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231篇 您的检索式：作者名="Doetsch"

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	题名	作者	年代	出处	被引量
1	肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells.	Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone	2010	中华神经外科疾病研究杂志2010，9，1：	16
2	DNA damage-induced re- active oxygen species (ROS) stress response in Saccharomyces cerevisiae显示文摘	Rowe LA Degtyareva N Doetsch PW	2008	Free Radical Biology and Med2008，45，8：	1
3	EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells显示文摘	Doetsch F Petreanu L Caille I	2002	Neuron2002，36，6：	1
4	MiR-124 regulates adult neurogenesis in the subventricular zone stem cell niche显示文摘	Cheng LC Pastrana E Tavazoie M Doetsch F		0，，：	1
5	Evalua- tion of paraffin/water emulsion as a phase change slurry for cooling applications显示文摘	Li Huang Marcus Petermann Christian Doetsch	2009	Energy2009，34，：	1
6	Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents显示文摘	Gritti A Bonfanti L Doetsch F	2002	Neurosei2002，22，2：	1
7	Architecture andCell types of the adult subventricular zone: in search of the stemcells显示文摘	Garcia-Verdugo JM Doetsch F Wichterle H	1998	J Neurobiol1998，36，：	1
8	Subventricular zone astrocytes are neural stem cells in the adult mammalian brain显示文摘	Doetsch F Gailie L Lim D A		0，，06：	1
9	A niche for adult neural stem cells显示文摘	Doetsch F	2003	Curr Opin Genet2003，13，5：	1
10	Architecture and cell types of the adult subventricular zone:in search of the stem cells显示文摘	Garcia-Verdugo JM Doetsch F Wichterle H	1998	J Neurobiol1998，36，2：	1
11	Subventricular zone astrocytesare neural stem cell in the adult mammalian brain显示文摘	Caille I Lim DA	1999	Cell1999，97，6：	1
12	DNA damage-in- duced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiae显示文摘	ROWELORI A DEGTYAREVA N DOETSCH P W	2008	Free Radical Biology and Medieine2008，45，8：	1
13	Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63显示文摘	Duijf PH Doetsch V	2001	Hum Mol Genet2001，10，3：	1
14	Challenges for brain repair:insights from adult neurogenesis in birds and mammals显示文摘	Doetsch F Scharff C	2001	Brain Behav Evol2001，58，5：	1
15	The glial identity of neural stem cells显示文摘	Doetsch F		0，，：	1
16	Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63显示文摘	McGrath JA Duijf PHG Doetsch V	2001	Hum Mol Genet2001，10，3：	1
17	The glial identity of neural stem cells显示文摘	Doetsch F	2003	Nat Neurosci2003，6，11：	1
18	Subventricular zone astrocytes are neural stem cells in the adult mammalian brain 显示文摘	Doetsch F Caille I Lim DA	1999	Cell1999，97，6：	1
19	Young and excitable: the function of new neurons in the adult mammalian brain 显示文摘	Doetsch F Hen R	2005	Curr Opin Neurobi- ol2005，15，1：	1
20	Identification of neural stem cells in the adult vertebrate brain显示文摘	Arturo Alvarez-Buylla Bettina Seri Fiona Doetsch	2002	Brain Research Bulletin2002，，6：	1

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