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| 1 | nsights into molecular therapy of glioma: current .-hallenges and next generation blueprint显示文摘Glioma 说明人的大脑肿瘤的多数。与占优势的治疗政体,病人有差的幸存率。尽管有在主流的 glioma 治疗的当前的开发,为 glioma 的痊愈看起来从活动范围。glioma 和获得的电阻的渗透性的性质 substancially 限制治疗学的选择。glioma 和 proteogenomic 描述的复杂 pathobiology 的更好的说明可能最后为更复杂、有效的联合政体的设计打开新奇大街。这能被个别地定制进步 neuroimaging 技术完成,终止有 激活prodrug 基因的 DNA 合成, silencing gliomagenesis 基因(基因治疗),指向的 miRNA oncogenic 活动( miRNA-mRNA 相互作用),有干细胞治疗的联合 Hedgehog-Gli/Akt 禁止者,作为抗原采用肿瘤 lysates 由细胞毒素的 T 淋巴细胞(树枝状的房间种痘)为肿瘤特定的癌症干细胞的有效弄空采购原料,妄想的反的采纳转移因此,现在的评论捕获与分子的机制象外科,放射和化疗的限制一样在 glial tumorigenesis 包含了联系的最近的趋势。在这篇文章,我们极其也讨论下一代为 glioma 的成功的治疗的分子的治疗学的策略和他们的机制。 | Y RAJESH Ipsita PAL Payel BANIK Sandipan CHAKRABORTY Sachin A BORKAR Goutam DEY Ahona MUKHERJEE Mahitosh MANDAL | 2017 | Acta Pharmacologica Sinica2017，38，5： | 16 |
| 2 | Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease显示文摘 | Edward M. Kennedy Leda C. Bassit Henrik Mueller Anand V.R. Kornepati Hal P. Bogerd Ting Nie Payel Chatterjee Hassan Javanbakht Raymond F. Schinazi Bryan R. Cullen | 2014 | Virology2014，，： | 3 |
| 3 | Nanoscale monitoring of mitochondria and lysosome interactions for drug screening and discover显示文摘Technology advances in genomics,proteomics,and metabolomics largely expanded the pool of potential therapeutic targets.Compared with the in vitro setting,cell-based screening assays have been playing a key role in the processes of drug discovery and development.Besides the commonly used strategies based on colorimetric and cell viability,we reason that methods that capture the dynamic cellular events will facilitate optimal hit identification with high sensitivity and specificity.Herein,we propose a live-cell screening strategy using structured illumination microscopy (SIM) combined with an automated cell colocalization analysis software,CellprofilerTM,to screen and discover drugs for mitochondria and lysosomes interaction at a nanoscale resolution in living cells.This strategy quantitatively benchmarks the mitochondria-lysosome interactions such as mitochondria and lysosomes contact (MLC) and mitophagy.The automatic quantitative analysis also resolves fine changes of the mitochondria-lysosome interaction in response to genetic and pharmacological interventions.Super-resolution live-cell imaging on the basis of quantitative analysis opens up new avenues for drug screening and development by targeting dynamic organelle interactions at the nanoscale resolution,which could facilitate optimal hit identification and potentially shorten the cycle of drug discovery. | Qixin Chen Xintian Shao Zhiqi Tian Yang Chen Payel Mondal Fei Liu Fengshan Wang Peixue Ling Weijiang He Kai Zhang Zijian Guo Jiajie Diao | 2019 | Nano Research2019，12，5： | 2 |
| 4 | Magneto-thermo-elastic waves in an infinite perfectly conducting elastic solid with energy dissipation显示文摘The generalized thermo-elasticity theory, i.e., Green and Naghdi (G-N) III theory, with energy dissipation (TEWED) is employed in the study of time-harmonic plane wave propagation in an unbounded, perfectly electrically conducting elastic medium subject to primary uniform magnetic field. A more general dispersion equation with com- plex coeffcients is obtained for coupled magneto-thermo-elastic wave solved in complex domain by using the Leguerre's method. It reveals that the coupled magneto-thermo- elastic wave corresponds to modified dilatational and thermal wave propagation with finite speeds modified by finite thermal wave speeds, thermo-elastic coupling, thermal diffusivity, and the external magnetic field. Numerical results for a copper-like material are presented. | Payel Das Mridula Kanoria | 2009 | Applied Mathematics and Mechanics(English Edition)2009，30，2： | 2 |
| 5 | Active learning of deep surrogates for PDEs:application to metasurface design显示文摘Surrogate models for partial differential equations are widely used in the design of metamaterials to rapidly evaluate the behavior of composable components.However,the training cost of accurate surrogates by machine learning can rapidly increase with the number of variables.For photonic-device models,we find that this training becomes especially challenging as design regions grow larger than the optical wavelength.We present an active-learning algorithm that reduces the number of simulations required by more than an order of magnitude for an NN surrogate model of optical-surface components compared to uniform random samples.Results show that the surrogate evaluation is over two orders of magnitude faster than a direct solve,and we demonstrate how this can be exploited to accelerate large-scale engineering optimization. | Raphaël Pestourie Youssef Mroueh Thanh V.Nguyen Payel Das Steven G.Johnson | 2020 | npj Computational Materials2020，，1： | 2 |
| 6 | Carotid artery stenosis: treatment with protected balloon angioplasty and stent placement 显示文摘 | Payelle GG Coskun O Huet HF Guimaraens L | 1996 | Radiology1996，201，3： | 1 |
| 7 | Role of shear stress in scratch deformation of soda-lime-silica glass显示文摘 | Payel B Arjun D Sudakshina R | 2013 | Journal of Non-Crystalline Solids2013，362，： | 1 |
| 8 | Effect of scratching speed on deformation of soda–lime–silica glass显示文摘 | Payel Bandyopadhyay Arjun Dey Ashoke Mandal Nitai Dey Sudakshina Roy Anoop Mukhopadhyay | 2012 | Applied Physics A2012，，3： | 1 |
| 9 | Comparison theorems for linear dynamic equations on time scales显示文摘 | ERBE LYNN PETERSON ALLAN R EHAK PAYEL | 2002 | J Math Anal Appl2002，275，： | 1 |
| 10 | Carotid artery stenosis:treatment with protected balloon angioplasty and stent placement显示文摘 | Payelle GG Coskun O | 1996 | Radiology1996，201，3： | 1 |
| 11 | Carotid artery stenosis:treatment with protected balloon angioplasty and stent placement显示文摘 | Payelle GG Coskun O | 1996 | Radiology1996，201，3： | 1 |
| 12 | Carotid artery stenosis:treatment with protected balloon angioplasty and stent placement显示文摘 | Payelle GG Coskun O | 1996 | Radiology1996，201，6： | 1 |
| 13 | Carotid artery stenosis:treatment with protected balloon angioplasty and stent placement显示文摘 | PAYELLE G G COSKUN O | 1996 | Radiology1996，201，： | 1 |
| 14 | Local intra-arterial thrombolysis in carotidterritory storkes (100 case)显示文摘 | Theron J Payelle G Hunt H | 1994 | Neuroradiology1994，，： | 1 |
| 15 | Microstructural, corrosion and nanomechanical behaviour of ceramic coatings developed on magnesium AZ31 alloy by micro arc oxidation显示文摘 | Arjun Dey R.Uma Rani Hari Krishna Thota Anand Kumar Sharma Payel Bandyopadhyay Anoop Kumar Mukhopadhyay | 2012 | Ceramics International2012，，： | 1 |
| 16 | Carotid artery stenosis: treatment with protected balloon angioplasty and stent placement显示文摘 | Theron JG Payelle GG Coskun 0 | 1996 | Radiology1996，201，3： | 1 |
| 17 | Local intra- arterial thrombolysis in asrotid territory strokes(100 cases,)显示文摘 | Therow J Payelle G Hunt H | 1994 | Neuroradiology1994，36，： | 1 |
| 18 | Carotid artery stenosis:Treatment with protecteb balloon angioplasty and sent placement显示文摘 | Theron JG Payelle GG Coskun O | 1996 | J Radiology1996，201，3： | 1 |
| 19 | Carotid artery stenosis:treat mentwith protected balloon angioplasty and stent placement显示文摘 | Payelle GG Coskun O | 1996 | Radiology1996，201，3： | 1 |
| 20 | Carotid artery stenosis: treatment with protected balloon angioplasty and stent placement显示文摘 | Theron JG Payelle GG Coskun O | 1996 | Radiology1996，201，3： | 1 |
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