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| 1 | microRNA-21a-5p/PDCD4 axis regulates mesenchymal stem cell-induced neuroprotection in acute glaucoma显示文摘间充质的干细胞(MSC ) 被表明了为许多神经病学的疾病有有希望的治疗学的好处;然而,内在的机制糟糕被理解。这里,我们显示出 MSC 的那 intravitreal 注入在尖锐绿内障的一个老鼠模型的支持的网膜的中心细胞(RGC ) 幸存与 microglial 激活的重要抑制, TNF- , IL-1,和反应的氧种类的生产,以及 caspase-8 和 caspase-3 激活。在 vitro, MSC 禁止了两 caspase-8-mediated RGC apoptosis 和 microglial 激活,部分经由 stanniocalcin 的行动 1 (STC1 ) 。而且,我们发现了那 microRNA-21a-5p (miR-21 ) 和它的目标, PDCD4,为 STC1 生产和在 vitro 并且在 vivo 的 MSC 的 neuroprotective 性质是必要的。重要地, miR-21 overexpression 或 PDCD4 尖锐绿内障上的击倒的扩充调停 MSC 的 neuroprotective 效果。miR-21/PDCD4 轴由导致 MSC 分泌施加 neuroprotective 的 STC1 和另外的因素的以前未被认出的 neuroprotective 机制完成的这些数据热点。因此, modulating miR-21/PDCD4 轴可能是为尖锐绿内障和另外的神经病学的疾病的临床的处理的有希望的策略。 | Wenru Su Zuohong Li Yu Jia Yingting Zhu Wenjia Cai Peixing Wan Yingying Zhang Song Guo Zheng Yehong Zhuo | 2017 | Journal of Molecular Cell Biology2017，9，4： | 5 |
| 2 | Somatic Embryogenesis in Iberian Grapevine (Vitis vinifera) Cultivars Using Carpels as Initial Explants: Protocol Establishment and Histological Evaluation显示文摘Trincadeira and Aragonez are two important grapevine cultivars in the Iberian Peninsula, used for high quality red wines production. Both cultivars are strongly affected by fungal diseases, with consequent high loses on plant productivity and fruit quality. A successful protocol for plant regeneration via somatic embryogenesis (SE) was established for both cultivars allowing further plant improvement based on gene transfer technology. Several factors were evaluated during the three different phases which characterize an SE plant regeneration protocol. The culture room temperature during the induction phase, a parameter usually accepted as standard by most researchers, proved in these trials to significantly affect the embryo induction rates. Concerning embryo conversion, it was specially affected by the embryo developmental stage, by the intensity and duration of the chilling treatment and by the supplementation of conversion culture medium with activated charcoal. The responses obtained, both for induction and conversion, proved to be highly genotype dependent. Calli structure, as well as embryo integrity, was histologically observed, allowing to characterize embryonic and non-embryonic masses and to identify abnormalities on embryo development. | Hélia Guerra Cardoso Maria Catarina Campos Maria Salomé Pais Augusto Peixe | 2019 | Journal of Agricultural Science and Technology(B)2019，9，1： | 2 |
| 3 | Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma显示文摘 | Augusto Villanueva Derek Y. Chiang Pippa Newell Judit Peix Swan Thung Clara Alsinet Victoria Tovar Sasan Roayaie Beatriz Minguez Manel Sole Carlo Battiston Stijn van Laarhoven Maria I. Fiel Analisa Di Feo Yujin Hoshida Steven Yea Sara Toffanin Alex Ramos | 2008 | Gastroenterology2008，，6： | 1 |
| 4 | Performance Evaluation Method for Automated Driving System in Logical Scenario显示文摘With the continuous improvement of automated driving technology,how to evaluate the performance of an automated driving system is attracting more and more attention.Meanwhile,with the creation of scenario-based test methods,the traditional evaluation index based on a single test can no longer meet the requirements of high-level safety verification for automated driving system,and the performance evaluation of such a system in logical scenarios will be the mainstream.Based on the scenario-based test method and Turing test theory,a performance evaluation method for an automated driving system in the whole parameter space of a logical scenario is proposed.The logical scenario parameter space is partitioned according to the risk degree of concrete scenario,and the evaluation process in different zones are determined.Subsequently,the anthropo-morphic index in the safe zone and the collision-avoidance index in the danger zone are defined by comparing test results of human driving and ideal vehicle motion.Taking front vehicle low-speed and cut-out scenarios as examples,two automated driving algorithms are tested in the virtual environment,and the test results are evaluated both by the proposed method and by human observation.The results show that the results of the proposed method are consistent with the subjective feelings of humans;additionally,it can be applied to scenario-based tests and the verification process of an automated driving system. | Peixing Zhang Bing Zhu Jian Zhao Tianxin Fan Yuhang Sun | 2022 | Automotive Innovation2022，5，3： | 1 |
| 5 | Muhiniehe screening reveals the clinically relevant metallo-β-lactamase VIM-2 in Pseudomonas aeruginosa far from the hospital setting: an ongoing dispersion process? 显示文摘 | Sandra Quinteira and Luisa Peixe | 2006 | Applied and Environmental Microbiology2006，72，5： | 1 |
| 6 | Emergence of carbapenem-hydrolyzing enzymes in Acinetobacter baumannil clinical isolates 显示文摘 | Silva G J D Leitao R Peixe L | 1999 | J Clin Microbiol1999，37，6： | 1 |
| 7 | Effectsofsingleasperitygeometryonfrictionand wearofPEEK显示文摘 | PeiX BennewitzR BusseM etal | 2013 | Wear2013，304，12： | 1 |
| 8 | Sfh-I, a Subclass B2 Metallo-β-Lactamase from a Serratia fontieola Environmental Isolate显示文摘 | Maria Jose Saavedra Luisa Peixe Joao Carlos Sousa | 2003 | Antimicrobial Agents and Chemotherapy2003，47，7： | 1 |
| 9 | Preparation,characterizaGtion,andtunablewettabilityofpoly (ionicliquid)bruGshesviasurfaceGinitiationatomtransferradicalpolymeriGzation显示文摘 | HeXY Yang W PeiX W | 2008 | Macromolecules2008，41，13： | 1 |
| 10 | Biodiversity of populations of phosphate solubilizing rhizobia that nodu- lates chickpea in different Spanish soils 显示文摘 | RIVAS R PEIX A MATEOS P | 2006 | Plant and Soil2006，287，12： | 1 |
| 11 | Modulation transfer function evaluation of linear solid- state X-ray-sensitive detectors using edge techniques 显示文摘 | Zhu Yuemin Kaftandjian Valerie Peix Gilles | 1995 | Appl Opt1995，34，22： | 1 |
| 12 | Cnidarians as a source of new marine bioactive compounds-an overview of the last decade and future steps for bioprospecting 显示文摘 | Rocha J Peixe L Gomes NCM | 2011 | Marine Drugs2011，9，10： | 1 |
| 13 | Characterization of In100,a new integron carrying a metallo2 lactamase and a carbenicillinase,from Pseudom onas aeruginosa显示文摘 | Quinteira S Sousa J C Peixe L | 2005 | Antimicrob Agents Chemother2005，49，45： | 1 |
| 14 | Microorganisms and cancer: scientific evidence and new hypotheses 显示文摘 | Velazquez E Peix A G6mez-Alonso A | 2011 | Cir Esp2011，89，3： | 1 |
| 15 | Emergence of carbapenem-hydrolyzing enzymes in Acinetobacter baumannii clinical isolates显示文摘 | Da Silva G Leitao O Peixe L | | 0，，06： | 1 |
| 16 | Nondestructive measurement of density and effective atomic nuclear by photon scattering显示文摘 | Berodias G Peix G | 1988 | Materials Evaluation1988，46，： | 1 |
| 17 | Drainage after thyroidectomy: A randomized clinical trial 显示文摘 | Teboul F Feldman H | 1992 | Int Surg1992，77，： | 1 |
| 18 | Relations between X-ray tomography density and mechanical properties in carbon-carbon composites 显示文摘 | Douarche N Rouby D Peix G | 2001 | Carbon2001，39，10： | 1 |
| 19 | Role of total thyroidectomy in the treatment of benign thyroid diseases 显示文摘 | Peix JL Van Box Som P | 1996 | Ann Endocrinol paris1996，57，6： | 1 |
| 20 | Characterization of In100 ,a new integron carrying a metallo--lactamase and a carbenicillinase,from Pseudornonas aeruginosa 显示文摘 | Quinteira S Sousa J C Peixe L | 2005 | Antimicrob Agents Chemother2005，49，1： | 1 |
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