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| 1 | 全尾砂-粗骨料膏体早期抗压强度影响规律及固化机理显示文摘以某矿尾砂、废石、棒磨砂为实验材料,采用正交设计实验方法,研究膏体质量分数、水泥掺量、尾骨比(全尾砂、废石和棒磨砂质量比)、泵送剂掺量对充填体早期抗压强度的影响规律。对实验数据进行三维曲面可视化分析和多元非线性回归分析,最后根据实验结果对膏体固结性能的机理进行分析。研究结果表明:水泥掺量和质量分数是早期抗压强度的主要影响因素,m(全尾砂)꞉m(废石)꞉m(棒磨砂)以及泵送剂掺量存在最优值,最优值范围分别为5.0꞉2.5꞉2.5~4꞉3꞉3和1.5%~2.0%。多元非线性二次多项式回归拟合效果最佳,根据所选模型和主观权重T可知,所得目标函数f存在最大值和最小值,最大值为8.97 MPa,最小值为2.87 MPa,均满足7 d强度要求(R7≥2.5 MPa);粗骨料的掺入不仅能进一步提高早期抗压强度,而且粗骨料中的活性物质能与Ca(OH)2发生反应,起到部分胶凝效果。 | 尹升华 刘家明 邵亚建 张海胜 ARMELLE Belibi 寇永渊 | 2020 | 中南大学学报(自然科学版)2020，51，2： | 36 |
| 2 | 基于RSM的胶结充填体强度回归及料浆寻优研究显示文摘为了提升充填料浆性价比,针对多种骨料混合充填类矿山开展料浆优化配比研究。首先,根据骨料物化性质,采用Talbol理论分析碎石-棒磨砂的最大堆积密实度并确定碎石与棒磨砂这2种材料的最优配比范围;然后,根据响应面法(RSM)提供的中心复合试验方案进行17组配比试验,构建强度为响应值的回归模型,揭示料浆质量分数、碎棒比(碎石与棒磨砂的质量比)和胶砂比(水泥和骨料的质量比)单一或交互作用对充填体强度的影响机制。最后,采用目标规划法对充填料浆配合比寻优。研究结果表明:强度对单一因素的响应极敏感,对因素交互的响应具有显著性;在因素交互下,早期强度对料浆质量分数和胶砂比交互作用敏感,中期强度受碎棒比和胶砂比的交互作用影响大,料浆质量分数和碎棒比的交互作用对后期强度影响显著;考虑性价比的料浆最优配合比是料浆质量分数为77%,碎棒比为2.33,胶砂比为1:5,该配合比满足金川二矿区输送与充填强度设计标准。 | 尹升华 郝硕 邹龙 寇永渊 李希雯 ARMELLE Belibi | 2020 | 中南大学学报(自然科学版)2020，51，6： | 13 |
| 3 | Developmental pathways associated with cancer metastasis:Notch,Wnt,and Hedgehog显示文摘Master developmental pathways, such as Notch, Wnt, and Hedgehog, are signaling systems that control proliferation, cell death,motility, migration, and stemness. These systems are not only commonly activated in many solid tumors, where they drive or contribute to cancer initiation, but also in primary and metastatic tumor development. The reactivation of developmental pathways in cancer stroma favors the development of cancer stem cells and allows their maintenance, indicating these signaling pathways as particularly attractive targets for efficient anticancer therapies, especially in advanced primary tumors and metastatic cancers. Metastasis is the worst feature of cancer development. This feature results from a cascade of events emerging from the hijacking of epithelial-mesenchymal transition, angiogenesis, migration, and invasion by transforming cells and is associated with poor survival, drug resistance, and tumor relapse. In the present review, we summarize and discuss experimental data suggesting pivotal roles for developmental pathways in cancer development and metastasis, considering the therapeutic potential. Emerging targeted antimetastatic therapies based on Notch, Wnt, and Hedgehog pathways are also discussed. | Armel Herve Nwabo Kamdje Paul Takam Kamga Richard Tagne Simo Lorella Vecchio Paul Faustin Seke Etet Jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera | 2017 | Cancer Biology & Medicine2017，14，2： | 10 |
| 4 | Antimicrobial Activity of the Methanolic Extract and Compounds from the Stem Bark of Drypetes tessmanniana显示文摘从茎评估甲醇摘录的抗菌剂活动的目的 Drypetes tessmanniana ,部分( DTB1-5 )以及混合物吠叫[ friedelin ( 2 ), 3,7-dioxofriedelane ( 3 ), 3,15-dioxofriedelane ( 4 ), 3 尾-O-(E) -3,5-dihydroxycinnamoyl-11-oxo-olean-12-ene ( 6 ),和 3 尾, 6 伪- dihydroxylup-20 ( 29 ) -ene ( 7 )。方法琼脂圆盘散开被用来决定上述样品的敏感,虽然 microdilution 方法被用于最小的禁止的集中(MIC ) 和最小的 microbicidal 集中(MMC ) 的决心。散开测试显示出的结果粗略的摘录能阻止所有的生长,这测试了有机体。所有另外的样品显示出选择活动。部分 DTB2 的禁止的效果在 63.7% 上被注意, 54.6% 上的 DTB1 和 DBT3,虽然 DTB4 和 DTB5 开是活跃的, 11 中的 9.1% 个测试了有机体。测试混合物为混合物阻止了 81.8% 测试微生物引起的种类的生长 3 和 4, 36.7% 为化合物 6,和 18.2% 为化合物 7。MIC 决心的结果为 DTB 和化合物显示了可察觉的价值 4 在 81.8% 测试有机体上。为另外的样品, MIC 在 0 鈥 ? 上被检测 3.7% 。为粗略的摘录和部分(DTB2 ) 的最低 MIC 价值(78.12 渭 g /mL ) 在 M 上被观察。audouinii。为孤立的混合物(156.25 渭 g /mL ) 的相应价值与混合物被注意 3 在 S 上。faecalis 并且 4 在 M 上。audouinii audouinii。MMC 决心的结果建议大多数学习微生物上的测试样品的 microbicidal 效果能被期望。结论从茎的甲醇摘录 Drypetes 吠叫。象一些孤立的混合物一样的 tessmanniana (Euphorbiaceae ) 可能是新抗菌剂药的潜在的来源。关键词 Drypetes tessmanniana - Euphorbiaceae - 混合物 - 抗菌剂活动为科学由国际基础支持了(没有。IFS/2624-3F ) 。 | Victor Kuete Marlise D.J.Dongfack Armelle T.Mbaveng Marie-Christine Lallemand Hanh T.Van-Dufat Jean-Duplex Wansi Elisabeth Seguin Francois Tillequin Jean Wandji | 2010 | Chinese Journal of Integrative Medicine2010，16，4： | 7 |
| 5 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 6 | Mesenchymal stromal cells' role in tumor microenvironment:involvement of signaling pathways显示文摘Mesenchymal stromal cells(MSCs) are adult multipotent stem cells residing as pericytes in various tissues and organs where they can differentiate into specialized cells to replace dying cells and damaged tissues. These cells are commonly found at injury sites and in tumors that are known to behave like 'wounds that do not heal.' In this article, we discuss the mechanisms of MSCs in migrating, homing, and repairing injured tissues. We also review a number of reports showing that tumor microenvironment triggers plasticity mechanisms in MSCs to induce malignant neoplastic tissue formation, maintenance, and chemoresistance, as well as tumor growth. The antitumor properties and therapeutic potential of MSCs are also discussed. | Armel Herve Nwabo Kamdje Paul Takam Kamga Richard Tagne Simo Lorella Vecchio Paul Faustin Seke Etet Jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera | 2017 | Cancer Biology & Medicine2017，14，2： | 4 |
| 7 | Relationship between the severity of hepatitis C virus-related liver disease and the presence of Helicobacter species in the liver: A prospective study显示文摘AIM: To determine the presence of Helicobacter species DNA in the liver of chronic hepatitis C (CHC) patients with and without cirrhosis as compared to controls, and to identify the bacterial species involved. METHODS: Seventy-nine consecutive patients (HBV and HIV negative) with a liver sample obtained after liver biopsy or hepatic resection were studied: 41 with CHC without cirrhosis, 12 with CHC and cirrhosis, and 26 controls (HCV negative). Polymerase chain reactions (PCRs) targeting Helicobacter 16S rDNA and species- specific were performed on DNA extracted from the liver. A gastric infection with H pylori was determined by serology and confirmed by 13C-urea breath test. RESULTS: Overall, Helicobacter 16S rDNA was found in 16 patients (20.2%). Although positive cases tended to be higher in CHC patients with cirrhosis (41.6%) than in those without cirrhosis (17.0%) or in controls (15.4%), the difference was not statistically significant (P =0.08). H pylori-like DNA was identified in 12 cases and H. pullorum DNA in 2, while 2 cases remained unidenti- fied. Gastric infection with H pylori was found in only 2 of these patients. CONCLUSION: Our results do not confirm the associ- ation of Helicobacter species DNA in the liver of CHC patients with advanced liver disease. The lack of correlation between positive H pylori serology and the presence of H pylori-like DNA in the liver may indicate the presence of a variant of this species. | Laurent Castéra Anne Pedeboscq Marcia Rocha Brigitte Le Bail Corinne Asencio Victor de Lédinghen Pierre-Henri Bernard Christophe Laurent Marie-Edith Lafon Maylis Capdepont Patrice Couzigou Paulette Bioulac-Sage Charles Balabaud FrancisMégraud Armelle Ménard | 2006 | World Journal of Gastroenterology2006，12，45： | 3 |
| 8 | Aphis (Hemiptera: Aphididae) species groups found in the Midwestern United States and their contribution to the phylogenetic knowledge of the genus显示文摘类蚜虫属 Linnaeus 的发展史, 1 758 首先从在美国的中西部收集的标本被造。一个数据矩阵与有翼、无翅的胎生的女性的各自的字符国家与 68 种类和 41 个词法字符被构造。用 UPGMA (有算术平均数的未加权的对组方法) 执行的分析的 Dendrogram 拓扑学,最大的吝啬和细胞色素 Oxidase 的贝叶斯的分析我,延伸因素 1-α
并且主要 endosymbiont Buchnera aphidicola 16S 序列不适合。贝叶斯的分析强烈支持了种系发生的树的大多数终端节点。发展史被 COI 的 EF1-α 和 EF1-α 强烈支持分子的数据与词法人物结合了。它没被 COI 或 Buchnera aphidicola 16S 的单个分析支持。从贝叶斯的发展史的结果给 4 个主要种类组看:asclepiadis, fabae, gossypii,和 middletonii。结果地方蚜虫属和类 Protaphis Börner 的种类, 1952, Toxoptera Koch, 1856 并且 Xerobion Nevsky, 1928 在 monophyletic clade。词法人物也 monophyly 支持这。发展史证明北美的 middletonii 种类组的 monophyletic clade 属于类 Protaphis:P。debilicornis (吉勒特与帕尔默, 1929 ) ,梳子。nov, P。echinaceae (拉各斯和 Voegtlin, 2009 ) ,梳子。nov,和 P。middletonii (托马斯, 1879 ) 。类 Toxoptera 应该被认为蚜虫属的亚属(stat。nov ) 。分析也显示当前的类 Iowana Frison, 1954 应该被认为蚜虫属的亚属(stat。nov ) 。 | Doris M. Lagos David J. Voegtlin Armelle Coeur d'aciert Rosanna Giordano | 2014 | Insect Science2014，21，3： | 2 |
| 9 | Regulatory and Functional Aspects of Indolic Metabolism in Plant Systemic Acquired Resistance显示文摘导出色氨酸, indolic 代谢物在 Arabidopsis 天生的免疫拥有多样的功能到微生物引起的病原体感染。这里,我们在全身的获得的抵抗(SAR ) 由细菌的病原体 Pseudomonas syringae 触发了的 Arabidopsis 调查功能的角色和 indolic 新陈代谢的规章的特征。Indolic 新陈代谢广泛地在两 P 被激活。接种 syringae 、远,非接种的叶子。在接种地点, camalexin, indol-3-ylmethylamine (I3A ) ,和 indole-3-carboxylic,酸(集成通信适配器) 是主要积累混合物。Camalexin 累积被 MYB122,和细胞色素 P450 基因 CYP81F1 和 CYP81F2 断然影响。由对比,本地 I3A 生产由 PEN2- 依赖、独立的小径经由吲哚 glucosinolate 故障发生。而且,防卫荷尔蒙水杨酸酸的外长的申请在损坏它的先锋的情况下刺激 I3A 产生 indol-3-ylmethylglucosinolate (I3M ) ,和 SAR 管理者 pipecolic 酸为提高的 P 告知植物。indolic 新陈代谢的不同分支的导致 syringae 的激活。在 uninfected 全身的织物,新陈代谢的反应与 indolics I3A,集成通信适配器,和 indole-3-carbaldehyde (国际计算中心) 的提高的层次更特定、联系。全身的吲哚累积充分取决于功能的 CYP79B2/3, PEN2,和 MYB34/51/122,并且要求功能的 SAR 发信号。基因分析建议全身地提高的吲哚为 SAR 是非必需的并且联系水杨酸酸的全身的增加。然而,土壤成年然而并非水耕法地栽培的 cyp79b2/3 和 pen2 种,在 indolic 有缺点的两个第二等的新陈代谢,展出预先导致的免疫,它废除他们的内在的能力导致 SAR。 | Elia Stahl Patricia Bellwon Stefan Huber Klaus Schlaeppi Friederike Bernsdorff Armelle Vallat-Michel Felix Mauch Jurgen Zeier | 2016 | Molecular Plant2016，9，5： | 2 |
| 10 | Comparison and relative quality assessment of the GLC2000, GLOBCOVER, MODIS and ECOCLIMAP land cover data sets at the African continental scale显示文摘 | Armel Thibaut Kaptué Tchuenté Jean-Louis Roujean Steven M. De Jong | 2010 | International Journal of Applied Earth Observations and Geoinformation2010，，2： | 2 |
| 11 | Trace metals as paleoredox and paleoproductivity proxies: An update显示文摘 | Nicolas Tribovillard Thomas J. Algeo Timothy Lyons Armelle Riboulleau | 2006 | Chemical Geology2006，，1： | 2 |
| 12 | Importance and Role of Biodiversity and Tropical Forests in the Cultural, Socio-Economic and Religious Life of African Black People: Case of Benin显示文摘 | Adjovi Edmond Codjo Amadji Togbe Armel Olodo Emmanuel | 2017 | Journal of Environmental Science and Engineering(B)2017，6，6： | 1 |
| 13 | Antimicrobial activity of the crude extracts and five flavonoidsfrom the twigs of Dorstenia barteri (Moraceae) 显示文摘 | Armelle T M Bathelemt N Victor K | 2008 | Journal of Ethhop Harmacology2008，116，： | 1 |
| 14 | Integration of cell attachment, cytoskeletal localization, and signaling by integrinlinked kinase (ILK) ,CH -ILKBP and the tumor suppressor PTEN显示文摘 | Sarah A Julia M Armelle T | 2003 | Mol Biol Cell2003，14，12： | 1 |
| 15 | Extended Hopfield models for combinatorial optimization显示文摘 | Vassilis Z | 1999 | IEEE Transactions on Neural Networks1999，10，1： | 1 |
| 16 | Leaf tissue pigments and chlorophyll fluorescence parameters vary among sweet corngenotypes of differential herbicidesensitivity 显示文摘 | Kopsell D A Armel G R Abney K R | 2011 | Pest Biochem Physiol2011，99，： | 1 |
| 17 | Signaling pathways bridging fate determination of neural crest cells to glial lineages in the developing peripheral nervous system显示文摘 | Maulilio John Kipanyula Wahabu Hamisi Kimaro Faustin N. Yepnjio Yousef H. Aldebasi Mohammed Farahna Armel Herve Nwabo Kamdje Eltuhami M. Abdel-Magied Paul Faustin Seke Etet | 2013 | Cellular Signalling2013，，： | 1 |
| 18 | The Late Frasnian Kellwasser horizons of the Harz Mountains (Germany): Two oxygen-deficient periods resulting from different mechanisms显示文摘 | Laurent Riquier Nicolas Tribovillard Olivier Averbuch Xavier Devleeschouwer Armelle Riboulleau | 2006 | Chemical Geology2006，，1： | 1 |
| 19 | Novel Functions for Mucosal SIg A显示文摘 | Armelle Phalipon Blaise Corthésy | 1998 | Mucosal Immune Defense:Immunoglobulin A1998，167，： | 1 |
| 20 | Performance measurement in R&D and new product development: setting the scene 显示文摘 | Klas Eric Soderquist Armelle Godener | 2004 | International Journal of Business Performance Management2004，2004，： | 1 |
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