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| 1 | Systems Biology of Plant-Microbiome Interactions显示文摘In natural environments,plants are exposed to diverse microbiota that they interact with in complex ways.While plant-pathogen interactions have been intensely studied to understand defense mechanisms in plants,many microbes and microbial communities can have substantial beneficial effects on their plant host.Such beneficial effects include improved acquisition of nutrients,accelerated growth,resilience against pathogens,and improved resistance against abiotic stress conditions such as heat,drought,and salinity.However,the beneficial effects of bacterial strains or consortia on their host are often cultivar and species specific,posing an obstacle to their general application.Remarkably,many of the signals that trigger plant immune responses are molecularly highly similar and often identical in pathogenic and beneficial microbes.Thus,it is unclear what determines the outcome of a particular microbe-host interaction and which factors enable plants to distinguish beneficials from pathogens.To unravel the complex network of genetic,microbial,and metabolic interactions,including the signaling events mediating microbe-host interactions,comprehensive quantitative systems biology approaches will be needed. | Patricia A.Rodriguez Michael Rothballer Soumitra Paul Chowdhury Thomas Nussbaumer Caroline Gutjahr Pascal Falter-Braun | 2019 | Molecular Plant2019，12，6： | 20 |
| 2 | Experiments on thermo-hydro-mechanical behaviour of Opalinus Clay at Mont Terri rock laboratory, Switzerland显示文摘Repositories for deep geological disposal of radioactive waste rely on multi-barrier systems to isolate waste from the biosphere.A multi-barrier system typically comprises the natural geological barrier provided by the repository host rock e in our case the Opalinus Clay e and an engineered barrier system(EBS).The Swiss repository concept for spent fuel and vitrified high-level waste(HLW)consists of waste canisters,which are emplaced horizontally in the middle of an emplacement gallery and are separated from the gallery wall by granular backfill material(GBM).We describe here a selection of five in-situ experiments where characteristic hydro-mechanical(HM)and thermo-hydro-mechanical(THM)processes have been observed.The first example is a coupled HM and mine-by test where the evolution of the excavation damaged zone(EDZ)was monitored around a gallery in the Opalinus Clay(ED-B experiment).Measurements of pore-water pressures and convergences due to stress redistribution during excavation highlighted the HM behaviour.The same measurements were subsequently carried out in a heater test(HE-D)where we were able to characterise the Opalinus Clay in terms of its THM behaviour.These yielded detailed data to better understand the THM behaviours of the granular backfill and the natural host rock.For a presentation of the Swiss concept for HLW storage,we designed three demonstration experiments that were subsequently implemented in the Mont Terri rock laboratory:(1)the engineered barrier(EB)experiment,(2)the in-situ heater test on key-THM processes and parameters(HE-E)experiment,and(3)the full-scale emplacement(FE)experiment.The first demonstration experiment has been dismantled,but the last two ones are on-going. | Paul Bossart David Jaeggi Christophe Nussbaum | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，3： | 3 |
| 3 | Novel Aspects of Mevalonate Pathway Inhibitors as Antitumor Agents显示文摘 | Martin Thurnher Oliver Nussbaumer Georg Gruenbacher | 2012 | Clinical Cancer Research2012，，13： | 2 |
| 4 | Defining the Learning Curve for Team-Based Laparoscopic Pancreaticoduodenectomy显示文摘 | Paul J. Speicher Daniel P. Nussbaum Rebekah R. White Sabino Zani Paul J. Mosca Dan G. Blazer Bryan M. Clary Theodore N. Pappas Douglas S. Tyler Alexander Perez | 2014 | Annals of Surgical Oncology2014，，12： | 2 |
| 5 | Reperfusion injury after focal cerebral ischemia:the role of inflammation and the therapeutic horizon显示文摘 | Jean WC Spellman SR Nussbaum ES | 1998 | Neurosurgery1998，43，6： | 2 |
| 6 | Pediatric bronchoscopy with a laryneal mask airway显示文摘 | Nussbaum E Lagnoev M | 2001 | Chest2001，120，： | 1 |
| 7 | Experimental study on the fatigue behaviour of welded tubular K-joints for bridges 显示文摘 | Ann Schumacher Alain Nussbaumer | 2006 | Engineer Structures2006，28，： | 1 |
| 8 | Mitogenicity of the recombinant myco- bacterial 27-kilodalton lipoprotein is not connected to its anti- protective effect 显示文摘 | Hovav AH Davidoviteh L Nussbaum G Mullerad J Fish- man Y Bercovier H | 2004 | Infect Immun2004，72，6： | 1 |
| 9 | Using the World Wide Web for predicting CTL epitopes显示文摘 | Nussbaum A K Kuttler C Tenzer S | 2003 | Curr Opin Immunol2003，15，1： | 1 |
| 10 | Simple FFT and DCT Algotithms with Reduced Number of Operations显示文摘 | Vetterli M Nussbaumer H | 1984 | Signal Processing1984，6，4： | 1 |
| 11 | Molecular confirmation of carriers for Lowe syndrome显示文摘 | Lin T Lewis RA Nussbaum RL | 1999 | Ophthalmology1999，106，1： | 1 |
| 12 | Strengthening mechanisms in the rapidly solidified AZ91 magnesium alloy显示文摘 | NUSSBAUM G SAINFORT P REGAZZONI G | 1989 | Scripta Metallurgiea1989，23，7： | 1 |
| 13 | Multifactorial index of cardiac risk in non-cardiac surgical procedures显示文摘 | Goldman L Calder D L Nussbaum S R | 1977 | N Eng J Med1977，297，16： | 1 |
| 14 | Radiographic demonstration of unknown sites of gastrointestinal bleeding显示文摘 | Nussbaum M Baum S | 1963 | Surgery1963，14，： | 1 |
| 15 | Dose- response study of alendronate sodium for the treatment of cancer-associated hypercalcemia显示文摘 | Nussbaum SR | 1993 | J Clin Oncol1993，11，8： | 1 |
| 16 | Identification, localization and characterization of the human γ-synuclein gene显示文摘 | Christian Lavedan Elisabeth Leroy Anindya Dehejia Stephanie Buchholtz Amalia Dutra Robert L. Nussbaum M. H. Polymeropoulos | 1998 | Human Genetics1998，，1： | 1 |
| 17 | Laquinimod modulates B cells and their regulatory effects on T cells in multiple sclerosis显示文摘 | Toubi E Nussbaum S Staun-Ram E | 2012 | J Neuroimmunol2012，251，12： | 1 |
| 18 | Long-term evaluation of extended thymectomy with anterior mediastinal dissection for myasthenia gravis显示文摘 | Lawrence E. Stern Michael S. Nussbaum John G. Quinlan Josef E. Fischer | 2001 | Surgery2001，，4： | 1 |
| 19 | Multiple intracranial aneurysms as delayed complications of an atrial myxoma:case report显示文摘 | Jean WC Walski-Easton SM Nussbaum ES | 2001 | Neurosurgery2001，49，1： | 1 |
| 20 | Strengthening Mechaniums in the Rapidly Solidified AZ Magnesium Alloy显示文摘 | Sainfort P Regazzoni G | 1989 | Scripta Metallurgica1989，，23： | 1 |
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