|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A deep learning-enabled portable imaging flow cytometer for cost-effective, highthroughput, and label-free analysis of natural water samples显示文摘We report a deep learning-enabled field-portable and cost-effective imaging flow cytometer that automatically captures phase-contrast color images of the contents of a continuously flowing water sample at a throughput of 100 mL/h.The device is based on partially coherent lens-free holographic microscopy and acquires the diffraction patterns of flowing micro-objects inside a microfluidic channel.These holographic diffraction patterns are reconstructed in real time using a deep learning-based phase-recovery and image-reconstruction method to produce a color image of each micro-object without the use of external labeling.Motion blur is eliminated by simultaneously illuminating the sample with red,green,and blue light-emitting diodes that are pulsed.Operated by a laptop computer,this portable device measures 15.5 cm×15 cm×12.5 cm,weighs 1 kg,and compared to standard imaging flow cytometers,it provides extreme reductions of cost,size and weight while also providing a high volumetric throughput over a large object size range.We demonstrated the capabilities of this device by measuring ocean samples at the Los Angeles coastline and obtaining images of its micro-and nanoplankton composition.Furthermore,we measured the concentration of a potentially toxic alga(Pseudo-nitzschia)in six public beaches in Los Angeles and achieved good agreement with measurements conducted by the California Department of Public Health.The cost-effectiveness,compactness,and simplicity of this computational platform might lead to the creation of a network of imaging flow cytometers for largescale and continuous monitoring of the ocean microbiome,including its plankton composition. | Zoltán Gӧrӧcs Miu Tamamitsu Vittorio Bianco Patrick Wolf Shounak Roy Koyoshi Shindo Kyrollos Yanny Yichen Wu Hatice Ceylan Koydemir Yair Rivenson Aydogan Ozcan | 2018 | Light(Science & Applications)2018，7，1： | 14 |
| 2 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 3 | Use of a plane jet for flow-induced noise reduction of tandem rods显示文摘Unsteady wake from upstream components of landing gear impinging on downstream components could be a strong noise source.The use of a plane jet is proposed to reduce this flow-induced noise.Tandem rods with different gap widths were utilized as the test body.Both acoustic and aerodynamic tests were conducted in order to validate this technique.Acoustic test results proved that overall noise emission from tandem rods could be lowered and tonal noise could be removed with use of the plane jet.However,when the plane jet was turned on,in some frequency range it could be the subsequent main contributor instead of tandem rods to total noise emission whilst in some frequency range rods could still be the main contributor.Moreover,aerodynamic tests fundamentally studied explanations for the noise reduction.Specifically,not only impinging speed to rods but speed and turbulence level to the top edge of the rear rod could be diminished by the upstream plane jet.Consequently,the vortex shedding induced by the rear rod was reduced,which was confirmed by the speed,Reynolds stress as well as the velocity fluctuation spectral measured in its wake.This study confirmed the potential use of a plane jet towards landing gear noise reduction. | 赵鲲 杨希祥 Patrick N Okolo 张为华 | 2016 | Chinese Physics B2016，25，6： | 4 |
| 4 | Human immune cells' behavior and survival under bioenergetically restricted conditions in an in vitro fracture hematoma model显示文摘骨头骨折愈合的起始的煽动性的阶段为愈合的过程的结果代表关键步。然而,开始这个煽动性的阶段的机制和在破裂地点在场的有免疫力的房间的功能糟糕被理解。以便在破裂 hematoma 以内学习早事件,我们建立了一在里面 vitro 破裂 hematoma 模型:我们有教养的 hematomas 在 bioenergetically 控制的条件下面在 vitro 在全部的新潮的关节造形术(THA ) 期间在腿节的截骨术(人工的骨头破裂) 期间形成。这个模型允许我们在跟随破裂的早阶段期间监视有免疫力的房间人口,房间幸存和 cytokine 表示。而且,这个模型使我们能改变 bioenergetical 条件以便模仿在里面 vivo 状况,它被假定被组织缺氧描绘并且限制了营养素的数量。用这个模型,我们发现有免疫力的房间经由 angiogenic 因素, chemoattractants 和支持 inflammatory 分子的表示适应组织缺氧。另外,联合了氧的限制,滋养的供应与 myeloid 的比较提高了淋巴细胞的选择幸存导出的房间(即, neutrophils ) 。笔记,非限制的 bioenergetical 条件没关于 cytokine 表示或有免疫力的房间子集的不同幸存率显示出任何类似的效果。在结论,我们发现 bioenergetical 条件在导致骨折愈合的起始的煽动性的阶段的关键因素之中并且因此是为在早破裂 hematoma 影响有免疫力的房间的幸存和功能的一个关键步骤。 | Paula Hoff Patrick Maschmeyer Timo Gaber Tabea Schiitze Tobias Raue Katharina Schmidt-Bleek Rene Dziurla Saskia Schellmann Ferenz Leonard Lohanatha Eric Rohner Andrea Ode Gerd-Riidiger Burmester Georg N Duda Carsten Perka Frank Buttgereit | 2013 | Cellular & Molecular Immunology2013，10，2： | 3 |
| 5 | Crude Protein Content Determination of Potatoes by NIRS Technology显示文摘 | Ainara López Silvia Arazuri Carmen Jarén Jesús Mangado Pedro Arnal José Ignacio Ruiz de Galarreta Patrick Riga Raquel López | 2013 | Procedia Technology2013，，： | 2 |
| 6 | Support vector machines for histogram-based image classification显示文摘 | Olivier Chapelle Patrick Haffner Vladimir N Vapnik | 1999 | IEEE Transaction 0n Neural Networks1999，10，5： | 2 |
| 7 | Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study显示文摘 | Andri Rauch Zoltán Kutalik Patrick Descombes Tao Cai Julia Di Iulio Tobias Mueller Murielle Bochud Manuel Battegay Enos Bernasconi Jan Borovicka Sara Colombo Andreas Cerny Jean–Fran?ois Dufour Hansjakob Furrer Huldrych F. Günthard Markus Heim Bernard Hirs | 2010 | Gastroenterology2010，，4： | 2 |
| 8 | Psychological benefits of greenspace increase with biodiversity显示文摘 | Fuller Richard A Irvine Katherine N Devine-Wright Patrick Warren Philip H Gaston Kevin J | 2007 | Biology Letters2007，，4： | 2 |
| 9 | Characterization and genetic mapping of a new blood-flesh trait controlled by the single dominant locus DBF in peach显示文摘 | Zhijun Shen Carole Confolent Patrick Lambert Jean-Luc Po?ssel Bénédicte Quilot-Turion Mingliang Yu Ruijuan Ma Thierry Pascal | 2013 | Tree Genetics & Genomes2013，，6： | 2 |
| 10 | Transjugular intrahepatic portosystemic shunting versus paracentesis plus albumin for refractory ascites in cirrhosis显示文摘 | Pere Ginès Juan Uriz Blas Calahorra Guadalupe Garcia–Tsao Patrick S. Kamath Luis Ruiz Del Arbol Ramón Planas Jaime Bosch Vicente Arroyo Juan Rodés | 2002 | Gastroenterology2002，，6： | 2 |
| 11 | Contrasted effect of biochar and earthworms on rice growth and resource allocation in different soils显示文摘 | Diana Noguera Marco Rondón Kam-Rigne Laossi Valerio Hoyos Patrick Lavelle Maria Helena Cruz de Carvalho Sébastien Barot | 2010 | Soil Biology and Biochemistry2010，，7： | 2 |
| 12 | Simultaneous preperitoneal hernia repair duringradical pelvic surgery显示文摘 | Patrick C W | 1987 | J Urol1987，137，6： | 1 |
| 13 | Equidistant Fish-Eye Calibration and Rectification by Vanishing Point Extraction 显示文摘 | Ciara'n Hughes Patrick Denny Martin Glavin and Edward Jones | 2010 | IEEE Transactions on Pattern Analysis and Machine Intelligence2010，32，12： | 1 |
| 14 | Metamictization and chemical durability of detrital zircon显示文摘 | BALAN E DANIEL R N PATRICK T | 2001 | Am Mineral2001，86，： | 1 |
| 15 | Procaleitonin as a diagnostic tetct for sepsis in critically ill adults and after surgery or trauma:a systematic review and mets-analysis显示文摘 | Bernard U Regis C Patrick N | | 0，，07： | 1 |
| 16 | Effects of Bacillus subtilis in the Dynamics of Infiltration of Immunological Cells in the Intestinal Mucosa of Chickens Challenged with Salmonella Minnesota显示文摘 | Camargo L M Leandro K N Patrick W | 2012 | Int J Poult Sci2012，11，5： | 1 |
| 17 | Cross-sectional analysis of adverse outcomes in 1029 pregnancies of Afro-Caribbean women in Trinidad with and without systemic lupus erythematosus显示文摘 | Molokhia M Maconochie N Patrick AL | 2007 | Arthritis Res Ther2007，9，6： | 1 |
| 18 | Dynamics of sediment discharge in relation to land use and hydro-climatol- ogy in a humid tropical watershed in costa rica 显示文摘 | JAGDISH K PATRICK N H DANIEL D R | 2001 | Journal of Hydrology2001，253，14： | 1 |
| 19 | EEG biofeedback in the treatment of Attention Deficit/Hyperactivity Disorder 显示文摘 | Patrick N Friel B S | 2007 | Alternative Medicine Review2007，12，2： | 1 |
| 20 | A dynamic model selec- tion strategy for support vector machine classifiers显示文摘 | Macrelo N K Robert S Patrick M | 2012 | Applied Soft Computing2012，12，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员