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| 1 | Is there a role for Tc-99m (V) DMSA scintigraphy in ischemic colitis?显示文摘AIM: To evaluate the role of pentavalent Tc-99m dimercaptosuccinic acid [Tc-99m (V) DMSA] in the diagnosis of ischemic colitis. METHODS: Fourteen patients with endoscopically and histologically confirmed ischemic colitis were included in the study. Tc-99m (V) DMSA scintigraphy was performed within 2 d after colonoscopy. Images were considered positive when an area of increased activity was observed in the region of interest and negative when no abnormal tracer uptake was detected. RESULTS: In 3 out of the 14 patients, Tc-99m (V) DMSA images showed moderate activity in the bowel. The scintigraphic results corresponded with the endoscopic findings. In the other 11 patients, no abnormal tracer uptake was detected in the abdomen. CONCLUSION: Besides the limited number of patients, Tc-99m (V) DMSA could not be considered as a useful imaging modality for the evaluation of ischemic colitis. | Maria I Stathaki Ioannis E Koutroubakis Sophia I Koukouraki Elias A Kouroumalis Nikolaos S Karkavitsas | 2008 | World Journal of Gastroenterology2008，14，35： | 4 |
| 2 | Impairment of pre-mRNA splicing in liver disease: Mechanisms and consequences显示文摘Pre-mRNA splicing is an essential step in the process of gene expression in eukaryotes and consists of the removal ofintrons and the linking of exons to generate mature mRNAs. This is a highly regulated mechanism that allows the alternative usage of exons, the retention ofintronic sequences and the generation of exonic sequences of variable length. Most human genes undergo splicing events, and disruptions of this process have been associated with a variety of diseases, including cancer. Hepatocellular carcinoma (HCC) is a molecularly heterogeneous type of tumor that usually develops in a cirrhotic liver. Alterations in pre-mRNA splicing of some genes have been observed in liver cancer, and although still scarce, the available data suggest that splicing defects may have a role in hepatocarcinogenesis. Here we briefly review the general mechanisms that regulatepre-mRNA splicing, and discuss some examples that illustrate how this process is impaired in liver tumorigenesis, and may contribute to HCC development. We believe that a more thorough examination of pre-mRNA splicing is still needed to accurately draw the molecular portrait of liver cancer. This will surely contribute to a better understanding of the disease and to the development of new effective therapies. | Carmen Berasain Saioa Gońi Josefa Castillo Maria Ujue Latasa Jesús Prieto Matias A Avila | 2010 | World Journal of Gastroenterology2010，16，25： | 2 |
| 3 | Mean platelet volume: a useful marker of inflammatory bowel disease activity显示文摘 | Andreas N Kapsoritakis Michael I Koukourakis Aekaterini Sfiridaki Spiros P Potamianos Maria G Kosmadaki Ioannis E Koutroubakis Elias A Kouroumalis | 2001 | The American Journal of Gastroenterology2001，，3： | 2 |
| 4 | Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial显示文摘 | John R Teerlink Gad Cotter Beth A Davison G Michael Felker Gerasimos Filippatos Barry H Greenberg Piotr Ponikowski Elaine Unemori Adriaan A Voors Kirkwood F Adams Maria I Dorobantu Liliana R Grinfeld Guillaume Jondeau Alon Marmor Josep Masip Peter S Pang | 2013 | The Lancet . 2013 (9860)2013，，9860： | 1 |
| 5 | Polydatin, a natural precursor of resveratrol, in- duces cell cycle arrest and differentiation of hu- man colorectal CaCO3 cell 显示文摘 | De Maria S Scognamiglio I Lombardi A | 2013 | J Transl Med2013，11，1： | 1 |
| 6 | Genome-wide analysis of differentially expressed genes during the early stages of tomato infection by a potyvirus显示文摘 | ALFENAS-ZERBINI P MARIA I G F(A)VARO R D | | 0，，3： | 1 |
| 7 | 1-Deoxy-D-xy- lulose 5-phosphate reductoisomerase and plastid isoprenoid biosyn- thesis during tomato fruit ripening 显示文摘 | RODRtGUEZ-CONCEPCION M AHUMADA I DIEZ-JUEZ E SAURET-GUETO S MARIA LOIS L GALLEGO F CAR- RETERO-PAULET L CAMPOS N BORONAT A | 2001 | Plant J2001，27，3： | 1 |
| 8 | Evaluation of Intrinsic and Extrinsic Contributions to the Piezoelectric Properties of Pb,(Zr1-xTx) O3 Thin Films as a Function of Composition显示文摘 | Kim D J Maria J P Kingon A I | | 0，，： | 1 |
| 9 | Micellar electrokinetic capillary chromatography of methylated flavone aglycones 显示文摘 | MARIA I G FEDERICO F FRANCISCO A | 1995 | J Liq Chromatogr1995，18，15： | 1 |
| 10 | 显示文摘 | Kinggon A I Maria J Streiffer S K | 2000 | Nature2000，406，： | 1 |
| 11 | Polyurethane foams based on modified tung oil and reinforced with rice husk ash I: Synthesis and physical chemical characterization 显示文摘 | Virginia R Mima A Maria I | 2013 | Pol- 3 mer Testing2013，32，2： | 1 |
| 12 | Antioxidant Acton of Bixin Against CisplatinInduced Chromosome Aberrations and Lipid Peroxidation in Rats显示文摘 | Cec(I)lia Rodrigues Siva Lus(a)nua M Greggu Abtyes abd Maria De Lourdes P | 2001 | Pharmacological Research2001，43，6： | 1 |
| 13 | Zirconium carbide thin films deposited by pulsed laser ablation显示文摘 | ALESSIO L D SANTAGATA A TEGHIL R ZACCAGNINO M ZACCARDO I MAROTTA V FERRO D MARIA G D | 2000 | Appl Surf Sci2000，168，14： | 1 |
| 14 | Incidence of congenital hydrocephalus and the role of the prenatal diagnosis 显示文摘 | Denise P Cavalcant I Maria A | 2003 | J Pediatr (RioJ)2003，79，2： | 1 |
| 15 | Use of boron-doped diamond electrode pre-treated cathodically for the determination of trace metals in honey by differential pulse voltammetry显示文摘 | Gl ouc i o G H Gustavo C A Maria A C M | 2014 | Food Control2014，36，： | 1 |
| 16 | Characterization of short chain fatty acid microcapsules produced by spray drying 显示文摘 | Maria I T Leonardo R A Farina M | 2004 | Materials Science and Engineering2004，24，5： | 1 |
| 17 | Role of preoperative ultrasonography in the surgical management of patients with thyroid cancer显示文摘 | Maria A Kouvaraki Suzanne E Shapiro Bruno D Fornage Beth S Edeiken-Monro Steven I Sherman Rena Vassilopoulou-Sellin Jeffrey E Lee Douglas B Evans | 2003 | Surgery2003，，6： | 1 |
| 18 | Changes in Strawberry Anthocyanins and Other Polyphenols in Re- sponse to Carbon Dioxide Treatments 显示文摘 | MARIA I G DEIRDRE M H KADER A A | 1997 | J Agric Food Chem1997，，45： | 1 |
| 19 | Post-column terbium complexation and sensitized fluorescence detection for the determination of norepinephrine,epinephrine and dopamine using high-performance liquid chromatography显示文摘 | Maria A F Penelope C I | 2002 | Anal Chim Acta2002，34，09： | 1 |
| 20 | Preparation, characterization, cytotoxicity and pharmacokinetics of liposomes containing docetaxel显示文摘 | MARIA L I PAOLA B SIINIA A | 2003 | J Controlled Release2003，91，： | 1 |
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