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| 1 | 中国狂犬病的流行病学特征及防制建议显示文摘狂犬病是一种由狂犬病毒引起的人兽共患传染病。几乎所有的温血动物对狂犬病毒易感,但犬类是本病的主要宿主,在携带和传播狂犬病过程中起主要作用。人狂犬病通常由患病动物咬伤或黏膜接触后唾液中的狂犬病毒侵入体内而发生感染。狂犬病是迄今为止人类病死率最高的急性传染病,一旦发病,死亡率高达100%。全世界每年约有35000~50000人死于狂犬病,主要分布在亚洲、非洲和拉丁美洲等发展中国家。 | 张永振 俞永新 董关木 Zhen F Fu | 2007 | 中华预防医学杂志2007，41，3： | 50 |
| 2 | Interaction of hepatitis C virus envelope glycoprotein E2 with the large extracellular loop of tupaia CD81显示文摘AIM: To further analyze the interaction of tupaia CD81 with hepatitis C virus (HCV) envelope protein E2. METHODS: A tupaia CD81 large extracellular loop (CD81 LEL), which binds to HCV E2 protein, was cloned and expressed as a GST-fusion protein, and interaction of HCV E2 protein with a tupaia CD81 LEL was evaluated by enzyme-linked immunosorbent assay (EIA). RESULTS: Although tupaia and human CD81 LEL differed in 6 amino acid changes, tupaia CD81 LEL was strongly recognized by anti-CD81 antibodies against human CD81 LEL conformation-dependent epitopes. Investigating LEL CD81-E2 interactions by EIA, we demonstrated that binding of tupaia CD81 LEL GST fusion protein to recombinant HCV E2 protein was markedly reduced compared to binding of human CD81 LEL GST fusion protein to recombinant HCV E2 protein. CONCLUSION: These data suggest that the structural differences in-between the tupaia and human CD81 may alter the interaction of the large extracellular loop with HCV envelope glycoprotein E2. These findings may be important for the understanding of the mechanisms of binding and entry of HCV to PTHs. | Zhan-Fei Tian Hong Shen Xi-Hua Fu Yi-Chun Chen Hubert E Blum Thomas F Baumert Xi-Ping Zhao | 2009 | World Journal of Gastroenterology2009，15，2： | 16 |
| 3 | Interoperability of Design Intent in Integrated Product and Process Design显示文摘Concurrent engineering is currently an overwhelming t rend in product development since it takes the down-stream product development issues and product life-cycle issues into consideration in up-front design pro cess. At this stage, evaluation, verification and validation of design concepts and design schemes is critical to the right-to-market product development. I dentification and extraction of design intent from the part digital mock-ups in different data formats and created in different CAD systems for DFX considerati on, evaluation, verification, and validation is crucial too. Traditionally, fro m manufacturing point of view, feature identification and extraction is to get t he features and feature-related information for manufacturing planning and inte gration. Presently, from the viewpoint of product development and product servi ce life cycle, design intent identification and extraction is to get all the des ign-related information for DFX consideration in early design stage, such as de sign for assembly, design for service, design for tooling, design for functional ity and design for environment etc. Therefore, how to successfully extract desi gn intent such as design and machining features and design-related information from the prototyping digital mock-ups created by different CAD systems for DFX consideration in upstream design stage is a very useful topic in integrated prod uct and process design and development. Presently, there are heterogeneous CAD systems in the market and the interoperat ion among the different CAD systems is indispensable. The interoperability of d ifferent CAD systems is by way of data exchanged technology such as STEP and IGE S. The critical weakness of this interoperation technology is that much of the design intent is lost in the interoperation process. Once the product digital m ock-ups is exchanged via data exchange technology such as IGES or STEP, the des ign intent including the dimension-driven design features and other attributes embedded in the part model are lost in the data translation process. Models rea d out of CAD systems come into other systems as featureless chunks of geometry e ntities. Obviously, the interoperation technology does not satisfy the industry need. It has been reported that this poor interoperation technology, which pro vides poor CAD models in neutral-format geometry had cost the automobile indust ry alone $1 billon per year. Fortunately, some researchers have been aware of t he criticality of this since only the United States industry spends billons of d ollars as a result of poor interoperability between computer-aided engineering software tools. In the past, product development was often done within a single company by co-located design team. In more recent years, there has been a busi ness paradigm shift in product development as the product development is being d one more often by geographically and temporally distributed design teams. There is a high level of outsourcing, not only of manufacturing but also of actual pr oduct development effort. Besides, product development across companies, and ev en within a single company, is often done within a heterogeneous software tool e nvironment. How to improve the interoperability of design intent created in het erogeneous software tool environment geographically has become a critical issue in next-generation product development system. Design intent in this research is defined as the outcome of design process. Des ign process goes from the identification of needs to satisfaction of that needs. Design intent satisfies this kind of needs. In this research, design intent i s created in a CAD system and embedded in part CAD model. The detailed design i ntent here includes design and manufacturing features and the feature-relat ed information such as feature parameters, feature relationships and some relate d characteristics such as associativity. Interoperability refers to the ability to share and communicate in the heterogeneous environment or heterogeneous soft | M W Fu W F Lu A Y C Nee S K Ong | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 2 |
| 4 | Transfusion of autologous cytokine-induced killer cells inhibits viral replication in patients with chronic hepatitis B virus infection显示文摘 | Shi M Fu J Shi F | | Clinical Immunology0，，： | 2 |
| 5 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 6 | The Multi-staged Formation Process of Titanium Oxide Nanotubes and its Thermal Stability 显示文摘 | Li W Fu T Xie F | 2007 | Materials Letters2007，61，： | 1 |
| 7 | 显示文摘 | Fu Z P Yang B F Li L | 2003 | J Phys Condens Matter2003，15，： | 1 |
| 8 | Bone tunnel enlargement after anterior cruciate ligament reconstruction:acomparison of hamstring and patellartendon autografts显示文摘 | Hoher J Moller H D Fu F H | 1998 | Knee Surg Sports Traumatol Arthroscopy1998，6，3： | 1 |
| 9 | The electrochemical reaction of zinc oxide thin films with Lithium 显示文摘 | Huang F Qin Q Z | 2003 | J Electrochem Soc2003，150，6： | 1 |
| 10 | Effect of Nanoparticles on the Performance of Thermally Conductive Epoxy Adhesives显示文摘 | Fu J F Shi L Y Zhang D S | 2010 | Polymer Engineering and Science2010，50，9： | 1 |
| 11 | DNA gyrase inhibitory and antibacterial activity of some flavones ( I ) 显示文摘 | Chemeng K A Schwender C F Fu K P | 1993 | Vioorg Med Chem Lett1993，3，2： | 1 |
| 12 | Spectral sensitization of the heterogeneous photocatalytic oxidation of hydroquinone in aqueous solutions at phthalocyanine - coated titanium dioxide powders显示文摘 | Fu - Ren F Fan Allen J Bard | 1979 | J Am Chem Soc1979，101，20： | 1 |
| 13 | Effective therapy of metastatic ovarian cancer with an oncolytic herpes simplex vinus incorporating two membrane fusion meelumisms显示文摘 | NAKAMORI M FU X MENG F | 2003 | Clin Can Res2003，9，4： | 1 |
| 14 | Differential expression of blaSHV related to susceptibility to ampicillin in Klebsiella pneumoniae显示文摘 | FU Y ZHANG F ZHANG W | 2007 | Int J Antimicrob Agents2007，29，： | 1 |
| 15 | 显示文摘 | Tu Y F Fu Z Q Chen H Y | 2001 | Sensors and Actuators B2001，80，： | 1 |
| 16 | Uncertainty Analysis of Creep and Shrinkage Effects in Long-span Continuous Rigid Frame of Sutong Bridge显示文摘 | PAN Z F FU C C JIANG Y | 2011 | Journal of Bridge Engi- neering ASCE2011，16，2： | 1 |
| 17 | Chinese minimally invasive percuta- neous nephrolithotomy for intrarenal stones in patients with solitary kidney: a single-center experience 显示文摘 | Huang Z Fu F Zhong Z | 2012 | PLoS One2012，7，40： | 1 |
| 18 | Concentration and mode of occurrence of trace elements in marine oil shale from the Bilong Co area,northern Tibet,China显示文摘 | FU X G WANG J ZENG Y H TAN F W FENG X L | | 0，，01： | 1 |
| 19 | miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes显示文摘 | Liu Q Fu H Sun F | | 0，，16： | 1 |
| 20 | 查看详情显示文摘 | Zhang Y H Fu S Y Li R K Y Wu J T Li L F Ji J H | | 0，，11： | 1 |
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