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| 1 | miRNAs in precancerous lesions of the gastrointestinal tract显示文摘In spite of the well-established understanding of the phenotypic lesions occurring in the shift from native epithelia to invasive (adeno) carcinoma, the molecular typing of the precancerous changes in the gastrointestinal tract remains unreliable. In recent years, no biomarkers have aroused as much interest as the miRNAs,a class of non-coding RNA molecules that function as endogenous silencers of numerous target genes. Aberrant miRNA expression is a hallmark of human disease,including cancer. Unlike most mRNAs, miRNAs are both long-living in vivo and very stable in vitro . Such characteristics allow their testing in paraffin-embedded tissue samples, which is essential in the biological profiling of small (phenotypically characterized) preneoplastic lesions of the gastrointestinal tract (as well as in other fields of human pathology). The upcoming challenge lies in the reliable identification of disease-specific targets of dysregulated miRNAs, to enable miRNA testing in the clinical management of the secondary prevention of gastrointestinal cancer. | Matteo Fassan Carlo M Croce Massimo Rugge | 2011 | World Journal of Gastroenterology2011，17，48： | 7 |
| 2 | The role of MicroRNAs in human cancer显示文摘MicroRNAs(miRNAs)are endogenous,small non-coding RNAs that function in regulation of gene expression.Compelling evidences have demonstrated that miRNA expression is dysregulated in human cancer through various mechanisms,including amplification or deletion of miRNA genes,abnormal transcriptional control of miRNAs,dysregulated epigenetic changes and defects in the miRNA biogenesis machinery.MiRNAs may function as either oncogenes or tumor suppressors under certain conditions.The dysregulated miRNAs have been shown to affect the hallmarks of cancer,including sustaining proliferative signaling,evading growth suppressors,resisting cell death,activating invasion and metastasis,and inducing angiogenesis.An increasing number of studies have identified miRNAs as potential biomarkers for human cancer diagnosis,prognosis and therapeutic targets or tools,which needs further investigation and validation.In this review,we focus on how miRNAs regulate the development of human tumors by acting as tumor suppressors or oncogenes. | Yong Peng Carlo M Croce | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 5 |
| 3 | Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis显示文摘 | Tetsuya Ueda Stefano Volinia Hiroshi Okumura Masayoshi Shimizu Cristian Taccioli Simona Rossi Hansjuerg Alder Chang-gong Liu Naohide Oue Wataru Yasui Kazuhiro Yoshida Hiroki Sasaki Sachiyo Nomura Yasuyuki Seto Michio Kaminishi George A Calin Carlo M Croce | 2010 | Lancet Oncology2010，，2： | 4 |
| 4 | miRNA profiling of cancer显示文摘 | Gianpiero Di Leva Carlo M Croce | 2013 | Current Opinion in Genetics & Development2013，，1： | 2 |
| 5 | The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers显示文摘 | Masataka Ohta Hiroshi Inoue Maria Grazia Cotticelli Kumar Kastury Raffaele Baffa Juan Palazzo Zurab Siprashvili Masaki Mori Peter McCue Teresa Druck Carlo M Croce Kay Huebner | 1996 | Cell1996，，4： | 2 |
| 6 | Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis显示文摘 | Tetsuya Ueda Stefano Volinia Hiroshi Okumura Masayoshi Shimizu Cristian Taccioli Simona Rossi Hansjuerg Alder Chang-gong Liu Naohide Oue Wataru Yasui Kazuhiro Yoshida Hiroki Sasaki Sachiyo Nomura Yasuyuki Seto Michio Kaminishi George A Calin Carlo M Croce | 2010 | Lancet Oncology2010，，2： | 2 |
| 7 | Causes and consequences of microRNA dysregulation in cancer显示文摘 | CROCE C M | 2009 | Nat Rev Genet2009，10，10： | 1 |
| 8 | MicrnRNA-cancer connection: the beginning of a new tale 显示文摘 | CALIN G A CROCE C M | 2006 | Cancer Res2006，66，15： | 1 |
| 9 | Causes and consequences of microRNA dysregulation in cancer显示文摘 | Croce C M | 2009 | Nat Rev Genet2009，10，10： | 1 |
| 10 | MicroRNA-cancer connection: the beginning of a new tale 显示文摘 | Calin G A Croce C M | 2006 | Cancer Res2006，66，15： | 1 |
| 11 | MicroRNAs in cancer显示文摘 | Garzon R Calin G A Croce C M | 2009 | Annu Rev Med2009，60，： | 1 |
| 12 | Pneumonia and stress ulceration in severely head injury patients:a prospective evaluation of the effects of stress ulcer prophylaxis显示文摘 | BOUCHER B A CROCE M A | 1993 | Arch Surg1993，128，2： | 1 |
| 13 | Cancer and the FRA3B/FHIT fragile locus: it' s a HIT 显示文摘 | Huebner K Croce C M | 2003 | Br J Cancer2003，88，10： | 1 |
| 14 | Prospective,randomized,controlledpilots study of partial liquid ventilation in adult acute respiratory distresssyndrome显示文摘 | HirschlDB Croce M Gore D | 2002 | Am J Respir Crit Care Med2002，165，： | 1 |
| 15 | Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines显示文摘 | Roz L Gramegna M Ishii H Croce C M Sozzi G | 2002 | Proc Natl Acad Sci USA2002，99，6： | 1 |
| 16 | Small intestinal submucosa for vascular reconstruction in the presence of gastrointestinal contamination 显示文摘 | Jemigan T W Croce M A Cagiannos C | 2004 | Ann Plast Surg2004，239，5： | 1 |
| 17 | MicroRNAs in Can- cer显示文摘 | DI LEVA G GAROFALO M CROCE CM | 2014 | Annu Rev Pathol2014，9，1： | 1 |
| 18 | Acute respiratory distress syndrome in blunt trauma:identification of independent risk factors 显示文摘 | Millre P R Croce M A Kilgo P D | 2002 | Am Surg2002，68，10： | 1 |
| 19 | Genetic approaches to the study of molecular basis of human cancer显示文摘 | CROCE C M | 1991 | Cancer Res1991，51，18： | 1 |
| 20 | Interferon modulation of celluiar microRNAs as an antiviral mechanism显示文摘 | Pedersen IM Cheng G Wielard S Volinia S Croce CM Chisari FV David M | | 0，，： | 1 |
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