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| 1 | Outcomes of partial splenic embolization in patients with massive splenomegaly due to idiopathic portal hypertension显示文摘AIM To determine the outcomes of partial splenic em-bolization(PSE) for massive splenomegaly due to idiopathic portal hypertension(IPH).METHODS In this prospective study, we evaluated the charac-teristics and prognosis of consecutive patients with IPH who underwent PSE for all indications at a single medical center between June 2009 and January 2015. The inclusion criteria were: presence of hypersplenism, massive splenomegaly, and resultant pancytopenia. The exclusion criteria were: presence of other diseases causing portal hypertension. During the post-PSE period, the patients were hospitalized. All patients underwent abdominal computed tomography imaging 4 wk post-PSE to determine total splenic and non-infarcted splenic volumes.RESULTS A total of 11 patients, with median age of 33.27 ± 4.8 years, were included in the study. Mean spleen size was 22.9 cm(21-28 cm), and severe hypersplenismwas diagnosed in all patients before PSE. Post-PSE, leukocyte and platelet counts increased significantly, reaching peak levels in the second week with gradual decreases thereafter. Liver function tests did not exhibit significant changes during post-intervention follow-up. All patients developed post-embolization syndrome, and one patient experienced serious complications; all complications were successfully treated with conservative therapy and no death occurred. CONCLUSION Our findings showed that PSE has a lower complication rate than previously-reported surgical complication rates, which supports this intervention as a viable alternative for high-risk operable patients with severe hypersplenism. | Omer Ozturk Gonca Eldem Bora Peynircioglu Taylan Kav Aysegul Gormez Barbaros Erhan Cil Ferhun Balkanci Cenk Sokmensuer Yusuf Bayraktar | 2016 | World Journal of Gastroenterology2016，22，43： | 18 |
| 2 | Assessment of the long-term visual and anatomical outcomes of ranibizumab to treat neovascular age-related macular degeneration显示文摘AIM: To investigate the long-term visual and anatomical outcomes of patients who underwent intravitreal ranibizumab monotherapy to treat neovascular age-related macular degeneration(AMD) and followed-up for at least 2 y.METHODS: A total of 74 eyes of 74 patients who underwent ranibizumab monotherapy for neovascular AMD were included in this retrospective study.RESULTS: The average patient age was 72.1±6.5(range, 57-85)y, the average follow-up time 46.2±13.1(range, 24-75)mo, and the average number of visits 24.1±9.5(range, 8-48). The mean number of injections in year 1 was 4.5, 1.6 in year 2, 0.9 in year 3, 0.4 on year 4, and 0.1 in the following years. Within the entire follow-up period, the mean number of injections was 7.6±4.4(range, 2-21). The mean visual acuity was 48.1±15(range, 15-76) letters at baseline and 45.7±19(range, 7-75) at year 5. The mean central macular thickness was 303±78(range, 178-552) μm at baseline and 251±51(range, 138-359) μm at year 5. Scars developed in 47(63.5%) eyes at the end of the follow-up period, and atrophy was evident in 6(8.1%) eyes.CONCLUSION: Ranibizumab monotherapy can stabilize visual acuity for a mean period of 4 y in patients with neovascular AMD. | Bekir Kücük Sibel Kadayifcilar Bora Eldem | 2018 | International Journal of Ophthalmology(English edition)2018，11，4： | 6 |
| 3 | Elevated intravitreal interleukin-6 levels in patients with proliferative diabetic retinopathy显示文摘 | MOCAN M C KADAYIFCILAR S ELDEM B | 2006 | Can J Ophthalmol2006，41，： | 1 |
| 4 | Polymorphic beh-avior of sprayed lipid micropellets and its evaluation by differential scanning calorimetry and scanning electron microscopy显示文摘 | ELDEM T SPEISER P ALTORFER H | 1991 | Pharm Res1991，8，2： | 1 |
| 5 | Management of moderate to advanced Coats' disease 显示文摘 | KIRATLI H ELDEM B | 1998 | Ophthalmologica1998，212，5： | 1 |
| 6 | Management of Moderate to advanced Coats disease显示文摘 | Kirath H Eldem B | 1998 | Ophthalmologica1998，212，1： | 1 |
| 7 | Two-year safety and efficacy of ranibizumab 0.5 mg in diabetic macular edema: Interim analysis of the RESTORE extension study显示文摘 | Gabriele E. Lang András Berta Bora M. Eldem Christian Simader Dianne Sharp Frank G. Holz Florian Sutter Ortrud Gerstner Paul Mitchell | 2013 | Ophthalmology2013，，： | 1 |
| 8 | Uveitis in childhood 显示文摘 | Kadayifcilar S Eldem B Tumer B | 2003 | J Pediatr Ophthalmol Strabismus2003，40，6： | 1 |
| 9 | Comparative analysis of internal ribosomal entry sites as molecular tools for bicistronic expression显示文摘 | Eldem Sadikoglou Elena Daoutsali Eleni Petridou Maria Grigoriou George Skavdis | 2014 | Journal of Biotechnology2014，，： | 1 |
| 10 | Efficacy and safety of monthly versus quarterly ranihizumah treatment in neovascular age-related macular degeneration: the EXCITE study显示文摘 | Schmidt-Erfurth U Eldem B Guymer R | 2011 | Ophthalmology2011，18，5： | 1 |
| 11 | Determination of amphotericin B in human plasma using solid-phase extraction and high-performance liquid chromatography显示文摘 | Eldem T Arican-Cellat N | 2001 | J Pharm Biomed Anal2001，25，1： | 1 |
| 12 | The effect of CFH polymorphisms on the response to the treatment of age-related macular degeneration ( AMD ) with intravitreal ranibizumab 显示文摘 | Dikmetas O Kadayyifeilar S Eldem B | 2013 | Mol Vis2013，19，： | 1 |
| 13 | Determination of amphotericin B in human plasma using solid-phase extraction and highperformance liquid chromatography 显示文摘 | Eldem T Arican-Cellat N | 2001 | J Pharm Biomed Anal2001，25，1： | 1 |
| 14 | Plant microRNAs : new players in functional genomics 显示文摘 | Eldem V Okay S | 2013 | Turk J Agric For2013，37，1： | 1 |
| 15 | Optimization of spraydried and congealed lipid micropellets and characterization of their surface morphology by scanning electron microscopy显示文摘 | Eldem T Speiser P Hincal A | 1991 | Pharm Res1991，8，： | 1 |
| 16 | Efficacy and safety of monthly versus quarterly Lucnetis treatment in neovascular age-related macular degeneration:the EXCITE study显示文摘 | Schmidt-Erfurth U Eldem B Guymer R | 2013 | Ophthalmology2013，，5： | 1 |
| 17 | Using reduced rule base with Expert System for the diagnosis of disease in hypertension显示文摘 | Basciftci F Eldem A | 2013 | Med Biol Eng Comput2013，51，12： | 1 |
| 18 | Elevated intravitreal in- terleukin-6 levels in patients withproliferative diabeticretinopa thy显示文摘 | M'ocan MC Kadayifcilar S Eldem B | 2006 | Canadian Journal of Ophthalmology2006，41，6： | 1 |
| 19 | Angiographic embohza- tion for the treatment of epistaxis: A review of 108 cases 显示文摘 | Eldem I Montanera W Terbrugge K | 1994 | Otolar- ynol Head Neck Surg1994，111，1： | 1 |
| 20 | Genome-wide identification of miRNAs responsive to drought in peach( Prunus persica) by high throughput deep sequencing显示文摘 | Eldem V Akgay UQ Qzhuner E Baklr Y Uranbey S Unver T | 2012 | PIoS One2012，7，50： | 1 |
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