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| 1 | New strategy for designing orangish-redemitting phosphor via oxygen-vacancyinduced electronic localization显示文摘Phosphor-converted white-light-emitting diodes(pc-WLED)have been extensively employed as solid-state lighting sources,which have a very important role in people’s daily lives.However,due to the scarcity of the red component,it is difficult to realize warm white light efficiently.Hence,red-emitting phosphors are urgently required for improving the illumination quality.In this work,we develop a novel orangish-red La_(4)GeO_(8):Bi^(3+) phosphor,the emission peak of which is located at 600 nm under near-ultraviolet(n-UV)light excitation.The full width at half maximum(fwhm)is 103 nm,the internal quantum efficiency(IQE)exceeds 88%,and the external quantum efficiency(EQE)is 69%.According to Rietveld refinement analysis and density functional theory(DFT)calculations,Bi^(3+) ions randomly occupy all La sites in orthorhombic La_(4)GeO_(8).Importantly,the oxygen-vacancy-induced electronic localization around the Bi3+ions is the main reason for the highly efficient orangish-red luminescence.These results provide a new perspective and insight from the local electron structure for designing inorganic phosphor materials that realize the unique luminescence performance of Bi^(3+) ions. | Yi Wei Gongcheng Xing Kang Liu Guogang Li Peipei Dang Sisi Liang Min Liu Ziyong Cheng Dayong Jin Jun Lin | 2019 | Light(Science & Applications)2019，8，1： | 12 |
| 2 | Prognostic implications of epidermal growth factor receptor variant Ⅲ expression and nuclear translocation in Chinese human gliomas显示文摘Objective: To determine the prognostic implications and clinical significance of epidermal growth factor receptor variant Ⅲ(EGFRvⅢ) expression and EGFRvⅢ nuclear translocation in Chinese human gliomas.Methods: We retrospectively examined EGFRvⅢ expression and EGFRvⅢ nuclear translocation using immunohistochemistry in specimens of 240 Chinese patients with glioma, including 84 World Health Organization(WHO) II gliomas, 84 WHO Ⅲ gliomas and 72 glioblastomas(WHO IV). Factors that correlated with EGFRvⅢ and EGFRvⅢ nuclear translocation expression were analyzed by the Chi-square test. Kaplan-Meier methodology and Cox regression were used for the survival analysis.Results: Log-rank tests showed that patient age, Karnofsky performance scale(KPS) score, tumor grade,EGFRvⅢ expression, EGFRvⅢ nuclear translocation, 1 p/19 q codeletion, isocitrate dehydrogenase(IDH)mutation, Ki-67 labeling index and O6-methylguanine-DNA methyltransferase(MGMT) status(P<0.05) were significantly correlated with overall survival(OS) time. Multivariate Cox regression analysis revealed that patient age, tumor grade, EGFRvⅢ nuclear translocation, 1 p/19 q codeletion, and IDH mutation(P<0.05) were significantly correlated with OS. Patients with a high level of EGFRvⅢ nuclear translocation(≥7%) had both significantly shorter OS [hazard ratio(HR): 1.920, 95% confidence interval(95% CI): 1.228-3.003, P=0.004] and progression-free survival(PFS) times(HR: 1.661, 95% CI: 1.116-2.471, P=0.012) than those with a low level of EGFRvⅢ nuclear translocation(<7%).Conclusions: A high level of EGFRvⅢ nuclear translocation in glioma is an independent factor indicating a poor prognosis, but EGFRvⅢ expression is not an independent clinical prognostic factor. The level of EGFRvⅢ nuclear translocation maybe a novel and crucial prognostic biomarker in glioma. | Kaiyuan Yang Xiaohui Ren Liyuan Tao Peipei Wang Haihui Jiang Li Shen Yiming Zhao Yong Cui Mingxiao Li Song Lin | 2019 | Chinese Journal of Cancer Research2019，31，1： | 8 |
| 3 | Thermally stable and highly efficient red-emitting Eu^(3+)-doped Cs3GdGe309 phosphors for WLEDs:non-concentration quenching and negative thermal expansion显示文摘Red phosphor materials play a key role in improving the lighting and backlit display quality of phosphor-converted white light-emitting diodes(pc-WLEDs).However,the development of a red phosphor with simultaneous high efficiency,excellent thermal stability and high colour purity is still a challenge.In this work,unique non-concentration quenching in solid-solution Cs_(3)Gd_(1-x)Ge_(3)O_(9):xEu^(3+)(CGGO:xEu^(3+))(x=0.1-1.0)phosphors is successfully developed to achieve a highly efficient red-emitting Cs_(3)EuGe_(3)0_(9)(CEGO)phosphor.Under the optimal 464 nm blue light excitation,CEGO shows a strong red emission at 611 nm with a high colour purity of 95.07%and a high internal quantum efficiency of 94%.Impressively,this red-emitting CEGO phosphor exhibits a better thermal stability at higher temperatures(175-250℃,>90%)than typical red K2SiF6:Mn^(4+)and Y203:Eu^(3+)phosphors,and has a remarkable volumetric negative thermal expansion(coefficient of thermal expansion,a=—5.06×10^(-5)/℃,25-250℃).By employing this red CEGO phosphor,a fabricated pc-WLED emits warm white light with colour coordinates(0.364,0.383),a high colour rendering index(CRI=89.7),and a low colour coordinate temperature(CCT=4508 K).These results indicate that this highly efficient red-emitting phosphor has great potential as a red component for pc-WLEDs,opening a new perspective for developing new phosphor materials. | Peipei Dang Guogang Li Xiaohan Yun Qianqian Zhang Dongjie Liu Hongzhou Lian Mengmeng Shang Jun Lin | 2021 | Light(Science & Applications)2021，10，2： | 6 |
| 4 | A novel PDZ domain-containing gene is essential for male sex differentiation and maintenance in yellow catfish(Pelteobagrus fulvidraco)显示文摘The sex-determining genes are found to be variable among different fish species. Yellow catfish(Pelteobagrus fulvidraco) is an important aquaculture fish species in China with XX/XY sex-determining type. Recently, YY super-male yellow catfish has been successfully produced by combining hormonalinduced sex reversal method with sex chromosome-linked markers. Here, we identified a novel PDZ domain-containing gene in yellow catfish designated as pfpdz1, in whose intron the sex-linked marker was located. The coding sequence of pfpdz1 in Y chromosome was identical to that in X chromosome except a missense SNP(A/T) that changes an amino acid(E8V) in the N-terminal region. Pfpdz1 displayed male-specific expression during sex differentiation. Overexpression of pfpdz1 using additive transgenesis induces XX ovary to differentiate into testis-like tissue, while the targeted inactivation of pfpdz1 in Y chromosome using CRISPR/Cas9-mediated mutagenesis triggers ovarian differentiation. Furthermore,we demonstrated that pfpdz1 initiates testicular differentiation through upregulating expression of amh, dmrt1 and sox9a1, as well as downregulating expression of cyp19a1, foxl2 and wnt4. Our data provide functional evidence that pfpdz1 is significant for male differentiation and maintenance in yellow catfish. | Cheng Dan Qiaohong Lin Gaorui Gong Tianyi Yang Shuting Xiong Yang Xiong Peipei Huang Jian-Fang Gui Jie Mei | 2018 | Science Bulletin2018，63，21： | 4 |
| 5 | Interface science in polymer-based composite solid electrolytes in lithium metal batteries显示文摘Solid-state lithium metal batteries(SSLMBs)have attracted considerable attention as one of the most promising energy storage systems owing to their high safety and energy density.Solid electrolytes,particularly polymer-based composite solid electrolytes(CSEs),are considered promising electrolyte candidates for SSLMBs.However,theirwide application is inhibited by various electrochemical issues,such as low ionic conductivity,the growth of lithium dendrites,and poor cycling stability,which are related to interface issues within SSLMBs.In this review,the parameters related to various interfaces in the CSE of SSLMBs,including the interfaces between the polymer matrix and inorganic fillers,between the CSEs and the cathode,and between the CSEs and the lithium metal anode,are examined.Relevant issues and corresponding remediation strategies are proposed.Finally,future perspectives based on interfacial engineering and the characterization of polymer/inorganic filler interactions are proposed for building high-performance CSEs for use in SSLMBs. | Lingqiao Wu Yongtao Wang Xianwei Guo Peipei Ding Zhiyuan Lin Haijun Yu | 2022 | SusMat2022，2，3： | 2 |
| 6 | Identification of two novel mutations in the GALNT3 gene in a Chinese family with hyperphosphatemic familial tumoral calcinosis显示文摘Hyperphosphatemic familial tumoral calcinosis(HFTC) is a rare, autosomal recessive genetic disease.This disease is characterized by the progressive calcification of soft tissues leading to symptoms of pressure and hyperphosphatemia but normal concentrations of serum calcium with or without an elevation of1,25-dihydroxyvitamin D3 levels.HFTC is caused by loss-of-function mutations in the GALNT3, FGF23 or KL genes. Here, we identified two novel mutations in the GALNT3 gene in a Chinese family with HFTC.Identification of a novel genotype in HFTC provides clues for understanding the phenotype–genotype relationships in HFTC and may assist not only in the clinical diagnosis of HFTC but also in the interpretation of the genetic information used for prenatal diagnosis and genetic counseling. | Lihao Sun Lin Zhao Lianiun Du Peipei Zhang Minjia Zhang Min Li Tingting Liu Lei Ye Bei Tao Hongyan Zhao Jianmin Liu Xiaoyi Ding | 2016 | Bone Research2016，4，4： | 2 |
| 7 | Clinical characteristics and prognostic values of 1p32.3 deletion detected through fluorescence in situ hybridization in patients with newly diagnosed multiple myeloma: a single-center study in China显示文摘This study aimed to investigate the prevalence,clinical characteristics,and prognostic impact of 1p32.3 deletion in patients with newly diagnosed multiple myeloma (MM).A retrospective analysis was conducted on 411 patients with newly diagnosed MM;among which,270 received bortezomib-based therapies,and 141 received thalidomide-based therapies.Fluorescence in situ hybridization (FISH) was performed to detect six cytogenetic abnormalities,namely,del(1p32.3),gain(1q21),del(17p13),del(13q14),t(4;14),and t(11;14).Results showed that 8.3% of patients with MM were detected with del(1p32.3) and had significantly more bone marrow plasma cells (P =0.025),higher β2-microglobulin levels (P =0.036),and higher lactate dehydrogenase levels (P =0.042) than those without del(1p32.3).Univariate analysis showed that patients with del(1p32.3) under thalidomide-based therapies were strongly associated with short progression-free survival (PFS) (median PFS 11.6 vs.31.2 months,P =0.002) and overall survival (OS) (median OS 16.8 vs.45.9 months,P < 0.001).Multivariate analysis revealed that del(1p32.3) remained a powerful independent factor with worse PFS (P =0.006) and OS (P =0.016) for patients under thalidomide-based treatments.Patients with del(1 p32.3) under bortezomib-based treatments tended to have short PFS and OS.In conclusion,del(1p32.3) is associated with short PFS and OS in patients with MM who received thalidomide-or bortezomib-based treatments. | Huanping Wang Haitao Meng Jinghan Wang Yinjun Lou Yile Zhou Peipei Lin Fenglin Li Lin Liu Huan Xu Min Yang Jie Jin | 2020 | Frontiers of Medicine2020，14，3： | 2 |
| 8 | Small-molecule fluorescent probes for the detection of carbon dioxide显示文摘During the last few years, the preparation of novel fluorescent probes for the detection of carbon dioxide has attracted considerable attention since carbon dioxide plays extremely important roles in widespread fields including chemical, environmental, clinical analysis, and agri-food industry. This review focuses on the recent advances in the design principles, recognition mechanisms, and preparation of small-molecule fluorescent probes for the selective detection and monitoring of CO_2. Moreover, their properties and functions will be discussed detailedly as well. | Junlong Zhu Peipei Jia Nuo Li Shaoying Tan Junhai Huang Lin Xu | 2018 | Chinese Chemical Letters2018，29，10： | 2 |
| 9 | An adjusted ELISpot-based immunoassay for evaluation of SARS-CoV-2-specific T-cell responses显示文摘Like antibody evaluation,using an effective antigen‐specific T‐cell immunity assessment method in coronavirus disease 2019(COVID‐19)patients,survivors and vaccinees is crucial for understanding the immune persistence,prognosis assessment,and vaccine development for COVID‐19.This study evaluated an empirically adjusted enzyme‐linked immunospot assay for detecting severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2)‐specific T‐cell immunity in 175 peripheral blood samples from COVID‐19 convalescents and healthy individuals.Results of viral nucleic acid were used as the gold standard of infection confirmation.The SARS‐CoV‐2M peptide pool had higher sensitivity of 85%and specificity of 71%for the single peptide pool.For combined peptide pools,the parallel evaluation(at least one of the peptide pools is positive)of total peptide pools(S1&S2&M&N)had higher sensitivity(up to 93%),and the serial evaluation(all peptide pools are positive)of total peptide pools had higher specificity(up to 100%).The result of the serial evaluation was better than that of the parallel evaluation as a whole.The detection efficiency of M and N peptide pool serial evaluation appeared the highest,with a sensitivity of 80%and specificity of 93%.This T‐cell immunity detection assay introduced in this report can achieve high operability and applicability.Therefore,it can be an effective SARS‐CoV‐2‐specific cellular immune function evaluation method. | Hao Lin Jie Zhang Shaobo Dong Yaning Liu Peipei Liu George F.Gao William J.Liu Guizhen Wu | 2022 | Biosafety and Health2022，4，3： | 1 |
| 10 | Mapping of wheat stripe rust resistance gene Yr041133 by BSR-Seq analysis显示文摘Puccinia striiformis Westend. f. sp. tritici(Pst) pathotype CYR34 is widely virulent and prevalent in China.Here, we report identification of a strpie rust resistance(Yr) gene, designated Yr041133, in winter wheat line 041133. This line produced a hypersensitive reaction to CYR34 and conferred resistance to 13 other pathotypes. Resistance to CYR34 in line 041133 was controlled by a single dominant gene. Bulked segregant RNA sequencing(BSR-Seq) was performed on a pair of RNA bulks generated by pooling resistant and susceptible recombinant inbred lines. Yr041133 was mapped to a 1.7 c M genetic interval on the chromosome arm 7 BL that corresponded to a 0.8 Mb physical interval(608.9–609.7 Mb) in the Chinese Spring reference genome. Based on its unique physical location Yr041133 differred from the other Yr genes on this chromosome arm. | Yahui Li Ruiming Lin Jinghuang Hu Xiaohan Shi Dan Qiu Peipei Wu Gebremedhin Habteab Goitom Siqi Wang Hongjun Zhang Li Yang Hongwei Liu Qiuhong Wu Jingzhong Xie Yang Zhou Zhiyong Liu Hongjie Li | 2022 | The Crop Journal2022，10，2： | 1 |
| 11 | Highly efficient Fe^(3+)-doped A_(2)BB′O_(6)(A=Sr^(2+),Ca^(2+);B,B′=In^(3+),Sb^(5+),Sn^(4+))broadband nearinfrared-emitting phosphors for spectroscopic analysis显示文摘Near-infrared(NIR)-emitting phosphor-converted light-emitting diodes have attracted widespread attention in various applications based on NIR spectroscopy.Except for typical Cr^(3+)-activated NIR-emitting phosphors,next-generation Cr^(3+)-free NIR-emitting phosphors with high efficiency and tunable optical properties are highly desired to enrich the types of NIR luminescent materials for different application fields.Here,we report the Fe^(3+)-activated Sr2−yCay(InSb)1−zSn_(2)zO_(6)phosphors that exhibit unprecedented long-wavelength NIR emission.The overall emission tuning from 885 to 1005 nm with broadened full-width at half maximum from 108 to 146 nm was realized through a crystallographic site engineering strategy.The NIR emission was significantly enhanced after complete Ca^(2+)incorporation owing to the substitution-induced lower symmetry of the Fe^(3+)sites.The Ca_(2)InSbO_(6):Fe^(3+)phosphor peaking at 935 nm showed an ultra-high internal quantum efficiency of 87%.The as-synthesized emission-tunable phosphors demonstrated great potential for NIR spectroscopy detection.This work initiates the development of efficient Fe^(3+)-activated broadband NIR-emitting phosphors and opens up a new avenue for designing NIR-emitting phosphor materials. | Dongjie Liu Guogang Li Peipei Dang Qianqian Zhang Yi Wei Lei Qiu Maxim S.Molokeev Hongzhou Lian Mengmeng Shang Jun Lin | 2022 | Light(Science & Applications)2022，11，5： | 1 |
| 12 | MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation显示文摘 | Xiaorong Zhang Xinxin Zuo Bo Yang Zongran Li Yuanchao Xue Yu Zhou Jie Huang Xiaolu Zhao Jie Zhou Yun Yan Huiqiong Zhang Peipei Guo Hui Sun Lin Guo Yi Zhang Xiang-Dong Fu | 2014 | Cell2014，，： | 1 |
| 13 | 5-15 Investigation of the Neutron Transport Behavior in Granular Tungsten Target显示文摘A new concept of the Gravity-driven dense granular flow spallation target for ADS was proposed. The target material is discrete Tungsten-based alloys solid particles. The neutron transport behavior in granular Tungsten is very important for the design of spallation target.The neutron transport behavior in granular Tungsten target was studied in detail. | Han Rui Chen Zhiqiang Gou Boxing Shi Fudong Lin Weiping Ren Peipei Tian Guoyu Luo Fei Sun Qi | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 14 | 5-16 Benchmarking of Evaluated Neutron Nuclear Data for Granular Tungsten Target显示文摘The design of ADS spallation target requires precise and reliable nuclear data. ADS research team of Chinese Academy of Sciences (CAS) proposed a new concept for a Gravity-driven dense granular flow spallation target[1].The target material is Tungsten-based alloys solid particles. The neutron nuclear data of granular Tungsten is very important for the design of spallation target. | Han Rui Chen Zhiqiang Gou Boxing Shi Fudong Lin Weiping Ren Peipei Tian Guoyu Luo Fei Sun Qi | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 15 | 5-17 Measurement of Leakage Neutron Spectra from Silicon Carbide Cylinders显示文摘The Accelerator-Driven Systems (ADS) is mainly used for nuclear transmutation of long-lived fission products, fuel breeding and energy production. China has started to develop the ADS project and is now underway vigorously.The combination of nuclear data with a Monte Carlo transportation code like MCNP-4C is widely applied to design such kind of nuclear engineering facilities. The integral experiment is conducted to benchmark the nuclear data, involved in design calculations, both with regard to the activation and the particle transport behavior. | Luo Fei Chen Zhiqiang Han Rui Shi Fudong Gou Boxing Lin Weiping Ren Peipei Tian Guoyu Sun Qi | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 16 | 5-18 Measurement of Leakage Neutron Spectra from Graphite Cylinders显示文摘Graphite is applied to many applications in the field of atomic energy. In the design of nuclear reactors, such as ADS, HTGRs and fusion reactors, graphite is among the primary candidate materials for a reflector zone to soften the neutron spectrum. Moreover, the accurate prediction of tritium breeding ratio and nuclear heating rate sets the necessity of using adequate nuclear data for carbon since they have strong influence on the feasibility of the overall design of fusion reactors. | Luo Fei Chen Zhiqiang Han Rui Shi Fudong Gou Boxing Lin Weiping Ren Peipei Tian Guoyu Sun Qi | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 17 | Formation Time of Fragments显示文摘 | Yang Kun Liu Xingquan Xi Yinyin Huang Meirong Zhang Suyalatu Lin Weiping Ren Peipei Chen Zhiqiang R. Wada | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 18 | 2-25 Interpretation on the Mass Dependent Behavior of Transverse Flow Using Collective-thermal Competition (Percolation) Model显示文摘According to the interplay model proposed in Ref. [1], an improved model, Collective-thermal Competition(Percolation) Model (CTCPM) is developed. The improvements are made by adding the momentum conservationinto the interplay of the thermal motion and the collective motion and limiting the emitting system to be finite.For a nuclear system at a thermal equilibrium, the momentum of the thermal motion distributes isotropically in x,y, z directions (z is the beam direction) and make no effect on the flow (Px) in average. | Liu Xingquan Wada Roy Chen Zhiqiang Huang Meirong Lin Weiping Ren Peipei Zhang Suyalatu Jin Zengxue Jia Baolu Han Rui Liu Jianli Shi Fudong | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 19 | 2-26 Effect on Transverse Flow Definition from Different Reaction Mechanisms in AMD and CoMD — Semi-transparency显示文摘In general, the definition of the transverse flow can be classified into the slope flow[1] and the average flow[2]in the certain mid-rapidity region. For a given type of isotope with mass number A, these two definitions are,respectively, expressed | Liu Xingquan Wada Roy Chen Zhiqiang Huang Meirong Lin Weiping Ren Peipei Zhang Suyalatu Jin Zengxue Jia Baolu Han Rui Liu Jianli Shi Fudong | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 20 | Origin and chromatin remodeling of young X/Y sex chromosomes in catfish with sexual plasticity显示文摘Assembly of a complete Y chromosome is a significant challenge in animals with an XX/XY sex-determination system.Re cently,we created YY-supermale yellow catfish by crossing XY males with sex-reversed XY females,providing a valuable model for Y-chromosome assembly and evolution.Here,we assembled highly homomorphic Y and X chromosomes by sequencing genomes of the YY supermale and XX female in yellow catfish,reve aling their nucleotide divergences with only less than 1%and with the same gene compositions.The sex-determining region(SDR)was identified to locate within a physical distance of0.3 Mb by FSTscanning.Strikingly,the incipient sex chromosomes were revealed to originate via autosome-autosome fusion and were characterized by a highly rearranged region with an SDR downstream of the fusion site.We found that the Y chromosome was at a very early stage of differentiation,as no clear evidence of evolutionary strata and classical structure features of recombination suppression for a rather late stage of Y-chromosome evolution were observed.Significantly,a number of sex-antagonistic mutations and the accumulation of repetitive elements were discovered in the SDR,which might be the main driver of the initial establishment of recombination suppression between young X and Y chromosomes.Moreover,distinct three-dimensional chromatin organizations of the Y and X chromosomes were identified in the YY supermales and XX females,as the X chromosome exhibited denser chromatin structure than the Y chromosome,while they respectively have significantly spatial interactions with female-and male-related genes compared with other autosomes.The chromatin configuration of the sex chromosomes as well as the nucleus spatial organization of the XX neomale were remodeled after sex reversal and similar to those in YY supermales,and a male-specific loop containing the SDR was found in the open chromatin region.Our results elucidate the origin of young sex chromosomes and the chromatin remodeling configuration in the catfish sexual plasticity. | Gaorui Gong Yang Xiong Shijun Xiao Xi-Yin Li Peipei Huang Qian Liao Qingqing Han Qiaohong Lin Cheng Dan Li Zhou Fan Ren Qi Zhou Jian-Fang Gui Jie Mei | 2023 | National Science Review2023，10，2： | 0 |
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