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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Multifactorial index of cardiac risk in non-cardiac surgical procedures显示文摘 | Goldman L Calder D L Nussbaum S R | 1977 | N Eng J Med1977，297，16： | 1 |
| 3 | DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children 显示文摘 | Pérez-Maldonado IN D??az-Barriga F de la Fuente H González-Amaro R Calderón J Yá?ez L | 2004 | Environ Res2004，94，1： | 1 |
| 4 | Apoptosis-a significant cause of bone cell death in osteonecrosis of the femoral head显示文摘 | CALDER J D BUTTERY L REVELL P A | 2004 | J Bone Joint Surg Br2004，86，8： | 1 |
| 5 | Incidence of adverse biological effects within ranges of chemical concentrations in marine and estuary sediments 显示文摘 | Long E R MacDonald D D Smith S L Calder F D | 1995 | Environ Manage1995，19，： | 1 |
| 6 | Responsiveness of bovine cumulus-oocyte-complexes (COC) to porcine and recombinant human FSH, and the effect of COC quality on gonadotropin receptor and Cx43 marker gene mRNAs during maturation in vitro 显示文摘 | Calder M D Caveney A N Smith L C | 2003 | Reproductive Biology and Endocrinology2003，1，1： | 1 |
| 7 | A Review of formal theories of consumer socialization 显示文摘 | ] ROEDDER D L DIDOW N M CALDER B J | 1978 | Advances in Consumer Re- search1978，，5： | 1 |
| 8 | Results of isolated Lisfranc injuries and the effect of compensation claims显示文摘 | Calder J D Whitehouse S L Saxby T S | 2004 | J Bone Joint Surg Br2004，86，4： | 1 |
| 9 | Results of isolated Lis- franc injuries and the effect of compensation claims 显示文摘 | Calder J D Whitehouse S L Saxby T S | 2004 | J Bone Joint Surg Br2004，86，4： | 1 |
| 10 | A double-blind, randomized placebo-controllcd, parallel study to determine the efficacy of topiramate in theprophylactic treatment of Mmgraine 显示文摘 | Potter D L Hart D E Calder C S | 2000 | Neurology2000，54，3： | 1 |
| 11 | Natural trace metal concentrations in estuarine and coastal marine sediments of the southeastern United States显示文摘 | WINDOM H L SCHROPP S J CALDER F D | 1989 | Environmen- tal Science ~ Technology1989，23，31： | 1 |
| 12 | A comparative study of the turbulent Rayleigh-Taylor instability using high-resolution three-dimensional numerical simulations: the Alpha-Group collaboration 显示文摘 | Dimonte G Youngs D L Dimits A Weber S Marinak M Wunsch S Garasi C Robinson A Andrews M J Ramaprabhu P Calder A C Fryxell B Biello J Dursi L MacNeice P Olson K Ricker P Rosner R Timmes F Tufo H Young Y N Zingale M | 2004 | Physics of Fluids2004，16，5： | 1 |
| 13 | Indentification and characterization of cells infiltrating the graft and aqueous humour in rat allograft rejection显示文摘 | LARKIN D F CALDER V L LIGHTMAN S L | 1997 | Clin Exp Immunol1997，107，2： | 1 |
| 14 | Motor Unit Potential Morphology Differences in Individuals with Non-Specific Arm Pain and Lateral Epicondylitis显示文摘 | Calder K M Stashuk D W Mclean L | 2008 | J Neuroeng Rehabil( S1743-0003 )2008，5，： | 1 |
| 15 | Identification and characterization of cells infiltrating the graft and aqueous hu- mour in rat corneal allograft rejection 显示文摘 | Larkin D F Calder V L Lightman S L | 1997 | Clin Exp Immu- nol1997，107，2： | 1 |
| 16 | Natural trace metal concentrations in estuarine and coastal marine sediments of the southeastem United States 显示文摘 | Windom H L Schropp S J Calder F D | 1989 | Environmental Science and Teehnology1989，23，： | 1 |
| 17 | Induction of abortion with mifepristone (RU486) and oral or vagianl misoprostol显示文摘 | El-Refaey H Rajasekar D Alxalia M Calder L ana Templeton A | 1995 | N Engl J Med1995，332，： | 1 |
| 18 | The role of dopamine and GABA in the frontal cortex of mice in modulating a motor-stimulant effect of amphetamine and cocaine显示文摘 | Karler R Calder L D Thai D K | 1998 | Pharmacol Biochem Behav1998，60，1： | 1 |
| 19 | Natural trace metal concentrations in estuarine and coastal marine sediments of the southeastern United States显示文摘 | Windom H L schropp S J Calder F D | 1989 | Environmental Science and Technology1989，23，： | 1 |
| 20 | Responsive-ness of bovine cumulus-oocyte-complexes(COC)to porcine and recombinant human FSH,and the effect of COC quality on ganado-tropin receptor and Cx43 marker gene mRNAs during maturation in vitro显示文摘 | CALDER M D CAVENEY A N SMITH L C | 2003 | Reprod Biol Endocrinol2003，1，： | 1 |
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