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| 1 | Recombinant streptokinase vs phenylephrine-based suppositories in acute hemorrhoids, randomized, controlled trial(THERESA-3)显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) and phenylephrine-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(14 sites), randomized(1:1), open, parallel groups, active controlled trial was done. After inclusion, subjects with acute symptoms of hemorrhoids, who gave their written, informed consent to participate, were centrally randomized to receive, as outpatients, rSK(200000 IU) or 0.25% phenylephrine suppositories, which had different organoleptic characteristics. Treatment was administered by the rectal route, one unit every 6 h during 48 h for rSK, and up to a maximum of 5 d(20 suppositories) for phenylephrine. Evaluations were performed at 3, 5 and 10 d postinclusion. The main end-point was the 5th-day complete clinical response(disappearance of pain and edema, and ≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were evaluated too. RESULTS: 5thday complete response rates were 83/110(75.5%) and 36/110(32.7%) with rSK and phenylephrine suppositories, respectively. This 42.7% difference(95%CI: 30.5-54.2) was highly significant(P < 0.001). The advantage was detected since the early 3rdday evaluation(37.3% vs 6.4% for the rSK and active control groups, respectively; P < 0.001) and was kept even at the late 10thday assessment(83.6% vs 58.2% for rSK and phenylephrine, respectively; P < 0.001). Time for complete response was significantly shorter(P = 0.031; log-rank test) in the rSK group(median: 4.9 d; 95%CI: 4.8-5.0) with respect to the active control(median: 9.8 d; 95%CI: 9.8-10.0). Thrombectomy was necessary in 1/59 and 8/57 patients with baseline thrombosis in the rSK and phenylephrine groups, respectively(P = 0.016). There were no adverse events attributable to the experimental treatment. CONCLUSION: rSK suppositories showed a significant advantage over a widely used over-the-counter phen-ylephrine preparation for the treatment of acute hemorrhoidal illness, with an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-lvarez Roselin Valle-Cabrera Ana Aguilera-Barreto Pedro A López-Saura | 2014 | World Journal of Gastroenterology2014，20，6： | 4 |
| 2 | Disabling portosystemic encephalopathy in a non-cirrhotic patient: successful endovascular treatment of a giant inferior mesenteric-caval shunt via the left internal iliac vein显示文摘Hepatic encephalopathy is suspected in non-cirrhotic cases of encephalopathy because the symptoms are accompanied by hyperammonaemia. Some cases have been misdiagnosed as psychiatric diseases and consequently patients hospitalized in psychiatric institutions or geriatric facilities. Therefore, the importance of accurate diagnosis of this disease should be strongly emphasized. A 68-year-old female patient presented to the Emergency Room with confusion, lethargy, nausea and vomiting. Examination disclosed normal vital signs. Neurological examination revealed a minimally responsive woman without apparent focal deficits and normal reflexes. She had no history of hematologic disorders or alcohol abuse. Her brain TC did not demonstrate any intracranial abnormalities and electroencephalography did not reveal any subclinical epileptiform discharges. Her ammonia level was > 400 mg/d L(reference range < 75 mg/d L) while hepatitis viral markers were negative. The patient was started on lactulose, rifaximin and low-protein diet.On the basis of the doppler ultrasound and abdomen computed tomography angiography findings, the decision was made to attempt portal venography which confirmed the presence of a giant portal-systemic venous shunt. Therefore, mechanic obliteration of shunt by interventional radiology was performed. As a consequence, mesenteric venous blood returned to hepatopetally flow into the liver, metabolic detoxification of ammonia increased and hepatic encephalopathy subsided. It is crucial that physicians immediately recognize the presence of non-cirrhotic encephalopathy, in view of the potential therapeutic resolution after accurate diagnosis and appropriate treatments. | Luca de Martinis Gloria Groppelli Riccardo Corti Lorenzo Paolo Moramarco Pietro Quaretti Pasquale De Cata Mario Rotondi Luca Chiovato | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 3 | Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids:A randomized controlled trial显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) vs hydrocortisone acetate-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(11 sites), randomized(1:1:1), open, controlled trial with parallel groups was performed. All participating patients gave their written,informed consent. After inclusion, patients with acute symptoms of hemorrhoids were centrally randomized to receive, as outpatients, by the rectal route, suppositories of rSK 200000 IU of one unit every 8 h(first 3 units)and afterwards every 12 h until 8 administrations were completed(schedule A), one unit every 8 h until 6 units were completed(schedule B), or 25 mg hydrocortisone acetate once every 8 h up to a maximum of 24 administrations. Evaluations were performed at 3, 5,and 10 d post-inclusion. The main end-point was the 5thday response(disappearance of pain and bleeding, and≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were also evaluated.RESULTS: Groups were homogeneous with regards to demographic and baseline characteristics. Fifth day complete response rates were 156/170(91.8%; 95%CI:87.3-96.2), 155/170(91.2%; 95%CI: 86.6%-95.7%),and 46/170(27.1%; 95%CI: 20.1%-34.0%) with rSK(schedule A and B) and hydrocortisone acetate suppositories, respectively. These 64.6% and 63.9%differences(95%CI: 56.7%-72.2% and 55.7%-72.0%)were highly significant(P < 0.001). This advantage was detected since the early 3rd day evaluation(68.8% and64.1% vs 7.1% for the rSK and active control groups,respectively; P < 0.001) and was maintained even at the late 10 th day assessment(97.1% and 93.5% vs67.1% for rSK and hydrocortisone acetate, respectively;P < 0.001). Time to response was 3 d(95%CI: 2.9-3.1)for both rSK groups and 10 d(95%CI: 9.3-10.7) in the hydrocortisone acetate group. This difference was highly significant(P < 0.001). All subgroup stratified analyses(with or without thrombosis and hemorrhoid classification) showed a statistically significant advantage for the rSK groups. Thrombectomy was necessary in4/251 and 14/133 patients with baseline thrombosis in the rSK and hydrocortisone acetate groups, respectively(P < 0.001). There were no adverse events attributable to the experimental treatment.CONCLUSION: rSK suppositories showed a significant advantage over a widely-used over-the-counter hydrocortisone acetate preparation for the treatment of acute hemorrhoidal illness, as well as having an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-Alvarez Osmany Martínez-Serrano Odalys C Lazo-Diago Cimara H Bermúdez-Badell José R Causa-García Juan E Domínguez-Suárez Pedro A López-Saura 无 | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 4 | Effects of surgery, general anesthesia, and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer显示文摘 | Juan P. Cata Maria Bauer Telemate Sokari María F. Ramirez David Mason Gregory Plautz Andrea Kurz | 2013 | Journal of Clinical Anesthesia2013，，： | 2 |
| 5 | Dexmedetomidine for deep brain stimulator placement in a child with primary generalized dystonia:case report and literature review显示文摘 | Maurtua MA Cata JP Martirena M | 2009 | J Clin Anesth2009，21，3： | 1 |
| 6 | Neighborhoods of certain class of analytic functions with negative coefficients 显示文摘 | CATAS A | 2009 | Banach J Math Anal2009，，3： | 1 |
| 7 | Effects of postoperative epidural analgesia on recurrence-free and overall survival in patients with nonsmall cell lung cancer显示文摘 | Juan P. Cata Vijaya Gottumukkala Dilip Thakar Dinesh Keerty Rodolfo Gebhardt Diane D. Liu | 2014 | Journal of Clinical Anesthesia2014，，1： | 1 |
| 8 | Effects of surgery,general anesthe- sia, and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer显示文摘 | Cata JP Bauer M Sokari T | 2013 | J C lin Anesth2013，25，4： | 1 |
| 9 | Effects of postoperative epidural analgesia on recurrence-free and overall survival in patients with nonsmall cell lung cancer显示文摘 | Cata JP Gottumukkala V Thakar D | 2014 | J Clin Anesth2014，26，1： | 1 |
| 10 | How regional anesthesiamight reduce postoperative cancer recurrence显示文摘 | Cata J P Gottumukkala V Sessler D I | 2011 | Eur J Pain Sup-pl2011，5，： | 1 |
| 11 | Effects of surgery, general anesthesia, and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer显示文摘 | Cata JP Bauer M Sokari T | 2013 | J Clin Anesth2013，25，4： | 1 |
| 12 | Management of chemotherapy-induced peripheral neuropathy 显示文摘 | Stillman M Cata JP | 2006 | Curr Pain Headache Rep2006，10，4： | 1 |
| 13 | Effects of surgery, general anesthesia, and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer 显示文摘 | Cata JP Bauer M Sokari T | 2013 | J Clin Anesth2013，25，4： | 1 |
| 14 | Effects of surgery, general anesthesia, and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer 显示文摘 | Cata JP Bauer M Sokari T | 2013 | J Clin Anesth2013，25，25： | 1 |
| 15 | Dexmedetomidine as sole sedative during percuta, neous carotid artery stenting in a patient with severe chronic obstructive pulmonary disease显示文摘 | Cata JP Folch E | 2009 | Minerva Anestesiol2009，75，11： | 1 |
| 16 | Dynamic analysis of the guiding mechanisms used for the rear axle of the commercial vehicles显示文摘 | Cata|in Alexandru | 2009 | International Review of Mechanical Engineering2009，3，1： | 1 |
| 17 | Carcinoma of the colon:long time survival ang prognosis arter surgical treatment in a series of 798 parients显示文摘 | Cata M | 1987 | world J Surg1987，206，1： | 1 |
| 18 | Inhibition of glutamate uptake in the spinal cord induces hyperalgesia and increased responses of spinal dorsal horn neurons to peripheral afferent stimulation 显示文摘 | Weng HR Chen JH Cata JP | 2006 | Neuroscience2006，138，： | 1 |
| 19 | Clinical and experimental findings in humans and animals with chemotherapy-induced peripheral neuropathy显示文摘 | Cata J P Weng H R Lee B N etal | 2006 | Minerva Anestesiol2006，72，3： | 1 |
| 20 | Taxol- induced sensory disturbance is characteized by preferential impairment of myelinated fiber function in cancer patien 显示文摘 | DOUGHERTY PM CATA JP CORDELLA JV | 2004 | Pain2004，109，12： | 1 |
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