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| 1 | Utility of fluorescent cholangiography during laparoscopic cholecystectomy: A systematic review显示文摘AIM: To verify the utility of fluorescent cholangiography for more rigorous identification of the extrahepatic biliary system.METHODS: MEDLINE and Pub Med searches were performed using the key words 'fluorescent cholangiography', 'fluorescent angiography', 'intraoperative fluorescent imaging', and 'laparoscopic cholecystectomy' in order to identify relevant articles published in English, French, German, and Italian during the years of 2009 to 2014. Reference lists from the articles were reviewed to identify additional pertinent articles. For studies published in languages other than those mentioned above, all available information was collected from their English abstracts. Retrieved manuscripts(case reports, reviews, and abstracts) concerning the application of fluorescent cholangiography were reviewed by the authors, and the data were extracted using a standardized collection tool. Data were subsequently analyzed with descriptive statistics. In contrast to classic meta-analyses, statistical analysis was performed where the outcome was calculated as the percentages of an event(without comparison) in pseudo-cohorts of observed patients.RESULTS: A total of 16 studies were found that involved fluorescent cholangiography during standard laparoscopic cholecystectomies(n = 11), singleincision robotic cholecystectomies(n = 3), multiport robotic cholecystectomy(n = 1), and single-incision laparoscopic cholecystectomy(n = 1). Overall, these preliminary studies indicated that this novel technique was highly sensitive for the detection of important biliary anatomy and could facilitate the prevention of bile duct injuries. The structures effectively identified before dissection of Calot's triangle included the cystic duct(CD), the common hepatic duct(CHD), the common bile duct(CBD), and the CD-CHD junction. A review of the literature revealed that the frequenciesof detection of the extrahepatic biliary system ranged from 71.4% to 100% for the CD, 33.3% to 100% for the CHD, 50% to 100% for the CBD, and 25% to 100% for the CD-CHD junction. However, the frequency of visualization of the CD and the CBD were reduced in patients with a body mass index > 35 kg/m2 relative to those with a body mass index < 35 kg/m2(91.0% and 64.0% vs 92.3% and 71.8%, respectively).CONCLUSION: Fluorescent cholangiography is a safe procedure enabling real-time visualization of bile duct anatomy and may become standard practice to prevent bile duct injury during laparoscopic cholecystectomy. | Antonio Pesce Gaetano Piccolo Gaetano La Greca Stefano Puleo | 2015 | World Journal of Gastroenterology2015，21，25： | 21 |
| 2 | Diet and functional dyspepsia: Clinical correlates and therapeutic perspectives显示文摘Hypervigilance and symptoms anticipation,visceral hypersensitivity and gastroduodenal sensorimotor abnormalities account for the varied clinical presentation of functional dyspepsia(FD)patients.Many patients recognize meals as the main triggering factor;thus,dietary manipulations often represent the first-line management strategy in this cohort of patients.Nonetheless,scarce quality evidence has been produced regarding the relationship between specific foods and/or macronutrients and the onset of FD symptoms,resulting in nonstandardized nutritional approaches.Most dietary advises are indeed empirical and often lead to exclusion diets,reinforcing in patients the perception of“being intolerant”to food and self-perpetuating some of the very mechanisms underlying dyspepsia physiopathology(i.e.,hypervigilance and symptom anticipation).Clinicians are often uncertain regarding the contribution of specific foods to dyspepsia physiopathology and dedicated professionals(i.e.,dietitians)are only available in tertiary referral settings.This in turn,can result in nutritionally unbalanced diets and could even encourage restrictive eating behaviors in severe dyspepsia.In this review,we aim at evaluating the relationship between dietary habits,macronutrients and specific foods in determining FD symptoms.We will provide an overview of the evidence-based nutritional approach that should be pursued in these patients,providing clinicians with a valuable tool in standardizing nutritional advises and discouraging patients from engaging into indiscriminate food exclusions. | Marcella Pesce Martina Cargiolli Sara Cassarano Barbara Polese Barbara De Conno Laura Aurino Nicola Mancino Giovanni Sarnelli | 2020 | World Journal of Gastroenterology2020，26，5： | 14 |
| 3 | Chronic functional constipation is strongly linked to vitamin D deficiency显示文摘BACKGROUND Few studies have examined intestinal motility disorders, which are disabling conditions associated with chronic functional constipation, whose pathogenesis is actually not well-defined.AIM To investigate the relationship between serum 25-hydroxyvitamin D levels and functional chronic constipation associated to intestinal motility disorders.METHODS We performed a prospective case-control study, from May-June to November2017. Glucose/lactulose breath tests, radiopaque markers(multiple capsule techniques) and wireless motility capsule analysis were used to assess colonicand oro-cecal transit time, after excluding small-intestinal bacterial overgrowth condition. Then, we measured 25-hydroxyvitamin D levels in patients with intestinal motility disorders and we further evaluated the influence of intestinal motility disorders on psychological symptoms/quality of life using validated questionnaires, the Irritable Bowel Syndrome Quality of life(IBS-QOL), the Short Form Health Survey 12, and the Hospital Anxiety and Depression Scale 14(HADS-14 A and HADS-14 D).RESULTS We enrolled 86 patients with chronic functional constipation associated to intestinal motility disorders and 86 matched healthy subjects. Patients with intestinal motility disorders had lower 25-hydroxyvitamin D levels(P < 0.001), and they showed a significant impairment of all health-related quality of life and psychological tests(IBS-QOL, Short Form Health Survey 12-Physical Component Summary, Short Form Health Survey 12-Mental Component Summary, HADS-14 A and HADS-14 D), as compared to the control group(P < 0.001), which significantly correlated with low vitamin D levels(r =-0.57, P < 0.001; r = 0.21, P = 0.01; r =-0.48, P < 0.001; r =-0.57, P < 0.001; r =-0.29, P < 0.001, respectively). At multivariate analysis vitamin D low levels remained a significant independent risk factor for the occurrence of intestinal motility disorder(odds ratio = 1.19; 95% confidence interval: 1.14-1.26, P < 0.001).CONCLUSION Vitamin D deficiency, anxiety and depression symptoms are commonly associated with chronic functional constipation induced by intestinal motility disorders. Vitamin D serum levels should be routinely measured in these patients. | Alba Panarese Francesco Pesce Piero Porcelli Giuseppe Riezzo Palma Aurelia Iacovazzi Carla Maria Leone Massimo De Carne Caterina Mammone Rinaldi Endrit Shahini | 2019 | World Journal of Gastroenterology2019，25，14： | 8 |
| 4 | 运动与儿童认知:运动特性的影响和元认知的作用(英文)显示文摘关于运动干预对儿童心理功能的作用,因为各项研究的过程存在差异,很难得出确定性结论。本文为叙述性综述,评价两种运动干预对儿童认知的影响。根据所掌握的任务复杂程度以及由此推出的心理参与,将急性和慢性运动干预进行定量或定性区分。两种干预均能提高儿童认知,但对元认知过程的作用还是未知。本文强调了元认知过程的影响及其对儿童行为和学业表现的调节作用。 | Phillip D.Tomporowski Bryan Mc Cullick Daniel M.Pendleton Caterina Pesce | 2015 | Journal of Sport and Health Science2015，4，1： | 8 |
| 5 | Eosinophilic esophagitis: From pathophysiology to treatment显示文摘Eosinophilic esophagitis(Eo E) is a chronic immune disease, characterized by a dense eosinophilic infiltrate in the esophagus, leading to bolus impaction and refluxlike symptoms. Traditionally considered a pediatric disease, the number of adult patients with Eo E is continuously increasing, with a relatively higher incidence in western countries. Dysphagia and food impaction represent the main symptoms complained by patients, but gastroesophageal reflux-like symptoms may also be present. Esophageal biopsies are mandatory for the diagnosis of Eo E, though clinical manifestations and proton pump inhibitors responsiveness must be taken into consideration. The higher prevalence of Eo E in patients suffering from atopic diseases suggests a common background with allergy, however both the etiology and pathophysiology are not completely understood. Elimination diets are considered the firstline therapy in children, but this approach appears less effective in adults patients, who often require steroids; despite medical treatments, Eo E is complicated in some cases by esophageal stricture and stenosis, that require additional endoscopic treatments. This review summarizes the evidence on Eo E pathophysiology and illustrates the safety and efficacy of the most recent medical and endoscopic treatments. | Alessandra D’Alessandro Dario Esposito Marcella Pesce Rosario Cuomo Giovanni Domenico De Palma Giovanni Sarnelli | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 4 |
| 6 | 对上面的胃肠的道的活动性混乱的基因贡献显示文摘 Motility disorders of the upper gastrointestinal tract encompass a wide range of different diseases. Esophageal achalasia and functional dyspepsia are representative disorders of impaired motility of the esophagus and stomach, respectively. In spite of their variable prevalence, what both diseases have in common is poor knowledge of their etiology and pathophysiology. There is some evidence showing that there is a genetic predisposition towards these diseases, especially for achalasia. Many authors have investigated the possible genes involved, stressing the autoimmune or the neurological hypothesis, but there is very little data available. Similarly, studies supporting a post-infective etiology, based on an altered immune response in susceptible individuals, need to be validated. Further association studies can help to explain this complex picture and find new therapeutic targets. The aim of this review is to summarize current knowledge of genetics in motility disorders of the upper gastrointestinal tract, addressing how genetics contributes to the development of achalasia and functional dyspepsia respectively. | Giovanni Sarnelli Alessandra D’Alessandro Marcella Pesce Ilaria Palumbo Rosario Cuomo | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，4： | 3 |
| 7 | Fluorescent cholangiography: An up-to-date overview twelve years after the first clinical application显示文摘Laparoscopic cholecystectomy(LC)is one of the most frequently performed gastrointestinal surgeries worldwide.Bile duct injury(BDI)represents the most serious complication of LC,with an incidence of 0.3%-0.7%,resulting in significant perioperative morbidity and mortality,impaired quality of life,and high rates of subsequent medico-legal litigation.In most cases,the primary cause of BDI is the misinterpretation of biliary anatomy,leading to unexpected biliary lesions.Near-infrared fluorescent cholangiography is widely spreading in clinical practice to delineate biliary anatomy during LC in elective and emergency settings.The primary aim of this article was to perform an up-to-date overview of the evolution of this method 12 years after the first clinical application in 2009 and to highlight all advantages and current limitations according to the available scientific evidence. | Antonio Pesce Gaetano Piccolo Francesca Lecchi NicolòFabbri Michele Diana Carlo Vittorio Feo | 2021 | World Journal of Gastroenterology2021，27，36： | 2 |
| 8 | The human brain hexacoordinated neuroglobin three-dimensional structure 显示文摘 | Pesce A Dewilde S Nardini M | 2004 | Micron2004，35，1： | 1 |
| 9 | Visual analog scale (VAS) for assessment of acute mountain sickness (AMS) on Aconca~,ua 显示文摘 | Van Roo JD Lazio MP Pesce C | 2011 | Wilderness Environ Med2011，22，1： | 1 |
| 10 | Performance of Eu- roSCORE in CABG and off-pump coronary artery bypass grafting: single institution experience and meta-analysis 显示文摘 | Parolari A Pesce LL Trezzi M | 2009 | Eur Heart J2009，30，3： | 1 |
| 11 | Negative feedback interaction of HO-1/INOS in PBMC: of acute congestive heart fail- ure patients 显示文摘 | Speranza L Franceschelli S Pesce M | 2013 | J Biol Regul Homeost Agents2013，27，3： | 1 |
| 12 | Non-palpable testis : modem diagnostic and therapeutic trends 显示文摘 | Battaglino F Pesce C Musi L | 1996 | Pediatr Med Chir1996，18，： | 1 |
| 13 | Hydrogenation of α, β- unsaturated aldehydes over Pt-Sn/Nylon 显示文摘 | Farnetti E Pesce M Kaspar J | 1986 | J Chem Soc Chem Commun1986，，10： | 1 |
| 14 | Crystal structure of cytoglobin:the fourth globin type discovered in man displays heme hexa-coordination显示文摘 | de SD Dewilde S Pesce A | 2004 | J Mol Biol2004，336，4： | 1 |
| 15 | Clinical chemistry and post-liver-transplant monitoring显示文摘 | Hickman PE Potter JM Pesce AJ | 1997 | Clin Chem1997，43，8： | 1 |
| 16 | The human brainhexacoordinated neuroglobin three-dimensional structure显示文摘 | Pesce A Dewilde S Nardini M | 2004 | Micron2004，35，12： | 1 |
| 17 | Glomerular cell replication and cell loss through apoptosis in experimental diabetes mellitus显示文摘 | Pesce C Menini S Pricci F | 2002 | Nephron2002，90，4： | 1 |
| 18 | Ductal carcinoma in situ of the breast and heparanase-1 expression:a molecular explanation for more aggressive subtypes显示文摘 | Maxhimer JB Pesce CE Stewart RA | 2005 | J Am Coll Surg2005，200，3： | 1 |
| 19 | Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients 显示文摘 | Pesce B Soto L Sabugo F | 2013 | Clin Exp Immunol2013，171，3： | 1 |
| 20 | Worldwide distribution of glomerular diseases: the role of renal biopsy registries显示文摘 | Pesce F Schena F P | 2010 | Nephrol Dial Transplant2010，25，2： | 1 |
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