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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Development of a group-specific immunoassay for sulfonamides application to bee honey analysis显示文摘 | NURIA P N ESTER G I ANGEL M | 2007 | Talanta2007，71，2： | 1 |
| 3 | Volatile composition and descriptive sensory analysis of pomegranate juice and wine显示文摘 | Antonio J.Andreu-Sevillaa Pedro M Nuria M Cristina G V | | 0，，54： | 1 |
| 4 | Chilling and heat requirements of sweet cherry cultivars and the relationship between altitude and the probability of satisfying the chill require- rnents显示文摘 | NURIA A FEDERICO G M ANTONIO C LORENZO B | 2008 | Environmental and Exoerimental Botany2008，，1： | 1 |
| 5 | Characterisation of low-fat high-dietary fibre frankfurters显示文摘 | NURIA G M MARIA 1 A A OLGA M B | 1999 | Meat Science1999，52，： | 1 |
| 6 | Development of a group- specific immtmoassay for sulfonamides application to bee honey analysis 显示文摘 | NURIA P N ESTER G I ANGEL M | 2007 | Talanta2007，71，： | 1 |
| 7 | Feelings of well being in elderly people : relationship to physical activity and physical function 显示文摘 | Nuria G Olga M Raquel M | 2009 | Arch Gerontol Gefiatr2009，48，3： | 1 |
| 8 | Characterisation of low-fat high-dietary fibre frankfurters显示文摘 | Nuria G M Maria I A A Olga M B | 1999 | Meat Science1999，，52： | 1 |
| 9 | Specific-based im-munoassays for sulfathiazole显示文摘 | Nuria P N Cristina G B Angel M | | 0，，12： | 1 |
| 10 | Generation of induced pluripotent stem eells from human cord blood using OCT4 and SOX2显示文摘 | ALESSANDRA G NURIA M TROND A | 2009 | Cell Stem Cell2009，5，： | 1 |
| 11 | First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial显示文摘 | Gareth J Morgan Faith E Davies Walter M Gregory Kim Cocks Sue E Bell Alex J Szubert Nuria Navarro-Coy Mark T Drayson Roger G Owen Sylvia Feyler A John Ashcroft Fiona Ross Jennifer Byrne Huw Roddie Claudius Rudin Gordon Cook Graham H Jackson J Anthony Chil | 2010 | The Lancet . 2010 (9757)2010，，： | 1 |
| 12 | Specific-based Immunoassays for sulfathiazole 显示文摘 | Nuria P N Cristina G B Angel M | 2004 | Analytical Biochemistry2004，，12： | 1 |
| 13 | Specificpolyclonal-based immunoassays for sulfathiazole显示文摘 | Cristina G B (A)ngel M | 2004 | Anal Bioanal Chem2004，379，： | 1 |
| 14 | IBQS:A synthetic index of soil quality based on soil macro-invertebrate communities显示文摘 | Nuria R Jér?me M Léonide C Christine R Gérard H Etienne I Patrick L | | 0，，： | 1 |
| 15 | Development of a group specific immunoassay for sulfonamides application to bee honey analysis显示文摘 | NURIA P N ESTER G I ANGEL M | 2007 | Talanta2007，71，2： | 1 |
| 16 | Specific polyclonal-based immunoassays for sulfathiazole 显示文摘 | Nuria P N Cristina G B Angel M | 2004 | Anal Bioanal Chem2004，379，： | 1 |
| 17 | Effects of zoledronic acid versus clodronic acid on skeletal morbidity in patients with newly diagnosed multiple myeloma (MRC Myeloma IX): secondary outcomes from a randomised controlled trial显示文摘 | Gareth J Morgan J Anthony Child Walter M Gregory Alex J Szubert Kim Cocks Sue E Bell Nuria Navarro-Coy Mark T Drayson Roger G Owen Sylvia Feyler A John Ashcroft Fiona M Ross Jennifer Byrne Huw Roddie Claudius Rudin Gordon Cook Graham H Jackson Ping Wu Fai | 2011 | Lancet Oncology2011，，8： | 1 |
| 18 | Daytime sleepiness and polysomnography in obstructive sleep apnea patients显示文摘 | Nuria R Silvia G Olga M | 2008 | Sleep Med2008，9，7： | 1 |
| 19 | Chilling and heat requirements of sweet cherry cultivars and the relationship between altitude and the probability of satisfying the chill requirements 显示文摘 | NURIA A FEDERICO G M ANTONIO C | 2008 | Environmental and Experimental Botany2008，，1： | 1 |
| 20 | Some insights into protein structural class prediction 显示文摘 | Zhou G P Nuria A M | 2001 | Proteins:Structure Function and Genetics2001，44，1： | 1 |
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