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| 1 | A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer显示文摘The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy. However, despite great promise for a variety of cancers, the efficacy of immune checkpoint inhibitors is still low in colorectal cancer(CRC). This is mainly due to the immunosuppressive feature of the tumor microenvironment(TME). Emerging evidence reveals that certain chemotherapeutic drugs induce immunogenic cell death(ICD), demonstrating great potential for remodeling the immunosuppressive TME. In this study, the potential of ginsenoside Rg3(Rg3) as an ICD inducer against CRC cells was confirmed using in vitro and in vivo experimental approaches. The ICD efficacy of Rg3 could be significantly enhanced by quercetin(QTN) that elicited reactive oxygen species(ROS). To amelioratein vivo delivery barriers associated with chemotherapeutic drugs, a folate(FA)-targeted polyethylene glycol(PEG)-modified amphiphilic cyclodextrin nanoparticle(NP) was developed for co-encapsulation of Rg3 and QTN. The resultant nanoformulation(CD-PEG-FA.Rg3.QTN) significantly prolonged blood circulation and enhanced tumor targeting in an orthotopic CRC mouse model, resulting in the conversion of immunosuppressive TME. Furthermore, the CD-PEG-FA.Rg3.QTN achieved significantly longer survival of animals in combination with Anti-PD-L1. The study provides a promising strategy for the treatment of CRC. | Dandan Sun Yifang Zou Liu Song Shulan Han Hao Yang Di Chu Yun Dai Jie Ma Caitriona M.O’Driscoll Zhuo Yu Jianfeng Guo | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 2 | 瞬态诱发耳声发射在农村学龄儿童听力筛查中的应用显示文摘目的探讨瞬态诱发耳声发射(transient evoked otoaeoustic emission,TEOAE)应用于中国农村学龄儿童听力筛查的意义和可行性。方法用Madsen Celesta 503耳声发射仪对317例(634耳)正常农村小学1-6年级学生进行听力筛查,并用耳镜、纯音测听和鼓室导抗图系列检查作为“金标准”,验证其结果。结果317例(634耳)儿童TEOAE的通过率为94.64%(600/634),金标准的通过率为94.48%(599/634)。TEOAE测试中,一致百分率为96.69%±0.71%,灵敏度为0.69±0.078(69%±7.8%),特异度为0.98±0.0052(98%±0.52%),漏诊率β=0.31,误诊率α=0.02,Youden指数J=0.67±0.078,阳性似然比LR+=34.5,阴性似然比LR_=0.32,阳性预报值PV+=0.71(71%),阴性预报值PV_=0.98(98.%),AZ=0.8。结论TEOAE测试具有方便、快速、无创、灵敏、客观等优点,是较好的中国农村学龄儿童听力筛查的方法。 | 李晓璐 卜行宽 Carlie Driscoll | 2006 | 听力学及言语疾病杂志2006，14，2： | 7 |
| 3 | 提高母猪妊娠后期和哺乳期日粮能量浓度对其生产性能、仔猪活力和后代终生生长的影响(下)显示文摘人们对高产母猪的选育,导致每窝活产仔数显著增加,但是随之而来的仔猪活力和生长性能会因此降低。为了增强仔猪活力和提高生长性能,提高母猪哺乳期能量摄入越来越重要。研究旨在探索提高哺乳期母猪日粮能量(DE)浓度对母猪体重、背膘厚、乳成分及其后代仔猪活力和生长的影响。在妊娠108 d时将妊娠母猪(N=100;大白×长白)随机分配饲喂4种能量浓度日粮(消化能,DE,MJ/kg)直到再次配种:13.8(LL)、14.5(L)、15.2(H)、15.9(HH)。所有日粮均含有1.2%总赖氨酸。妊娠108 d和断奶(哺乳期第26天)时采集血样,哺乳期采集初乳(0 d)和常乳(14 d)。每天记录母猪哺乳期采食量。仔猪出生时记录每窝(总活)产仔数、仔猪初生重、宫内生长受限(IUGR)特征和肌张力。在出生时和出生后24 h记录仔猪鼓膜耳温(TEMP)。在后代猪第1、6、14、26、33、40、54、75和141日龄时称重。后代猪于断奶后(PW)饲喂标准谷物基础日粮。后代猪屠宰时(141日龄)记录胴体数据。HH母猪的哺乳期消化能摄入高于其他处理组(P<0.01)。初乳和常乳成分以及哺乳期采食量不受日粮处理影响。各处理组间的每窝产仔猪数和仔猪初生重相近。与其他处理组相比,LL母猪的后代表现出更多的IUGR特征(P<0.01),而HH母猪的后代表现出更好的肌张力(P<0.01)。与HH母猪的后代仔猪相比,LL母猪(P<0.01)和H母猪(P<0.01)的后代具有更高的24 h TEMP。H母猪断奶仔猪数高于L母猪(P<0.05)和HH母猪(P<0.01),而L母猪断奶仔猪窝重低于H母猪(P<0.05)和LL母猪(P<0.05)。断奶后仔猪生长不受日粮各处理影响。高DE日粮提高母猪能量摄入水平,但并不抑制食欲。饲喂HH日粮提高了仔猪出生时肌张力,而饲喂H日粮提高每窝断奶仔猪数。此次研究观察到仔猪活力的其他特征和断奶前窝生长性能结果互相矛盾。 | 何颖(编译) Rooney H B O’driscoll Keelin O’doherty John V | 2020 | 猪业科学2020，37，9： | 5 |
| 4 | Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies显示文摘 | S. O’Neill L. O’Driscoll | 2015 | Obes Rev2015，，1： | 2 |
| 5 | Flexural strength of steel- concrete composite beams 显示文摘 | SLUTFER R G DRISCOLL G C | 1965 | Proceedings of ASCE Structural Division1965，91，4： | 2 |
| 6 | Virus-Induced Gene Silencing in the Culinary Ginger (Zingiber officinale): An Effective Mechanism for Down-Regulating Gene Expression in Tropical Monocots显示文摘导致病毒的基因 silencing (VIGS ) 被显示了有效为短暂在植物到的基因表示击倒在开发和压力相关的回答分析特定的基因的效果。VIGS 很好在 Solanaceae, Brassicaceae, Leguminaceae,和 Poaceae 以内为模型系统和庄稼的研究被建立,但是仅仅最近被用于住在这些家庭外面的植物。这里,我们证明了那个大麦条纹马赛克病毒(BSMV ) 能在 Zingiberaceae 以内感染二种,并且那 BSMVVIGS 能被用于明确地在厨房的生姜姜 officinale 的下面调整 phytoene desaturase。这些结果建议到除谷物以外的 monocots 的 BSMVVIGS 的扩展为许多重要适度、热带的庄稼种类的指导基因分析有潜力。 | Tanya Renner Jennifer Bragg Heather E. Driscoll Juliana Cho Andrew O. Jackson Chelsea D. Specht | 2009 | Molecular Plant2009，2，5： | 2 |
| 7 | Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome 显示文摘 | Legro RS Driscoll D Strauss JF | 1998 | Proc Natl Acad Sci USA1998，95，14： | 2 |
| 8 | 汞污染渔业的恢复显示文摘本文中,我们综合了有关生态系统无机汞(Hg)载荷变化与鱼体内甲基汞(MeHg)浓度之间联系的现有信息。尽管人们普遍假定水生生态系统汞载荷的增加导致鱼体内甲基汞浓度的增加,验证这一假定的定量数据尚很有限。这里,我们研究了源于一系列出处的现有证据:关于被工业排放物污染的生态系统的研究;关于鱼类甲基汞对大气载荷的响应的观测资料;跨越空间和环境梯度的研究以及实验操作。本文概述了目前对从汞载荷到鱼体甲基汞的运输和转化所涉及的主要过程的了解情况。还结合影响与鱼体内甲基汞响应的时机和大小有关的汞循环和生物积累的其他因素探讨了汞载荷的作用。所得出的主要结论是,汞载荷的变化(增加或减少)将引起鱼体内甲基汞的反应,这种反应的时间和大小将根据生态系统特有的变量和所添加的汞的形态而变化。 | John Munthe R. A. (Drew) Bodaly Brian A. Branfireun Charles T. Driscoll Cynthia C. Gilmour Reed Harris Milena Horvat Marc Lucotte Olaf Malm 林宝法(译) | 2007 | AMBIO-人类环境杂志2007，36，1： | 2 |
| 9 | 网络游戏领导力的实验室显示文摘玩家在网络游戏中展现出的领导力技巧,不仅会改变未来的领导模式,如果合理借鉴.也能够帮助我们提升当前企业中的领导力。 | 拜伦·里夫斯(Byron Reeves) 托马斯·马隆(Thomas W.Malone) 托尼·奥德里斯科尔(Tony O'Driscoll) | 2008 | 商业评论2008，，5： | 2 |
| 10 | Adaptive high-order sliding mode control based on quasi-time delay estimation for uncertain robot manipulator显示文摘This paper presents the design,and validation of a new adaptive control system based on quasi-time delay estimation(Q-TDE)augmented with new integral second-order terminal sliding mode control(ISOTSMC)for a manipulator robot with unknown dynamicuncertainty and disturbances.Contrary to the conventional[TDE,the proposed Q-TDE becomes sufficient to invoke a fixed artficial time delay and utilize the past data only of the control input to approximate the unknown system's dynamic uncertainties.The incorporating of new adaptive reachinglaw with ISOTSMCaugmented with Q-TDE policy ensures the continuous performance tracking of the robot manipulator's trajectories using output feedback.This combination may achieve high performance with a significant chattering reducing procedure.By utilizing the Lyapunov function theory,it can be demonstrated that the robot system is stable and all signals in closed-loop are converging in finite time.Consequently,Simulation and comparative studies with two degrees of freedom robot manipulator were carried out to validate the effectiveness of the designed control scheme. | Brahim BRAHMI Mark DRISCOLL Mohamed Hamza LARAKl Abdelkrim BRAHMI | 2020 | Control Theory and Technology2020，18，3： | 2 |
| 11 | Combined aerobic and resistance exercise improves glycemic control and fitness in type 2 diabetes显示文摘 | Andrew Maiorana Gerard O'Driscoll Carmel Goodman Roger Taylor Daniel Green | 2002 | Diabetes Research and Clinical Practice2002，，2： | 2 |
| 12 | Long-term effects of acid rain : Response and recovery, of a forest ecosystem 显示文摘 | LIKENS G E DRISCOLL C T BUSO D C | 1996 | Science1996，272，5259： | 1 |
| 13 | A genetic etiology for a DiGeorge syndrome:comistent deletions and mi-crodeletions of 22q11显示文摘 | Driscoll D A Budarf M L Emanuel B S | 1992 | The American Journal of Human Genetics1992，50，： | 1 |
| 14 | Flexure strength of steel- concrete composite beams 显示文摘 | Slutter R G Driscoll G C | 1965 | Journal of the Structural Division ASCE1965，91，2： | 1 |
| 15 | The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes显示文摘 | Maiorana A O'Driscoll G Cheetham C | 2001 | Journal of the American College of Cardiology2001，38，3： | 1 |
| 16 | Impact of ND-YAG laser drilled holes on the strength and stiffness of laminar flow carbon fibre reinforced composite panels显示文摘 | Young T O'Driscoll D | 2002 | Coznposite2002，33，1： | 1 |
| 17 | Ligand exchange sorption of arsenate and arsenite anions by chelating resins in ferric ion form 显示文摘 | CHANDA M O' DRISCOLL K F REMPEL G L | 1998 | Anionic Polymers1998，8，： | 1 |
| 18 | Retinoid-X receptors and the effects of 9-cis-retinoic acid on insulin secretion from RINm5F cells 显示文摘 | Chertow B S Driscoll H K C oidng NQ | 1997 | Metabolism1997，46，6： | 1 |
| 19 | DNA ligase Ⅳmutations identified in patients exhibiting developnental delay and immunodeficiency显示文摘 | O'Driscoll M Cerosaletti KM Girard PM | 2001 | Mol Cell2001，8，6： | 1 |
| 20 | Matrix metalloproteinase expression and production by alveolar macrophages in emphysema显示文摘 | Finlay GA O'Driscoll LR Russell KJ | 1997 | Am J Respir Crit Care Med1997，156，1： | 1 |
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