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| 1 | Developmental pathways associated with cancer metastasis:Notch,Wnt,and Hedgehog显示文摘Master developmental pathways, such as Notch, Wnt, and Hedgehog, are signaling systems that control proliferation, cell death,motility, migration, and stemness. These systems are not only commonly activated in many solid tumors, where they drive or contribute to cancer initiation, but also in primary and metastatic tumor development. The reactivation of developmental pathways in cancer stroma favors the development of cancer stem cells and allows their maintenance, indicating these signaling pathways as particularly attractive targets for efficient anticancer therapies, especially in advanced primary tumors and metastatic cancers. Metastasis is the worst feature of cancer development. This feature results from a cascade of events emerging from the hijacking of epithelial-mesenchymal transition, angiogenesis, migration, and invasion by transforming cells and is associated with poor survival, drug resistance, and tumor relapse. In the present review, we summarize and discuss experimental data suggesting pivotal roles for developmental pathways in cancer development and metastasis, considering the therapeutic potential. Emerging targeted antimetastatic therapies based on Notch, Wnt, and Hedgehog pathways are also discussed. | Armel Herve Nwabo Kamdje Paul Takam Kamga Richard Tagne Simo Lorella Vecchio Paul Faustin Seke Etet Jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera | 2017 | Cancer Biology & Medicine2017，14，2： | 10 |
| 2 | Mesenchymal stromal cells' role in tumor microenvironment:involvement of signaling pathways显示文摘Mesenchymal stromal cells(MSCs) are adult multipotent stem cells residing as pericytes in various tissues and organs where they can differentiate into specialized cells to replace dying cells and damaged tissues. These cells are commonly found at injury sites and in tumors that are known to behave like 'wounds that do not heal.' In this article, we discuss the mechanisms of MSCs in migrating, homing, and repairing injured tissues. We also review a number of reports showing that tumor microenvironment triggers plasticity mechanisms in MSCs to induce malignant neoplastic tissue formation, maintenance, and chemoresistance, as well as tumor growth. The antitumor properties and therapeutic potential of MSCs are also discussed. | Armel Herve Nwabo Kamdje Paul Takam Kamga Richard Tagne Simo Lorella Vecchio Paul Faustin Seke Etet Jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera | 2017 | Cancer Biology & Medicine2017，14，2： | 4 |
| 3 | Insulin resistance and cancer:the role of insulin and IGFs显示文摘 | Djiogue S Nwabo Kamdje AH Vecchio L | 2013 | Endocr Relat Cancer2013，20，1： | 1 |
| 4 | Signaling pathways bridging fate determination of neural crest cells to glial lineages in the developing peripheral nervous system显示文摘 | Maulilio John Kipanyula Wahabu Hamisi Kimaro Faustin N. Yepnjio Yousef H. Aldebasi Mohammed Farahna Armel Herve Nwabo Kamdje Eltuhami M. Abdel-Magied Paul Faustin Seke Etet | 2013 | Cellular Signalling2013，，： | 1 |
| 5 | Role of stromal cellmediatedNotch signaling in CLL resistance to chemotherapy显示文摘 | Nwabo Kamdje AH Bassi G Pacelli L | 2012 | Blood Cancer J2012，2，5： | 1 |
| 6 | Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with hu- man bone marrow-derived mesenchymal stromal cells显示文摘 | Nwabo Kamdje AH Mosna F Bifari F | 2011 | Blood2011，118，： | 1 |
| 7 | Insulin resistance and cancer: the role of insulin and IGFs 显示文摘 | DJIOGUE S NWABO KAMDJE A H VECCHIO L | 2013 | Endocr Relat Cancer2013，20，1： | 1 |
| 8 | Signaling pathways in chronic myeloid leukemia and leukemic stem cell maintenance:key role of stromal microenvironment显示文摘 | Seke Etet PF Vecchio L Nwabo Kamdje AH | 2012 | Cell Signal2012，24，9： | 1 |
| 9 | Signaling pathways in chronic myeloid leukemia and leukemic stem cell maintenance: key role of stromal microenvironment 显示文摘 | Seke Etet PF Veechio L Nwabo Kamdje AH | 2012 | Cell Signal2012，24，9： | 1 |
| 10 | Interactions between bone marrow stromal microenvironment and Bchronic lymphocytic leukemia cells:any role for Notch,Wnt and Hh signaling pathways显示文摘 | Seke Etet PF Vecchio L Nwabo Kamdje AH | | 0，，07： | 1 |
| 11 | Interactions between bone marrow stromal microenvironment and B-chronic lymphocytic leukemia cells:any role for Notch,Wnt and Hh signaling pathways显示文摘 | Seke Etet PF Vecchio L Nwabo Kamdje AH | | 0，，07： | 1 |
| 12 | Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy显示文摘 | Nwabo Kamdje AH Bassi G Pacelli L | 2012 | Blood Cancer J2012，2，5： | 1 |
| 13 | Insulin resistance and cancer:The role of insulin and IGEs 显示文摘 | Djiogue S Nwabo Kamdje AH Vecchio L | 2013 | Endocr Relat Canc- er2013，20，1： | 1 |
| 14 | Interac- tions between bone marrow stromal microenvironment and B-chronic lymphocytic leukemia cells: any role for Notch, Wnt and Hh signaling pathways? 显示文摘 | Seke Etet PF Vecchio L Nwabo Kamdje AH | 2012 | Cell Signal2012，24，7： | 1 |
| 15 | Insulin resistance and cancer: the role of insulin and IGFs显示文摘 | Djiogue S Nwabo Kamdje AH Vecchio L | 2013 | Endocr Relat Cancer2013，20，1： | 1 |
| 16 | Notch signaling in acute lymphoblastic leukemia:any role for stromal microenvironment显示文摘 | Nwabo Kamdje AH Krampera M | | 0，，25： | 1 |
| 17 | Signaling pathways in chronic myeloid leukemia and leukemic stem cell maintenance: Key role of stromal microenvironment显示文摘 | P.F. Seke Etet L. Vecchio A.H. Nwabo Kamdje | 2012 | Cellular Signalling2012，，9： | 1 |
| 18 | Sig- naling pathways in breast cancer:therapeutic targeting of the microenvironment显示文摘 | Nwabo Kamdje AH Seke Etet PF Vecchio L | 2014 | Cell Signal2014，26，12： | 1 |
| 19 | Signaling pathways in chronic myeloid leukemia and leukemic stem cell maintenance: Key role of stromal microenvironment显示文摘 | P.F. Seke Etet L. Vecchio A.H. Nwabo Kamdje | 2012 | Cellular Signalling2012，，9： | 1 |
| 20 | Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells显示文摘 | Nwabo Kamdje AH Mosna F Bifari F | 2011 | Blood2011，118，2： | 1 |
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