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| 1 | Curative endoscopic therapy in patients with early esophageal squamous-cell carcinoma or high-grade intracpithelial neoplasia显示文摘 | Pech O May A Gossner L Rabenstein T | 2007 | Endoscopy2007，39，1： | 1 |
| 2 | Endoscopic resection of early oesophageal cancer显示文摘 | Pech O May A Rabenstein T | 2007 | Gut2007，56，11： | 1 |
| 3 | Charaterization of ripening-regulated cDNAs and their expression in ethylene-suppressed charentais melon fruit显示文摘 | HADFIELD K A DANG T PECH J C | 2000 | Plant Physiology2000，122，3： | 1 |
| 4 | High-throughput microsatellite isolation through 454 GS-FLX Titanium pyrosequencing of enriched DNA libraries 显示文摘 | Malausa T Gilles A Megl~cz E Blanquart H Duthoy S Costedoat C Dubut V Pech N Cast- agnone-Sereno P Delye C Feau N Frey P Gau- thier P Guillemaud T Hazard L Corre VL Lung- Escarmant B Malt~ PJG Ferreira S Martin JF | 2011 | Me/ Ecol Res2011，11，4： | 1 |
| 5 | New members of the tomato ERF family show specific expression pattern and diverse DNA-binding capacity to GCC box element显示文摘 | Tournier B Sanchez-Ballesta M T Jones B Pesquet E Regad F Latche A Pech J C Bouzayen M | | 0，，550： | 1 |
| 6 | The crystal structure of archaeal nascent polypeptide associated complex(NAC)reveals a unique fold and the presence of a ubiquitin associated domain显示文摘 | Spreter T Pech M Beatrix B | 2005 | J Biol Chem2005，280，15： | 1 |
| 7 | MR guided interstitial laser thermotherapy of colorectal liver metastases: efficiency, safety and patient survival 显示文摘 | Pech M Wieners G Freund T | 2007 | Eur J Med Res2007，12，4： | 1 |
| 8 | Inducible nitric oxide synthase expression in the intestinal muscularis mediates severe smooth muscle dysfunction during acute rejection in allogenic rodent small bowel transplantation显示文摘 | Schaefer N Tahara K Pech T | 2008 | J Surg Res2008，150，2： | 1 |
| 9 | EQCM study of electrodeposited PbO2: Investigation of the gel formation and discharge mechanisms显示文摘 | Pech D Brousse T B61anger D | 2009 | Electrochimica Acta2009，54，28： | 1 |
| 10 | Confocal laser endomi-croscopy for in vivo diagnosis of early squamous cell carcinoma in the esophagus显示文摘 | Pech O Rabenstein T Manner H | 2007 | Gagtrointest Endosc2007，65，5： | 1 |
| 11 | Confocal laser endomicroscopy for in vivo diagnosis of early squamous cell carcinoma in the esophagus显示文摘 | Pech O Rabenstein T Manner H | 2008 | Clin Gastroenterol Hepatol2008，6，1： | 1 |
| 12 | Trends in the management of anorectal melanoma:A multiinstitutional retrospective study and review of the world literature显示文摘BACKGROUND Anorectal melanoma(ARM)is a rare disease with a poor prognosis.Evidence on optimal treatment is limited and surgical management varies widely.We hypothesized that the frequency of abdominoperineal resection used as primary treatment of ARM has decreased over the past several decades.AIM To update our understanding of outcomes for patients with ARM and analyze management trends around the world.METHODS This is a multi-institutional,retrospective study of patients treated for ARM at 7 hospitals.Hospitals included both large,academic,tertiary care centers and smaller,general community hospitals.Using prospectively maintained institutional tumor registries,we identified 24 patients diagnosed with ARM between January 2000 and May 2019.We analyzed factors prognostic for recurrence and survival.We then used Cox regression to measure overall survival(OS)and melanoma-specific survival.We also performed a literature review to assess trends in surgical management and outcomes.RESULTS Of the 24 patients diagnosed with ARM,12(50.0%)had local,8(33.3%)regional,and 4(16.7%)distant disease at diagnosis.Median time to recurrence was 10.4 mo[interquartile range(IQR)7.5-17.2]with only 2 patients(9.3%)not developing recurrence following surgical resection.Median OS was 18.8 mo(IQR 13.5-33.9).One patient is still alive without recurrence at 21.4 mo from diagnosis;no other patient survived 5 years.Primary surgical management with abdominoperineal resection(APR)vs wide excision(WE)did not lead to differences in OS[hazard ratio=1.4(95%CI:0.3-6.8)].Review of the literature revealed geographic differences in surgical management of ARM,with increased use of WE in the United States and Europe over time and more frequent use of APR in Asia and India.There was no significant improvement in survival over time.CONCLUSION There is wide variation in the management of ARM and survival outcomes remain poor regardless of approach.Surgical management should aim to minimize morbidity. | Josh Bleicher Jessica N Cohan Lyen C Huang William Peche T Bartley Pickron Courtney L Scaife Tawnya L Bowles John R Hyngstrom Elliot A Asare | 2021 | World Journal of Gastroenterology2021，27，3： | 1 |
| 13 | Confocal laser endomicroscopy for in vivo diagnosis of early squamous cell carcinoma in the esophagus显示文摘 | Pech O Rabenstein T Manner H | 2007 | Gastrointest Endosc2007，65，5： | 1 |
| 14 | Inducible Nitric Oxide Synthase Expression in the Intestinal Muscular is Mediates Severe Smooth Muscle Dysfunction During Acute Rejection in Allogenic Rodent Small Bowel Transplantation显示文摘 | Schaefer N Tahara K Pech T | | 0，，02： | 1 |
| 15 | Arterial blood pressure andrenal sodium excretion in dopamine D3 receptor knockout mice 显示文摘 | Staudacher T Pech B Tappe M | 2007 | Hypertens Res2007，30，1： | 1 |
| 16 | The tomato genome sequence provides insights into fleshy fruit evolution 显示文摘 | Sato S Tabata S Hirakawa H Asamizu E Shlrasawa K Isobe S Kaneko T Nakamura Y Shibata D Aoki K Egholm M Knight J Bogden R Li C Shuang Y Xu X Pan S Cheng S Liu X Ren Y Wang J Albiero A Dal Pero F Todesco S Van Eck J Buels R M Bombarely A Gosselin J R Huang M Leto J A Menda N Strickler S Mao L Gao S Tecle I Y York T Zheng Y Vrebalov JT Lee J Zhong S Mueller L A Stiekema W J Ribeca P Alioto T Yang W Huang S Du Y Zhang Z Gao J Guo Y Wang X Li Y He J Li C Cheng Z Zuo J Ren J Zhao J Yan L Jiang H Wang B Li H Li Z Fu F Chen B Feng Q Fan D Wang Y Ling H Xue Y Ware D McCombie W R Lippman Z B Chia J M Jiang K Pasternak S Gelley L Kramer M Anderson L K Chang S B Royer S M Shearer L A Stack S M Rose J K Xu Y Eannetta N Matas A J McQuinn R Tanksley S D Camara F Guiga R Rombauts S Fawcett J Van de Peer Y Zamir D Liang C Spannagl M Gundlach H Bruggmann R Mayer K Jia Z Zhang J Ye Z Bishop G J Butcher S Lopez-Cobollo R Buchan D Filippis I Abbott J Dixit R Singh M Singh A Pal J K Pandit A Singh P K Mahato A K Gaikwad V D Sharma R R Mohapatra T Singh N K Causse M Rothan C Schiex T Noirot C Bellec A Klopp C Delalande C Berges H Mariette J Frasse P Vautrin S Zouine M Latch6 A Rousseau C Regad F Pech J C Philippot M Bouzayen M Pericard P Osorio S Fernandez del Carmen A Monforte A Granell A Fernandez-Mufioz R Conte M Lichtenstein G Carrari F De Bellis G Fuligni F Peano C Grandillo S Termolino P Pietrella M Fantini E Falcone G Fiore A Giuliano G Lopez L Facella P Perotta G Daddiego L Bryan G Orozco M Pastor X Torrents D van Schriek M G Feron R M van Oeveren J de Heer P daPonte L Jacobs-Oomen S Cariaso M Prins M van Eijk M J Janssen A van Haaren M J Jungeun Kim S H Kwon S Y Kim S Koo D H Lee S Hur C G Clouser C Rico A Hallab A Gebhardt C Klee K Jocker A Warfsmann J Gobel U Kawamura S Yano K Sherman J D Fukuoka H Negoro S Bhutty S Chowdhury P Chattopadhyay D Datema E Smit S Schijlen E G van de Belt J van Haarst J C Peters S A van Staveren M A Henkens M H Mooyman P J Hesselink T van Ham R C Jiang G Droege M Choi D Kang B C Kim B D Park M Kim S Yeom SI Lee YH Choi Y D Li G Gao J Liu Y Huang S Fernandez-Pedrosa V Collado C Zufiiga S Wang G Cade R Dietrich R A Rogers J Knapp S Fei Z White R A Thannhauser T W Giovannoni J J Botella M A Gilbert L Gonzalez R Goieoechea J L Yu Y Kudrna D Collura K Wissotski M Wing R Meyers BC Gurazada AB Green P J Vyas S M Solanke A U Kumar R Gupta V Sharma A K Khurana P Khurana J P Tyagi A K Dalmay T Mohorianu 1 Waits B Chamala S Barbazuk W B Li J Guo H Lee T H Wang Y Zhang D Paterson A H Wang X Tang H Barone A Chiusano M L Ereolano M R D' Agostino N Di Filippo M Traini A Sanseverino W Frusciante L Seymour G B Elharam M Fu Y Hua A Kenton S Lewis J Lin S Najar F Lai H Qin B Qu C Shi R White D White J Xing Y Yang K Yi J Yao Z Zhou L Roe B A Vezzi A D' Angelo M Zimbello R Sehiavon R Caniato E Rigobello C Campagna D Vitulo N Valle G Nelson D R De Paoli E Szinay D de Jong H H Bai Y Visser R G Klein R Beasley H McLaren K Nicholson C Riddle C Gianese G | 2012 | Nature2012，485，7400： | 1 |
| 17 | Ef ects of immunosuppressive therapy after experimental smal bowel transplantation in rats显示文摘 | Pech T Fujishiro J Finger T | | 0，，2： | 1 |
| 18 | Confocal laser endomicroscopy for in vivo diagnosis of early squamous cell carcinoma in the esophagus 显示文摘 | Pech O Rabenstein T Manner H | 2008 | Clin Gastroenterol Hepatol2008，6，1： | 1 |
| 19 | Confocal laser endomicroscopy for in vivo diagnosis of early squamous cell carcinoma in the esophagus 显示文摘 | Pech O Rabenstein T Manner H Petrone MC Pohl J Vieth M Stohe M Ell C | 2008 | Clin Gas- troenterolHepato12008，6，： | 1 |
| 20 | Rilmenidine prevents blood pressure increase in rats with compromised nitric oxide production显示文摘AIM: To search tools of high blood pressure in the model of nitric oxide (NO)-defective hypertension, and the study focused on the effect of rilmenidine, agonist of imidazoline receptors, which was suggested to modulate central sympathetic outflow. METHODS: Three experimental groups, each consisting of 7 rats, were used: (I) rats with inhibition of NO synthase (NOS) by NG-nitro-L-arginine methyl ester (L-NAME) 40 mg·kg-1·d-1 for 4 weeks in drinking water, (II) rats with inhibited NOS as in group I , plus agonist of imidazoline receptors rilmenidine 3 mg·kg-1·d-1 for 4weeks by gavage, and(III) control rats. Systolic blood pressure wasmeasured weekly noninvasively. At the end of experiment aortic ring isometric tension was followed, NOS expression (aorta, left ventricle), and NOS activity (left ventricle and brain) were determined. RESULTS: In the group I systolic blood pressure in- creased significantly, aortic ring relaxation to acetylcholine was significantly attenuated. Rilmenidine administered simultaneously with L-NAME (group II) prevented the increase of blood pressure which did not differ significantly from control values; aortic ring relaxation to acetylcholine did not differ from control. No change in NOS expres- sion (aorta and left ventricle) was found in groups I and II. Significant decline in NOS activity (left ventricle and brain) wasfound in groups I and II. CONCLUSION: Rilmenidinehas aremarkable role inNO-defective hypertension, possibly by inhibiting central sympathetic outflow and by affecting receptors in vascular smooth muscle also. The prime cause of hypertension in this experimental model - the compromised production of NO due to inhibition of NOS - was not affected by rilmenidine. | Mria GEROV Jozef TRK Ol’ga PECHV Jana MATUKOV | 2004 | Acta Pharmacologica Sinica2004，25，12： | 0 |
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