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| 1 | 东海内陆架泥质沉积反映的古环境演化显示文摘通过对东海内陆架闽浙沿岸泥质沉积体的MD06-3040孔进行粒度及年代测试,重建了东海内陆架1万年以来的古环境。认为研究区的沉积环境曾发生过3次变化:孔深18·6m至底部(10~10.7kaBP)对应近滨环境;15·13~18.6m(7.1~10kaBP)为过渡带环境;0~15.13m(0~7.1kaBP)是海侵结束后高海平面的浅海环境,自10kaBP以来东海沿岸流开始影响本区并不断输送河流来源物质,7kaBP起形成稳定的泥质沉积体。根据该孔沉积物的沉积速率与粒度组分特征,说明不能简单地应用平均粒径指示冬季风强度,在东海地区,不仅冬季风控制着沿岸流强度,夏季风也会影响河流入海物质的搬运沉积作用。 | 王可 郑洪波 Maarten Prins 郑妍 | 2008 | 海洋地质与第四纪地质2008，28，4： | 43 |
| 2 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 3 | Gateway重组系统快速构建花生条纹病毒cp基因反向重复序列载体显示文摘Gateway重组系统是Invitrogen公司推出一种新的克隆策略。鉴于一般用于农杆菌转化植物的质粒比较大,采用常规的酶切和连接的克隆策略耗时、费力,Gaytewayw重组系统为大载体的操作提供了一种快速和可靠的手段。该系统利用噬菌体转染细菌后整合细菌DNA的位点特异性重组策略(Landy,1989),重组过程是保守位点特异性DNA链的切割和重接,整个过程中没有DNA的合成。应用Gateway重组系统构建植物反向重复序列表达载体包括两个重组过程:第一,BP重组:目的片段重组至入门载体(Entry clone);第二,LR重组,目的片段自入门载体重组至植物表达载体。本实验室拟利用这一系统构建花生条纹病毒(PStV)红安株系的cp反向重复序列载体,进行烟草转化,期望获得抗性的转基因植株。 | 晏立英 许泽永 陈坤荣 Rob Goldbach Marcel Prins | 2007 | 农业生物技术学报2007，15，2： | 5 |
| 4 | Progression From Paroxysmal to Persistent Atrial Fibrillation显示文摘 | Cees B. de Vos Ron Pisters Robby Nieuwlaat Martin H. Prins Robert G. Tieleman Robert-Jan S. Coelen Antonius C. van den Heijkant Maurits A. Allessie Harry J.G.M. Crijns | 2010 | Journal of the American College of Cardiology2010，，8： | 4 |
| 5 | 反向重复RNA介导转基因烟草对花生条纹病毒抗性显示文摘将花生条纹病毒(Peanut stripe virus,PStV)外壳蛋白基因(cp)反向重复序列重组至植物表达载体pK7GW1WG2,通过根癌农杆菌(Agrobacterium tumefaciens)菌株GV3101导入本生烟(Nicotiana benthamiana)。卡那霉素抗性植株5~6叶期摩擦接种PStV,通过症状观察和ELISA检测,T0代转基因烟草植株87%表现免疫,不同抗性系T1代植株的免疫比例为60%~100%,多数抗性系T2代植株免疫比例达到100%。利用PStV cp基因特异探针对转基因植株T1代进行特异小干扰性RNA(siRNA)的Northern blot检测,转基因植株都检测出不同含量的特异siRNA,而非转基因植株未检测到特异siRNA;对病毒接种前的转基因植株进行特异siRNA检测,免疫植株比感病植株特异siRNA含量高;对免疫转基因植株进行不同时期的siRNA检测,植株在接种前、接种15和50d后的叶片中都检测到特异siRNA,同一植株不同时期siRNA含量相对稳定;各个转化系植株体内siRNA含量存在差异。实验成功地利用双链RNA(dsRNA)策略获得对PStV具有较高比例抗性的转基因烟草植株。 | 晏立英 许泽永 陈坤荣 Rob Goldbach Marcel Prins | 2007 | 农业生物技术学报2007，15，4： | 3 |
| 6 | Molecular approaches for spinal cord injury treatment显示文摘Injuries to the spinal cord result in permanent disabilities that limit daily life activities.The main reasons for these poor outcomes are the limited regenerative capacity of central neurons and the inhibitory milieu that is established upon traumatic injuries.Despite decades of research,there is still no efficient treatment for spinal cord injury.Many strategies are tested in preclinical studies that focus on ameliorating the functional outcomes after spinal cord injury.Among these,molecular compounds are currently being used for neurological recovery,with promising results.These molecules target the axon collapsed growth cone,the inhibitory microenvironment,the survival of neurons and glial cells,and the re-establishment of lost connections.In this review we focused on molecules that are being used,either in preclinical or clinical studies,to treat spinal cord injuries,such as drugs,growth and neurotrophic factors,enzymes,and purines.The mechanisms of action of these molecules are discussed,considering traumatic spinal cord injury in rodents and humans. | Fernanda Martins de Almeida Suelen Adriani Marques Anne Caroline Rodrigues dos Santos Caio Andrade Prins Fellipe Soares dos Santos Cardoso Luiza dos Santos Heringer Henrique Rocha Mendonça Ana Maria Blanco Martinez | 2023 | Neural Regeneration Research2023，18，1： | 3 |
| 7 | The diagnostic odds ratio: a single indicator of test performance显示文摘 | Afina S. Glas Jeroen G. Lijmer Martin H. Prins Gouke J. Bonsel Patrick M.M. Bossuyt | 2003 | Journal of Clinical Epidemiology2003，，11： | 3 |
| 8 | 侵染花生的黄瓜花叶病毒CA株核酸全序列分析显示文摘对侵染花生的黄瓜花叶病毒CA(CMVCA)株系进行克隆和序列分析。CMVCARNA1全长3356个核苷酸(nt),编码分子量为111kDa的1a蛋白;RNA2全长3045nt,编码分子量为96.7kDa的2a蛋白和13.1kDa的2b蛋白;RNA3全长2219nt,编码分子量为30.5kDa的3a蛋白和分子量为24kDa的外壳蛋白(CP)。序列同源性比较表明,CMVCARNA1、2、3与CMV亚组IACMVFny、亚组IBCMVSD、亚组IICMVQ株系序列同源性,RNA1分别为91.3%、91.1%和76.5%,RNA2分别为92.1%、90%和71.2%,RNA3分别为96.1%、92.6%和74.5%;与同属花生矮化病毒(Peanutstuntvirus,PSV)RNA1、2、3序列同源性分别为67.1%、58.2%和55.7%。上述研究未发现CMVCA基因组与PSVRNA链的重组,CMVCA对花生的侵染应是该株系适应于花生的遗传变异、长期进化的结果;对RNA35′NTR结构分析以及RNA35′NTR和CP系统进化树分析表明,CMVCA属CMVIB亚组。 | 晏立英 许泽永 陈坤荣 Rob Goldbach Marcel Prins | 2005 | 中国病毒学2005，20，3： | 3 |
| 9 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 10 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 11 | Single-port laparoscopic cholecystectomy vs standard laparoscopic cholecystectomy:A non-randomized,agematched single center trial显示文摘AIM: To compare the safety of single-port laparoscopic cholecystectomies with standard four-port cholecystectomies.METHODS: Between January 2011 and December 2012 datas were gathered from 100 consecutive patients who received a single-port cholecystectomy. Patient baseline characteristics of all 100 single-port cholecystectomies were collected(body mass index, age, etc.) in a database. This group was compared with 100 age-matched patients who underwent a conventional laparoscopic cholecystectomy in the same period. Retrospectively, per- and postoperative data were added. The two groups were compared to each other using independent t-tests and χ2-tests, P values below 0.05 were considered significantly different.RESULTS: No differences were found between both groups regarding baseline characteristics. Operating time was significantly shorter in the total single-port group(42 min vs 62 min, P < 0.05); in procedures performed by surgeons the same trend was seen(45 min vs 59 min, P < 0.05). Peroperative complications between both groups were equal(3 in the single-port group vs 5 in the multiport group; P = 0.42). Although not significant less postoperative complications were seen in the single-port group compared with the multiport group(3 vs 9; P = 0.07). No statistically significant differences were found between both groupswith regard to length of hospital stay, readmissions and mortality. CONCLUSION: Single-port laparoscopic cholecystectomy has the potential to be a safe technique with a low complication rate, short in-hospital stay and comparable operating time. Single-port cholecystectomy provides the patient an almost non-visible scar while preserving optimal quality of surgery. Further prospective studies are needed to prove the safety of the single-port technique. | Yoen TK van der Linden Koop Bosscha Hubert A Prins Daniel J Lips | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 2 |
| 12 | Absence of galectin-3 attenuates neuroinflammation improving functional recovery after spinal cord injury显示文摘After spinal cord injury(SCI),a cascade of events begins.At first,there is physical damage with disruption of the blood-brain barrier(BBB)and the integrity of the nervous tissue.The disruption of central nervous system(CNS)BBB alters the endothelial permeability,the protein and chemokines expression and the propensity to release in situ inflammatory cytokines,overcoming anti-inflammatory signals,facilitating the | Caio Andrade Prins Fernanda Martins Almeida Ana Maria Blanco Martinez | 2016 | Neural Regeneration Research2016，11，1： | 2 |
| 13 | The Long-term Results of a Randomized Clinical Trial of Laparoscopy-assisted Versus Open Surgery for Colon Cancer显示文摘 | Antonio M. Lacy Salvadora Delgado Antoni Castells Hubert A. Prins Vicente Arroyo Ainitze Ibarzabal Josep M. Pique | 2008 | Annals of Surgery2008，，1： | 2 |
| 14 | Synthesis and characterization of silica - supported transition- metal phosphides as HDN catalysts显示文摘 | ZUZANIUK V PRINS R | 2003 | Journal of Catalysis2003，219，： | 2 |
| 15 | Crop type mapping using LiDAR,Sentinel-2 and aerial imagery with machine learning algorithms显示文摘LiDAR data are becoming increasingly available,which has opened up many new applications.One such application is crop type mapping.Accurate crop type maps are critical for monitoring water use,estimating harvests and in precision agriculture.The traditional approach to obtaining maps of cultivated fields is by manually digitizing the fields from satellite or aerial imagery and then assigning crop type labels to each field-often informed by data collected during ground and aerial surveys.However,manual digitizing and labeling is time-consuming,expensive and subject to human error.Automated remote sensing methods is a cost-effective alternative,with machine learning gaining popularity for classifying crop types.This study evaluated the use of LiDAR data,Sentinel-2 imagery,aerial imagery and machine learning for differentiating five crop types in an intensively cultivated area.Different combinations of the three datasets were evaluated along with ten machine learning.The classification results were interpreted by comparing overall accuracies,kappa,standard deviation and f-score.It was found that LiDAR data successfully differentiated between different crop types,with XGBoost providing the highest overall accuracy of 87.8%.Furthermore,the crop type maps produced using the LiDAR data were in general agreement with those obtained by using Sentinel-2 data,with LiDAR obtaining a mean overall accuracy of 84.3%and Sentinel-2 a mean overall accuracy of 83.6%.However,the combination of all three datasets proved to be the most effective at differentiating between the crop types,with RF providing the highest overall accuracy of 94.4%.These findings provide a foundation for selecting the appropriate combination of remotely sensed data sources and machine learning algorithms for operational crop type mapping. | Adriaan Jacobus Prins Adriaan Van Niekerk | 2021 | Geo-Spatial Information Science2021，24，2： | 2 |
| 16 | Controls on terrigenous sediment supply to the Arabian Sea during the late Quaternary: the Makran continental slope显示文摘 | M.A Prins G Postma G.J Weltje | 2000 | Marine Geology2000，，3： | 2 |
| 17 | Formation, Structure, and HDN Activity of Unsupported Molybdenum Phosphide显示文摘 | C. Stinner R. Prins Th. Weber | 2000 | Journal of Catalysis2000，，2： | 2 |
| 18 | Parameters of rumen fermentation in a continuously fed sheep: evidence of a microbial rumina-tion pool 显示文摘 | Hungate R E Reichl J Prins R | 1971 | Appl Microbiol Biot1971，22，6： | 1 |
| 19 | Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences: Rotterdam Scan study显示文摘 | Van DE J Prins ND Vrooman HA | 2008 | Stroke2008，39，10： | 1 |
| 20 | A meta-analysis on the efficacy of preoperative biliary drainage for tumor causing obstructive jaundice显示文摘 | Sewnath ME Karsten TM Prins MH | 2002 | Ann Surg2002，236，1： | 1 |
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