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| 1 | Endoscopic submucosal dissection in dogs in a World Gastroenterology Organisation training center显示文摘AIM: To evaluate if canine models are appropriate for teaching endoscopy fellows the techniques of endoscopic submucosal dissection (ESD). METHODS: ESD was performed in 10 canine models under general anesthesia, on artificial lesions of the esophagus or stomach marked with coagulation points. After ESD, each canine model was euthanized and surgical resection of the esophagus or stomach was carried out according to 'The Principles of Humane Experimental Technique, Russel and Burch'. The ESD specimens were fixed with needles on cork submerged in a formol solution with the esophagus or stomach, and delivered to the pathology department to be analyzed. RESULTS: ESD was completed without complications using the Hook-knife in five esophageal areas, with a procedural duration of 124 ± 19 min, a length of 27.4 ± 2.6 mm and a width of 21 ± 2.4 mm. ESD was also completed without complications using the IT-knife2 in five gastric areas, with a procedural duration of 92.6 ± 19 min, a length of 32 ± 2.5 mm and a width of 18 ± 3.7 mm. CONCLUSION: ESD is feasible in the normal esopha- gus and stomach of canine models, which are appropriate for teaching this technique. | Miguel A Tanimoto Gonzalo Torres-Villalobos Rikiya Fujita Patricio Santillan-Doherty Jorge Albores-Saavedra German Gutierrez Luis A Martin-del-Campo Carlos Bravo-Reyna Octavio Villanueva Jose J Villalobos Misael Uribe Miguel A Valdovinos | 2010 | World Journal of Gastroenterology2010，16，14： | 7 |
| 2 | The transcription factor ZEB1 promotes chemoresistance in prostate cancer cell lines显示文摘One of the factors promoting tumoral progress is the abnormal activation of the epithelial-mesenchymal transition(EMT)program which has been associated with chemoresistance in tumoral cells.The transcription factor zinc finger E-box-binding homeobox 1(ZEB1),a key EMT activator,has recently been related to docetaxel resistance,the main chemotherapeutic used in advanced prostate cancer treatment.The mechanisms involved in this protective effect are still unclear.In a previous work,we demonstrated that ZEB1 expression induced an EMT-like phenotype in prostate cancer cell lines.In this work,we used prostate cancer cell lines 22Rvl and DU145 to study the effect of ZEB1 modulation on docetaxel resistance and its possible mechanisms.The results showed that ZEB1 overexpression conferred to 22Rvl cell resistance to docetaxel while its silencing made DU145 cells more sensitive to it.Analysis of resistance markers showed no presenee of ATP-binding cassette subfamily B member 1(MDR1)and no changes in breast cancer resistance protein(BCRP)or ATP-binding cassette subfamily C member 10(MRP7).However,a correlation between ZEB1,multidrug resistance-associated protein 1(MRP1),and ATP-binding cassette subfamily C member 4(MRP4)expression was observed.MRP4 inhibition,using MK571,resensitized cells with ZEB1 overexpression to docetaxel treatment.In addition,modulation of ZEB1 and subsequent change in MRP4 expression correlated with a lower apoptotic response to docetaxel,characterized by lower B-cell lymphoma 2(Bcl2),high BCL2-associated X protein(Bax),and high active caspase 3 expression.The response to docetaxel in our model seems to be mediated mainly by activation of the apoptotic death program.Our results showed that modulation of MRP4 could be a mediator of ZEBl-related resistance to docetaxel in prostate cancer,making it a possible marker for chemotherapy response in patients who do not express MDR1. | Octavio Orellana-Serradell Daniela Herrera Enrique A Castellon Hector R Contreras | 2019 | Asian Journal of Andrology2019，21，5： | 5 |
| 3 | The transcription factor ZEB1 promotes an aggressive phenotype in prostate cancer cell lines显示文摘 | Octavio Orellana-Serradell Daniela Herrera Enrique A Castellon Hector R Contreras | 2018 | Asian Journal of Andrology2018，20，3： | 4 |
| 4 | A dynamic decision support system for farm water management in surface irrigation: modal development and application显示文摘 | Carlos I Flores Eduardo A Holzapfel Octavio Lagos | 2010 | Chilean journal of agricultural research2010，70，2： | 1 |
| 5 | Effect of ibuprofen exposure on blood, gill, liver, and brain on common carp ( Cyprinus carpio ) using oxidative stress biomarkers显示文摘 | Hariz Islas-Flores Leobardo Manuel Gómez-Oliván Marcela Galar-Martínez Sandra García-Medina Nadia Neri-Cruz Octavio Dublán-García | 2014 | Environmental Science and Pollution Research2014，，7： | 1 |
| 6 | Effect of the Trapped Mass and its Composition on the Heat Transfer in the Compression Cycle of a Reciprocating Engine显示文摘 | OCTAVIO A JOSE R FRANCISCO P | 2005 | Applied Thermal Engineering2005，25，： | 1 |
| 7 | Laparoscopic Adrenalectomy for Adrenal Masses:Dose SizeMatter显示文摘 | Octavio A Castillo Gonzalo Vitagliano Fernando P Secin etal | 2008 | Urology2008，71，6： | 1 |
| 8 | Staggered heat sinks with aerodynamic cooling fins 显示文摘 | Octavio A L | 2004 | Microelectronics Reliability2004，44，： | 1 |
| 9 | The effect of ionic liquids with imidazolium and pyridinium cations on the corrosion inhibition of mild steel in acidic environment显示文摘 | Natalya V Likhanova Marco A Domínguez-Aguilar Octavio Olivares-Xometl | 2010 | Corrosion Science2010，52，6： | 1 |
| 10 | Effect of Biodiesel Fuels on Diesel Engine Emissions 显示文摘 | MAGIN L OCTAVIO A JOSE R F | 2008 | Progress in Energy and Combustion Science2008，34，： | 1 |
| 11 | Menegario Elias A G Zagattoand Maria Fernanda Gine显示文摘 | Luis Fernando R Machado Antonio Octavio Jacintho Amauri A | | 0，，： | 1 |
| 12 | Effect of Biodiesel Fuels on Diesel Engine Emissions显示文摘 | MAGIN L OCTAVIO A JOSE R F | | 0，，02： | 1 |
| 13 | Crop-Yield Distributions Revisited显示文摘 | Octavio A R Sukant K M James F | 2003 | American journal of agricultural economics2003，85，1： | 1 |
| 14 | A dynamic decision support system for farm water management in surface irrigation:model development and application显示文摘 | FLORES C I HOLZAPFEL E A OCTAVIO LAGOS | 2010 | Chilean Journal of Agricultural Research2010，70，2： | 1 |
| 15 | DNA markers define two major phylogenetic lineages of Trypanosoma cruzi显示文摘 | Ricardo P. Souto Octavio Fernandes Andréa M. Macedo David A. Campbell Bianca Zingales | 1996 | Molecular & Biochemical Parasitology1996，，2： | 1 |
| 16 | Production of β-galactosidase by Kluyveromyces marxianus under Oscillating Dissolved Oxygen Tension显示文摘 | Gabriel A C Mauricioa T Octavio T R | 2005 | Process Biochemistry2005，，： | 1 |
| 17 | Sodium Phthalamates as Corrosion Inhibitors for Carbon Steel in Aqueous Hydrochloric Acid Solution显示文摘 | FLORES Eugenio A OLIVARES Octavio LIKHANOVA Na- talya V | 2011 | Corrosion Science2011，53，12： | 1 |
| 18 | Enhanced phosphorus uptake in transgenic tobacco plants that Over-produce citrate显示文摘 | Lo pez-Bucio J Octavio de la Vega M Guevara-Garci a A | 2000 | Nature Biotechnology2000，，： | 1 |
| 19 | Optimization of the Isoelectric Precipitation Method to Obtain Protein Isolates from Amaranth Seeds 显示文摘 | Beatriz Saleedo-Chavez Juan A Osuna-Castro Fidel Guevam-Lara Jorge Dominguez-Dominguez Octavio Paredes-Lopez | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 20 | Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-γ-producing NK cell and regulatory T cell subsets显示文摘 | Octavio Aravena Bárbara Pesce Lilian Soto Natalia Orrego Francisca Sabugo Pamela Wurmann María Carmen Molina Jorge Alfaro Miguel Cuchacovich Juan Carlos Aguillón Diego Catalán | 2011 | Immunobiology2011，，12： | 1 |
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