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| 1 | The immune tolerant phase of chronic HBV infection: new perspectives on an old concept显示文摘长期的肝炎 B 病毒(HBV ) 感染通过强烈与耐心的年龄被联系的不同疾病阶段进行。所谓的免疫者容忍(信息技术) 阶段代表感染的古典早阶段;它与 HBV 复制的高水平和肝发炎的临床的符号的缺乏被联系。HBV 感染的这个阶段是否也与免疫学的被联系, “ 展示; tolerance' 最近被质问了。这里,我们考察数据那争论有免疫力的忍耐的这个概念然后建议发生在 CHB 感染的这个早阶段期间的 immunopathological 事件的其他的解释。 | Antonio Bertoletti Patrick T Kennedy | 2015 | Cellular & Molecular Immunology2015，12，3： | 36 |
| 2 | Effectiveness of exercise in hepatic fat mobilization in nonalcoholic fatty liver disease: Systematic review显示文摘AIM: To investigate the efficacy of exercise interventions on hepatic fat mobilization in non-alcoholic fatty liver disease(NAFLD) patients.METHODS: Ovid-Medline, Pub Med, EMBASE and Cochrane database were searched for randomized trials and prospective cohort studies in adults aged ≥ 18 which investigated the effects of at least 8 wk of exercise only or combination with diet on NAFLD from 2010 to 2016. The search terms used to identify articles, in which exercise was clearly described by type, duration, intensity and frequency were: 'NASH', 'NAFLD', 'nonalcoholic steatohepatitis', 'non-alcoholic fatty liver disease', 'fat', 'steatosis', 'diet', 'exercise', 'MR spectroscopy' and 'liver biopsy'. NAFLD diagnosis, as well as the outcome measures, was confirmed by either hydrogen-magnetic resonance spectroscopy(H-MRS) or biopsy. Trials that included dietary interventions along with exercise were accepted if they met all criteria. RESULTS: Eight studies met selection criteria(6 with exercise only, 2 with diet and exercise with a total of 433 adult participants). Training interventions ranged between 8 and 48 wk in duration with a prescribed exercise frequency of 3 to 7 d per week, at intensities between 45% and 75% of VO2 peak. The most commonly used imaging modality was H-MRS and one study utilized biopsy. The effect of intervention on fat mobilization was 30.2% in the exercise only group and 49.8% in diet and exercise group. There was no difference between aerobic and resistance exercise intervention, although only one study compared thetwo interventions. The beneficial effects of exercise on intrahepatic triglyceride(IHTG) were seen even in the absence of significant weight loss. Although combining an exercise program with dietary interventions augmented the reduction in IHTG, as well as improved measures of glucose control and/or insulin sensitivity, exercise only significantly decreased hepatic lipid contents.CONCLUSION: Prescribed exercise in subjects with NAFLD reduces IHTG independent of dietary intervention. Diet and exercise was more effective than exercise alone in reducing IHTG. | Pegah Golabi Cameron T Locklear Patrick Austin Sophie Afdhal Melinda Byrns Lynn Gerber Zobair M Younossi | 2016 | World Journal of Gastroenterology2016，22，27： | 30 |
| 3 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 4 | GOBO projection for 3D measurements at highest frame rates: a performance analysis显示文摘Aperiodic sinusoidal patterns that are cast by a GOBO(GOes Before Optics)projector are a powerful tool for optically measuring the surface topography of moving or deforming objects with very high speed and accuracy.We optimised the first experimental setup that we were able to measure inflating car airbags at frame rates of more than 50 kHz while achieving a 3D point standard deviation of~500μm.Here,we theoretically investigate the method of GOBO projection of aperiodic sinusoidal fringes.In a simulation-based performance analysis,we examine the parameters that influence the accuracy of the measurement result and identify an optimal pattern design that yields the highest measurement accuracy.We compare the results with those that were obtained via GOBO projection of phase-shifted sinusoidal fringes.Finally,we experimentally verify the theoretical findings.We show that the proposed technique has several advantages over conventional fringe projection techniques,as the easy-to-build and cost-effective GOBO projector can provide a high radiant flux,allows high frame rates,and can be used over a wide spectral range. | Stefan Heist Patrick Dietrich Martin Landmann Peter Kühmstedt Gunther Notni Andreas Tünnermann | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 5 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 6 | Metamictization and chemical durability of detrital zircon显示文摘 | BALAN E DANIEL R N PATRICK T | 2001 | Am Mineral2001，86，： | 1 |
| 7 | Disposition of the selective cholesterol absorption inhibitor ezetimibe in healthy male subjects显示文摘 | PATRICK J E KOSOGLOU T STAUBER K L | 2002 | Drug Metab Dispos2002，30，4： | 1 |
| 8 | The Detection of Peste des Petits Ruminants (PPR)Virus Antigen by Agar Gel Precipitation Test and CounterImmunoelectrophoresis显示文摘 | Obi T U Patrick D | 1984 | J Hyg (led)1984，93，3： | 1 |
| 9 | Mean platelet volume and platelet distribution width in the neonate显示文摘 | Patrick CH Lazarchick J Stubbs T | 1987 | Am J Pediatr Hematol Oncol1987，9，2： | 1 |
| 10 | Stability of silico-ferrite of calcium and aluminum (SFCA) in air-solid solution lim- its between 1240 degrees C and 1390 degrees C and phase relationships within the Fe203-CaO-Al2O2-SiO2 (FCAS) system显示文摘 | Patrick T R C Pownceby M I | 2002 | Metallurgical and Materials Transac- tions B-Process Metallurgy and Materials Processing Sci-ence2002，33，1： | 1 |
| 11 | Financial Development and Economic Growth in Underdeveloped Countries显示文摘 | Patrick T | | 0，，02： | 1 |
| 12 | Preferred risk allocation in target cost contracts in con- struction显示文摘 | Joseph H L Chan Daniel W M Chan Patrick T I Lam | 2011 | Facilities2011，29，1314： | 1 |
| 13 | Whorl and stalk dam- age by European and Southwestern corn borers to four events of Bacillus thuringiensis transgenic maize 显示文摘 | Archer T L Schuster G Patrick C | 2000 | Crop Protec- tion2000，19，3： | 1 |
| 14 | Axillary lymph node metastases in patients with a final diagnosis nf ductal carcinoma in situ显示文摘 | Kelly T A Kim J A Patrick R | 2003 | Am J Surg2003，186，： | 1 |
| 15 | Extractives from new Zealand Uniflorl honeys 显示文摘 | SENG T T ALISTAIR L W PATRICK T H | 1989 | J Agric Food Chem1989，37，： | 1 |
| 16 | Financial Development and Economic Growth in Underdeveloped Countries显示文摘 | Patrick H T | 1966 | Economic Development and Cultural Change1966，，14： | 1 |
| 17 | Financial Development and Economic Growth in Underdeveloped Countries显示文摘 | Patrick H T | 1966 | Economic Development and Cultural Change1966，，14： | 1 |
| 18 | A comparativestudy of dexmedetomidine with midazolam and midazolam alone forsedation during elective awake fiberoptic intubation显示文摘 | Berges S D Patrick Bender S McSweeney T D | 2010 | J Clin Anesth2010，22，1： | 1 |
| 19 | Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex显示文摘 | Shingo K Patrick S Takuya T | | 0，，： | 1 |
| 20 | Measuring system of systems per-formance显示文摘 | Thomas J M Patrick T H | 2012 | International Journal of System of Systems Engi neering2012，3，3： | 1 |
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