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| 1 | Iron and liver fibrosis: Mechanistic and clinical aspects显示文摘Liver fibrosis is characterised by excessive deposition of extracellular matrix that interrupts normal liver functionality. It is a pathological stage in several untreated chronic liver diseases such as the iron overload syndrome hereditary haemochromatosis, viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and diabetes. Interestingly, regardless of the aetiology, iron-loading is frequently observed in chronic liver diseases. Excess iron can feed the Fenton reaction to generate unquenchable amounts of free radicals that cause grave cellular and tissue damage and thereby contribute to fibrosis. Moreover, excess iron can induce fibrosis-promoting signals in the parenchymal and non-parenchymal cells, which accelerate disease progression and exacerbate liver pathology. Fibrosis regression is achievable following treatment, but if untreated or unsuccessful, it can progress to the irreversible cirrhotic stage leading to organ failure and hepatocellular carcinoma, where resection or transplantation remain the only curative options. Therefore,understanding the role of iron in liver fibrosis is extremely essential as it can help in formulating iron-related diagnostic, prognostic and treatment strategies. These can be implemented in isolation or in combination with the current approaches to prepone detection, and halt or decelerate fibrosis progression before it reaches the irreparable stage. Thus, this review narrates the role of iron in liver fibrosis. It examines the underlying mechanisms by which excess iron can facilitate fibrotic responses. It describes the role of iron in various clinical pathologies and lastly,highlights the significance and potential of iron-related proteins in the diagnosis and therapeutics of liver fibrosis. | Kosha J Mehta Sebastien Je Farnaud Paul A Sharp | 2019 | World Journal of Gastroenterology2019，25，5： | 39 |
| 2 | Molecular mechanisms involved in intestinal iron absorption显示文摘铁是在人的食谱的必要踪迹金属由于它的要求在很多个新陈代谢的过程的角色。在食谱,铁在很多种不同形式是在场的,是通常描述了哈他们(从在动物织物的血色素和肌球素) 并且 non-haem 铁(包括氧化铁和盐,含铁锡和 lactoferrin ) 。这评论描述从食谱和它的版本协调铁的吸收进发行量的分子的机制。当铁运输小径的许多部件被阐明了时,很多个关键问题尚待被决定。在这个区域的未来工作将由饮食、体液的因素关于铁和它的规定的 transcellular 流动提供一幅更清楚的图画。 | Paul Sharp Surjit Kaila Srai | 2007 | World Journal of Gastroenterology2007，13，35： | 3 |
| 3 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 4 | Structure of Apolipoprotein B-100 of Human Low Density Lipoproteins显示文摘 | Chao-yuh Yang Zi-Wei Gu Shi-ai Weng Tae W. Kim San-Hwan Chen Henry J. Pownall Paul M. Sharp Shyan-Woei Liu Wen-Hsiung Li Antonio M. Gotto Lawrence Chan | 1989 | Arteriosclerosis, Thrombosis, and Vascular Biology1989，，1： | 2 |
| 5 | An evolutionary perspective on synonymous codon usage in unicellular organisms显示文摘 | Paul M. Sharp Wen-Hsiung Li | 1986 | Journal of Molecular Evolution1986，，： | 2 |
| 6 | Cost Effectiveness of Fecal DNA Screening for Colorectal Cancer: A Systematic Review and Quality Appraisal of the Literature显示文摘 | Mairead Skally Paul Hanly Linda Sharp | 2013 | Applied Health Economics and Health Policy2013，，3： | 1 |
| 7 | Choline Acetyltransferase Activity in Vascular Dementia and Stroke显示文摘 | Sharp Sally I Francis Paul T Elliott Mark S J Kalaria Rajesh N Bajic Natasha Hortobagyi Tibor Ballard Clive G | 2009 | Dementia and Geriatric Cognitive Disorders2009，，3： | 1 |
| 8 | Diversification, Fee Income, and Credit Union Risk显示文摘 | Neil Esho Paul Kofman Ian G. Sharpe | 2005 | Journal of Financial Services Research2005，，3： | 1 |
| 9 | Two-year safety and efficacy of ranibizumab 0.5 mg in diabetic macular edema: Interim analysis of the RESTORE extension study显示文摘 | Gabriele E. Lang András Berta Bora M. Eldem Christian Simader Dianne Sharp Frank G. Holz Florian Sutter Ortrud Gerstner Paul Mitchell | 2013 | Ophthalmology2013，，： | 1 |
| 10 | 亚历山大技术课程、体育锻炼以及按摩(ATEAM)治疗慢性复发性腰背痛的随机对照试验显示文摘目的确定亚历山大技术课程、按摩疗法以及按照医生运动处方在护士指导下进行体育锻炼对慢性或复发性腰背痛治疗的效果。设计析因随机试验。地点英格兰的64个全科医疗机构。参试者579例慢性复发性腰背痛患者;144例随机接受常规治疗,147例接受按摩治疗,144例接受6节亚历山大技术课程,144例接受24节亚历山大技术课程;每组均有半数患者随机给予运动处方。干预常规治疗(对照)、6次按摩、6或24节亚历山大技术课程以及按照医生运动处方在护士指导下进行体育锻炼。主要结局指标RolandMorris残疾评分(疼痛受损活动数)和疼痛天数。结果体育锻炼和亚历山大技术课程,而非按摩,1年时依然有效(与对照组RolandMorris残疾评分8.1比较:按摩组为-0.58,95%可信区间-1.94-0.77;6节亚历山大技术课程-1.40,-2.77--0.03;24节亚历山大技术课程-3.4,-4.76--2.03;体育锻炼组-1.29,-2.25--0.34)。6节课程之后体育锻炼的疗效为单独24节亚历山大技术课的72%(Roland Morris残疾评分分别为-2.98和-4.14)。课程后前4周腰背痛天数减少(与对照组中位数21天相比,24节课程-18天,6节课程-10天,按摩组-7天);而且生活质量显著改善。没有明显的损害报告。结论由注册教师提供的一对一亚历山大技术课程可使慢性腰背痛患者长期受益。6节亚历山大技术课程后辅以体育锻炼处方的效果接近24节亚历山大技术课程。 | Paul Little George Lewith Fran Webley Maggie Evans Angela Beattie Karen Middleton Jane Barnett Kathleen Ballard Frances Oxford Peter Smith Lucy Yadley Sandra Hollinghurst Debbie Sharp 张扬红(译) | 2008 | 英国医学杂志中文版2008，11，6： | 1 |
| 11 | Surviving,not thriving;LEAs since the Education Reform Act of 1988显示文摘 | Paul Sharp | 2002 | Oxford Review of Education2002，28，23： | 1 |
| 12 | Consumer Decisions in the MetropolitanFamily 显示文摘 | Sharp Harry Paul Mott | 1956 | Journal of Marketing1956，21，2： | 1 |
| 13 | The aetiology of symptomatic gallstones quantification of the effects of obesity, alcohol and serum lipids on risk. Epidemiological and biomarker data from a UK prospective cohort study (EPIC-Norfolk)显示文摘 | Paul J.R. Banim Robert N. Luben Heerajnarain Bulluck Stephen J. Sharp Nicholas J. Wareham Kay-Tee Khaw Andrew R. Hart | 2011 | European Journal of Gastroenterology & Hepatology2011，，8： | 1 |
| 14 | Codon Usage in Regulatory Genes in Escherichia Coli Does Not Reflect Selection for ‘rare' Codons显示文摘 | Paul M Sharp W H Li | 1986 | Nucleic Acids Res1986，14，19： | 1 |
| 15 | Codon Usage in Yeast: Cluster Analysis Clearly Differentiates Highly and Lowly Expressed Genes 显示文摘 | Paul M Sharp T M Tuohy K R Mosurski | 1986 | Nucleic Acids Res1986，14，13： | 1 |
| 16 | The chemicatcue tetrabromopyrrole from a biofilm bacterium induces settlement of multiple Caribbean corals显示文摘 | SNEED J M SHARP K H RITCHIE K B PAUL V J | 2014 | Proceedings of the Royal Society of London B: Biologicalaiences2014，281，20： | 1 |
| 17 | The Codon Adaptation Index-a Measure of Directional Synonymous Codon usage Bias, and Its Potential Applications显示文摘 | Paul M Sharp W H Li | 1987 | Nucleic Acids Res1987，15，： | 1 |
| 18 | COST-EFFECTIVENESS OF COMPUTED TOMOGRAPHY COLONOGRAPHY IN COLORECTAL CANCER SCREENING: A SYSTEMATIC REVIEW显示文摘 | Paul Hanly Mairead Skally Helen Fenlon Linda Sharp | 2012 | International Journal of Technology Assessment in Health Care2012，，4： | 1 |
| 19 | Rapid regulationof divalent metal transporter(DMT) protein but not mRNA expression by non-haem iron in human intestinal Caco-2 cells显示文摘 | Paul Sharp Sarah Tandy Sachie Yamaji | 2002 | FEBS Letters2002，510，： | 1 |
| 20 | Optical Projection Tomography as a Tool for 3D Microscopy and Gene Expression Studies 显示文摘 | James Sharpe Ulf Ahlgren Paul Perry | 2002 | Science2002，296，5567： | 1 |
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