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| 1 | Oxidative stress:New insights on the association of nonalcoholic fatty liver disease and atherosclerosis显示文摘Non-alcoholic fatty liver disease(NAFLD) represents the most common and emerging chronic liver disease worldwide. It includes a wide spectrum of liver diseasesranging from simple fatty liver to non-alcoholic steatohepatitis(NASH),which may progress to fibrosis and more severe liver complications such as cirrhosis,hepatocellular carcinoma and liver mortality. NAFLD is strongly associated with obesity,insulin resistance,hypertension,and dyslipidaemia,and is now regarded as the liver manifestation of the metabolic syndrome. The increased mortality of patients with NAFLD is primarily a result of cardiovascular disease and,to a lesser extent,to liver related diseases. Increased oxidative stress has been reported in both patients with NAFLD and patient with cardiovascular risk factors. Thus,oxidative stress represents a shared pathophysiological disorder between the two conditions. Several therapeutic strategies targeting oxidative stress reduction in patients with NAFLD have been proposed,with conflicting results. In particular,vitamin E supplementation has been suggested for the treatment of non-diabetic,non-cirrhotic adults with active NASH,although this recommendation is based only on the results of a single randomized controlled trial. Other antioxidant treatments suggested are resveratrol,silybin,L-carnitine and pentoxiphylline. No trial so far,has evaluated the cardiovascular effects of antioxidant treatment in patients with NAFLD. New,large-scale studies including as end-point also the assessment of the atherosclerosis markers are needed. | Licia Polimeni Maria Del Ben Francesco Baratta Ludovica Perri Fabiana Albanese Daniele Pastori Francesco Violi Francesco Angelico | 2015 | World Journal of Hepatology2015，7，10： | 23 |
| 2 | Modern approach to the clinical management of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common and emerging form of chronic liver disease worldwide.It includes a wide spectrum of liver diseases ranging from simple fatty liver to steatohepatitis,which may progress to cirrhosis,liver cancer,and liver mortality.Common metabolic diseases,which are well established cardiovascular risk factors,have been associated to NAFLD and cardiovascular disease is the single most important cause of morbidity and mortality in this patient population.The pathogenesis of NAFLD appears multifactorial and many mechanisms have been proposed as possible causes of fatty liver infiltration.Management of fatty liver has become a major challenge to healthcare systems as the consequence of the increasing rates of obesity worldwide.First-line management focuses on lifestyle modifications.Moderate weight reduction either by dietary restriction or by increased habitual physical activity is safe and highly recommended.Several therapeutic interventions have been proposed.These include insulin sensitizer agents,lipid lowering drugs,antioxidants such as vitamin E and supplementation of vitamin D3.However,therapeutic strategies have been largely empirical so far,and experimental trials have mostly been carried out in uncontrolled settings with small sample sizes.Metabolic conditions such as diabetes mellitus,obesity,hypertension and hyperlipidemia,should be strongly considered and a multidisciplinary approach should be personalized for individual patients.Treatment of co-morbidities should be regarded as of paramount importance in the management of these patients.The purpose of this review is to examine different approaches for the clinical management of non-alcoholic fatty liver disease. | Maria Del Ben Licia Polimeni Francesco Baratta Daniele Pastori Lorenzo Loffredo Francesco Angelico | 2014 | World Journal of Gastroenterology2014，20，26： | 8 |
| 3 | 肠道衍生的血清脂多糖与心房颤动患者主要不良心血管事件的风险增加相关:地中海膳食的影响显示文摘肠道微生物群正在成为动脉粥样硬化血栓形成的新型危险因素,但肠道衍生的脂多糖的预测作用尚不清楚。来自意大利罗马Sapienza大学的Pastori等进行了一项前瞻性单中心研究,分析了脂多糖与心房颤动中主要不良心血管事件(major adverse cardiovascular events,MACE)之间的关系,以及坚持地中海膳食(Mediterranean diet,Med-diet)对上述关系的影响。 | 刘莉 叶鹏 Pastori D Carnevale R Nocella C Novo M Santulli M Cammisotto V Menichelli D Pignatelli P Violi F | 2017 | 中华高血压杂志2017，25，9： | 5 |
| 4 | Epigenetic pathways and glioblastoma treatment显示文摘 | Jennifer Clarke Clara Penas Chiara Pastori Ricardo J Komotar Amade Bregy Ashish H Shah Claes Wahlestedt Nagi G Ayad | 2013 | Epigenetics2013，，8： | 2 |
| 5 | The mitochondrial electon transfer alteration as a facer involved in the brain againg显示文摘 | Benzi G Pastoris O Maratice F | 1992 | J Neurobiol Aging1992，13，3： | 1 |
| 6 | Leaf vitamin C con- tents modulate plant defense transcripts and regulate genes that control development through hormone signaling 显示文摘 | Pastori G M Kiddie G Antoniw J | 2003 | The Plant Cell2003，15，： | 1 |
| 7 | Effects of esomeprazole on glutathione levels and mitochondrial oxidative phosphorylation in the gastric mucosa of rats treated with indomethacin显示文摘 | O. Pastoris M. Verri F. Boschi O. Kastsiuchenka B. Balestra F. Pace M. Tonini G. Natale | 2008 | Naunyn-Schmiedeberg’s Archives of Pharmacology2008，，4： | 1 |
| 8 | Ascorbate biosynthesis in mitochondrial is linked to the electron transport chain between complexes IIl and IV 显示文摘 | BARTOLI C G PASTORI G M FOYER C H | 2000 | Plant Physiology2000，123，1： | 1 |
| 9 | Natural senescence of pea leaves(an activated-oxygen-mediated function for peroxisomes) 显示文摘 | Pastori G M Del Rio L A | 1997 | Plant Physiology1997，113，2： | 1 |
| 10 | Leaf vitamin C contents modulate plant defense transcripts and regulate genes that control development through hormone signaling显示文摘 | PASTORI G M KIDDLE G ANTONIW J | 2003 | The Plant Cell2003，15，4： | 1 |
| 11 | Immediate Antioxidant and Antiplatelet Effect of Atorvastatin via Inhibition of Nox2显示文摘 | Pignatelli P Carnevale R Pastori D | 2012 | Circulation2012，126，1： | 1 |
| 12 | Low temperature-induced changes in the distribution of H2O2and antioxidants between the bundle sheath and mesophyll cells of maize leaves显示文摘 | Pastori G Foyer C H Mullineaux P | 2000 | Journal of Experimental Botany2000，342，51： | 1 |
| 13 | Modifications by chronic intermittent hypoxia and drug treatment on keletal muscle metabolism显示文摘 | Pastoris O Dossena M Foppa P | 1995 | Neurochem Res1995，20，2： | 1 |
| 14 | Pulsatile ocular blood flow variations with axial length and refractive error 显示文摘 | Ravalico G Pastori G Croce M Toffoli G | 1997 | Ophthalmologica1997，211，5： | 1 |
| 15 | Drought controls on H2O2 accumulation,catalase (CAT) activity and CATgene expression in wheat显示文摘 | LUNA C M PASTORI G M DRISCOLL S | | 0，，： | 1 |
| 16 | Role of the ascorbate-glutathione cycle of mitochondria and peroxisomes in the senes-cence of pea leaves显示文摘 | Jiménez A Hernández J A Pastori G | 1998 | Plant Physiol1998，118，： | 1 |
| 17 | Oxidative stress induces high rate of glutathione reductase synthesis in a drought - resistant maize strain显示文摘 | Pastori GM and Trippi VS | 1992 | Plant and Cell Physiology1992，33，7： | 1 |
| 18 | Relation of Nonalcoholic Fatty Liver Disease and Framingham Risk Score to Flow-Mediated Dilation in Patients With Cardiometabolic Risk Factors显示文摘 | Daniele Pastori Lorenzo Loffredo Ludovica Perri Francesco Baratta Laura Scardella Licia Polimeni Arianna Pani Monica Brancorsini Fabiana Albanese Elisa Catasca Maria Del Ben Francesco Violi Francesco Angelico | 2015 | The American Journal of Cardiology2015，，10： | 1 |
| 19 | Distribution of l~gionella species and serogrcmps isolated by culture in patients with sporadic community- acquired legionellosis :an international collaborative sur- vey 显示文摘 | Victr L Y Plouft J F Pastoris M C eta/ | 2002 | J Infect Dis2002，186，1： | 1 |
| 20 | Natural senescence of pea leaves-anacfi- rated oxygen-mediated function for peroxisemes显示文摘 | Pastori G M DelRio L A | 1997 | Plant Physiolo- gy1997，113，： | 1 |
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