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| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 2 |
| 3 | Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis显示文摘 | Maarten Boers Arco C Verhoeven Harry M Markusse Mart AFJ van de Laar Rene Westhovens J Christiaan van Denderen Derkjen van Zeben Ben AC Dijkmans Andre J Peeters Piet Jacobs Hans R van den Brink Hubert JA Schouten Désirée MFM van der Heijde Annelies Boonen | 1997 | The Lancet1997，，9074： | 1 |
| 4 | Tumor infiltrating lymphocytes and macrophages have a potential dual role in lung cancer by supporting both host-defense and tumor progression显示文摘 | Kataki A Scheid P Piet M | 2002 | J Lab Clin Med2002，140，5： | 1 |
| 5 | Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction显示文摘AIM: To characterise the effect of energy restriction (ER) on liver lipid and primary metabolite profile by using metabolomic approach. We also investigated whether the effect of energy restriction can be further enhanced by modif ication of dietary protein source and calcium. METHODS: Liver metabolomic profile of lean and obese C57Bl/6J mice (n = 10/group) were compared with two groups of weight-reduced mice. ER was performed on control diet and whey protein-based high-calcium diet (whey + Ca). The metabolomicanalyses were performed using the UPLC/MS based lipidomic platform and the HPLC/MS/MS based primary metabolite platform. RESULTS: ER on both diets significantly reduced hepatic lipid accumulation and lipid droplet size, while only whey + Ca diet significantly decreased blood glucose (P < 0.001) and serum insulin (P < 0.01). In hepatic lipid species the biggest reduction was in the level of triacylglycerols and ceramides while the level of cholesterol esters was significantly increased during ER. Interestingly, diacylglycerol to phospholipid ratio, an indicator of relative amount of diabetogenic diglyceride species, was increased in the control ER group, but decreased in the whey + Ca ER group (P < 0.001, vs obese). ER on whey + Ca diet also totally reversed the obesity induced increase in the relative level of lipotoxic ceramides (P < 0.001, vs obese; P > 0.05, vs lean). These changes were accompanied with up-regulated TCA cycle and pentose phosphate pathway metabolites. CONCLUSION: ER-induced changes on hepatic metabolomic profile can be significantly affected by dietary protein source. The therapeutic potential of whey protein and calcium should be further studied. | Taru K Pilvi Tuulikki Seppnen-Laakso Helena Simolin Piet Finckenberg Anne Huotari Karl-Heinz Herzig Riitta Korpela Matej Orei Eero M Mervaala | 2008 | World Journal of Gastroenterology2008，14，28： | 1 |
| 6 | Extending the enterprise through multi - level supply control显示文摘 | Piet van Vlist Jurgen J E M Hoppembrouwers Herman M H Hegge | 1997 | International Journal of Production Economics1997，53，： | 1 |
| 7 | The effect of estrogen receptor genotype on litter size and placental traits at term in F2 crossbred gilts显示文摘 | Birgitte T T M V R Piet N D G Tette V D L | 2002 | Theriogenology2002，57，： | 1 |
| 8 | Effect of addi- tion of graft copolymer on the microstructure and impact strength of PS/LDPE blends 显示文摘 | Barentsen W M Heikens D Piet P | 1974 | Polymer1974，15，2： | 1 |
| 9 | Focal Nodular Hyperplasia: Findings at state of the art MR imaging, US, CT and Pathologic Analysis显示文摘 | S hahid M H ussain T T Piet er E | 2004 | Radiographics2004，7，24： | 1 |
| 10 | The Fibroneetin Binding Proteins of Staphylococcus aureus Are Requiredand Invasion of Bovine Mammary Gland Cells显示文摘 | Aart L Piet J M Nuijtenl | 1999 | FEMS Microbiology Lettres1999，1，180： | 1 |
| 11 | Antiviral activity of C-Alkylated pruine nueleosides obtained by erose-eoupling with tetralkyltin reagnts显示文摘 | Van A A Petros M Piet A | 1993 | Journal of Medicinal Chemistry1993，36，： | 1 |
| 12 | Lubricant replenishment in rolling bearing contacts显示文摘 | Leonid G Mats G L Piet M L | 2008 | STLE Trans2008，51，： | 1 |
| 13 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 1 |
| 14 | An analysis of real-Fourier domain-based adaptive algorithms implemented with the Hartley transform using cosine-sine symmetries显示文摘 | Vasanthan Raghavan Prabhu K M M Sommen Piet C W | 2005 | IEEE Transactions on signal processing2005，53，2： | 1 |
| 15 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 1 |
| 16 | Cardiac resynchronization therapy can reverse abnormal myocardial strain distribution in patients with heart failure and left bundle branch block显示文摘 | Ole-A Breithardt Christoph Stellbrink Lieven Herbots Piet Claus Anil M Sinha Bart Bijnens Peter Hanrath George R Sutherland | 2003 | Journal of the American College of Cardiology2003，，： | 1 |
| 17 | A water-soluble diphosphine ligand with a large ‘natural' bite angle for two-phase hydroformylation of alkenes显示文摘 | MARCEL SCHREUDER GOEDHEIJT PAUL C J KAMER PIET W N M VAN LEEUWEN | 1998 | J Mol Catal A:Chem1998，134，： | 1 |
| 18 | Application of bacteriainvolved in the biological sulfur cycle for paper mill effluent purification 显示文摘 | Albert J H J Piet N L L Alfons J M S | 2009 | Science of the Total Environment2009，407，： | 1 |
| 19 | The Effect of Roads and Traffic on Hedgenhog (Erinaceus Europaeus) Populations 显示文摘 | Marcel P H Piet J M B | 2000 | Biological Conservation2000，95，： | 1 |
| 20 | Self-medication with antibiotics-dose it really happen in Europe显示文摘 | Vaananen MH Piet ila K Airaksinen M | 2006 | Health Pol icy2006，77，： | 1 |
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