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| 1 | Developmental pathways associated with cancer metastasis:Notch,Wnt,and Hedgehog显示文摘Master developmental pathways, such as Notch, Wnt, and Hedgehog, are signaling systems that control proliferation, cell death,motility, migration, and stemness. These systems are not only commonly activated in many solid tumors, where they drive or contribute to cancer initiation, but also in primary and metastatic tumor development. The reactivation of developmental pathways in cancer stroma favors the development of cancer stem cells and allows their maintenance, indicating these signaling pathways as particularly attractive targets for efficient anticancer therapies, especially in advanced primary tumors and metastatic cancers. Metastasis is the worst feature of cancer development. This feature results from a cascade of events emerging from the hijacking of epithelial-mesenchymal transition, angiogenesis, migration, and invasion by transforming cells and is associated with poor survival, drug resistance, and tumor relapse. In the present review, we summarize and discuss experimental data suggesting pivotal roles for developmental pathways in cancer development and metastasis, considering the therapeutic potential. Emerging targeted antimetastatic therapies based on Notch, Wnt, and Hedgehog pathways are also discussed. | Armel Herve Nwabo Kamdje Paul Takam Kamga Richard Tagne Simo Lorella Vecchio Paul Faustin Seke Etet Jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera | 2017 | Cancer Biology & Medicine2017，14，2： | 10 |
| 2 | Mesenchymal stromal cells' role in tumor microenvironment:involvement of signaling pathways显示文摘Mesenchymal stromal cells(MSCs) are adult multipotent stem cells residing as pericytes in various tissues and organs where they can differentiate into specialized cells to replace dying cells and damaged tissues. These cells are commonly found at injury sites and in tumors that are known to behave like 'wounds that do not heal.' In this article, we discuss the mechanisms of MSCs in migrating, homing, and repairing injured tissues. We also review a number of reports showing that tumor microenvironment triggers plasticity mechanisms in MSCs to induce malignant neoplastic tissue formation, maintenance, and chemoresistance, as well as tumor growth. The antitumor properties and therapeutic potential of MSCs are also discussed. | Armel Herve Nwabo Kamdje Paul Takam Kamga Richard Tagne Simo Lorella Vecchio Paul Faustin Seke Etet Jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera | 2017 | Cancer Biology & Medicine2017，14，2： | 4 |
| 3 | Hypolipidemic,antioxidant and anti-atherosclerogenic effects of aqueous extract of Zanthoxylum heitzii stem bark in diet-induced hypercholesterolemic rats显示文摘Objective:To evaluate anti-dyslipidemic,antioxidant and anti-atherosclerogenic properties of this extract in diet-induced hypercholesterolemic rat.a model of metabolic syndrome-induced atherosclerosis and associated cardiovascular diseases.Methods:Normocholeslerolemic(NC) male rats were divided into six groups(n=10) and fed a high-cholesterol(HC) diet for 30 days(5 groups),or normal rat chow(normal control group).Rats given a HC diet also received distilled water(disease control),the potent hypocholcsterolcmic agent with antiatherosclerotic activity atorvastatin(2 mg/kg,positive control),or one of the three doses of Zanthoxylum heitzii stem bark aqueous extract tested(225,300 and 375 mg/kg) concomitantly for four months.Signs of general toxicity,body temperature and weight,and water and food intake were monitored in live animals.After sacrifice,lipid profiles and oxidative stress markers were assessed in the blood and liver,aorta,and feces,and histopathological analysis of aorta was performed.Results:Plant extract prevented the elevation of aortic total cholesterol and triglycerides,and hepatic low density lipoprotein,very low density lipoprotein,and total cholesterol.Lipid peroxidation(TBARS) was decreased and aortic atherosclerotic plaque formation prevented.Conclusions:These observations strongly suggest that stem bark aqueous extract of Zanthoxylum heitzii has anti-atherosclerogenic properties,at least partly mediated by antioxidant and hypolipidemic effects. | Fidele Ntchapda Kakesse Maguirgue Hamadjida Adjia Paul Faustin Seke Etet Théophile Dimo | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，5： | 3 |
| 4 | Diuretic and antioxidant activities of the aqueous extract of leaves of Cassia occidentalis(Linn.) in rats显示文摘Objective: To assess the putative diuretic and antioxidant properties of Cassia occidentalis(C. occidentalis) leaves' aqueous extract. Methods: Adult rats were administered with C. occidentalis leaves aqueous extract acutely(24-h) and subchronically(7 d), at doses 80, 160, 240, 320, and 400 mg/kg(per os). Negative control group received only an equivalent volume of distilled water, while the two positive control groups received the diuretic drugs furosemide(20 mg/kg, i.p.) and hydrochlorothiazide(HCTZ, 20 mg/kg, i.p.). Urinary elimination of electrolytes in response to treatments was evaluated, together with changes in concentrations of creatinine, urea, aldosterone, glucose, and albumin in urine and plasma. Various urinary indicators of kidney function and plasmatic markers of oxidative stress were also assessed. Results: The acute administration of C. occidentalis increased the urinary excretion of 107.58% at the higher dose tested, compared to negative control. The reference drugs furosemide and HCTZ induced increases of 84.27 % and 48.05 %, respectively. Acutely, the extract induced Na+ and Cl- elimination, whereas subchronically an increase in K+ elimination was also observed. The extract also improved the kidney function indexes and oxidative stress markers. These effects were dose-dependent and comparable with positive control observations. Conclusions: Our i ndings strongly suggest that C. occidentalis aqueous extract has diuretic and antioxidant activities, and deserves further studies considering the potential for the treatment of hypertension. | Théophile Dimo Fidèle Ntchapda Joseph Barama David Romain Kemeta Azambou Paul Faustin Seke Etet | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，9： | 2 |
| 5 | Effects of the textural and surface properties of activated carbon on the adsorption of fold dieyanide显示文摘 | Seke M D Sandenbergh R F Vegter N M | 2000 | Minerals Engineering2000，13，： | 1 |
| 6 | Effect of cuprous cyanide, dry and wet milling on the selective flotation of galena and sphalerite 显示文摘 | Seke M D Pistorius P C | 2006 | Minerals Engineering2006，19，1： | 1 |
| 7 | Signaling pathways bridging fate determination of neural crest cells to glial lineages in the developing peripheral nervous system显示文摘 | Maulilio John Kipanyula Wahabu Hamisi Kimaro Faustin N. Yepnjio Yousef H. Aldebasi Mohammed Farahna Armel Herve Nwabo Kamdje Eltuhami M. Abdel-Magied Paul Faustin Seke Etet | 2013 | Cellular Signalling2013，，： | 1 |
| 8 | Volume change of clays induced by heating as observed in consolidation tests显示文摘 | Towhata I Kuntiwatlanakul P Seke I | 1993 | Soils and Foundations1993，33，4： | 1 |
| 9 | Isolation of angiotensin converting enzyme inhibitora from tuna muscle显示文摘 | Kohama Y Matsufuji H Seke E | 1988 | Biochem Biophys Res Commun1988，155，： | 1 |
| 10 | The Relationship of Headquarters Country and Industry Classification to Financial Structure显示文摘 | Collins J Markham Sekely William S | | Financial Management0，，： | 1 |
| 11 | Iterative superresolution reconstruction using modified subgradient method显示文摘 | OZKAN K SEKE E ADAR N | 2006 | Lecture Notes in Computer Science2006，4105，： | 1 |
| 12 | Nwabo kamdje AH Signaling pathways in chronic myeloid leukemia and leukemic stem cell maintenance:Key role of stromal microenvironment显示文摘 | Seke Etet PF Vecchio L | | 0，，09： | 1 |
| 13 | Numerical analysis of 2D vortex-induced oscillation of a circular cylinder 显示文摘 | WEI R SEKING A SHINUAR M | 1995 | International Journal for Numerical Method in Fluids1995，21，： | 1 |
| 14 | Increasing the accuracy of thermal transient measurements显示文摘 | Sekely V Rencz M | 2002 | IEEE T Compon Pack T2002，25，4： | 1 |
| 15 | Signaling pathways in chronic myeloid leukemia and leukemic stem cell maintenance:key role of stromal microenvironment显示文摘 | Seke Etet PF Vecchio L Nwabo Kamdje AH | 2012 | Cell Signal2012，24，9： | 1 |
| 16 | Signaling pathways in chronic myeloid leukemia and leukemic stem cell maintenance: key role of stromal microenvironment 显示文摘 | Seke Etet PF Veechio L Nwabo Kamdje AH | 2012 | Cell Signal2012，24，9： | 1 |
| 17 | Fourteen Days Post-Ovariectomy Estrogens Decline Is Associated with Anxiogenic Effects on Wistar Rats显示文摘 | Zemo Gamo Franklin Djiogue Sefirin Ketcha Wanda Germain Jean Magloire Seke Etet Paul Faustin Yonkeu Tatchou Floriane Gaelle Djikem Tadah Rudig Nikanor Awounfack Charline Florence Njamen Dieudonne | 2017 | Journal of Pharmacy and Pharmacology2017，5，12： | 1 |
| 18 | Effect of cuprous cyanide,dry and wet milling onthe selective flotation of galena and sphalerite显示文摘 | Pistorius P C | 2006 | Minerals Engineering2006，19，1： | 1 |
| 19 | Workshop report from the division of cancer etiology, mational cancer institute, mational institutes of health current perspectives and future trends in hormonal carcinogenesis 显示文摘 | Li JJ Mueller GL Sekely LI | 1991 | cANCER rES1991，51，13： | 1 |
| 20 | Interactions between bone marrow stromal microenvironment and Bchronic lymphocytic leukemia cells:any role for Notch,Wnt and Hh signaling pathways显示文摘 | Seke Etet PF Vecchio L Nwabo Kamdje AH | | 0，，07： | 1 |
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