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| 1 | Nonalcoholic fatty liver disease and aging: Epidemiology to management显示文摘Nonalcoholic fatty liver disease(NAFLD) is common in the elderly, in whom it carries a more substantial burden of hepatic(nonalcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma) and extra-hepatic manifestations and complications(cardiovascular disease, extrahepatic neoplasms) than in younger age groups. Therefore, proper identification and management of this condition is a major task for clinical geriatricians and geriatric hepatologists. In this paper, the epidemiology and pathophysiology of this condition are reviewed, and a full discussion of the link between NAFLD and the aspects that are peculiar to elderly individuals is provided; these aspects include frailty, multimorbidity, polypharmacy and dementia. The proper treatment strategy will have to consider the peculiarities of geriatric patients, so a multidisciplinary approach is mandatory. Non-pharmacological treatment(diet and physical exercise) has to be tailored individually considering the physical limitations of most elderly people and the need for an adequate caloric supply. Similarly, the choice of drug treatment must carefully balance the benefits and risks in terms of adverse events and pharmacological interactions in the common context of both multiple health conditions and polypharmacy. In conclusion, further epidemiological and pathophysiological insight is warranted. More accurate understanding of the molecular mechanisms of geriatric NAFLD will help in identifying the most appropriate diagnostic and therapeutic approach for individual elderly patients. | Marco Bertolotti Amedeo Lonardo Chiara Mussi Enrica Baldelli Elisa Pellegrini Stefano Ballestri Dante Romagnoli Paola Loria | 2014 | World Journal of Gastroenterology2014，20，39： | 15 |
| 2 | Intraocular inflammation after Ultrasound Cyclo Plasty for the treatment of glaucoma显示文摘This is a prospective interventional clinical study evaluating intraocular inflammation developed after Ultrasound Cyclo Plasty(UCP) for the treatment of glaucoma. Eighteen eyes of 18 patients were treated with UCP second-generation probes(Eye OP1). After treatment, the mean intraocular pressure(IOP) significantly decreased from 26.8±7.2 to 18.8±6.1 mm Hg at day 1 and to 14.7±3.4 mm Hg at month 6(all P<0.001). Mean laser flare-cell photometry value steeply increased after surgery from 12.1±7.5 to 64.1±53.9 ph/ms(P=0.001) at day 1, and then progressively decreased to respectively 60.6±49.7 at day 7, 43.5±38.5 at day 14 and 28.2±18.3 at month 1(all P<0.05), returning at levels similar to baseline ones at month 3 and month 6(respectively 16.7±6.2 and 12.8±10.2, both P>0.05). A significant negative correlation was found between postoperative increase of aqueous flare values and anterior chamber depth(R=-0.568, P=0.014). This timeframe may be considered reasonable for repeating UCP treatment, when required. | Marco Pellegrini Stefano Sebastiani Giuseppe Giannaccare Emilio C.Campos | 2019 | International Journal of Ophthalmology(English edition)2019，12，2： | 8 |
| 3 | Intestinal epithelial barrier and neuromuscular compartment in health and disease显示文摘A number of digestive and extra-digestive disorders,including inflammatory bowel diseases,irritable bowel syndrome,intestinal infections,metabolic syndrome and neuropsychiatric disorders,share a set of clinical features at gastrointestinal level,such as infrequent bowel movements,abdominal distension,constipation and secretory dysfunctions.Several lines of evidence indicate that morphological and molecular changes in intestinal epithelial barrier and enteric neuromuscular compartment contribute to alterations of both bowel motor and secretory functions in digestive and extra-digestive diseases.The present review has been conceived to provide a comprehensive and critical overview of the available knowledge on the morphological and molecular changes occurring in intestinal epithelial barrier and enteric neuromuscular compartment in both digestive and extra-digestive diseases.In addition,our intent was to highlight whether these morphological and molecular alterations could represent a common path(or share some common features)driving the pathophysiology of bowel motor dysfunctions and related symptoms associated with digestive and extra-digestive disorders.This assessment might help to identify novel targets of potential usefulness to develop original pharmacological approaches for the therapeutic management of such disturbances. | Vanessa D’Antongiovanni Carolina Pellegrini Matteo Fornai Rocchina Colucci Corrado Blandizzi Luca Antonioli Nunzia Bernardini | 2020 | World Journal of Gastroenterology2020，26，14： | 6 |
| 4 | Mature versus emerging technologies for CO2 capture in power plants: Key open issues in post-combustion amine scrubbing and in chemical looping combustion显示文摘 | Giorgia De Guido Matteo Compagnoni Laura A. Pellegrini Ilenia Rossetti | 2018 | Frontiers of Chemical Science and Engineering2018，12，2： | 6 |
| 5 | Pacing and predictors of performance during cross-country skiing races:A systematic review显示文摘Background: Cross-country skiing(XCS) racing, a popular international winter sport, is complex and challenging from physical, technical, and tactical perspectives. Despite the vast amount of research focusing on this sport, no review has yet addressed the pacing strategies of elite XCS racers or the factors that influence their performance. The aim was to review the scientific literature in an attempt to determine the effects of pacing strategy on the performance of elite XCS racers.Methods: Four electronic databases were searched using relevant subject headings and keywords. Only original research articles published in peerreviewed journals and the English language and addressing performance, biomechanics, physiology, and anthropometry of XCS racers were reviewed.Results: All 27 included articles applied correlative designs to study the effectiveness of different pacing strategies. None of the articles involved the use of an experimental design. Furthermore, potential changes in external conditions(e.g., weather, ski properties) were not taken into consideration. A comparable number of studies focused on the skating or classical technique. In most cases, positive pacing was observed, with certain indications that higher-level athletes and those with more endurance and strength utilized a more even pacing strategy. The ability to achieve and maintain a long cycle length on all types of terrain was an important determinant of performance in all of the included studies, which was not the case for cycle rate. In general, uphill performance was closely related to overall race performance, with uphill performance being most closely correlated to the success of female skiers and performance on flat terrain being more important for male skiers. Moreover, pacing was coupled to the selection and distribution of technique during a race, with faster skiers employing more double poling and kick double poling,less diagonal stride, and more V2(double dance) than V1(single dance) skating across a race.Conclusion: We propose that skiers at all levels can improve their performance with more specific training in techniques(i.e., maintaining long cycles without compromising cycle rate and selecting appropriate techniques) in combination with training for endurance and more strength. Furthermore, we would advise less experienced skiers and/or those with lower levels of performance to apply a more even pacing strategy rather than a positive one(i.e., starting the race too fast). | thomas stoggl barbara pellegrini hans-christer holmberg | 2018 | Journal of Sport and Health Science2018，7，4： | 6 |
| 6 | Significant factors associated with fatal outcome in emergency open surgery for perforated peptic ulcer显示文摘AIM: To evaluate the main factors associated with mortality in patients undergoing surgery for perforated peptic ulcer referred to an academic department of general surgery in a large southern Italian city.METHODS: One hundred and forty-nine consecutive patients (M:F ratio=110:39, mean age 52 yrs, range 16-95) with peptic ulcer disease were investigated for clinical history (including age, sex, previous history of peptic ulcer, associated diseases, delayed abdominal surgery, ulcer site, operation type, shock on admission, postoperative general complications,and intra-abdominal and/or wound infections), serum analyses and radiological findings.RESULTS: The overall mortality rate was 4.0%. Among all factors, an age above 65 years, one or more associated diseases, delayed abdominal surgery, shock on admission,postoperative abdominal complications and/or wound infections, were significantly associated (χ2) with increased mortality in patients undergoing surgery (0.0001 | Mario Testini Piero Portincasa Giuseppe Piccinni Germana Lissidini Fabio Pellegrini Luigi Greco | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 7 | Constipation,deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alphasynucleinopathy显示文摘Background:Gastrointestinal dysfunction can affect Parkinson’s disease(PD)patients long before the onset of motor symptoms.However,little is known about the relationship between gastrointestinal abnormalities and the development of PD.Contrary to other animal models,the human A53T alpha-synuclein(αS)transgenic mice,Line G2–3,developsαS-driven neurological and motor impairments after 9 months of age,displaying a long presymptomatic phase free of central nervous system(CNS)dysfunction.Methods:To determine whether this line can be suitable to study constipation as it occurs in prodromal PD,gastrointestinal functionality was assessed in young mice through a multidisciplinary approach,based on behavioral and biochemical analysis combined with electrophysiological recordings of mouse intestinal preparations.Results:We found that the A53TαS mice display remarkable signs of gastrointestinal dysfunction that precede motor abnormalities andαS pathology in the CNS by at least 6 months.YoungαS mice show a drastic delay in food transit along the gastrointestinal tract,of almost 2 h in 3 months old mice that increased to more than 3 h at 6 months.Such impairment was associated with abnormal formation of stools that resulted in less abundant but longer pellets excreted,suggesting a deficit in the intestinal peristalsis.In agreement with this,electrically evoked contractions of the colon,but not of the ileum,showed a reduced motor response in both longitudinal and circular muscle layers inαS mice already at 3 months of age,that was mainly due to an impaired cholinergic transmission of the underlying enteric nervous system.Interestingly,the presence of insoluble and aggregatedαS was found in enteric neurons in both myenteric and submucosal plexi only in the colon of 3 months oldαS mice,but not in the small intestine,and exacerbated with age,mimicking the increase in transit delay and the contraction deficit showed by behavioral and electrical recordings data.Conclusions:Gastrointestinal dysfunction in A53TαS mice represents an early sign ofαS-driven pathology without concomitant CNS involvement.We believe that this model can be very useful to study disease-modifying strategies that could extend the prodromal phase of PD and haltαS pathology from reaching the brain. | Lucia Rota Carolina Pellegrini Laura Benvenuti Luca Antonioli Matteo Fornai Corrado Blandizzi Antonino Cattaneo Emanuela Colla | 2019 | Translational Neurodegeneration2019，8，1： | 5 |
| 8 | Antioxidant activity applying an improved ABTS radical cation decolorization assay显示文摘 | Roberta Re Nicoletta Pellegrini Anna Proteggente Ananth Pannala Min Yang Catherine Rice-Evans | 1999 | Free Radical Biology and Medicine1999，，9： | 5 |
| 9 | The size of cell-free mitochondrial DNA in blood is inversely correlated with tumor burden in cancer patients显示文摘Circulating cell-free DNAs(cfDNAs)are fragmented DNA molecules released into the blood by cells.Previous studies have suggested that mitochondria-originated cfDNA fragments(mt-cfDNAs)in cancer patients are more fragmented than those from healthy controls.However,it is still unknown where these short mtcfDNAs originate,and whether the length of mt-cfDNAs can be correlated with tumor burden and cancer progression.In this study,we first performed whole-genome sequencing analysis(WGS)of cfDNAs from a human tumor cell line-xenotransplantation mouse model and found that mt-cfDNAs released from transplanted tumor cells were shorter than the mouse counterpart.We next analyzed blood cfDNA samples from hepatocellular carcinoma and prostate cancer patients and found that mt-cfDNA lengths were inversely related to tumor size as well as the concentration of circulating tumor DNA.Our study suggested that monitoring the size of mt-cfDNAs in cancer patients would be a useful way to estimate tumor burden and cancer progression. | Qin An Youjin Hu Qingjiao Li Xufeng Chen Jiaoti Huang Matteo Pellegrini Xianghong Jasmine Zhou Matthew Rettig Guoping Fan | 2019 | Precision Clinical Medicine2019，2，3： | 4 |
| 10 | COVID-19 and its effects on the digestive system显示文摘Coronavirus disease 2019(COVID-19)is caused by infection of the coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with typical respiratory symptoms.SARS-CoV-2 invades not only the respiratory system,but also other organs expressing the cell surface receptor angiotensin converting enzyme 2.In particular,the digestive system is a susceptible target of SARS-CoV-2.Gastrointestinal symptoms of COVID-19 include anorexia,nausea,vomiting,diarrhea,abdominal pain,and liver damage.Patients with digestive damage have a greater chance of progressing to severe or critical illness,a poorer prognosis,and a higher risk of death.This paper aims to summarize the digestive system symptoms of COVID-19 and discuss fecal-oral contagion of SARS-CoV-2.It also describes the characteristics of inflammatory bowel disease patients with SARSCoV-2 infection and discusses precautions for preventing SARS-CoV-2 infection during gastrointestinal endoscopy procedures.Improved attention to digestive system abnormalities and gastrointestinal symptoms of COVID-19 patients may aid health care providers in the process of clinical diagnosis,treatment,and epidemic prevention and control. | Ting-Ting Cao Gu-Qin Zhang Emily Pellegrini Qiu Zhao Jin Li Lin-jie Luo Hua-Qin Pan | 2021 | World Journal of Gastroenterology2021，27，24： | 3 |
| 11 | Internet of things: Vision, applications and research challenges显示文摘 | Daniele Miorandi Sabrina Sicari Francesco De Pellegrini Imrich Chlamtac | 2012 | Ad Hoc Networks2012，，7： | 3 |
| 12 | NKG2A and COVID-19: another brick in the wall显示文摘Coronavirus disease 2019(COVID-19)is a viral infection caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2;formerly designated as 2019-nCoV),a novel betacoronavirus firstly identified during a burst of respiratory illness cases in Wuhan City,Hubei Province,China.1 Unfortunately,within a few weeks,the SARS-COV2 virus started to spread globally,producing a pandemic of an extremely spreadable and potentially fatal disease,becoming a cause of great concern for global public health.1 Despite the current estimates of COVID-19 case fatality rate suggest that this coronavirus is less deadly than other pathogens driving other large-scale outbreaks,such as SARS,Middle East respiratory syndrome,or Ebola,the main concern is that this infection is able to spread more easily than other diseases,including seasonal influenza. | Luca Antonioli Matteo Fornai Carolina Pellegrini Corrado Blandizzi | 2020 | Cellular & Molecular Immunology2020，17，6： | 3 |
| 13 | Mycoplasma pneumoniae infection associated with an acute brainstem syndrome显示文摘 | Pellegrini M Obrien TJ Hoy J | 1996 | Acta Neurol Scand1996，93，23： | 2 |
| 14 | Omega-3 fatty acid supplementation reduces one-year risk of atrial fibrillation in patients hospitalized with myocardial infarction显示文摘 | Alejandro Macchia Simona Monte Fabio Pellegrini Marilena Romero Daniel Ferrante Hernán Doval Antonio D'Ettorre Aldo Pietro Maggioni Gianni Tognoni | 2008 | European Journal of Clinical Pharmacology2008，，6： | 2 |
| 15 | Modeling the methyldiethanolamine-piperazine scrubbing system for CO2 removal: Thermodynamic analysis显示文摘methyldiethanolamine (MDEA ) 和 piperazine (PZ ) 的水的答案现在是通常使用的溶剂。在这个工作,与 Electrolyte-NRTL 模型一起的热力学的分析被执行了因为系统酸的气体和 MDEA + PZ 填写了水的答案。白杨加?被用于热力学的建模。为液体阶段活动系数的二进制相互作用参数的值从试验性的数据的回归被估计了。而且,在离子对和 MDEA 或 PZ 之间的相互作用的影响分子的种类被分析了。最后的目的是为吸收和脱衣的列的设计和模拟获得一个可靠工具,也,节省的精力学习以便执行的基础。 | Stefania Moioli Laura A. Pellegrini | 2016 | Frontiers of Chemical Science and Engineering2016，10，1： | 2 |
| 16 | Antioxidant activity applying an improved ABTS radical cation decolorization assay显示文摘 | Roberta Re Nicoletta Pellegrini Anna Proteggente Ananth Pannala Min Yang Catherine Rice-Evans | 1999 | Free Radical Biology and Medicine1999，，9： | 2 |
| 17 | Genome-wide High-Resolution Mapping and Functional Analysis of DNA Methylation in Arabidopsis显示文摘 | Xiaoyu Zhang Junshi Yazaki Ambika Sundaresan Shawn Cokus Simon W.-L. Chan Huaming Chen Ian R. Henderson Paul Shinn Matteo Pellegrini Steve E. Jacobsen Joseph R. Ecker | 2006 | Cell2006，，6： | 2 |
| 18 | Bone suture anchors versus the pullout button for repair of dis tal profundus tendon injuries:a comparison of s trength in human cadaveric hands显示文摘 | Brus tein M Pellegrini J Choueka J | 2001 | J Hand Surg2001，26，3： | 1 |
| 19 | Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis显示文摘 | Tobin RW Pope CE Pellegrini CA | 1998 | Am J Respir Crit Care Med1998，158，6： | 1 |
| 20 | FoxO3a-dependent regulation of puma in response to cytokine/growth factor withdrawal显示文摘 | You H Pellegrini M Tsuchihara K | 2006 | J Exp Med2006，203，7： | 1 |
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