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| 1 | Transjugular intrahepatic portosystemic stent shunt for medically refractory hepatic hydrothorax:A systematic review and cumulative meta-analysis显示文摘AIM:To assess the effectiveness of transjugular intrahepatic portosystemic stent shunt(TIPSS) in refractory hepatic hydrothorax(RHH) in a systematic review and cumulative meta-analysis.METHODS:A comprehensive literature search was conducted on MEDLINE,EMBASE,and Pub Med covering the period from January 1970 to August 2014.Two authors independently selected and abstracted data from eligible studies.Data were summarized using a random-effects model.Heterogeneity was assessed using the I2 test.RESULTS:Six studies involving a total of 198 patients were included in the analysis.The mean(SD) age of patients was 56(1.8) years.Most patients(56.9%) had Child-Turcott-Pugh class C disease.The mean duration of follow-up was 10 mo(range,5.7-16 mo).Response to TIPSS was complete in 55.8%(95%CI:44.7%-66.9%),partial in 17.6%(95%CI:10.9%-24.2%),and absent in 21.2%(95%CI:14.2%-28.3%).The mean change in hepatic venous pressure gradient post-TIPSS was 12.7 mm Hg.The incidence of TIPSS-related encephalopathy was 11.7%(95%CI:6.3%-17.2%),and the 45-d mortality was 17.7%(95%CI:11.34%-24.13%).CONCLUSION:TIPSS is associated with a clinically relevant response in RHH.TIPSS should be considered early in these patients,given its poor prognosis. | Ivo C Ditah Badr F Al Bawardy Behnam Saberi Chobufo Ditah Patrick S Kamath | 2015 | World Journal of Hepatology2015，7，13： | 5 |
| 2 | Conserved Cytochrome P450 Evolved in Seed Plants Regulates Flower Maturation显示文摘植物染色体的全球检查识别越过 taxa 并且在强壮的净化的选择下面在低拷贝维持的基因,它是可能的有必要功能。基于这个基本原理,我们调查了在种子植物早出现了并且在强壮的否定选择下面演变的低副本的 CYP715 细胞色素 P450 基因家庭的功能。Arabidopsis CYP715A1 在开花期之上在花芽的 tapetum 并且在花药细丝显示出限制织物特定的表情。cyp715a1 插入线在花粉 intine 免职的花瓣开发,和短暂改变显示出一个强壮的缺点。比较表达式分析揭示了涉及花粉开发,房间墙生物的续生说,荷尔蒙动态平衡,和花的 sesquiterpene 的基因的 downregulated 表达式生合成,特别 TPS21 和调整象 MYB21, MYB24,和 MYC2 那样的花的开发的几关键基因。因此,花的 sesquiterpene 排放在 cyp715a1 异种被压制。另外,花荷尔蒙介绍显示了 gibberellinhomeostasis 和 jasmonic 酸衍生物的周转的强壮的骚乱的修正。花瓣生长被活跃赤霉素 GA 3 或 jasmonoyl 异白氨酸的功能的类似物部分恢复, coronatine。CYP715 看起来作为花成熟的一个关键管理者工作,同步花瓣扩大和不稳定的排放。是一个重要决定因素 offlower 昆虫相互作用因此被期望。 | Zhenhua Liu Benoit Boachon RaphaelLugan Raquel Tavares Mathieu Erhardt Jerome Mutterer Valerie Demais Stephanie Pateyron Veronique Brunaud Toshiyuki Ohnishi Ales Pencik Patrick Achard Fan Gong Peter Hedden Daniele Werck-Reichhart Hugues Renault | 2015 | Molecular Plant2015，8，12： | 3 |
| 3 | Efficiency and patient experience with propofol vsconventional sedation:A prospective study显示文摘AIM: To determine whether anaesthesiologistadministered sedation with propofol(AAP) or endoscopist-administered conscious sedation(EAC) with fentanyl/midazolam shortens colonoscopy duration/total room time. METHODS: This is a prospective, non-randomized, comparative study that enrolled patients greater than 18 years of age undergoing colonoscopy in a single Canadian academic outpatient endoscopy unit over a three-month consecutive period. Colonoscopies in this unit are performed both with AAP and EAC. Patient demographics, procedure-related data and adverse events were documented. Additionally, the level of procedure difficulty, and whether a staff endoscopist, trainee with assistance, or independent trainee, performed the procedure were documented. A validated modified 4-question, 5-point Likert scale telephone survey was used to assess patient satisfaction with colonoscopy. The telephone patient satisfaction survey was conducted 24-72 h following the procedure.RESULTS: Two hundred and thirty patients were enrolled during the study period with 126 patients in the AAP group and 104 patients in the EAC group. Mean procedure time was 18.3 ± 10.1 min in the AAP group and 14.7 ± 7.1 min in the EAC group(P = 0.002). Mean total room time was 36.8 ± 13.7 with AAP and 30.1 ± 11 min with EAC(P < 0.001). Multivariate analysis revealed the use of AAP(P = 0.002), resident participation(P < 0.001), diagnostic interventions(P = 0.033), therapeutic interventions(P < 0.001), lower body mass index(P = 0.008) and American Society of Anaesthesiologist class(P = 0.016), to be predictors of longer total room time. Patient age and gender were not significant predictors. After excluding cases in which trainees were involved, there was no significant difference in procedure time between the two groups(P = 0.941), however total room time was still prolonged in the AAP group(P = 0.019). The amount of pain experienced was lower with AAP(P = 0.02), with a trend toward overall higher patient satisfaction(P = 0.074). There were 2 sedation-related adverse events, both in the AAP group involving a patient with aspiration requiring hospitalization and a patient with hypoxia managed with bronchodilators.CONCLUSION: EAC results in reduced total room time compared to AAP. Resident participation doubles procedure time regardless of sedation type. | Patrick Thornley Mohammad Al Beshir James Gregor Andreas Antoniou Nitin Khanna | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，4： | 2 |
| 4 | 非洲血统男性的肌肉衰减与新发高血压的关系显示文摘骨骼肌中异位脂肪组织浸润增加与胰岛素抵抗和糖尿病相关。该研究评估骨骼肌脂肪组织的变化能否预测非洲血统男性随后的高血压发展。在Tobago健康研究中,使用计算机断层扫描测定非洲血统男性(年龄40-91岁)的小腿肌肉间脂肪组织和骨骼肌衰减情况,进行前瞻性纵向研究。高血压定义为收缩压≥140和(或)舒张压≥90mmHg(1mmHg=0.133kPa),或接受降压药物治疗。 | 刘莉 叶鹏 Zhao Q Zmuda JM Kuipers AL Bunker CH Patrick AL Youk AO Miljkovic I | 2017 | 中华高血压杂志2017，25，3： | 2 |
| 5 | Exploiting nonlinear recurrence and fractal scaling properties for voice disorder detection显示文摘 | Max AL Patrick EM StephenJR | 2007 | Biomed Eng Online2007，6，： | 1 |
| 6 | Cross-sectional analysis of adverse outcomes in 1029 pregnancies of Afro-Caribbean women in Trinidad with and without systemic lupus erythematosus显示文摘 | Molokhia M Maconochie N Patrick AL | 2007 | Arthritis Res Ther2007，9，6： | 1 |
| 7 | Heterologous protein production using the Pichia pastoris expression system显示文摘 | Macauley Patrick S Fazenda M L MeNeil B at al | 2005 | Yeast2005，22，： | 1 |
| 8 | Noninvasive positivepressure ventilation in acute respiratory distress without prior chronic respiratory failure显示文摘 | Patrick W Webster K Ludwig L el al | 1996 | Am J Respir Crit Care Med1996，153，： | 1 |
| 9 | Coupled electrical-fluid model of pulsed electric field treatment in a model food system显示文摘 | ALES FIALA PATRICK C WOUTERS | 2001 | Innovative Food Science and Emerging Technologies2001，，2： | 1 |
| 10 | 显示文摘 | Zareen A Patrick AL Sian P | 2002 | Neurobiol Dis2002，9，2： | 1 |
| 11 | Matrix converter: a technology review显示文摘 | PATRICK W W JOSE R JON C C et al | 2009 | IEEE Trans on Inst Elect2009，49，2： | 1 |
| 12 | Synthesis and electronic structure of cationic, neutral, and anionicbis(imino)pyridine iron alkyl complexes: evaluation of redox activity in single-component ethylene polymerization catalysts显示文摘 | TONDREAU A M MILSMANN C PATRICK A D at al | 2010 | J Am Chem Soc2010，132，15： | 1 |
| 13 | Validation of a screening questionnaire for androgen deficiency in aging males 显示文摘 | Morley JE Charlton E Patrick P ct al | 2000 | Metabo- lism2000，49，9： | 1 |
| 14 | A comparative study of dexmedetomidine with midazolam and midazolam ahme hJr sedation during elective awake fibernptic intubatinn 显示文摘 | Bergese SD Patrick Bender S McSweeney TD eL al | 2010 | J Clin Aneslh2010，22，5： | 1 |
| 15 | Body invest- ment, depression, and alcohol use as risk factors for suicide prone- ness in college students显示文摘 | DORIAN AL PATRICK SM JENNIFER LR | 2010 | Crisis2010，31，3： | 1 |
| 16 | Attachment in old age: Theoretical assumptions,empirical findings and implications for clinical practice显示文摘 | Van Lies A Patrick L Ronny B ct al | 2012 | Clin Psychol Rev2012，33，1： | 1 |
| 17 | Fiber grating sensors显示文摘 | Kersey A D Davis M A Patrick H J el al | 1997 | Journal of Lightwave Technology1997，15，18： | 1 |
| 18 | Ciprofloxacin Resist ance in Campylobacter jejuni Evolves Rapidly in Chickens Freatedwith Fluoroquinolones显示文摘 | Patrick F McI)ermotl Sonya M el al | 2002 | J Infect Dis2002，185，6： | 1 |
| 19 | HDS on doped molybdenum carbides: From probe moieties to real feedstocks显示文摘 | Patrick Da Costa Jean-Marie Manoli Claude Potvin Deep ct al | 2005 | Catalysis Today2005，，： | 1 |
| 20 | Heterologous proteinproduction using the FHchia pastoris expression system 显示文摘 | Macauley Patrick S Fazenda M L Mcneil B et al | 2005 | Yeast2005，22，4： | 1 |
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