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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Non-thermal food preservation: Pulsed electric fields 显示文摘 | Humberto Vega-Mercado Olga M B Qin B L | 1997 | Trends in Food Science& Technology1997，，8： | 2 |
| 3 | Characterisation of low-fat high-dietary fibre frankfurters显示文摘 | NURIA G M MARIA 1 A A OLGA M B | 1999 | Meat Science1999，52，： | 1 |
| 4 | Effect of the nature of carbon support on the formation of active sites in Pd/C and Ru/C catalysts for hydrogena- tion of furfural显示文摘 | Roman M Mironenko Olga B Belskaya Tatyana I Gulyaeva | 2015 | Catalysis Today2015，249，： | 1 |
| 5 | A natural clouding agent from orange peels obtained using polygalacturonase and cellulase 显示文摘 | Alexandre E B Robert C S F Olga M B | 2005 | Food Chemistry2005，92，1： | 1 |
| 6 | Characterisation of low-fat high-dietary fibre frankfurters显示文摘 | Nuria G M Maria I A A Olga M B | 1999 | Meat Science1999，，52： | 1 |
| 7 | Synthesis of carbon-coated MgO nanoparticles显示文摘 | Alexander F Bedilo Jake Sigel M Olga B Koper | 2002 | J Mate Chem2002，12，： | 1 |
| 8 | The effects of vacuum annealing on the structure and surface chemistry of iron: Nickel alloy nanoparticles显示文摘 | MICHELLE D THOMAS B S RICHARD A C OLGA R ROBERT J B GARETH M H | 2010 | Journal of Nanoparticle Research2010，12，6： | 1 |
| 9 | Erythropoietin modula- tion of podocalyxin and a proposed erythroblast niche显示文摘 | Pradeep S Madhu P M Olga B | 2007 | Blood2007，110，2： | 1 |
| 10 | Using polysaccharide-based edible coatings to maintain quality of fresh-cut Fuji apples显示文摘 | Maria A R Maria S T Olga M B | 2008 | LWT2008，41，： | 1 |
| 11 | Changes in bioactive composition of fresh-cut strawberries stored under super atmospheric oxygen,low-oxygen or passive atmospheres显示文摘 | Odriozola S Robert S F Olga M B | 2010 | Food composition and analysis2010，23，1： | 1 |
| 12 | A simple and efficient oxidation procedure for the synthesis of acid -sensitive epoxides 显示文摘 | OLGA B FANTIN G FOGAGNOLO M | 2009 | Synthesis2009，，7： | 1 |
| 13 | Homogeneous Oxidation of Aromatics in Nucleus with Peracetic Acid Catalyzed by Iron and Manganese Phthalocyanine Complexes显示文摘 | Svetlana V B Valentina M C Olga V D | 1996 | Tetrahedron Letter1996，37，10： | 1 |
| 14 | Effect of Packaging Conditions on Quality and Shelf-Life of Fresh-Cut Pineapple显示文摘 | Marta M C Maria A R Olga M B | 2008 | Postharvest Biology and Technology2008，50，23： | 1 |
| 15 | Electronic noses in the quality control of alcoholic beverages显示文摘 | Pilar M M Ricard B Olga B Josep G | 2005 | Trends in Analytical Chemistry2005，24，： | 1 |
| 16 | Mid- to Late Holocene climate change: an overview显示文摘 | Heinz Wanner Jürg Beer Jonathan Bütikofer Thomas J. Crowley Ulrich Cubasch Jacqueline Flückiger Hugues Goosse Martin Grosjean Fortunat Joos Jed O. Kaplan Marcel Küttel Simon A. Müller I. Colin Prentice Olga Solomina Thomas F. Stocker Pavel Tarasov Mayke W | 2008 | Quaternary Science Reviews2008，，19： | 1 |
| 17 | Aroma profile and volatiles odor activity along gold culfivar pineapple flesh显示文摘 | Marta M C Maria Alejandra R G Olga M B | 2010 | Journal of Food Science2010，75，： | 1 |
| 18 | Synthesis and effects on cell viability of- flavonols and 3-methyl ether derivatives on human leukemia cells显示文摘 | Olga B Maria T M Sara E | 2014 | European Journal of Medicinal Chemistry2014，84，： | 1 |
| 19 | Co-dellvery of siRNA and an anticancer drug for treatment of multidrug-resistant cancer 显示文摘 | MAHA S OLGA B G TAMARA M | 2008 | Nanomedicine2008，3，6： | 1 |
| 20 | Effect of ripeness on t he shelf-life of fresh-cut melon preserved by modified atmosphere packaging显示文摘 | Gemma O O Robert S F Olga M B | 2007 | European Food Research and Technology2007，，225： | 1 |
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