|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Model predictive control for adaptive cruise control with multi-objectives: comfort,fuel-economy,safety and car-following显示文摘For automated vehicles,comfortable driving will improve passengers’ satisfaction.Reducing fuel consumption brings economic profits for car owners,decreases the impact on the environment and increases energy sustainability.In addition to comfort and fuel-economy,automated vehicles also have the basic requirements of safety and car-following.For this purpose,an adaptive cruise control (ACC) algorithm with multi-objectives is proposed based on a model predictive control (MPC) framework.In the proposed ACC algorithm,safety is guaranteed by constraining the inter-distance within a safe range; the requirements of comfort and car-following are considered to be the performance criteria and some optimal reference trajectories are introduced to increase fuel-economy.The performances of the proposed ACC algorithm are simulated and analyzed in five representative traffic scenarios and multiple experiments.The results show that not only are safety and car-following objectives satisfied,but also driving comfort and fuel-economy are improved significantly. | Li-hua LUO Hong LIU Ping LI Hui WANG | 2010 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2010，11，3： | 34 |
| 2 | PVT v2:Improved baselines with Pyramid Vision Transformer显示文摘Transformers have recently lead to encouraging progress in computer vision.In this work,we present new baselines by improving the original Pyramid Vision Transformer(PVT v1)by adding three designs:(i)a linear complexity attention layer,(ii)an overlapping patch embedding,and(iii)a convolutional feed-forward network.With these modifications,PVT v2 reduces the computational complexity of PVT v1 to linearity and provides significant improvements on fundamental vision tasks such as classification,detection,and segmentation.In particular,PVT v2 achieves comparable or better performance than recent work such as the Swin transformer.We hope this work will facilitate state-ofthe-art transformer research in computer vision.Code is available at http://gffzz188fe103f8f1460as50wf6cf60vb56of9.ffgz.tsg.suse.edu.cn/whai362/PVT. | Wenhai Wang Enze Xie Xiang Li Deng-Ping Fan Kaitao Song Ding Liang Tong Lu Ping Luo Ling Shao | 2022 | Computational Visual Media2022，8，3： | 30 |
| 3 | Association between serum homocysteine and arterial stiffness in elderly: a community-based study显示文摘BackgroundArterial 僵硬和 homocysteine 两个都是心血管的疾病的强大的预言者,特别在更旧的人口。以前的研究在人的题目与动脉的僵硬调查了 homocysteine 的协会,当时在 homocysteine 和动脉的僵硬在之间的关系老仍然是不定的。当前的学习在相关浆液在 780 个参加者 homocysteine 铺平到动脉的僵硬(颈动脉大腿骨的脉搏波浪速度( PWV )和颈动脉光线的 PWV )的二项措施的中国基于社区的老 persons.MethodsWe 与动脉的僵硬检验了 homocysteine 的协会(46.3%人,意味着年龄 71.9 年(变化 65-96 岁))从中国北京的二个社区。动脉的僵硬在二天 biomarker measurement.ResultsIn 多重调整模型,的时间以内被测量 homocysteine 层次强烈与颈动脉大腿骨的 PWV 被联系(标准化 β= 0.13, P <0.001 ) ,甚至在为心血管的疾病的古典风险因素的调整以后。当而有 homocysteine 的重要协会都没为颈动脉光线的 PWV.ConclusionsIn 中国老人,被观察,颈动脉大腿骨的 PWV 在正常上面被提高时,协会也更强壮浆液 homocysteine 层次与大动脉的僵硬的改变被联系。 | Song ZHANG Yong-Yi BAI Lei-Ming LUO Wen-Kai XIAO Hong-Mei WU Ping YE | 2014 | Journal of Geriatric Cardiology2014，11，1： | 28 |
| 4 | Influence of temperature and solution composition on the formation of calcium sulfates显示文摘Calcium sulfates (anhydrite and hydrates) were synthesized by mixing CaCl 2 and Na 2 SO 4 solutions at room temperature followed by aging the resulting slurries at elevated temperatures. The variation of the morphology and structure of the calcium sulfates with aging temperature was investigated. Experimental results indicated that CaSO 4 ·2H 2 O plates, CaSO 4 ·0.5H 2 O whiskers and CaSO 4 spindles were formed at ≤100 °C, 130–160 °C and ≥170 °C, respectively. The formation and conversion of the calcium sulfates were discussed on the basis of characterization of the products and chemical analysis of the solutions. Compared to NaCl solution, pure water favors one-dimensional hydrothermal growth of CaSO 4 ·0.5H 2 O whiskers owing to lower supersaturation. | Kangbi Luo Chunmei Li Lan Xiang Huping Li Ping Ning | 2010 | Particuology2010，8，3： | 26 |
| 5 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 6 | Endoscopic Surgery versus External Ventricular Drainage Surgery for Severe Intraventricular Hemorrhage显示文摘The efficacy and applied value of endoscopic hematoma evacuation vs. external ventricular drainage (EVD) in the treatment of severe ventficular hemorrhage (IVH) were explored and compared.From Jan.2015 to Dec.2016,the clinical data of 42 cases of IVH were retrospectively analyzed,including 18 patients undergoing endoscopic hematoma evacuation (group A),and 24patients receiving EVD (group B).The hematoma clearance rate was calculated by 3D Slicer software,and complications and outcomes were compared between the two groups.There were no significant differences in age,sex and Graeb score between groups A and B (P>0.05).The hematoma clearance rate was 70.81%±27.64% in group A and 48.72%±36.58% in group B with a statistically significant difference (P<0.05).The operative time in groups A and B was 72.45±25.26 min and 28.54±15.27min,respectively (P<0.05).The Glasgow Coma Scale (GCS) score increased from 9.28±2.72 at baseline to 11.83±2.91 at 1 week postoperatively in group A,and from 8.25±2.62 at baseline to 10.79±4.12 at 1 week postoperatively in group B (P<0.05).The length of hospital stay was 12.67±5.97 days in group A and 17.33±8.91 days in group B with a statistically significant difference (P<0.05).The GOS scores at 6 months after surgery were 3.83±1.12 in group A,and 2.75±1.23 in group B (P<0.05). These results suggested that endoscopic hematoma evacuation has an advantage of a higher hematoma clearance rate,fewer complications and better outcomes in the treatment of severe IVH,indicating it is a safe,effective and promising approach for severe IVH. | Ping SONG Fa-liang DUAN Qiang CAI Jing-lei WU Xiao-bin CHEN Yuan WANG Cong-gang HUANG Ji-qiang LI Zhu-qiang HE Qiao-chun HUANG Mei LIU Yan-gao ZHANG Ming LUO | 2018 | Current Medical Science2018，38，5： | 21 |
| 7 | Anti-inflammatory and anti-thrombogenic effects of atorvastatin in acute ischemic stroke显示文摘Atorvastatin decreases inflammation and thrombogenesis in patients with carotid artery plaque. Atorvastatin is administered to lower lipid levels, but its anti-inflammatory and anti-thrombogenic effects remain unclear. Eighty-nine patients from northeastern China with acute ischemic stroke caused by large-artery atherosclerosis were randomly divided into the study and control groups. All patients received routine treatment, including antiplatelet therapy, circulatory support, and symp-tomatic treatment. The study group (n=43) also received daily atorvastatin 20 mg/d, and the control group (n=46) received daily placebo pills containing glucose. After 4 weeks, the levels of C-reactive protein, fibrinogen, and D-dimer were significantly lower in the study group than in the control group. Decreases in the levels of C-reactive protein, fibrinogen, and D-dimer were not associated with de-creases in the levels of triacylglycerol and low-density lipoprotein cholesterol. These results suggest that atorvastatin reduces inflammation and thrombogenesis independent of its lipid-lowering effects in patients with acute ischemic stroke caused by large-artery atherosclerosis. | Lianqiu Min Shuai Shao Xiaoning Wu Lin Cong Ping Liu Haiping Zhao Yumin Luo | 2013 | Neural Regeneration Research2013，8，23： | 19 |
| 8 | Growth-inhibiting effects of taxol on human liver cancer in vitro and in nude mice显示文摘AIM To investigate the effects of taxol onSMMC-7721 human hepatoma and itsmechanisms.METHODS In vitro cell growth was assessedby trypan blue exclusion method.Experimentalhepatoma model was established by seedingSMMC-7721 cells subcutaneously into Balb/c(nu/nu)nude mice.In vivo tumor growth wasdetermined by measurement of tumor diameterwith Vernier calipers.The syntheses of DNA,RNA and protein were analyzed by incorporationof ~3H-thymidine,~3H-uridine and ~3H-leucinerespectively.Using light and electronmicroscopes to observe the morphologicalchanges of cells including mitosis andapoptosis.RESULTS Taxol was effective against SMMC-7721 human hepatoma cell growth in the rangesof 2.5 nmol/L-10 nmol/L with mitotic arrestand apoptosis in vitro.DNA,RNA and proteinsyntheses in cells were also obviouslysuppressed by in vitro treatment of taxol for72 h.Taxol at 2.5 nmol/L reduced ~3H-thymidineuptake to about 34% of the control value(P<0.05).Increasing the dose of taxol to20 nmol/L resulted in a greater decrease in ~3H-thymidine incorporation to 60% of the controlvalue(P<0.01).At a concentration of 20 nmol/L,the ~3H-uridine and ~3H-leucine uptakeswere reduced to 52%(P<0.05)and 63%(P<0.01),respectively.In vivo,taxolsignificantly inhibited SMMC-7721 tumor growthat 10 mg/kg,i.p.,once daily for 10 d.A morethan 90% decrease in tumor volume wasobserved by day 11(P<0.01)similarly withmitotic arrest and cell apoptosis.CONCLUSION Taxol has a marked anticanceractivity in SMMC-7721 human hepatoma both invitro and in nude mice.Its mechanisms might beassociated with mitotic arrest,subsequently,apoptosis of the hepatoma cells.No obvioustoxicity was observed with in vivoadministration of taxoi. | Jin Hui Yuan Ru Ping Zhang Ru Gang Zhang Li Xia Guo Xing Wang Wang Dan Luo Yong Xie Hong Xie | 2000 | World Journal of Gastroenterology2000，6，2： | 18 |
| 9 | High Potassium Aggravates the Oxidative Stress Inducedy by Magnesium Deficiency in Rice Leaves显示文摘Magnesium(Mg) deficiency in plant affects photosynthesis and many other metabolic processes.Rice(Oryza sativa L.cv.'Wuyunjing 7') plants were grown in hydroponics culture at three Mg and two potassium(K) levels under greenhouse conditions to examine the induction of oxidative stress and consequent antioxidant responses in rice leaves due to Mg deficiency.At low Mg(0.2 mmol L-1 Mg supply for two weeks after transplanting) and high K(6 mmol L-1) for 21 days,the rice plants showed severe Mg deficiency and a significant decreases in the dry matter production.The Mg deficiency in leaves decreased chlorophyll concentrations,photosynthetic activity,and soluble protein,but significantly increased the concentrations of soluble sugars and malondialdehyde(MDA) and the activities of superoxide dismutase(SOD,EC 1.15.1.1),catalase(CAT,EC 1.11.1.6) and peroxidase(POD,EC 1.11.1.7).In addition,Mg concentrations in the leaves and in the shoot biomass were negatively related to the activities of the three antioxidative enzymes and the concentration of MDA in leaves.There were very significant interactive effects between Mg and K supplied in the culture solution on shoot biomass yield,chlorophyll content,photosynthesis rate,the activities of SOD,CAT and POD,and MDA content in the leaves of rice.It is suggested that the high K level in the nutrient solution aggravated the effect of low Mg supply-induced Mg deficiency and created the oxidative damage in rice plants. | DING Yu-Chuan CHANG Chun-Rong LUO Wen WU Yan-Shou REN Xiao-Li WANG Ping XU Guo-Hua | 2008 | Pedosphere2008，18，3： | 17 |
| 10 | Finite element formulation based on proper orthogonal decomposition for parabolic equations显示文摘A proper orthogonal decomposition (POD) method is applied to a usual finite element (FE) formulation for parabolic equations so that it is reduced into a POD FE formulation with lower dimensions and enough high accuracy. The errors between the reduced POD FE solution and the usual FE solution are analyzed. It is shown by numerical examples that the results of numerical computations are consistent with theoretical conclusions. Moreover, it is also shown that this validates the feasibility and efficiency of POD method. | LUO ZhenDong CHEN Jing SUN Ping YANG XiaoZhong | 2009 | Science China Mathematics2009，52，3： | 16 |
| 11 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 12 | Spin-decoupled metasurface for simultaneous detection of spin and orbital angular momenta via momentum transformation显示文摘With inherent orthogonality,both the spin angular momentum(SAM)and orbital angular momentum(OAM)of photons have been utilized to expand the dimensions of quantum information,optical communications,and information processing,wherein simultaneous detection of SAMs and OAMs with a single element and a single-shot measurement is highly anticipated.Here,a single azimuthal-quadratic phase metasurface-based photonic momentum transformation(PMT)is illustrated and utilized for vortex recognition.Since different vortices are converted into focusing patterns with distinct azimuthal coordinates on a transverse plane through PMT,OAMs within a large mode space can be determined through a single-shot measurement.Moreover,spin-controlled dual-functional PMTs are proposed for simultaneous SAM and OAM sorting,which is implemented by a single spin-decoupled metasurface that merges both the geometric phase and dynamic phase.Interestingly,our proposed method can detect vectorial vortices with both phase and polarization singularities,as well as superimposed vortices with a certain interval step.Experimental results obtained at several wavelengths in the visible band exhibit good agreement with the numerical modeling.With the merits of ultracompact device size,simple optical configuration,and prominent vortex recognition ability,our approach may underpin the development of integrated and high-dimensional optical and quantum systems. | Yinghui Guo Shicong Zhang Mingbo Pu Qiong He Jinjin Jin Mingfeng Xu Yaxin Zhang Ping Gao Xiangang Luo | 2021 | Light(Science & Applications)2021，10，4： | 14 |
| 13 | Correlation between tongue manifestations and glucose, total cholesterol, and high-density lipoprotein cholesterol in patients with acute cerebral infarction显示文摘OBJECTIVE: To analyze the association between tongue manifestations and the levels of glucose (GLU), total cholesterol(TCH), and high-density lipoprotein cholesterol(HDL-C) in subjects with acute cerebral infarction.METHODS: Hospitalized patients with first unilateral cerebral infarction in the Neurological Department of Xuanwu Hospital were included and the correlation between tongue fur color, fur nature,and the levels of GLU,TCH, HDL-C were analyzed.RESULTS: HDL level in the thin fur group was higher than that in the thick fur group(P=0.02). The difference in the levels of GLU,TCH, and HDL-C among the groups was significant(P<0.05), classified in terms of slippery, moist, and dry fur. Further comparison between the groups by Student-Newman-Keuls test showed that GLU level in the dry fur group was the highest. Moreover, the TCH level in the slippery fur group was higher than the other two groups.CONCLUSION: A correlation between tongue manifestations and GLU, TCH, HDL-C was identified in the patients with acute cerebral infarction. | Ping Liu Li Gao Juexian Song Haiping Zhao XiaoguangWu Liyuan Huang Pingping Wang Yumin Luo | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 14 |
| 14 | Total pollution effect of urban surface runoff显示文摘For pollution research with regard to urban surface runoff,most sampling strategies to date have focused on differences in land usage. With single land-use sampling,total surface runoffpollution effect cannot be evaluated unless every land usage spot is monitored. Through a new sampling strategy known as mixed stormwater sampling for a street community at discharge outlet adjacent to river,this study assessed the total urban surface runoffpollution effect caused by a variety of land uses and the pollutants washed off from the rain pipe system in the Futian River watershed in Shenzhen City of China.The water quality monitoring indices were COD(chemical oxygen demand),TSS(total suspend solid),TP(total phosphorus),TN(total nitrogen)and BOD(biochemical oxygen demand).The sums of total pollution loads discharged into the river for the four indices of COD,TSS,TN,and TP over all seven rainfall events were very different.The mathematical model for simulating total pollution loads was established from discharge outlet mixed stormwater sampling of total pollution loads on the basis of four parameters:rainfall intensity,total land area,impervious land area,and pervious land area.In order to treat surface runoffpollution,the values of MFF30(mass first flush ratio)and FF30(first 30%of runoffvolume) can be considered as split-flow control criteria to obtain more effective and economical design of structural BMPs(best management practices)facilities. | LUO Hongbing LUO Lin HUANG Gu LIU Ping LI Jingxian HU Sheng WANG Fuxiang XU Rui HUANG Xiaoxue | 2009 | Journal of Environmental Sciences2009，21，9： | 13 |
| 15 | Effect of high glucose levels on the calcification of vascular smooth muscle cells by inducing osteoblastic differentiation and intracellular calcium deposition via BMP-2/Cbfα-1 pathway显示文摘In this paper,we investigate the effect and the possible mechanism of high glucose levels on the calcification of human aortic smooth muscle cells (HASMCs).HASMCs were divided into four groups: normal glucose group (NG),osmolality control group (OC),high glucose group (HG,HASMCs culture medium containing 30 mmol/L glucose),and high glucose plus recombinant human Noggin protein (bone morphogenetic protein-2 (BMP-2) antagonist) group (HN).The mRNA levels and the protein expressions of BMP-2 and core binding factor alpha-1 (Cbfα-1) were measured by real-time quantitative polymerase chain reaction (PCR) and Western blot.After induced by 10 mmol/L β-glycerol phosphoric acid,cells were harvested for assessments of alkaline phosphatase (ALP) activities at Days 1,2,and 3,and intracellular calcium contents at Days 7 and 14,respectively.High glucose levels increased the mRNA levels and the protein expressions of BMP-2 and Cbfα-1 (P<0.05).The expression of Cbfα-1 was partially blocked by Noggin protein (P<0.05),while BMP-2 was not (P>0.05).After being induced by β-glycerol phosphoric acid,high glucose levels increased the ALP activity [(48.63±1.03) vs.(41.42±2.28) U/mg protein,Day 3;P<0.05] and the intracellular calcium content [(2.76±0.09) vs.(1.75±0.07) μmol/mg protein,Day 14;P<0.05] in a time-dependent manner when compared with the NG group,while the ALP activity could not be blocked by Noggin protein [(48.63±1.03) vs.(47.37±0.97) U/mg protein,Day 3;P>0.05].These results show that high glucose levels can evoke the calcification of HASMCs by inducing osteoblastic trans-differentiation and intracellular calcium deposition via the BMP-2/Cbfα-1 pathway,which can be partially blocked by Noggin protein. | Fang LIU Hui ZHONG Jing-yuan LIANG Ping FU Zhi-juan LUO Li ZHOU Rong GOU Jun HUANG | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，12： | 12 |
| 16 | Associations of plasma homocysteine and high-sensitivity C-reactive protein levels with arterial stiffness in Chinese population: a community-based study显示文摘背景动脉的僵硬与年龄增加并且是也与传统的心血管的风险 factors.Little 联系了在学习是与动脉的僵硬调查血浆 homocysteine 和 hs-CRP 层次的协会在里面的礼品的中国 community.The 目的对与动脉的僵硬的 homocysteine 和高敏感的C反应的蛋白质( hs-CRP )的关系被知道我们联系了的基于社区的 cohort.Methods homocysteine 和 hs-CRP 铺平到动脉的 stiffne | FENG Sheng-qiang YE Ping LUO Lei-ming XIAO Wen-kai BAI Yong-yi FENG Dan LIU De-jun WU Hong-mei XU Ru-yi BAI Jie | 2012 | Chinese Medical Journal2012，，1： | 12 |
| 17 | Enhanced absorption and inhibited metabolism of emodin by 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucopyranoside: Possible mechanisms for Polygoni Multiflori Radix-induced liver injury显示文摘Polygoni Multiflori Radix(PMR) has been commonly used as a tonic in China for centuries. However, PMR-associated hepatotoxicity is becoming a safety issue. In our previous in vivo study, an interaction between stilbenes and anthraquinones has been discovered and a hypothesis is proposed that the interaction between stilbene glucoside-enriching fraction and emodin may contribute to the side effects of PMR. To further support our previous in vivo results in rats, the present in vitro study was designed to evaluate the effects of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucopyranoside(TSG) on the cellular absorption and human liver microsome metabolism of emodin. The obtained results indicated that the absorption of emodin in Caco-2 cells was enhanced and the metabolism of emodin in human liver microsomes was inhibited after TSG treatment. The effects of the transport inhibitors on the cellular emodin accumulation were also examined. Western blot assay suggested that the depressed metabolism of emodin could be attributed to the down-regulation of UDP-glucuronosyltransferases(UGTs) 1A8, 1A10, and 2B7. These findings definitively demonstrated the existence of interaction between TSG and emodin, which provide a basis for a better understanding of the underlying mechanism for PMR-induced liver injury. | YU Qiong JIANG Li-Long LUO Na FAN Ya-Xi MA Jiang LI Ping LI Hui-Jun | 2017 | Chinese Journal of Natural Medicines2017，15，6： | 12 |
| 18 | Subcellular daunorubicin distribution and its relation to multidrug resistance phenotype in drug-resistant cell line SMMC-7721/R显示文摘AIM: To investigate the correlation between subcellulardaunorubicin distribution and the multidrug resistancephenotype in drug-resistant cell line SMMC-7721/R.METHODS: The multidrug resistant cell line SMMC-7721/R, a human hepatocellular carcinoma cell line,was established. Antisense oligonudeotides (AS-ODN)were used to obtain different multidrug resistancephenotypes by inhibiting the expression of mdr1 geneand/or multidrug resistance-related protein gene(mrp)using Lipofectamine as delivery agent. Expression ofmdr1 and mrp genes was evaluated by RT-PCR andWestern blotting. Intracellular daunorubicin (DNR)concentration was measured by flow cytometry.Subcellular DNR distribution was analyzed by confocallaser scanning microscopy. Adriamycin (ADM) and DMRsensitivity was examined by MTT method.RESULTS: Low level expression of mdr1 and mrp mRNAsand no expression of P-Glycoprotein(P-gp) andmultidrug resistance-related protein (P190) weredetected in parental sensitive cells SMMC-7721/S, butover-expression of these two genes was observed indrug-resistant cell SMMC-7721/R. The expression ofmdr1 and mrp genes in SMMC-7721/R cells was downregulated to the level in the SMMC-7721/S cells by AS-ODN. Intracellular DNR concentration in SMMC-7721/S cells was 10 times higher than that in SMMC-7721/Rcells. In SMMC7721/S cells intracellular DNRdistributed evenly in the nucleus and cytoplasm, whilein SMMC-7721/R cells DNR distributed in a punctatepattern in the cytoplasm and was reduced in thenucleus. DNR concentration in SMMC-7721/R cells co-transfected with AS-ODNs targeting to mdr1 and mrpmRNAs recovered to 25 percent of that in SMMC7721/Scells. Intracellular DNR distribution pattern in drug-resistant cells treated by AS-ODN was similar to drug-sensitive cell, and the cells resistance index (RI) to DNRand ADM decreased at most from 88.0 and 116.0 to 4.0and 2.3, respectively. Co-Transfection of two AS-ODNsshowed a stronger synergistic effect than separatetransfection.CONCLUSIONS: P-gp and P190 are two membersmediating MDR in cell line SMMC7721/R. Intracellulardrug concentration increase and subcellular distributionchange are two important factors in multidrugresistance (MDR) formation. The second factor, drugstransport by P-gp and P190 from cell nucleus to organellin cytoplasm, may play a more important role. | Jia-Yin Yang Hua-You Luo Qi-Yuan Lin Zi-Ming Liu Lu-Nan Yan Department of General Surgery,West China Hospital,Sichuan University,Chengdu 610044,Sichuan Province,China Ping Lin Cancer Research Institution,West China Hospital,Sichuan University,610044,Sichuan Province,China Jie Zhang Department of Confocal Laser Scanning Microscopy,West China Hospital,Sichuan University,610044,Sichuan Province,China Shong Lei Cancer Biotechnological Treatment Center,West China Hospital,Sichuan University,610044,Sichuan Province,China | 2002 | World Journal of Gastroenterology2002，8，4： | 12 |
| 19 | Seasonal and inter-annual variations in carbon fluxes and evapotranspiration over cotton field under drip irrigation with plastic mulch in an arid region of Northwest China显示文摘Xinjiang is the largest semi-arid and arid region in China, and drip irrigation under plastic mulch is widely used in this water-limited area. Quantifying carbon and water fluxes as well as investigating their environmental drivers over cotton fields is critical for understanding regional carbon and water budgets in Xinjiang, the largest cotton production basin of China. In this study, an eddy covariance(EC) technique was used to measure the carbon and water fluxes of cotton field under drip irrigation with plastic mulch in the growing seasons of 2009, 2010, 2012 and 2013 at Wulanwusu Agrometeorological Experiment Station, a representative oasis cropland in northern Xinjiang. The diurnal patterns of gross primary production(GPP), net ecosystem exchange(NEE) and evapotranspiration(ET) showed obviously sinusoidal variations from June to September, while the diurnal ecosystem respiration(Res) was stable between daytime and nighttime. The daytime hourly GPP and ET displayed asymptotic relationships with net solar radiation(Rnet), while showed concave patterns with raising vapor pressure deficit(VPD) and air temperature(Ta). The increases in hourly GPP and ET towards the maximum occurred over half ranges of VPD and Ta. The seasonal variations of GPP, NEE and ET were close to the cotton phenology, which almost reached the peak value in July. The cumulative GPP averaged 816.2±55.0 g C/m2 in the growing season(from April to October), and more than half of GPP was partitioned into NEE(mean value of –478.6±41.4 g C/m2). The mean seasonal ET was 501.3±13.9 mm, and the mean water use efficiency(WUE) was 1.0±0.1(mg C/g H2O)/d. The agro-ecosystem behaved as a carbon sink from squaring to harvest period, while it acted as a carbon source before the squaring time as well as after the harvest time. | Jie BAI Jin WANG Xi CHEN Ge Ping LUO Hao SHI Long Hui LI Jun Li LI | 2015 | Journal of Arid Land2015，7，2： | 12 |
| 20 | 源自前列腺基底细胞的前列腺部尿道再上皮化方式可能是2微米激光犬前列腺切除术后创面理想修复方式显示文摘本研究通过观察2微米激光犬前列腺切除术(two-micronlaser resection of the prostate,TmLRP)后前列腺部尿道创伤修复病理组织学改变,探讨前列腺部尿道创面再上皮化方式并评估该再上皮化方式的效果。选取15只成年健康雄性中华田园犬,分别行2微米激光前列腺汽化切除术及部分膀胱颈黏膜切除术,于术后3天、1、2、3及4周处死动物,留取前列腺部尿道及膀胱颈标本,苏木素伊红染色(Hematoxylin eosin,HE)染色光镜下观察创面再上皮化病理组织学改变,免疫组织化学染色检测前列腺部尿道创面细胞角蛋白14(Cytokeratin,CK14)、CK5、 CK18 , 突触素(Synaptophysin,Syn)、嗜铬素(Chromogranin A , CgA)、尿斑蛋白(uroplakin)、转化生长因子β1 (Transforming growth factor-β1, TGF-β1)和转化生长因子βII受体(Transforming growth factor-β type II receptor,TGF-βRI I)的表达,实时定量PCR方法检测前列腺部尿道创面CK14、CK5、CK18和Syn mRNA表达,Van Gieson染色分别检测前列腺部尿道和膀胱颈创面胶原纤维表达量。结果显示,前列腺部尿道由创面下残余前列腺上皮细胞增殖、迁移再分化完成再上皮化过程;创面下增殖的前列腺上皮细胞表达CK14,CK5,不表达CK18、Sy n和CgA,再生上皮术后3周开始表达uroplakin。增殖的前列腺细胞和再生上皮高表达TGF-β1和TGF-β RII,表达强度与创面修复再上皮化时间密切相关。与膀胱颈创面相比,前列腺部尿道创面再上皮化完成快,创面下胶原纤维形成少。因此,源自创面下前列腺基底细胞的再上皮化方式可能是机体实现由解剖修复到功能修复的最佳修复方式。 | Ying Cao Guang-Heng Luo Lei Luo Xiu-Shu Yang Jian-Xin Hu Hua Shi Ping Huang Zhao-Lin Sun Shu-Jie Xia | 2015 | Asian Journal of Andrology2015，17，5： | 12 |
您所在的机构暂未开通此部分的功能，请联系管理员