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| 1 | 动脉粥样硬化血栓形成门诊患者1年内心血管事件的发生率显示文摘背景:目前,有关社区中动脉粥样硬化血栓形成稳定患者心血管(cardiovascular,CV)事件发生率的资料比较少,既往也无国际性队列研究对冠状动脉病(coronary artery disease,CAD)、脑血管病(cerebrovascular disease,CVD)、外周动脉病(peripheral arterial disease,PAD)确诊患者以及此类疾病高危患者不同事件的发生率进行评估。
目的:在患有动脉疾病的门诊患者或存在多个动脉粥样硬化血栓形成危险因素的门诊患者中确定当今世界1年内CV事件的发生率。
设计、地点及参试者:“减少动脉粥样硬化血栓形成维系健康(Reduction of Artherotllrombosis for Continued Health,REACH)”注册研究是一项国际前瞻性队列研究。研究人员于2003—2004年从44个国家、5587名医生入选68236例已确诊的动脉粥样硬化性血管病患者(CAD、PAD、CVD;n=55814)以及至少存在3个动脉粥样硬化血栓形成危险因素的患者(n=12422)。
主要观测指标:CV死亡、心肌梗死(myocardial infarction,MI)及卒中的发生率。结果:截至2006年7月,共有95.22%的患者(n=64977)提供了1年内的结局。心血管死亡、MI及卒中的总体发生率为4.24%;动脉粥样硬化性血管病患者为4.69%,仅存在多个危险因素的患者为2.15%。CAD、CVD及PAD患者CV死亡、MI及卒中的总体发生率分别为4.52%、6.47%和5.35%。CAD、CVD及PAD患者发生终点事件(即CV死亡、MI、卒中)以及因动脉粥样硬化血栓形成事件入院的几率分别为15.20%、14.53%和21.14%。上述事件发生率随症状性动脉疾病病变部位数量的增加而增加,仅存在危险因素的患者为5.31%,有1处症状性动脉疾病的患者为12.58%,有2处症状性动脉疾病的患者为21.14%,有3处症状性动脉疾病的患者为26.27%(趋势P〈0.001)。
结论:在这项当代大型国际研究中,患有动脉粥样硬化性血管病的门诊患者以及有动脉粥样硬化血栓形成危险的门诊患者CV事件的年发生率相对较高。存在多部位病变者CV事件的1年发生率升高。 | Gabriel Steg Deepak L. Bhatt Peter W. F. Wilson Ralph D' Agostino E. Magnus Ohman Joachim Roether Chiau-Suong Liau Alan T. Hirsch Jean-Louis Mas Yasuo Ikeda Michael J. Pencina Shinya Goto 徐成斌(译) 李呈亿(校) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 20 |
| 2 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 3 | 经验证的多基因风险评分对中青年人冠状动脉粥样硬化性心脏病长期风险的预测作用显示文摘本文旨在了解先前获得的多基因风险评分(polygenic risk scores, PRS)对冠状动脉粥样硬化性心脏病(冠心病)长期风险的预测效用及其超越传统危险因素的附加价值,为预防策略提供信息。方法:纳入Framingham后代研究(Framingham offspring study, FOS)和社区动脉粥样硬化风险(atherosclerosis risk in communities, ARIC)研究中年龄20~59岁无冠心病的成年人数据进行分析。 | Khan SS Page C Wojdyla DM Schwartz YY Greenland P Pencina MJ 刘青(译) 郑武洪(审校) | 2022 | 中华高血压杂志2022，30，12： | 2 |
| 4 | General Cardiovascular Risk Profile for Use in Primary Care: The Framingham Heart Study显示文摘 | Ralph B. D’Agostino Ramachandran S. Vasan Michael J. Pencina Philip A. Wolf Mark Cobain Joseph M. Massaro William B. Kannel | 2008 | Circulation2008，，6： | 2 |
| 5 | Vitamin D Deficiency and Risk of Cardiovascular Disease显示文摘 | Thomas J. Wang Michael J. Pencina Sarah L. Booth Paul F. Jacques Erik Ingelsson Katherine Lanier Emelia J. Benjamin Ralph B. D?Agostino Myles Wolf Ramachandran S. Vasan | 2008 | Circulation2008，，4： | 2 |
| 6 | 父母心力衰竭与其子女心力衰竭风险的关联性显示文摘Background: The association between heart failure in parents and the prevalence of left ventricular systolic dysfunction and the risk of heart failure in their offspring has not been investigated in a community-based setting. Methods: We examined the cross-sectional association of heart failure in parents with the prevalence of left ventricular systolic dysfunction, as well as left ventricular mass, internal dimensions, and wall thickness, in 1497 participants of the Framingham Offspring Study(mean age, 57 years; 819 women) who underwent routine echocardiography. We also investigated prospectively whether heart failure in parents increased the risk of heart failure in 2214 offspring(mean age, 44 years; 1150 women). Results: As compared with the 1039 participants whose parents did not have heart failure, the 458 participants in the cross-sectional cohort who had at least one parent with heart failure were more likely to have increased left ventricular mass(17.0 percent vs. 26.9 percent), left ventricular internal dimensions(18.6 percent vs. 23.4 percent), and left ventricular systolic dysfunction(3.1 percent vs. 5.7 percent); the multivariable-adjusted odds ratios were 1.35(95 percent confidence interval, 0.99 to 1.84), 1.29(95 percent confidence interval, 0.96 to 1.72), and 2.37(95 percent confidence interval, 1.22 to 4.61), respectively. In the longitudinal cohort, heart failure developed in 90 offspring during follow-up(mean length of follow-up, 20 years). The age-and sex-adjusted 10-year incidence rates of heart failure were 2.72 percent among offspring with a parent with heart failure, as compared with 1.62 percent among those without a parent with heart failure. This increase in risk persisted after multivariable adjustment(hazard ratio, 1.70; 95 percent confidence interval, 1.11 to 2.60). Conclusions: Heart failure in parents is associated with an increased prevalence of left ventricular systolic dysfunction cross-sectionally and an elevated risk of heart failure longitudinally. Our data emphasize the contribution of familial factors to the heart-failure burden in the community. | Lee D.S. Pencina M.J. Benjamin E.J. R.S. Vasan 马超 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，，12： | 2 |
| 7 | C-reactive protein and reclassification of cardiovascular risk in the Framingham Heart Study显示文摘 | Wilson PW Pencina M Jacques P | 2008 | Circ Cardiovasc Qual Outcomes2008，1，2： | 1 |
| 8 | Impact of im -paired fasting glucose on cardiovascular disease~ the Framingham Heart Study显示文摘 | Levitzky YS Pencina MJ D'agostino RB | 2008 | J Am Coll Cardiol2008，51，3： | 1 |
| 9 | Lack of interaction of beta-cell-function-associated variants with hypertension on change in fasting glucose and diabetes risk:the framingham offspring study显示文摘 | De Miguel YJM Porneala B Pencina MJ | 2013 | Journal of Hypertension2013，31，5： | 1 |
| 10 | Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring显示文摘 | Lieb W Pencina MJ Wang TJ | 2008 | Hypertension2008，52，2： | 1 |
| 11 | Trends in Cardiovascular Disease Risk Factors in Individuals With and Without Diabetes Mellitus in the Framingham Heart Study显示文摘 | Sarah Rosner Preis Michael J. Pencina Shih-Jen Hwang Ralph B. D’Agostino Peter J. Savage Daniel Levy Caroline S. Fox | 2009 | Circulation2009，，3： | 1 |
| 12 | Hepatic steatosis and cardiovascular disease outcomes: An analysis of the Framingham Heart Study显示文摘 | Jessica L. Mellinger Karol M. Pencina Joseph M. Massaro Udo Hoffmann Sudha Seshadri Caroline S. Fox Christopher J. O’Donnell Elizabeth K. Speliotes | 2015 | Journal of Hepatology2015，，2： | 1 |
| 13 | Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts 显示文摘 | Bhasin S Pencina M Jasuja GK | 2011 | J Clin Endoerinol Metab2011，96，8： | 1 |
| 14 | Vitamin D deficiency and risk of cardiovascular disease 显示文摘 | Wang TJ Pencina M J Booth SL | 2008 | Circulation2008，117，4： | 1 |
| 15 | Improved Cardiac Risk Assessment With Noninvasive Measures of Coronary Flow Reserve显示文摘 | Venkatesh L. Murthy Masanao Naya Courtney R. Foster Jon Hainer Mariya Gaber Gilda Di Carli Ron Blankstein Sharmila Dorbala Arkadiusz Sitek Michael J. Pencina Marcelo F. Di Carli | 2011 | Circulation2011，，： | 1 |
| 16 | C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study显示文摘 | Wilson PW Nam BH Pencina M | 2005 | Arch Intern Med2005，165，21： | 1 |
| 17 | Electrocardiographic QRSduration and the risk of congestive heart failure : the FraminghamHeart Stady显示文摘 | Dhingra R Pencina MJ Wari- TJ ei al | 2006 | Hypertension2006，47，5： | 1 |
| 18 | General cardiovascular risk profile for use in primary care: the Framingham Heart Study显示文摘 | D' Agostino R B Sr Vasan R S Pencina M J | 2008 | Circulation2008，117，6： | 1 |
| 19 | Diet quality and obesity inwomen: the Framinghan nutrition studies显示文摘 | Wolongevicz DM Zhu L Pencina MJ | 2010 | BJ Nutr2010，10，3122： | 1 |
| 20 | Adjustment of the GRACE score by growth differentiation factor 15 ena- bles a more accurate appreciation of risk in non-ST-eleva- tion acute coronary syndrome 显示文摘 | Widera C Pencina MJ Meisner A | 2011 | Eur Heart J2011，33，： | 1 |
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