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| 1 | High Levels of Hepatitis B Surface Antigen Increase Risk of Hepatocellular Carcinoma in Patients With Low HBV Load显示文摘 | Tai–Chung Tseng Chun–Jen Liu Hung–Chih Yang Tung–Hung Su Chia–Chi Wang Chi–Ling Chen Stephanie Fang–Tzu Kuo Chen–Hua Liu Pei–Jer Chen Ding–Shinn Chen Jia–Horng Kao | 2012 | Gastroenterology2012，，5： | 6 |
| 2 | 肝移植治疗原发性胆汁性肝硬化的疗效分析显示文摘目的 观察原发性胆汁性肝硬化(PBC)患者和移植肝的实际生存时间,肝移植后死亡的原因及肝移植后的复发率。 方法 根据QLTS的数据库中的随访资料,回顾性分析52例共接受54次肝移植的PBC患者。52例PBC肝移植患者中,平均年龄(5 3.2±6.7)岁,平均随访时间是(5 5.4±11.3)个月。分析术前的临床特征、移植后生存情况和死亡原因,采用欧洲模式计算未接受肝移植患者和接受肝移植的患者的生存率。 结果 PBC肝移植患者的1、5、1 0年的实际生存率分别为8 8.4%、80.1%和76.9%,未接受肝移植患者实际生存率分别为80.9%、6 5.4%和19.8%。PBC患者移植后的生存率比未接受肝移植的患者(欧洲模型)预期生存率高。有6例患者经肝活检后证实PBC复发,平均复发时间(34.1±10.2)个月。肝移植术后死亡的原因是多器官功能衰竭、腹腔内出血、肾功能衰竭、败血症及心血管疾病。 结论 肝移植可提高P B C患者的生存率,延长其生存时间。 | 许崇恩 Stephen V.Lynch Glenda A.Balderson Jonathan Fawcett Russell W Strong Shinn Yeong | 2004 | 中华肝脏病杂志2004，12，9： | 6 |
| 3 | Serum Hepatitis B Surface Antigen Levels Predict Surface Antigen Loss in Hepatitis B e Antigen Seroconverters显示文摘 | Tai–Chung Tseng Chun–Jen Liu Tung–Hung Su Chia–Chi Wang Chi–Ling Chen Pei–Jer Chen Ding–Shinn Chen Jia–Horng Kao | 2011 | Gastroenterology2011，，2： | 4 |
| 4 | Peginterferon Alfa-2a Plus Ribavirin for the Treatment of Dual Chronic Infection With Hepatitis B and C Viruses显示文摘 | Chun–Jen Liu Wan–Long Chuang Chuan–Mo Lee Ming–Lung Yu Sheng–Nan Lu Shun–Sheng Wu Li–Ying Liao Chi–Ling Chen Hsing–Tao Kuo You–Chen Chao Shui–Yi Tung Sien–Sing Yang Jia–Horng Kao Chen–Hua Liu Wei–Wen Su Chih–Lin Lin Yung–Ming Jeng Pei–Jer Chen Ding–Shinn | 2009 | Gastroenterology2009，，2： | 3 |
| 5 | Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers显示文摘 | Jia–Horng Kao Pei–Jer Chen Ming–Yang Lai Ding–Shinn Chen | 2003 | Gastroenterology2003，，2： | 3 |
| 6 | Persistent risk for new, subsequent new and recurrent hepatocellular carcinoma despite successful anti-hepatitis B virus therapy and tumor ablation: The need for hepatitis B virus cure显示文摘Hepatitis B virus(HBV) is one of the most significant hepatocarcinogens. The ultimate goal of anti-HBV treatment is to prevent the development of hepatocellular carcinoma(HCC). During the last two decades, with the use of currently available anti-HBV therapies(lamivudine, entecavir and tenofovir disoproxil fumatate), there has been a decrease in the incidence of HBVassociated HCC(HBV-HCC). Furthermore, several studies have demonstrated a reduction in recurrent or new HCC development after initial HCC tumor ablation. However, during an observation period spanning 10 to 20 years, several case reports have demonstrated the development of new, subsequent new and recurrent HCC even in patients with undetectable serum HBV DNA. The persistent risk for HCC is attributed to the presence of covalently closed circular DNA(cccDNA) in the hepatocyte nucleus which continues to work as a template for HBV replication. While a functional cure(loss of hepatitis B surface antigen and undetectable viral DNA) can be attained with nucleos(t)ide analogues, these therapies do not eliminate cccDNA. Of utmost importance is successful eradication of the transcriptionally active HBV cccDNA from hepatocyte nuclei which would be considered a complete cure. The unpredictable nature of HCC development in patients with chronic HBV infection shows the need for a complete cure. Continued support and encouragement for research efforts aimed at developing curative therapies is imperative. The aims of this minireview are to highlight these observations and emphasize the need for a cure for HBV. | Brianna J Shinn Aaron Martin Robert M Coben Mitchell I Conn Jorge Prieto Howard Kroop Anthony J DiMarino Hie-Won Hann | 2019 | World Journal of Hepatology2019，11，1： | 3 |
| 7 | High Prevalence and Mapping of Pre-S Deletion in Hepatitis B Virus Carriers With Progressive Liver Diseases显示文摘 | Bing–Fang Chen Chun–Jen Liu Guey–Mei Jow Pei–Jer Chen Jia–Horng Kao Ding–Shinn Chen | 2006 | Gastroenterology2006，，4： | 2 |
| 8 | MicroRNA-18a Prevents Estrogen Receptor-α Expression, Promoting Proliferation of Hepatocellular Carcinoma Cells显示文摘 | Wan–Hsin Liu Shiou–Hwei Yeh Cho–Chun Lu Sung–Liang Yu Hsuan–Yu Chen Chien–Yu Lin Ding–Shinn Chen Pei–Jer Chen | 2009 | Gastroenterology2009，，2： | 2 |
| 9 | Estrogen Receptor α Represses Transcription of HBV Genes via Interaction With Hepatocyte Nuclear Factor 4α显示文摘 | Sheng–Han Wang Shiou–Hwei Yeh Wei–Hsiang Lin Kun–Huei Yeh Quan Yuan Ning–Shao Xia Ding–Shinn Chen Pei–Jer Chen | 2012 | Gastroenterology2012，，4： | 2 |
| 10 | Serum hepatitis B surface antigen levels help predict disease progression in patients with low hepatitis B virus loads显示文摘 | Tai‐Chung Tseng Chun‐Jen Liu Hung‐Chih Yang Tung‐Hung Su Chia‐Chi Wang Chi‐Ling Chen Cheng‐An Hsu Stephanie Fang‐Tzu Kuo Chen‐Hua Liu Pei‐Jer Chen Ding‐Shinn Chen Jia‐Horng Kao | 2012 | Hepatology2012，，： | 2 |
| 11 | Genome-wide High-Resolution Mapping and Functional Analysis of DNA Methylation in Arabidopsis显示文摘 | Xiaoyu Zhang Junshi Yazaki Ambika Sundaresan Shawn Cokus Simon W.-L. Chan Huaming Chen Ian R. Henderson Paul Shinn Matteo Pellegrini Steve E. Jacobsen Joseph R. Ecker | 2006 | Cell2006，，6： | 2 |
| 12 | Isolated posterior urethral injury: an unusual complication and presentation following male coital trauma显示文摘我们在与血性精液和 coital 以后的 3 年的历史介绍了粗野血尿症的一个 29 岁的人描述交媾的损伤的不平常的复杂并发症。用在一根半肿起的阴茎下面的尿道镜检查,有活跃流血的一处孤立的尿道损伤在职业人员静电干扰尿道被检测。病人成功地与经尿道的闪光被对待。当阴茎是松驰的,但是看征兆的流血阴茎什么时候是勃起的时,我们建议那处孤立的以后的尿道损伤是男交媾的损伤的原因之一,它可能是无征状的。 | Yu-Sheng Cheng Johnny Shinn Nan Lin Yung-Ming Lin | 2006 | Asian Journal of Andrology2006，8，3： | 1 |
| 13 | Joint price and lot size determination under condition of permissible delay in payment and quantity discounts for freight cost显示文摘 | Shinn S W Hwang H Park S S | 1996 | European Journal of Operation Research1996，91，： | 1 |
| 14 | Design of an optimal nearest neighbor classifier using an intelligent genetic algorithm显示文摘 | Shinn -Ying Ho Chia -Cheng Liu Soundy Liu | 2002 | Pattern Recognition Letters2002，23，13： | 1 |
| 15 | Reduced sleep spindles and spindle coherence in schizophrenia:mechanisms of impaired memory consolidation?显示文摘 | Wamsley EJ Tucker MA Shinn AK | 2012 | Biol Psychiatry2012，71，2： | 1 |
| 16 | From Coal to Single-stage and Two-stage Products:A Reactive Model of Coal Tructure显示文摘 | Shinn J H | 1984 | Fuel1984，63，： | 1 |
| 17 | Plastic and elastic properties of compositionally modulated thin films显示文摘 | BARNETT S A SHINN M | 1994 | Annual Reviews in Materials Science1994，24，： | 1 |
| 18 | A returns policy for distribution channel coordination of perishable items显示文摘 | Hahn K H Hwang H Shinn S W | 2004 | European Journal of Operational Research2004，152，3： | 1 |
| 19 | Growth, structure and microhardness of epitaxial TiN/NbN superlattices显示文摘 | Shinn M Huhman L Barnett S A | 1992 | J Mater Res1992，7，4： | 1 |
| 20 | Postnatal growth of fetus-in-fetu 显示文摘 | Kim OH Shinn KS | 1993 | Pediatr Radial1993，23，5： | 1 |
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