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| 1 | Current Status and Future Challenges of Weather Radar Polarimetry: Bridging the Gap between Radar Meteorology/Hydrology/Engineering and Numerical Weather Prediction显示文摘After decades of research and development, the WSR-88 D(NEXRAD) network in the United States was upgraded with dual-polarization capability, providing polarimetric radar data(PRD) that have the potential to improve weather observations,quantification, forecasting, and warnings. The weather radar networks in China and other countries are also being upgraded with dual-polarization capability. Now, with radar polarimetry technology having matured, and PRD available both nationally and globally, it is important to understand the current status and future challenges and opportunities. The potential impact of PRD has been limited by their oftentimes subjective and empirical use. More importantly, the community has not begun to regularly derive from PRD the state parameters, such as water mixing ratios and number concentrations, used in numerical weather prediction(NWP) models.In this review, we summarize the current status of weather radar polarimetry, discuss the issues and limitations of PRD usage, and explore potential approaches to more efficiently use PRD for quantitative precipitation estimation and forecasting based on statistical retrieval with physical constraints where prior information is used and observation error is included. This approach aligns the observation-based retrievals favored by the radar meteorology community with the model-based analysis of the NWP community. We also examine the challenges and opportunities of polarimetric phased array radar research and development for future weather observation. | Guifu ZHANG Vivek N.MAHALE Bryan J.PUTNAM Youcun QI Qing CAO ANDrew D.BYRD Petar BUKOVCIC Dusan S.ZRNIC Jidong GAO Ming XUE Youngsun JUNG Heather D.REEVES Pamela L.HEINSELMAN AlexANDer RYZHKOV Robert D.PALMER Pengfei ZHANG Mark WEBER Greg M.MCFARQUHAR Berrien MOORE III Yan ZHANG Jian ZHANG J.VIVEKANANDAN Yasser AL-RASHID Richard L.ICE Daniel S.BERKOWITZ Chong-chi TONG Caleb FULTON Richard J.DOVIAK | 2019 | Advances in Atmospheric Sciences2019，36，6： | 9 |
| 2 | Control of Cell Wall Extensibility during Pollen Tube Growth显示文摘在这评论,当时,我们探讨成长尖端的花粉试管怎么完成它延伸的快速的率的问题 maintainingan 未经触动的房间墙。尽管 turgor 是必要的让生长发生,本地扩大率被本地 changesin 控制顶端的墙的粘性。我们集中于是思维 tobe 的几不同结构和内在的过程肌动朊细胞骨架,钙和质子生理学的主要参加者包括 exocytosis,组织和活动,和细胞的 energetics。我们认为肌动朊细胞骨架,特别地顶端的外皮的肌动朊穗,指导泡的 theflow 到顶端的领域,在他们与血浆膜熔化并且作出贡献的地方,他们到 expandingcell 的内容围。当时 pH 坡度由沿着 clearzone 的方面位于血浆膜的 proton-ATPase 产生了可以在穗调整快速的肌动朊周转和新聚合,集中尖端的钙坡度偏爱 secretiontowards 极的轴。显示出新墙材料的那 exocytosis 的最近的数据先于并且预言过程 ofcell 延伸为最新分泌的果胶的摄取贡献减少 inapical 的想法提供支持墙粘性并且到房间扩大。另外的主要因素将是由果胶的酸的钙的酶 pectinmethyl-esterase,和 chelation 的本地化和活动。最后,我们为反应的氧 speciesin 承认一个角色墙 viscosity.Key 词的控制: | Peter K. Hepler Caleb M. Rounds Lawrence J. Winship | 2013 | Molecular Plant2013，6，4： | 9 |
| 3 | 粳稻杂种优势遗传基础剖析显示文摘为了解控制粳稻产量相关性状及其中亲优势的基因作用类型,利用秀堡RIL群体及其2个回交(BCF1)群体对株高、生育期、单株有效穗数、穗长、每穗颖花数、结实率、一次枝梗数和二次枝梗数8个性状及其中亲杂种优势进行QTL定位。共检测到58个显著的主效QTL(M-QTL),单个M-QTL的贡献率变幅为3.3%~41.9%。77.6%的M-QTL表现为加性效应,15.5%的M-QTL表现为部分或完全显性效应,6.9%的M-QTL表现为超显性效应。共检测到90对显著的双基因上位性QTL(E-QTL)。在RIL群体中检测到44对E-QTL,单对E-QTL的贡献率变幅为1.7%~8.0%,平均3.7%。在XSBCF1群体中检测到27对E-QTL,其中利用BCF1表型值检测到16对E-QTL,单对E-QTL的贡献率变幅为12.7%~78.5%,平均29.2%;利用中亲优势值检测到11对E-QTL,单对E-QTL的贡献率变幅为15.0%~71.8%,平均40.1%。在CBBCF1群体中检测到19对E-QTL,其中利用BCF1表型值检测到12对E-QTL,单对E-QTL的贡献率变幅为2.7%~64.4%,平均30.1%;利用中亲优势值检测到9对E-QTL,单对E-QTL的贡献率变幅为21.7%~64.1%,平均40.0%。在CBBCF1群体中,利用BCF1表型值和中亲优势值都检测到的E-QTL有2对。上述结果表明上位性效应是粳稻秀堡组合杂种优势的主要遗传基础。 | 江建华 刘强明 卢超 张红 刘晓丽 党小景 牛付安 Manamik Caleb BRERIA 赵凯铭 洪德林 | 2012 | 作物学报2012，38，12： | 6 |
| 4 | Obsessive-compulsive disorder:Evidence-based treatments and future directions for research显示文摘Over the past three decades, obsessive-compulsive disorder(OCD) has moved from an almost untreatable,life-long psychiatric disorder to a highly manageable one. This is a very welcome change to the 1%-3% of children and adults with this disorder as, thanks to advances in both pharmacological and psychological therapies, prognosis for those afflicted with OCD is quite good in the long term, even though most have comorbid disorders that are also problematic. We still have far to go, however, until OCD can be described as either easily treatable or the effective treatments are widely known about among clinicians. This review focuses on the current state of the art in treatment for OCD and where we still are coming up short in our work as a scientific community. For example, while the impact of medications is quite strong for adults in reducing OCD symptoms, current drugs are only somewhat effective for children. In addition, there are unacceptably high relapse rates across both populations when treated with pharmacological alone. Even in the cognitive-behavioral treatments, which show higher effect sizes and lower relapse rates than drug therapies, drop-out rates are at a quarter of those who begin treatment. This means a sizable portion of the OCD population who do obtain effective treatments(which appears to be only a portion of the overall population) are not effectively treated.Suggestions for future avenues of research are also presented. These are primarily focused on(1) increased dissemination of effective therapies;(2) augmentation of treatments for those with residual symptoms, both for psychotherapy and pharmacotherapy; and(3) the impact of comorbid disorders on treatment outcome. | Caleb W Lack | 2012 | World Journal of Psychiatry2012，2，6： | 4 |
| 5 | Ergosterol-loaded poly(lactide-co-glycolide) nanoparticles with enhanced in vitro antitumor activity and oral bioavailability显示文摘瞄准:麦角固醇是有反肿瘤和 anti-angiogenic 活动的植物甾醇,但是是糟糕可溶的。在这研究,我们试图提高它的反肿瘤行动和口头的 bioavailability 经由 poly (lactide-co-glycolide )(PLGA ) nanoparticle encapsulation.Methods:装载麦角固醇的 PLGA nanoparticles (NPs/Erg ) 用乳剂 / 溶剂蒸发技术被准备。他们的物理化学的性质被描绘,并且他们对人的癌症房间线的 cytotoxicity 与 MTT 试金被评估。NPs/Erg 的 pharmacokinetics 和织物分发在老鼠和老鼠被调查, respectively.Results:NPs/Erg 在有 156.9 ± 的一种粒子尺寸的形状是球形的; 4.8 nm 和 -19.27±1.13 mV 的一个希腊语的第六个字母潜力,和有的可接受的封装效率和装载能力。NPs/Erg 比免费麦角固醇对人的癌症房间施加了强壮得多的 cytotoxicity,并且显示出显著地减少的 IC 50 价值(14.69 ± 0.48 μ在 glioma U251 房间的 g/mL;9.43 ± 0.52 μ在乳癌 MCF-7 房间的 g/mL;4.70 ± 0.41 μ在 hepatoma HepG2 房间的 g/mL ) 。在在老鼠的单个剂量的口头的管理以后, NPs/Erg 与免费麦角固醇相比随口头的 bioavailability 的 4.9 褶层增加显示了延长血浆发行量。在老鼠收到了 NPs/Erg 以后,在 NPs/Erg 的麦角固醇很快在胃被散布,肾,肝,大脑,怒气,并且在心和肺几乎不存在。在大脑的 NPs/Erg 的存在特别地与免费 ergosterol.Conclusion 相比被改进:PLGA nanoparticles 为糟糕可溶的麦角固醇担任一个有希望的搬运人并且显著地改进它的 bioavailability, biodistribution 并且在 vitro 反肿瘤活动。 | Hui-yun ZHANG Caleb Kesse FIREMPONG Yuan-wen WANG Wen-qian XU Miao-miao WANG Xia CAO Yuan ZHU Shan-shan TONG Jiang-nan YU Xi-ming XU | 2016 | Acta Pharmacologica Sinica2016，37，6： | 3 |
| 6 | Modified Atmosphere Packaging Technology of Fresh and Fresh-cut Produce and the Microbial Consequences—A Review显示文摘 | Oluwafemi J. Caleb Pramod V. Mahajan Fahad Al-Julanda Al-Said Umezuruike Linus Opara | 2013 | Food and Bioprocess Technology2013，，2： | 3 |
| 7 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 2 |
| 8 | Development and Application of SCAR Markers for Discriminating Cytoplasmic Male Sterile Lines from Their Cognate Maintainer Lines in Indica Rice显示文摘The DNA fragments about 1 600 bp were amplified using random amplified polymorphism DNA (RAPD) primer OPA12 with the templates of mitochondrial DNA of Zhenshan 97A and Zhenshan 97B,and were sequenced.The nucleotide sequences and lengths of the fragments from Zhenshan 97A and Zhenshan 97B showed no difference.The precise length of the fragment was 1 588 bp.Sequence characterized amplification region (SCAR) primers were then developed to discriminate the cytoplasmic male sterile (CMS) lines and their maintainer lines.A specific 1 588 bp fragment could be amplified with SCAR primers,CHI19F2/CHI19R2 and CHI20F3/CHI23R3,in the mitochondrial DNA of Zhenshan 97A,but not Zhenshan 97B.Furthermore,the specific fragment could be also amplified from the total DNA from green leaf tissues of Zhenshan 97A with SCAR primers,but not Zhenshan 97B.With the corresponding primers,the specific fragment could also be amplified from the total DNA of green leaves of other two CMS lines with wild abortive type cytoplasm (CMS-WA),namely Zhenpin A and Tianfeng A,but not in their maintainer lines.Moreover,using total DNA as template,each of the four pairs of SCAR primers could also be used to amplify the 1 588 bp fragment in CMS-ID (Indonesia paddy type) line Ⅱ-32A,but not in II-32B,and the specific fragment was amplified from the DNA of both F1 and F2 seedlings of Shanyou 63.The results of detecting the genetic purity of a man-made mixture of the seeds of Zhenshan 97A using CHI20F3/CHI23R3 were completely consistent with the phenotypes.Taken together,these results indicated that the specific 1 588 bp-fragment amplified by CHI20F3/CHI23R3 was the unique amplification products of CMS mitochondrial DNA,and could be used to distinguish CMS-WA and CMS-ID lines from their corresponding maintainer lines at the seedling stage. | LU Chao LIU Jian JIANG Jian-hua Caleb Manamik BRERIA TAN He-lin Masahiko ICHII HONG De-lin | 2013 | Rice science2013，20，3： | 2 |
| 9 | Recent Progress in Exploiting Small Molecule Peptides as Supramolecular Hydrogelators显示文摘Small molecule peptides and their derivatives are an emerging class of supramolecular hydrogelators that have attracted rapidly growing interest in the fields of drug delivery and regenerative medicine due to their inherent biodegradability and biocompatibility, as well as versatility in molecular design and ease of synthesis. Built upon the directional, intermolecular interactions such as hydrogen bonding and π-π stacking, peptide-based molecular units can associate in aqueous solution into filamentous assemblies of various sizes and shapes. Under appropriate conditions, these filamentous assemblies can percolate into a 3D network with materials properties tailorable for specific biomedical applications. In this review, we survey the literature published over the past three years in the development of peptide-based hydrogelators for biomedical applications. We highlight several representative examples and center our discussion on the fundamentals of molecular design, assembly, and gelation conditions. | Hao Su Yuzhu Wang Caleb F.Anderson Jin Mo Koo Han Wang Honggang Cui | 2017 | Chinese Journal of Polymer Science2017，35，10： | 2 |
| 10 | Effect of modified atmosphere packaging and storage temperature on volatile composition and postharvest life of minimally processed pomegranate arils显示文摘 | Caleb OJ Opara UL Mahajan PV | 2013 | Postharvest Biology and Technology2013，79，： | 1 |
| 11 | Cross‐resistance with dieldrin of a novel tricyclic dinitrile GABA receptor antagonist显示文摘 | KazuhikoMatsuda Alastair MHosie Caleb WHolyoke James JRauh David BSattelle | 2009 | British Journal of Pharmacology2009，，6： | 1 |
| 12 | Intervention with the aldose reducatase inhibitor,tolrestat,in renal and retinal lesions of streptozotocin-diabetic rats显示文摘 | Caleb ML Kean ML Hohman TC | 1991 | Diabetologia1991，34，10： | 1 |
| 13 | Cataract blindness, surgical coverage, outcome and barriers to uptake of cataract services in Plateau State, Ni- geria显示文摘 | Ojo P Odugbo Caleb D | 2012 | Middle East Afr J Ophthalmol2012，19，： | 1 |
| 14 | Biobehavioral assessment of the anxiety disorders:Current progress and future directions显示文摘It is difficult to accurately assess and differentially diagnose the anxiety disorders.The current system of assessment relies heavily on the subjective measures of client self-report,clinical observation,and clinical judgment.Fortunately,recent technological advances may enable practitioners to utilize objective,biobehavioral measures of assessment in a clinical setting.The current body of literature on two of these biobehavioral tools(eyetracking and electrocardiogram devices) is promising,but more validation and standardization research is needed to maximize the utility of these devices.Eye-tracking devices are uniquely capable of providing data that can be used to differentially diagnose anxiety disorders from both other commonly comorbid and misdiagnosed disorders.Both eye-tracking and electrocardiogram devices are able to provide change-sensitive assessment information.This objective,real-time feedback can assist clinicians and researchers in assessing treatment efficacy and symptom fluctuation.Recently developed wearable and highly portable electrocardiogram devices,like the wearable fitness and behavior tracking devices used by many consumers,may be particularly suited for providing this feedback to clinicians.Utilizing these biobehavioral devices would supply an objective,dimensional component to the current categorical diagnostic assessment system.We posit that if adequate funding and attention are directed at this area of research,it could revolutionize diagnostic and on-going assessment practices and,in doing so,bring the field of diagnosis out of the 20 th century. | Deah Abbott Yasmin Shirali J Kyle Haws Caleb W Lack | 2017 | World Journal of Psychiatry2017，7，3： | 1 |
| 15 | National trends in treatment of type 2 diabetes mellitus,1994-2007显示文摘 | G Caleb Alexander Niraj L Sehgal Rachael M | 2008 | Arch Intern Med2008，168，19： | 1 |
| 16 | Sleep-related problems in pediatric obsessive-compulsive disorder显示文摘 | Eric A. Storch Tanya K. Murphy Caleb W. Lack Gary R. Geffken Marni L. Jacob Wayne K. Goodman | 2007 | Journal of Anxiety Disorders2007，，5： | 1 |
| 17 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 1 |
| 18 | Functional intrapelvic neuroanatomy of the male urethral sphincter assessed by intra operative nerve stimulation显示文摘 | Caleb PN John Twei | 2002 | J Urol2002，167，4： | 1 |
| 19 | A study of methodsof carbon dioxide capture and sequestration:The sustainability ofaphotosynthetic bioreactor approach显示文摘 | CALEB STEWART MIR-AKBAR HESSAMI | 2005 | Energy Conversion andManagement2005，，46： | 1 |
| 20 | A study of methods of carbon dioxide capture and sequestration 显示文摘 | Caleb S Hessami M | 2005 | Energy Convers Manage2005，46，3： | 1 |
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