou Cui Zuo Huang Qun | 2017 | Chinese Journal of Aeronautics2017，30，2： | 4 |
| 11 | Relationship Between Economic Growth and Water Environmental Quality of Anshan City in Northeast China显示文摘Based on the decomposition model of environmental quality and univariate regression model,the relationships of industrial wastewater drainage with economic scale,economic structure,and technological level in Anshan,a mining city in Northeast China,were studied. The results showed that,due to scale effect,the drainage of three important industrial wastewater pollutants(COD,NH3-N and petroleum) increased 8505t,671t and 384t,respectively,and due to structure effect,those pollutants drainage increased 3996t,174t and 120t from 2001 to 2006. While due to technological effect,the drainage of COD,NH3-N and petroleum reduced 4452t,458t and 331t,and due to cross effect,those pollutants drainage reduced 7270t,575t and 476t simultaneously. Meantime,the relationships between household consumption structure and domestic sewage discharge were analyzed,and domestic sewage discharges in different income levels were also compared. The results showed that,the domestic sewage discharges would increase 376t with 1000 yuan(RMB) increased in the traffic and communication consumption,and they would be 344t,219t,428t,1873t,respectively,in housing consumption,food consumption,medical consumption,miscellaneous commodity consumption. The proportion of domestic sewage discharge increased for high income residents significantly,but reduced for lower income residents. The industrial wastewater pollutants drainage tends to be reduced by technical progress,while domestic sewage discharge will be a more important factor for urban water environment quality. | GU Kangkang LIU Jingshuang WANG Yang | 2009 | Chinese Geographical Science2009，19，1： | 4 |
| 12 | Core-shell Ni_(3)Sn_(2)@C particles anchore d on 3D N-dope d porous carbon skeleton for modulated electromagnetic wave absorption显示文摘Synthesizing multi-component composites via a straightforward,reliable,and scalable approach has been challenging.Herein,a three-dimensional nitrogen-doped porous carbon decorated with core-shell Ni_(3)Sn_(2)@carbon particles(3D N-PC/Ni_(3)Sn_(2)@C)was customized through a simple salt-template pyrolysis approach.The formed Ni_(3)Sn_(2) particles are perfectly surrounded by crystalline carbon layers and em-bedded in 3D carbon walls during pyrolysis.The dual protection of crystalline carbon layers and porous carbon walls guarantees the electrical conductivity and stability of Ni_(3)Sn_(2).The intriguing 3D and core-shell structure coupled with the introduction of multiple components empowers the composite with rich heterogeneous interface and conductive network,and contributes to the lightweight,corrosion resistance,oxidation resistance,and superior stability of electromagnetic(EM)wave absorbers.The N-PC/Ni_(3)Sn_(2)@C possesses the minimum reflection loss(RL min)of-54.01 dB and wide effective absorption bandwidth(EAB)of 7.36 GHz under a low filler content of less than 10%.The concept in the work proposes a facile,eco-friendly,and scalable pathway for the synthesis of other heterogeneous structures of EM wave ab-sorbers. | Hongxia Zhang Kaige Sun Kangkang Sun Lei Chen Guanglei Wu | 2023 | Journal of Materials Science & Technology2023，，27： | 4 |
| 13 | OPTIMIZED MEANSHIFT TARGET REFERENCE MODEL BASED ON IMPROVED PIXEL WEIGHTING IN VISUAL TRACKING显示文摘The generic Meanshift is susceptible to interference of background pixels with the target pixels in the kernel of the reference model, which compromises the tracking performance. In this paper, we enhance the target color feature by attenuating the background color within the kernel through enlarging the pixel weightings which map to the pixels on the target. This way, the background pixel interference is largely suppressed in the color histogram in the course of constructing the target reference model. In addition, the proposed method also reduces the number of Meanshift iterations, which speeds up the algorithmic convergence. The two tests validate the proposed approach with improved tracking robustness on real-world video sequences. | Chen Ken Song Kangkang Kyoungho Choi Guo Yunyan | 2013 | Journal of Electronics(China)2013，30，3： | 4 |
| 14 | Biomineralized polymer matrix composites for bone tissue repair:a review显示文摘Bone defects caused by trauma, infection or bone tumor resection, are highly prevalent. A small number(5%–10%) of these injuries fail to heal due to non-union and require surgical intervention. Currently, the principal treatment options for these defects are autografts, allografts, xenografts or synthetic grafts. The main problems associated with these therapies include pain,infection and donor site morbidity. Bone tissue engineering is a diverse field that focuses on the regeneration of bone by combining cells, scaffolds, growth factors and dynamic forces. There have been many recent studies utilizing biomineralized polymer matrix composites which mimic the natural structure of bone. The principal focus of this review is on recent advances in the synthesis of various types of biomineralized polymer matrix composite. Examples of the biomineralization of naturallyderived and synthetic polymers widely used for bone engineering are also summarized. | Lin Zhong Ying Qu Kun Shi Bingyang Chu Minyi Lei Kangkang Huang Yingchun Gu Zhiyong Qian | 2018 | Science China Chemistry2018，61，12： | 4 |
| 15 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 16 | Parameter studies and evaluation principles of delamination damage in laminated composites显示文摘Delamination represents one of the most severe failure modes in composite laminates,especially when they are subjected to uniaxial compression loads.The evaluation of the delamination damage has always been an essential issue of composite laminates for durability and damage tolerance in engineering practice.Focusing on the most typical and representative elliptical delamination issue,an analytical model simultaneously considering the conservative buckling process and non-conservative delamination propagation process is implemented.Various computational cases considering different delamination depths,directions,aspect ratios,and areas are established,and the predicted results based on the analytical model are carefully compared.Effects of these geometrical delamination parameters on the buckling,delamination propagation,and failure behaviors of composite laminates are thoroughly analyzed,and innovative evaluation principles of the delamination damage have been concluded.It is found that the delamination area is the key factor that truly affecting the failure behaviors of delaminated composites,and the local/global buckling and failure loads show clear linearity with the delamination area,whilst the delamination depth and direction only have slight effects. | Kangkang WANG Libin ZHAO Haiming HONG Jianyu ZHANG Yu GONG | 2021 | Chinese Journal of Aeronautics2021，34，7： | 3 |
| 17 | Anthropogenic Effect on Deposition Dynamics of Lake Sediments Based on ^(137)Cs and ^(210)Pb_(ex) Techniques in Jiuzhaigou National Nature Reserve,China显示文摘Radionuclide dating techniques characterized by137Cs and210Pbex have recently been applied in the study of lake sediments around the world.In this study,a chronological series of sediment cores was established based on137Cs and210Pbex analyses along with the evaluation of sediment properties,such as particle size distribution,total organic carbon(TOC),carbonate content,and acid-insoluble residue,to study sediment accumulation rates,sediment sources,and responses to human activities in the Jiuzhaigou National Nature Reserve in southwestern China.In terms of the particle size distribution of sediments,silt content was the highest,and clay and sand contents were relatively low.The sediments displayed high TOC contents because of the significant amounts of vegetation grown in the lakes.The carbonate content was also high due to the overall geological background of carbonates in Jiuzhaigou.Carbonate content tended to decline from top to bottom in the sediment cores,whereas the acid-insoluble residue tended to increase.These results suggested that the depth variation of the environmental parameters of the sediments in two lakes in Jiuzhaigou would correspond to each other.The results indicated that the sediment rate of Jiuzhaigou was generally high with strong siltation,indicating that serious soil loss was induced by intensive human activities in the basin over the past decades.The increases in the mass accumulation rate,contents of acid-insoluble residue,and mean particle size during the periods of 1840–1900s,late 1930s–early 1950s,1966–1978,and2003–2006 revealed the occurrence of severe soil and water loss as a result of extensive agricultural expansion,large-scale deforestation,and road construction in Jiuzhaigou.The deposition rate and the properties of lacustrine sediments could reflect the significant impact of human activities on lake sedimentation during Jiuzhaigou′s history. | LIANG Kangkang HU Xinxin LI Shiguang HUANG Chengmin TANG Ya | 2014 | Chinese Geographical Science2014，24，2： | 3 |
| 18 | Transition Metal Aluminum Boride as a New Candidate for Ambient-Condition Electrochemical Ammonia Synthesis显示文摘Achieving more meaningful N2 conversion by reducing the energy input and carbon footprint is now being investigated through a method of N2 fixation instead of the Haber-Bosch process.Unfortunately,the electrochemical N2 reduction reaction(NRR)method as a rising approach currently still shows low selectivity(Faradaic efficiency<10%)and high-energy consumption[applied potential at least-0.2 V versus the reversible hydrogen electrode(RHE)].Here,the role of molybdenum aluminum boride single crystals,belonging to a family of ternary transition metal aluminum borides known as MAB phases,is reported for the electrochemical NRR for the first time,at a low applied potential(-0.05 V versus RHE)under ambient conditions and in alkaline media.Due to the unique nano-laminated crystal structure of the MAB phase,these inexpensive materials have been found to exhibit excellent electrocatalytic performances(NH3 yield:9.2μg h^-1cm^-2mgcat^-1.,Faradaic efficiency:30.1%)at the low overpotential,and to display a high chemical stability and sustained catalytic performance.In conjunction,further mechanism studies indicate B and Al as main-group metals show a highly selective affinity to N2 due to the strong interaction between the B 2p/Al 3p band and the N 2p orbitals,while Mo exhibits specific catalytic activity toward the subsequent reduction reaction.Overall,the MAB-phase catalyst under the synergy of the elements within ternary compound can suppress the hydrogen evolution reaction and achieve enhanced NRR performance.The significance of this work is to provide a promising candidate in the future synthesis of ammonia. | Yang Fu Peter Richardson Kangkang Li Hai Yu Bing Yu Scott Donne Erich Kisi Tianyi Ma | 2020 | Nano-Micro Letters2020，12，5： | 3 |
| 19 | Matrine inhibits mycelia growth of Botryosphaeria dothidea by affecting membrane permeability显示文摘Matrine is a promising botanical antifungal;however, the mechanism underlying the antifungal activity is yet limited. We studied the antifungal activity of matrine and the underlying mechanism in Botryosphaeria dothidea as a model strain. Matrine strongly inhibited mycelial growth of B. dothidea in a dose-dependent manner. Matrine-treated B. dothidea showed morphological and ultrastructural alterations, including shriveled hyphae, plasmolysis, and leakage of cytoplasm related to cell membrane deterioration. In addition, matrine caused significantly high conductivity and absorbance (260 nm) in extracellular matrices and low lipid contents in B. dothidea, indicating increased membrane permeability. Lipid peroxidation showed that matrine resulted in increased malondialdehyde content while enhancing the generation of reactive oxygen species and the activities of superoxide dismutase, catalase, and peroxidase. These results showed that matrine inhibited the mycelial growth of B. dothidea by enhancing cell membrane permeability via membrane lipid peroxidation. | Jialiang Pan Xin Hao Hanwen Yao Kangkang Ge Ling Ma Wei Ma | 2019 | Journal of Forestry Research2019，30，3： | 3 |
| 20 | Electrochemical migration, whisker formation, and corrosion behavior of printed circuit board under wet H2S environment显示文摘 | Shiwen Zou Xiaogang Li Chaofang Dong Kangkang Ding Kui Xiao | 2013 | Electrochimica Acta2013，，： | 2 |
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