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| 1 | On the combined effect of soil fertility and topography on tree growth in subtropical forest ecosystems—a study from SE China显示文摘Aims The aim of our research was to understand small-scale effects of topography and soil fertility on tree growth in a forest biodiversity and ecosystem functioning(BEF)experiment in subtropical SE China.Methods Geomorphometric terrain analyses were carried out at a spatial resolution of 5×5 m.Soil samples of different depth increments and data on tree height were collected from a total of 566 plots(667 m2 each).The soils were analyzed for carbon(soil organic carbon[SOC]),nitrogen,acidity,cation exchange capacity(CEC),exchangeable cations and base saturation as soil fertility attributes.All plots were classified into geomorphological units.Analyses of variance and linear regressions were applied to all terrain,soil fertility and tree growth attributes.Important Findings In general,young and shallow soils and relatively small differences in stable soil properties suggest that soil erosion has truncated the soils to a large extent over the whole area of the experiment.This explains the concurrently increasing CEC and SOC stocks downslope,in hollows and in valleys.However,colluvial,carbon-rich sediments are missing widely due to the convexity of the footslopes caused by uplift and removal of eroded sediments by adjacent waterways.The results showed that soil fertility is mainly influenced by topography.Monte-Carlo flow accumulation(MCCA),curvature,slope and aspect significantly affected soil fertility.Furthermore,soil fertility was affected by the different geomorphological positions on the experimental sites with ridge and spur positions showing lower exchangeable base cation contents,especially potassium(K),due to leaching.This geomorphological effect of soil fertility is most pronounced in the topsoil and decreases when considering the subsoil down to 50 cm depth.Few soil fertility attributes affect tree height after 1-2 years of growth,among which C stocks proved to be most important while pH_(KCl)and CEC only played minor roles.Nevertheless,soil acidity and a high proportion of Al on the exchange complex affected tree height even after only 1-2 years growth.Hence,our study showed that forest nutrition is coupled to a recycling of litter nutrients,and does not only depend on subsequent supply of nutrients from the mineral soil.Besides soil fertility,topography affected tree height.We found that especially MCCA as indicator of water availability affected tree growth at small-scale,as well as aspect.Overall,our synthesis on the interrelation between fertility,topography and tree growth in a subtropical forest ecosystem in SE China showed that topographic heterogeneity lead to ecological gradients across geomorphological positions.In this respect,small-scale soil-plant interactions in a young forest can serve as a driver for the future development of vegetation and biodiversity control on soil fertility.In addition,it shows that terrain attributes should be accounted for in ecological research. | Thomas Scholten Philipp Goebes Peter Kühn Steffen Seitz Thorsten Assmann Jürgen Bauhus Helge Bruelheide Francois Buscot Alexandra Erfmeier Markus Fischer Werner Härdtle Jin-Sheng He Keping Ma Pascal A.Niklaus Michael Scherer-Lorenzen Bernhard Schmid Xuezheng Shi Zhengshan Song Goddert von Oheimb Christian Wirth Tesfaye Wubet Karsten Schmidt | 2017 | Journal of Plant Ecology2017，10，1： | 22 |
| 2 | Liver surgery in cirrhosis and portal hypertension显示文摘The prevalence of hepatic cirrhosis in Europe and the United States, currently 250 patients per 100000 inhabitants, is steadily increasing. Thus, we observe a significant increase in patients with cirrhosis and portal hypertension needing liver resections for primary ormetastatic lesions. However, extended liver resections in patients with underlying hepatic cirrhosis and portal hypertension still represent a medical challenge in regard to perioperative morbidity, surgical management and postoperative outcome. The Barcelona Clinic Liver Cancer classification recommends to restrict curative liver resections for hepatocellular carcinoma in cirrhotic patients to early tumor stages in patients with Child A cirrhosis not showing portal hypertension. However, during the last two decades, relevant improvements in preoperative diagnostic, perioperative hepatologic and intensive care management as well as in surgical techniques during hepatic resections have rendered even extended liver resections in higher-degree cirrhotic patients with portal hypertension possible. However, there are few standard indications for hepatic resections in cirrhotic patients and risk stratifications have to be performed in an interdisciplinary setting for each individual patient. We here review the indications, the preoperative risk-stratifications, the morbidity and the mortality of extended resections for primary and metastatic lesions in cirrhotic livers. Furthermore, we provide a review of literature on perioperative management in cirrhotic patients needing extrahepatic abdominal surgery and an overview of surgical options in the treatment of hepatic cirrhosis. | Christina Hackl Hans J Schlitt Philipp Renner Sven A Lang | 2016 | World Journal of Gastroenterology2016，22，9： | 21 |
| 3 | Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-κB activation显示文摘AIM: Different strains of bifidobacteria were analysed for their effects on HT-29 intestinal epithelial cells (IECs) in in vitro models both of the non-inflamed and inflamed intestinal epithelium. METHODS: A reporter gene system in HT-29 cells was used to measure levels of NF-KB activation after challenge with bifidobacteria or after bacterial pre-treatment following LPS challenge. IL-8 protein and pro-inflammatory gene expression was investigated using normal HT-29 cells. RESULTS: None of the bifidobacteria tested induced activation of nuclear factor KB (NF-KB) indicating that bifidobacteria themselves do not induce inflammatory events in IECs. However, six out of eight bifidobacteria tested inhibited lipopolysaccharide- (LPS-) induced NFKB activation in a dose- and strain-dependent manner. In contrast, NF-KB activation in response to challenge with tumor necrosis factor-α(TNF-α) was affected by none of the tested bifidobacteria, indicating that the inhibitory effect of bifidobacteria is specific for LPS-induced inflammation in IECs. As shown with two of the six inhibitionpositive bifidobacteria, LPS-induced inhibition of NFKB activation was accompanied by a dose-dependent decrease of interleukin 8 (IL-8) secretion and by lower mRNA levels for IL-8, TNF-a, cyclooxygenase 2 (Cox-2), and intercellular adhesion molecule 1 (ICAM-1). CONCLUSION: Some strains of bifidobacteria are effective in inhibiting LPS-induced inflammation and thus might be appropriate candidates for probiotic intervention in chronic intestinal inflammation. | Christian U Riedel Francis Foata David Philippe Oskar Adolfsson Bernhard J Eikmanns Stephanie Blum | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 4 | 无桔霉素红曲色素突变株FM5183对单谷氨酸钠(MSG)、组氨酸的代谢特性显示文摘经过复合诱变处理得到的产无桔霉素的红曲色素变异株 ,编号为FM51 83,在摇瓶条件下分批深层培养 ,研究了菌株在碳源为葡萄糖条件下对单谷氨酸钠 (MSG)、组氨酸的代谢特性 ,该菌株分别在含MSG和组氨酸情况下 ,对产生的中间产物苹果酸和乙醇的代谢特性进行了比较 ,结果表明 :突变菌株FM51 83产生的酒精量为 2 5~ 2 7g L ,苹果酸浓度最大值为 5 8g L ;另外 ,在含MSG和组氨酸的培养基上对产生的色素量进行测定 ,其色价分别为 2 5 5和 1 1 8,对试验所用的氮源等条件下 ,整个发酵过程未有桔霉素检出。突变菌株FM51 83是一株较理想的无桔霉素红曲色素工业化生产菌株。 | 吴祖芳 翁佩芳 张礼星 Philippe J BLANC | 2002 | 生物技术2002，12，6： | 6 |
| 5 | 混合培养微生物利用甘油补料发酵生产乙醇研究显示文摘采用浸麻芽孢杆菌和红曲菌9906利用甘油混合发酵生产乙醇.结果表明,分批发酵中高浓度的甘油对乙醇发酵有着较强的抑制作用,分批发酵最佳甘油浓度为0.217molL-1.在分批发酵的基础上补料发酵,考察了不同甘油浓度的补料液和不同补料时间对乙醇发酵的影响.最终确定乙醇补料发酵较优的工艺条件为:反应器1L,装液量700mL红曲发酵液,甘油初始浓度为0.217molL-1,以补料方式每隔60h分5次补加0.217molL-1甘油浓度的红曲发酵液,每次补加100mL,发酵培养360h.当乙醇最高浓度达0.221molL-1,乙醇总产率0.628mmolh-1,乙醇/甘油转化率达87%(molmol-1).与分批发酵相比,补料发酵很大程度解除了高浓度甘油的抑制作用,有效地利用了甘油,提高了乙醇的产量,且乙醇产率较为稳定. | 张宏武 王璐 许赣荣 BLANC Philippe J | 2008 | 应用与环境生物学报2008，14，5： | 6 |
| 6 | Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial显示文摘 | Geert D’Haens Filip Baert Gert van Assche Philip Caenepeel Philippe Vergauwe Hans Tuynman Martine De Vos Sander van Deventer Larry Stitt Allan Donner Severine Vermeire Frank J Van De Mierop Jean-Charles R Coche Janneke van der Woude Thomas Ochsenkühn Ad A | 2008 | The Lancet2008，，9613： | 5 |
| 7 | Management of digestive bleeding related to portal hypertension in cirrhotic patients:A French multicenter cross-sectional practice survey显示文摘AIM: To investigate the conformity of management practices of gastrointestinal hemorrhage in cirrhotic patients with relevant guidelines. METHODS: A questionnaire on the management of digestive bleeding was completed for all consecutive cirrhotic patients admitted to 31 French hospitals. RESULTS: One hundred and twenty-six bleeding events were recorded. It was the first bleeding episode in 79 patients (63%), of whom 40 (51%) had a prior diagnosis of cirrhosis and 25 (32%) had previously undergone an endoscopy. The bleeding episode was a recurrence in 46 patients (37%). The median time between onset and admission was 4 h, but exceeded 12 h in 42% of cases. There was an agreement between centers forearly vasoactive drug administration (87% of cases), association with ligation (42%) more often than sclerosis (21%) at initial endoscopy, and antibiotic prophylaxis (64%). By contrast, prescription of beta-blockade alone or in combination (0 to 100%, P = 0.003) for secondary prophylaxis and lactulose (26% to 86%, P = 0.04), differed among centers. CONCLUSION: In French hospitals, management of bleeding related to portal hypertension in cirrhotic patients is generally in keeping with the consensus. Broad variability still remains concerning beta-blockade use for secondary prophylaxis. Screening for esophageal varices, the use of antibiotic prophylaxis and patients information need to be improved. | Pierre Ingrand Jérme Gournay Pierre Bernard Frédéric Oberti Brigitte Bernard-Chabert Arnault Pauwels Philippe Renard Eric Bartoli Jean-Franois Cadranel Jean-Claude Barbare Isabelle Ingrand Michel Beauchant | 2006 | World Journal of Gastroenterology2006，12，48： | 4 |
| 8 | Liver Transplantation for Neuroendocrine Tumors in Europe—Results and Trends in Patient Selection: A 213-Case European Liver Transplant Registry Study显示文摘 | Yves Patrice Le Treut Emilie Grégoire Jürgen Klempnauer Jacques Belghiti Elisabeth Jouve Jan Lerut Denis Castaing Olivier Soubrane Olivier Boillot Georges Mantion Kia Homayounfar Manuel Bustamante Daniel Azoulay Philippe Wolf Marek Krawczyk Andreas Pasche | 2013 | Annals of Surgery2013，，5： | 3 |
| 9 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 10 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 11 | ENETS Consensus Guidelines for the Management of Patients with Gastroduodenal Neoplasms显示文摘 | Delle Fave Gianfranco Kwekkeboom Dik J Van Cutsem Erik Rindi Guido Kos-kudla Beata Knigge Ulrich Sasano Hironobu Tomassetti Paola Salazar Ramon Ruszniewski Philippe | 2012 | Neuroendocrinology2012，，2： | 3 |
| 12 | Impact of age on transcatheter aortic valve implantation outcomes:a comparison of patients aged≤ 80 years versus patients > 80 years显示文摘 | Frank van der Kley Philippe J van Rosendael Spyridon Katsanos Vasileios Kamperidis Nina A Marsan Ioannis Karalis Arend de Weger Meindert Palmen Jeroen J Bax Martin J Schalij Victoria Delgado | 2016 | Journal of Geriatric Cardiology2016，13，1： | 2 |
| 13 | Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study显示文摘 | Markus Ketteler Philipp Bongartz Ralf Westenfeld Joachim Ernst Wildberger Andreas Horst Mahnken Roland B?hm Thomas Metzger Christoph Wanner Willi Jahnen-Dechent Jürgen Floege | 2003 | The Lancet2003，，9360： | 2 |
| 14 | 欧洲和德国的钢铁工业的环保现状和发展显示文摘欧洲钢铁工业的环境保护已经达到了很高的水平.20世纪60年代初,保护环境一般认为只是局限于限制工业对人们的影响.现在,尤其是在罗马协议(Club of Rome)的努力之下,环保的范围从节约资源延伸到到整个自然环境的保护,而后产生了目前应用中的工业过程和产品生产周期.整体来说,保护环境的所有途径都被视为是未来平衡发展的先决条件.欧盟环境保护技术的情况可以以德国为例,更准确地说是杜伊斯堡的蒂森克虏伯钢厂(ThyssenKruppStahl AG),其粗钢产量约占德国总产量的35%.钢铁工业环境保护的重点仍然是维护空气质量,在此目的下,进行除尘处理.由烟囱处取样获得目前的除尘水平来看,今后的除尘主要是控制粉尘扩散和减少细小微粒的排放.钢铁工业环境保护的关键策略就是循环利用,它能起到与环境协调一致的作用,能够解决相关工艺中需要的大量的原料问题.德国的蒂森克虏伯钢厂(ThyssenKrupp Stahl AG)现在炉渣的综合回收率水平已接近95%,其中冶金渣的回收利用率尤为突出.在德国,高炉渣利用率达到了100%,同时炼钢渣的利用率也超过了90%,每吨粗钢的耗水量也控制在在100 m3的范围内.大量的努力不仅保证了有效的回收和再生利用工序,而且冷却水的利用也保证了新水的补充率降低到每吨粗钢15 m3左右.污染控制除跟主要环境即空气、水和土壤有关外,已扩展到回收过程再利用的水平,更多地重点渐渐地放到相关产品的环境保护.产品和原料却日益受到生产商和消费者的重点检验,有点与环境协调性标准相反.组织机构的环境保护手段包括环境管理系统的认可、生态平衡、政府部门的自愿协议以及提高公众的信息、教育水平.欧洲的钢铁工业,当然也包括德国,都已经意识到环境保护的重要性同工业研究与开发的重要性处于同等地位.一个典型的例子就是超薄板汽车用钢项目,这个与产品相关的研究引入了35家合作厂商共同研究一个比目前传统的汽车车身更结实、更轻的项目.欧洲钢铁厂家的联合合作已经成功研究出应用于烧结厂的减少二恶英(dioxin)排放物的吸收工艺.用褐煤焦尘作为吸附剂,已能够平均减少排放物大约70%.很可能2003年在杜伊斯堡的ThyssenKrupp Stahl AG将被授权建全世界最先进的焦化厂.在这个项目过程中研究出的主要部分成果,例如低尘低烟煤湿熄法和减少PAH排放物的单室压力控制系统,会恰当的应用于新的工厂.另一个主要进步是ThyssenKrupp Stahl AG研制的Hamborn OxiCup竖炉,它有湿法冶炼和排除含铁残渣的功能.此技术预计成为回收利用铁水和钢产品中产生的粉尘和泥浆这一难题的解决方案.德国的局势尤其显示出环境法规的落实正开始对经济发展和劳动力市场起到不利影响.盛行的经济技术条件需要合法的体制治理环境保护的合理化.将来任何进一步的措施都要考虑这一事实,既要获得可持续发展,又要考虑到经济发展和社会需求. | Jürgen A. Philipp | 2003 | 钢铁2003，38，z1： | 2 |
| 15 | Malaria: current status of control, diagnosis, treatment, and a proposed agenda for research and development显示文摘 | Philippe J Guerin Piero Olliaro Francois Nosten Pierre Druilhe Ramanan Laxminarayan Fred Binka Wen L Kilama Nathan Ford Nicholas J White | 2002 | The Lancet Infectious Diseases2002，，9： | 2 |
| 16 | 蒂森克虏伯钢公司资源保护现状显示文摘以蒂森克虏伯钢公司(TKS)为例,重点介绍其在资源保护领域中的资源循环利用和能源有效利用。现代环境保护已经从过去纯介质上的研究进步到今天的综合治理,几乎涉及所有环境问题。这是基于道德伦理和持续发展的考虑,也就是为了子孙后代而保护环境。这里既有政治上的约束,在实践中还有技术和组织方面的因素。就资源保护而论,不同因素之间的相互影响特别明显。 | J A Philipp 周茂军(译) 尹杰(校) | 2007 | 世界钢铁2007，7，3： | 2 |
| 17 | 二甲双胍长期治疗2型糖尿病患者以及维生素B12缺乏的危险性:随机安慰剂对照研究(摘要)显示文摘目的 研究接受胰岛素治疗的2型糖尿病患者中,二甲双胍所致维生素B12缺乏(〈150pmol/L)、低浓度维生素B12(150—220pmol/L)的发生率,以及叶酸和同型半胱氨酸的浓度。 | Jolien de Jager Adriaan Kooy Philippe Lehert Michiel G Wulffele Jan van der Kolk Daniel Bets Joop Verburg Ab J M Donker Coen D A Stehouwer 许翎岭(译) | 2010 | 英国医学杂志中文版2010，13，5： | 2 |
| 18 | 欧洲和德国的钢铁工业的环保现状和发展(二)显示文摘 | Jürgen A. Philipp | 2004 | 中国冶金2004，14，4： | 2 |
| 19 | Prospective randomized comparison between axial- and lateral-viewing capsule endoscopy systems in patients with obscure digestive bleeding显示文摘 | Mathieu Pioche Geoffroy Vanbervliet Philippe Jacob Cloti de Duburque Rodica Gincul Bernard Filoche Jacques Daudet Jér?me Filippi Jean-Christophe Saurin | 2013 | Endoscopy2013，，： | 2 |
| 20 | The functional complex network approach to foster forest resilience to global changes显示文摘Human impacts on Earth's ecosystems have greatly intensified in the last decades. This is reflected in unexpected disturbance events, as well as new and increasing socio-economic demands, all of which are affecting the resilience of forest ecosystems worldwide and the provision of important ecosystem services. This Anthropocene era is forcing us to reconsider past and current forest management and silvicultural practices, and search for new ones that are more flexible and better at dealing with the increasing uncertainty brought about by these accelerating and cumulative global changes. Here, we briefly review the focus and limitations of past and current forest management and silvicultural practices mainly as developed in Europe and North America. We then discuss some recent promising concepts, such as managing forests as complex adaptive systems, and approaches based on resilience, functional diversity, assisted migration and multi-species plantations, to propose a novel approach to integrate the functionality of species-traits into a functional complex network approach as a flexible and multi-scale way to manage forests for the Anthropocene. This approach takes into consideration the high level of uncertainty associated with future environmental and societal changes. It relies on the quantification and dynamic monitoring of functional diversity and complex network indices to manage forests as a functional complex network. Using this novel approach, the most efficient forest management and silvicultural practices can be determined, as well as where, at what scale, and at what intensity landscape-scale resistance, resilience and adaptive capacity of forests to global changes can be improved. | Christian Messier Jürgen Bauhus Frederik Doyon Fanny Maure Rita Sousa-Silva Philippe Nolet Marco Mina Núria Aquilué Marie-Josée Fortin Klaus Puettmann | 2019 | Forest Ecosystems2019，6，3： | 2 |
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