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| 1 | 基于NMR的代谢组学方法最新进展及应用(英文)显示文摘代谢组学的定义“对病理/生理刺激以及基因改变时生物体系动态的代谢响应进行多参数的定量测量”已被广泛接受.本文对代谢组学研究的最新进展及其在系统生物学中所发挥的作用进行了综述.在代谢组学方法研究方面,着重讨论了现代NMR技术的进展及其对代谢组学所产生的影响,同时也包括用于分离的HPLC及其与质谱的连用技术.对代谢组学广泛应用的概述,主要包括:对正常生理变化的新认识;药物和其他外源性化学物质的副作用;外源性物质对环境污染的影响以及逐渐增多的代谢组学方法在疾病检测中应用. | LINDON J C HOLMES E NICHOLSON J K | 2006 | 波谱学杂志2006，23，1： | 10 |
| 2 | Barrett’s metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor显示文摘 | Anna M Nicholson Trevor A Graham Ashley Simpson Adam Humphries Nicola Burch Manuel Rodriguez-Justo Marco Novelli Rebecca Harrison Nicholas A Wright Stuart A C McDonald Janusz A Jankowski | 2012 | Gut2012，，10： | 3 |
| 3 | Transanal total mesorectal excision:a valid option for rectal cancer?显示文摘Low anterior resection can be a challenging operation, especially in obese male patients and in particular after radiotherapy. Transanal total mesorectal excision(Ta TME) might offer technical advantages over laparoscopic or open approaches particularly for tumors in the distal third of the rectum. The aim of this article is to review the current experience with Ta TME. The limits and future developments are also explored. Although the experience with Ta TME is still limited, it might be a promising alternative to laparoscopic TME, especially for difficult cases where laparoscopy is too demanding. The preliminary data on complications and short-term oncological outcomes are good, but also emphasize the importance of careful patient selection. Finally, there is a need for large-scale trials focusing on long-term outcomes and oncological safety before widespread adoption can be recommended. | Nicolas C Buchs Gary A Nicholson Frederic Ris Neil J Mortensen Roel Hompes | 2015 | World Journal of Gastroenterology2015，21，41： | 3 |
| 4 | Destruction of Cyanobacterial Peptide Hepatotoxins by Chlorine and Chloramine显示文摘 | Nicholson B C Rositano J Burch M D | 1994 | Water Res1994，28，： | 1 |
| 5 | Toxicological applications of magnetic resonance显示文摘 | LINDON J C HOLMES E NICHOLSON J K | | 0，，： | 1 |
| 6 | Metabonomics: a platform for studying drug toxicity and gene function显示文摘 | Nicholson J K Connelly J Lindon J C | 2002 | Nat Rev Drug Discov2002，1，2： | 1 |
| 7 | Synovial sarcoma of the pleura and its differentiation from other primary pleural tumours: a clincopathological and immunohistochemical review of three cases显示文摘 | Nicholson AG Goldstraw P Fisher C | 1998 | Histopathology1998，33，6： | 1 |
| 8 | Metabonomics techniques and applications to pharmaceutical research&development 显示文摘 | LINDON J C HOLMES E NICHOLSON J K | 2006 | Pharm Res2006，23，6： | 1 |
| 9 | Metabonomics:a platform for studying drug toxicity and gene function显示文摘 | Nicholson J K Connelly J Lindon J C | 2002 | Nat Rev Drug Discov2002，1，2： | 1 |
| 10 | The use of robotically assisted surgery for treating urachal anomalies显示文摘 | Madeb R Knopf JK Nicholson C | | 0，，04： | 1 |
| 11 | Metabonomics:a platform for studying drug toxicity and gene function显示文摘 | NICHOLSON J K CONNELLY J LINDON J C | | 0，，： | 1 |
| 12 | The challenges of modeling mammalian bioeomplexity显示文摘 | Nicholson J K Holmes E Lindon J C | 2004 | Nature Biotechnology2004，22，： | 1 |
| 13 | Coinfection of pigs with porcine respiratory coronavirus and Bordetella bronchiseptica显示文摘 | Brockmeier S L Loving C L Nicholson T L | 2008 | Veterinary Microbiology2008，128，12： | 1 |
| 14 | Destruction of Cyanobacterial Peptide Hepatotoxins by Chlorine and Chloramine显示文摘 | Nicholson B C Rositano J Burch M D | 1994 | Water Res1994，28，： | 1 |
| 15 | Evaluation of fetal cardiac dysrhythmias with tow-dimensional, M-mode, and pulse Doppler ultrasonography 显示文摘 | Cameron A Nicholson A Nimrod C | 1998 | Am J Obstet Gynecol1998，15，8： | 1 |
| 16 | Systems biology: Metabonomics 显示文摘 | Nicholson J K Lindon J C | 2008 | Nature2008，，： | 1 |
| 17 | Localiza tion of the herpes simplex virus type 1 major capsid pro tein VP5 to the cell nucleus requires the abundant scaf folding protein VP22a显示文摘 | Nicholson P Addison C Cross A M | 1994 | J Gen Virol1994，75，5： | 1 |
| 18 | Complex regulatory interactions control CRH gene expression 显示文摘 | Nicholson R C King B R Smith R | 2004 | Frontiers in Bioscience2004，9，1： | 1 |
| 19 | 'Metabonomics' understanding the metabolic responses of living systems to patho physiological stimuli viamuhivariate statistical analysis of biological NMR spectroscopicdata显示文摘 | Nicholson J K Lindon J C Holmes E | 1999 | Xenobiotica1999，29，11： | 1 |
| 20 | ‘Metabonomics':understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data显示文摘 | Nicholson L K Lindon J C Holmes E | 1999 | Xenobiotica1999，29，2： | 1 |
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