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| 1 | Specific probiotics alleviate allergic rhinitis during the birch pollen season显示文摘AIM:To investigate whether birch pollen allergy symptoms are linked with gut microbiota changes and whether probiotics have an effect on these.METHODS:Forty seven children with confirmed birch pollen allergy were randomized to receive either a probiotic combination of Lactobacillus acidophilus (L.acidophilus) NCFMTM (ATCC 700396) and Bifidobacterium lactis (B.lactis) Bl-04 (ATCC SD5219) or placebo in a double-blind manner for 4 mo,starting prior to onset of the birch pollen season.Symptoms were recorded in a diary.Blood samples were taken for analysis of cytokines and eosinophils.Fecal samples were analysed for microbiota components,calprotectin and IgA.Nasal swabs were taken for analysis of eosinophils.RESULTS:The pollen season induced a reduction in Bifidobacterium,Clostridium and Bacteroides which could not be prevented by the probiotic intervention.During the intervention,significantly higher numbers of B.lactis 11.2×107 ± 4.2×107 vs 0.1×107 ± 0.1×107 bacteria/g feces (P<0.0001) and L.acidophilus NCFMTM 3.5×106 ± 1.3×106 vs 0.2×106 ± 0.1×106 bacteria/g feces (P<0.0001) were observed in the probiotic group compared to the placebo group.During May,there was a tendency for fewer subjects,(76.2% vs 95.2%,P=0.078) to report runny nose,while during June,fewer subjects,11.1% vs 33.3%,reported nasal blocking in the probiotics group (P =0.101).Concomitantly,fewer subjects in the probiotic group had infiltration of eosinophils in the nasal mucosa compared to the placebo group,57.1% vs 95% (P=0.013).Eye symptoms tended to be slightly more frequent in the probiotic group,12.5 d [interquartile range (IQR) 6-18] vs 7.5 d (IQR 0-11.5) (P=0.066) during May.Fecal IgA was increased in the placebo group during the pollen season;this increase was prevented by the probiotics (P=0.028).CONCLUSION:Birch pollen allergy was shown to be associated with changes in fecal microbiota composition.The specific combination of probiotics used was shown to prevent the pollen-induced infiltration of eosinophils into the nasal mucosa,and indicated a trend for reduced nasal symptoms. | Arthur C Ouwehand Merja Nermes Maria Carmen Collado Nina Rautonen Seppo Salminen Erika Isolauri | 2009 | World Journal of Gastroenterology2009，15，26： | 19 |
| 2 | Gal microbiota composition is associated with body weight,weight gain and biochemical parameters in pregnant women 显示文摘 | SANTACRUZ A COLLADO M C GARCA-VALDI]S L | 2010 | Br J Nutr2010，104，1： | 1 |
| 3 | Effect of glucose in removal of microcystin - LR by viable com- mercial probi0tic strains and strains isolated from dadih fermented milk 显示文摘 | Nybom S A K Collado A C Surono I S | 2008 | Journal of Agricultural and Food Chemistry2008，56，10： | 1 |
| 4 | Super twisting control of a parametrically excited overiiead crane显示文摘 | VAZQUEZ C COLLADO J FRIDMAN L | 2014 | Journal of the Franklin Institute2014，351，4： | 1 |
| 5 | Adhesion of se- lected Bifidobacterium strains to human intestinal mucus and the role of adhesion in enteropathogen exclusion显示文摘 | Collado M C Gueimonde M Hemandez M | 2005 | Journal of Food Protection2005，68，12： | 1 |
| 6 | Probiotics in adhe- sion of pathogens: mechanisms of action显示文摘 | Collado M C Gueimonde M Salminen S | 2010 | Bio Food Pro Hea2010，23，： | 1 |
| 7 | Potential probiotic char- acteristics of Lactobac//lus and Enterococcus strains isolated from tra- ditional dadih fermented milk against pathogen intestinal colonization 显示文摘 | Collado M C Surono I S Meriluoto J | 2007 | Journal of Food Protection2007，70，： | 1 |
| 8 | Distinctcomposition of gut microbiota during pregnancy in overweight andnormal-weight women显示文摘 | COLLADO M C ISOLAURI E LAITINEN K | 2008 | American Journal of Clinical Nutrition2008，88，4： | 1 |
| 9 | Genetic variation in the physical properties of sweet potato starch 显示文摘 | Collado L S Mabesa R C Corke H | 1999 | Journal of agriculture and food chemistry1999，47，10： | 1 |
| 10 | Vasoactive intestinal peptide enhances growth and angiogenesis of human experimental prostate cancer in a xenograft model显示文摘 | Collado B Carmena MJ Clemente C | 2007 | Peptides2007，28，9： | 1 |
| 11 | Production of bac- teriocin-like inhibitory compounds by human fecal Bifidobacterium strains 显示文摘 | Collado M C Hernandez M Sanz Y | 2005 | Journal of Food Protection2005，68，5： | 1 |
| 12 | Innovation and Job Creation and Destruction:Evidence From Spain显示文摘 | Alonso-Borrego C Collado M.D | | 0，，： | 1 |
| 13 | lhylogenet- ie analysis of Verticillium dahliae vegetative compatibility grounps 显示文摘 | Collado R M Mercado B J Olivares G C | 2008 | Phytopathology2008，98，9： | 1 |
| 14 | Early ROS-me- diated DNA damage and oxidative stress biomarkers in mono- clonalB lymphocytosis显示文摘 | COLLADO R OLIVER I TORMOS C | 2012 | Cancer Lett2012，317，2： | 1 |
| 15 | In vitro analysis of probioticst rain combinations to inhibit pathogen adhesion to human intestinal mucus显示文摘 | COLLADO M C MERILUOTO J SALMINEN S | 2007 | Food Res Int2007，40，5： | 1 |
| 16 | Adhesion and aggregation properties of probiotie and pathogen strains显示文摘 | Collado M C Meriluoto J Salminen S | 2008 | European Food Re- search and Technology2008，226，5： | 1 |
| 17 | Detection of epstein-barr virus and human herpesvirus 7 and 8 genomes in primary T-and B-cell lymphoma显示文摘 | Nagore E Ledesma E Collado C | 2000 | Br J Dermatol2000，143，： | 1 |
| 18 | Genetic variation in the physical properties of sweet potato starch 显示文摘 | Collado L S Mabesa R C Corke H | 1999 | Journal of Agriculture and Food Chemistry1999，47，10： | 1 |
| 19 | Arbuscular mycorrhizal symbiosis can alleviate drought-induced nodule senescence in soybean plants 显示文摘 | Ruiz-Lozano JM Collados C Barea JM 2001 | 2001 | New Phytol2001，151，： | 1 |
| 20 | Antimicrobial peptides are among the antagonistic metabolites produced by ifidobacterium against Helicobacter pylori 显示文摘 | Collado M C A Gonz'alez R Gonz'alezc M | 2005 | International ournal of Antimicrobial Agents2005，25，： | 1 |
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