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| 1 | Multicenter study of endoscopic preoperative biliary drainage for malignant distal biliary obstruction显示文摘AIM: To determine the optimal method of endoscopic preoperative biliary drainage for malignant distal biliary obstruction.METHODS: Multicenter retrospective study was conducted in patients who underwent plastic stent(PS) or nasobiliary catheter(NBC) placement for resectable malignant distal biliary obstruction followed by surgery between January 2010 and March 2012. Procedurerelated adverse events, stent/catheter dysfunction(occlusion or migration of PS/NBC, developmentof cholangitis, or other conditions that required repeat endoscopic biliary intervention), and jaundice resolution(bilirubin level < 3.0 mg/d L) were evaluated. Cumulative incidence of jaundice resolution and dysfunction of PS/NBC were estimated using competing risk analysis. Patient characteristics and preoperative biliary drainage were also evaluated for association with the time to jaundice resolution and PS/NBC dysfunction using competing risk regression analysis.RESULTS: In total, 419 patients were included in the study(PS, 253 and NBC, 166). Primary cancers included pancreatic cancer in 194 patients(46%), bile duct cancer in 172(41%), gallbladder cancer in three(1%), and ampullary cancer in 50(12%). The median serum total bilirubin was 7.8 mg/d L and 324 patients(77%) had ≥ 3.0 mg/d L. During the median time to surgery of 29 d [interquartile range(IQR), 30-39 d]. PS/NBC dysfunction rate was 35% for PS and 18% for NBC [Subdistribution hazard ratio(SHR) = 4.76; 95%CI: 2.44-10.0, P < 0.001]; the pig-tailed tip was a risk factor for PS dysfunction. Jaundice resolution was achieved in 85% of patients and did not depend on the drainage method(PS or NBC).CONCLUSION: PS has insufficient patency for preoperative biliary drainage. Given the drawbacks of external drainage via NBC, an alternative method of internal drainage should be explored. | Naoki Sasahira Tsuyoshi Hamada Osamu Togawa Ryuichi Yamamoto Tomohisa Iwai Kiichi Tamada Yoshiaki Kawaguchi Kenji Shimura Takero Koike Yu Yoshida Kazuya Sugimori Shomei Ryozawa Toshiharu Kakimoto Ko Nishikawa Katsuya Kitamura Tsunao Imamura Masafumi Mizuide Nobuo Toda Iruru Maetani Yuji Sakai Takao Itoi Masatsugu Nagahama Yousuke Nakai Hiroyuki Isayama | 2016 | World Journal of Gastroenterology2016，22，14： | 18 |
| 2 | Influence of synovia constituents on tribological behaviors of articular cartilage显示文摘The extremely low friction and minimal wear in natural synovial joints appear to be established by effective lubrication mechanisms based on appropriate combination of articular cartilage and synovial fluid.The complex structure of cartilage composed of collagen and proteoglycan with high water content contributes to high load-carrying capacity as biphasic materials and the various constituents of synovial fluid play important roles in various lubrication mechanisms.However,the detailed differences in functions of the intact and damaged cartilage tissues,and the interaction or synergistic action of synovia constituents with articular cartilage have not yet been clarified.In this study,to examine the roles of synovia constituents and the importance of cartilage surface conditions,the changes in friction were observed in the reciprocating tests of intact and damaged articular cartilage specimens against glass plate lubricated with lubricants containing phospholipid,protein and/or hyaluronic acid as main constituents in synovial fluid.The effectiveness of lubricant constituents and the influence of cartilage surface conditions on friction are discussed.In addition,the protectiveness by synovia constituents for intact articular cartilage surfaces is evaluated. | Teruo MURAKAMI Seido YARIMITSU Kazuhiro NAKASHIMA Yoshinori SAWAE Nobuo SAKAI | 2013 | Friction2013，1，2： | 7 |
| 3 | Biomimetic artificial cartilage:fibre-reinforcement of PVA hydrogel to promote biphasic lubrication mechanism显示文摘The fibre-reinforced structure in synovial articular cartilage plays an important role in enhancing the fluid load support in the biphasic lubrication mechanism.Poly(vinyl alcohol)(PVA)hydrogel is a potential biomimetic articular cartilage material.In this study,PVA hydrogel was reinforced with PVA fibres to improve its frictional properties.By computational analysis,the position of the PVA fibre layer was examined with a migrating contact condition to reduce the friction coefficient.To improve the fibre reinforcement,a method for fibre placement was developed to retain the initial strain of the fibre in the hydrogel matrix.The experimental results showed that the fibre-reinforced PVA hydrogel with a surface fibre layer had a low friction coefficient of 0.031 in pure water.The fibre-reinforced PVA hydrogel successfully reduced friction coefficient. | Nobuo Sakai Seido Yarimitsu Yoshinori Sawae Mochimitsu Komori Teruo Murakami | 2019 | Biosurface and Biotribology2019，5，1： | 3 |
| 4 | Liposome-encapsulated hemoglobin (hemoglobin-vesicle) is not transferred from mother to fetus at the late stage of pregnancy in the rat model显示文摘 | Maiko Kaga Heng Li Hidenobu Ohta Kazuaki Taguchi Shigeru Ogaki Hitomi Izumi Masumi Inagaki Shigeru Tsuchiya Kunihiro Okamura Masaki Otagiri Hiromi Sakai Nobuo Yaegashi | 2012 | Life Sciences (-)2012，，11： | 1 |
| 5 | Effects of BLS training on factors associated with attitude toward CPR in college students显示文摘 | Shinya Hamasu Takeshi Morimoto Nobuo Kuramoto Masahito Horiguchi Taku Iwami Chika Nishiyama Kaori Takada Yoshie Kubota Susumu Seki Yuko Maeda Yoshiharu Sakai Atsushi Hiraide | 2008 | Resuscitation2008，，3： | 1 |
| 6 | Central administration of saikosaponin-d increases corticotropin-releasing factor mRNA levels in the rat hypothalamus显示文摘 | Izumi Dobashi Fumiko Tozawa Nobuo Horiba Yohko Sakai Ken Sakai Toshihiro Suda | 1995 | Neuroscience Letters1995，，3： | 1 |
| 7 | Transitional behaviour between biphasic lubrication and soft elastohydrodynamic lubrication of poly(vinyl alcohol)hydrogel using microelectromechanical system pressure sensor显示文摘The soft hydrogel material is expected for a candidate material as biomimetic artificial cartilage with synergisticfunctionalities of adaptive multimode lubrication.In boundary lubrication mode of hydrogel material,the biphasiclubrication mechanism cooperatively exerts its functionality.In hydrodynamic lubrication mode,it is preferable that thelubricating surfaces be impermeable to trap the fluid pressure in contact surfaces,whereas the actual biphasic materiallike a hydrogel is a permeable material with surface porosity.lt is indicated that the interstitial fluid pressurisation inthe permeable biphasic material can contribute to significant fluid load support under lower sliding speed condition.So,the authors examined how the contrary fluid pressure effect appears in the transition from the boundarylubrication mode to soft elastohydrodynamic lubrication mode.In the experiment,a small pressure sensor was utilisedto measure the in-situ fluid pressure in sliding condition.Although the experimental condition of this study wasselective,the result showed a possibility of the negative effect of the biphasic surface,in which the permeable surfacediminished the hydrodynamic fluid pressure.This means that one should manage and enhance the biphasic lubricationabilities in wide operation range when the hydrogel material was used as a load bearing material. | Nobuo Sakai Seido Yarimitsu Yoshinori Sawae Mochimitsu Komori Teruo Murakami | 2018 | Biosurface and Biotribology2018，4，1： | 1 |
| 8 | A large-scale nationwide multicenter prospective observational study of triple therapy using rabeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in Japan显示文摘 | Toshio Fujioka Nobuo Aoyama Kyoko Sakai Yoshiyuki Miwa Mineo Kudo Junichi Kawashima Yasuo Matsubara Jun Miwa Koji Yakabi | 2012 | Journal of Gastroenterology2012，，3： | 1 |
| 9 | A large-scale nationwide multicenter prospective observational study of triple therapy using rabeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in Japan显示文摘 | Toshio Fujioka Nobuo Aoyama Kyoko Sakai Yoshiyuki Miwa Mineo Kudo Junichi Kawashima Yasuo Matsubara Jun Miwa Koji Yakabi | 2012 | Journal of Gastroenterology2012，，3： | 1 |
| 10 | Erratum to: Influence of synovia constituents on tribological behaviors of articular cartilage显示文摘Erratum to Friction 1(2):150-162(2013)DOI 10.1007/s40544‐013‐0010‐6 The original version of this article unfortunately contained the incorrect lengend“HA 0.5 wt%+DPPC 0.01 wt%+albumin 1.4 wt%”in Fig.7 on page 155,instead of. | Teruo MURAKAMI Seido YARIMITSU Kazuhiro NAKASHIMA Yoshinori SAWAE Nobuo SAKAI | 2014 | Friction2014，2，4： | 0 |
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