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| 1 | Developmental pathways associated with cancer metastasis:Notch,Wnt,and Hedgehog显示文摘Master developmental pathways, such as Notch, Wnt, and Hedgehog, are signaling systems that control proliferation, cell death,motility, migration, and stemness. These systems are not only commonly activated in many solid tumors, where they drive or contribute to cancer initiation, but also in primary and metastatic tumor development. The reactivation of developmental pathways in cancer stroma favors the development of cancer stem cells and allows their maintenance, indicating these signaling pathways as particularly attractive targets for efficient anticancer therapies, especially in advanced primary tumors and metastatic cancers. Metastasis is the worst feature of cancer development. This feature results from a cascade of events emerging from the hijacking of epithelial-mesenchymal transition, angiogenesis, migration, and invasion by transforming cells and is associated with poor survival, drug resistance, and tumor relapse. In the present review, we summarize and discuss experimental data suggesting pivotal roles for developmental pathways in cancer development and metastasis, considering the therapeutic potential. Emerging targeted antimetastatic therapies based on Notch, Wnt, and Hedgehog pathways are also discussed. | Armel Herve Nwabo Kamdje Paul Takam Kamga Richard Tagne Simo Lorella Vecchio Paul Faustin Seke Etet Jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera | 2017 | Cancer Biology & Medicine2017，14，2： | 10 |
| 2 | Mesenchymal stromal cells' role in tumor microenvironment:involvement of signaling pathways显示文摘Mesenchymal stromal cells(MSCs) are adult multipotent stem cells residing as pericytes in various tissues and organs where they can differentiate into specialized cells to replace dying cells and damaged tissues. These cells are commonly found at injury sites and in tumors that are known to behave like 'wounds that do not heal.' In this article, we discuss the mechanisms of MSCs in migrating, homing, and repairing injured tissues. We also review a number of reports showing that tumor microenvironment triggers plasticity mechanisms in MSCs to induce malignant neoplastic tissue formation, maintenance, and chemoresistance, as well as tumor growth. The antitumor properties and therapeutic potential of MSCs are also discussed. | Armel Herve Nwabo Kamdje Paul Takam Kamga Richard Tagne Simo Lorella Vecchio Paul Faustin Seke Etet Jean Marc Muller Giulio Bassi Erique Lukong Raghuveera Kumar Goel Jeremie Mbo Amvene Mauro Krampera | 2017 | Cancer Biology & Medicine2017，14，2： | 4 |
| 3 | Adipose-derived stromal cells (ASCs)显示文摘 | Giulio Bassi Luciano Pacelli Roberta Carusone Jasmina Zanoncello Mauro Krampera | 2012 | Transfusion and Apheresis Science2012，，2： | 2 |
| 4 | Immunological properties of embryonic and adult stem cells显示文摘The possibility of treating degenerative diseases by stem cell-based approaches is a promising therapeutical option.Among major concerns for the clinical application of stem cells,some derive from the possibility that stem cells may be rejected by the immune system as a consequence of histoincompatibility and that stem cells themselves may interfere with the normal functions of host immune response.Therefore,the immunogenicity and the immunomodulatory properties of stem cells must be carefully addressed.Although these properties are common features of different stem cell types,some peculiarities can be recognized and characterized for their proper clinical use. | Francesco Bifari Luciano Pacelli Mauro Krampera | 2010 | World Journal of Stem Cells2010，2，3： | 2 |
| 5 | Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide 显示文摘 | Krampera M Glennie S Dyson J | 2003 | Blood2003，101，9： | 1 |
| 6 | Mesenchymal stem cells for bone, cartilage, tendon and skeletal muscle repair?显示文摘 | Krampera M Pizzolo G Aprili G | 2006 | Bone2006，39，4： | 1 |
| 7 | Mesenchy- real stem cells for clinical application 显示文摘 | Sensebe L Krampera M Schrezenmeier H | 2010 | Vox Sang2010，98，2： | 1 |
| 8 | Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen- specific T cells to their cognate peptide 显示文摘 | Krampera M Glennie S Dyson J | 2003 | Blood2003，101，9： | 1 |
| 9 | Mesenchymal stem cells for clinical application 显示文摘 | Senseb6 L Krampera M Schrezenmeier H | 2010 | Vox Sang2010，98，： | 1 |
| 10 | Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide显示文摘 | Krampera M Glennie S Dyson J | 2003 | Blood2003，101，9： | 1 |
| 11 | Bone marrow mesenchymal stem ceils inhibit the response of naive and memory antigen-specific T cells to their cognate peptide 显示文摘 | Krampera M Glennie S Dyson J | 2003 | Blood2003，101，9： | 1 |
| 12 | Bone marrow rnesenchyreal stem ceils inhibit the response of naive and memory antigen - specific T ceils to their cognate peptide显示文摘 | Krampera M Glennie S Dyson J | 2003 | Blood2003，101，9： | 1 |
| 13 | Role for interferon-γ in the immunomodulatory active of human bone marrow mesenchymal stem cells显示文摘 | Krampera M Cosmi L Angeli R | | 0，，： | 1 |
| 14 | Role of the interferon-gamma in the immunomodulatory activity of human mesenchymal stem cells显示文摘 | Krampera M Cosmi L Angeli R | | 0，，02： | 1 |
| 15 | Mesenchyreal stem cells for clinical application 显示文摘 | Sensebé L Krampera M Schrezenmeier H | 2010 | Vox Sang2010，98，： | 1 |
| 16 | Bone marrow mesenchymal stem cells inhibit the response of nal¨lve and memory antigen-specific T cells to their cognate peptide显示文摘 | KRAMPERA M GLENNIE S DYSON J | 2003 | Blood2003，101，： | 1 |
| 17 | Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cell to their cognate peptide 显示文摘 | Krampera M Glennie S Dyson J | 2003 | Blood2003，101，9： | 1 |
| 18 | Bone marrow mesenchymalstem ceils inhibit the response of naive antigen specific T-cells to their cognate peptide显示文摘 | Krampera M Glennie S Dyson J | 2003 | Blood2003，101，9： | 1 |
| 19 | Human Bone-Marrow And Adipose Tissue Mesenchymal Stem Cells:A User's Guide显示文摘 | Mosna F Sensebé L Krampera M | 2010 | Stem Cells Dev2010，19，10： | 1 |
| 20 | Role for interferon-γ in the immunomodulatory active of human bone marrow mesenchymal stem cells显示文摘 | Krampera M Cosmi L Angeli R | 2006 | Stem Cells2006，24，2： | 1 |
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